Combination of aztreonam, ceftazidime–avibactam and amikacin in the treatment of VIM-1 Pseudomonas aeruginosa ST235 osteomyelitis

2021

Abstract We describe a challenging case of patient with metallo-beta-lactamase-producing Pseudomonas aeruginosa sternal osteomyelitis following aortic valve replacement with biological prosthesis. The strain exhibited a multidrug-resistance phenotype carrying the blaVIM-1 gene and belonged to the high-risk clone sequence type ST235. The patient was successfully treated with surgical debridement plus antibiotic therapy with ceftazidime/avibactam, aztreonam, and amikacin. Time-kill curves showed that this triple antibiotic combination at 1 × MIC was strongly synergic after 8 h, achieving 99.9% killing and maintaining this until 48 h.

Dendrolatrie. Miti e pratiche dell'immaginario arboreo

2021

L’avvento dell’Antropoce, epoca in cui l’essere umano è diventato una forza geologica, scompagina la divisione del sapere tra scienze umane e naturali. Per comprenderlo, è necessario costruire nuove forme di alleanza tra discipline. È quanto invita a fare anche il fe- nomeno delle dendrolatrie. Diffuso in ogni luogo e in ogni epoca, il culto degli alberi testimonia come il mondo arboreo abbia plasma- to modi di vivere e di pensare, venendone a sua volta trasformato. Per scavare nella complessità di questo scambio, il volume racco- glie i frutti del dialogo tra un gruppo interdisciplinare di ricercatrici e ricercatori che esplorano l’immaginario arboreo in tre direzioni: quella degli studi s…

Today Is My Day: Analysis of the Awareness Campaigns’ Impact on Functional Diversity in the Press, on Google, and on Twitter

2021

(1) Every day, people with functional diversity face different kinds of difficulties that pose a barrier to their social inclusion. These difficulties often go unnoticed by most citizens. Social networks are a powerful tool to sensitize the population. With this objective, different organizations such as associations, federations, foundations, and other institutions have promoted campaigns through the celebration of world days for different types of functional diversity. This research aims to monitor and analyze the impact of these social campaigns in Spain, including Asperger’s syndrome, rare diseases, Down syndrome, autism, hearing and visual impairment, cerebral palsy, dyslexia, ADHD, sp…

Age-dependency in mortality of family caregivers : a nationwide register-based study

2021

Abstract Background Evidence on family caregivers' health is conflicting. Aim To investigate all-cause and cause-specific mortality in Finnish family caregivers providing high-intensity care and to assess whether age modifies the association between family caregiver status and mortality using data from multiple national registers. Methods The data include all individuals, who received family caregiver's allowance in Finland in 2012 (n = 42,256, mean age 67 years, 71% women) and a control population matched for age, sex, and municipality of residence (n = 83,618). Information on dates and causes of death between 2012 and 2017 were obtained from the Finnish Causes of Death Register. Results F…

Focal liver lesions: interobserver and intraobserver agreement of three-dimensional contrast-enhanced ultrasound-assisted volume measurements

2021

Purpose: This study was conducted to assess the interobserver and intraobserver agreement of three-dimensional contrast-enhanced ultrasound (3D-CEUS) volume calculations of focal liver lesions (FLLs).Methods: Thirty-nine patients (15 men and 24 women; mean age, 55.4 years) with 39 Flis (mean size, 3.1 +/- 1.8 cm; size range, 1 to 8 cm) prospectively underwent 3D-CEUS. Four readers calculated the volume of each lesion in an independent and blinded fashion in two separate sessions by means of a semi-automatic, commercially available proprietary software. The differences in lesion volumes (cm(3)) among sessions and readers were assessed using the Mann-Whitney U test and the Kruskal-Wallis test…

Qu’est-ce que la mobilité sociale ?

2021

International audience

Why retail investors traded equity during the pandemic? An application of artificial neural networks to examine behavioral biases

2021

Behavioral biases are known to influence the investment decisions of retail investors. Indeed, extant research has revealed interesting findings in this regard. However, the literature on the impact of these biases on millennials' trading activity, particularly during a health crisis like the COVID-19 pandemic, as well as the equity recommendation intentions of such investors, is limited. The present study addressed these gaps by investigating the influence of eight behavioral biases: overconfidence and self-attribution, over-optimism, hindsight, representativeness, anchoring, loss aversion, mental accounting, and herding on the trading activity and recommendation intentions of millennials …

P–543 Inhibition of cell proliferation and extracellular matrix formation in human uterine leiomyomas by 5-aza–2’-deoxycitidine via Wnt/ β-catenin pa…

2021

Abstract Study question Is DNA methylation reversion through DNA methyltransferases (DNMT) inhibitors, such as 5-aza–2’-deoxycitidine, a potential therapeutic option for treatment of patients with uterine leiomyomas (UL)? Summary answer 5-aza–2’-deoxycitidine reduces proliferation and extracellular matrix (ECM) formation by inhibition of Wnt/ β-catenin pathway on UL cells, suggesting DNMT inhibitors as an option to treat UL. What is known already: UL is a multifactorial disease with an unclear pathogenesis and inaccurate treatment. Aberrant DNA methylation have been found in UL compared to myometrium (MM) tissue, showing hypermethylation of tumor suppressor genes, which contributes to the d…

A model for estimating the health economic impact of earlier diagnosis of chronic thromboembolic pulmonary hypertension

2021

Background Diagnostic delay of chronic thromboembolic pulmonary hypertension (CTEPH) exceeds 1 year, contributing to higher mortality. Health economic consequences of late CTEPH diagnosis are unknown. We aimed to develop a model for quantifying the impact of diagnosing CTEPH earlier on survival, quality-adjusted life-years (QALYs) and healthcare costs. Material and methods A Markov model was developed to estimate lifelong outcomes, depending on the degree of delay. Data on survival and quality of life were obtained from published literature. Hospital costs were assessed from patient records (n=498) at the Amsterdam UMC – VUmc, which is a Dutch CTEPH referral center. Medication costs were ba…

RIGENERAZIONE URBANA E PATRIMONIO IMMOBILIARE PUBBLICO

2021

Rehabilitation and/or redevelopment of the built heritage is a strategy for urban and territorial balance. The rehabilitation project is mainly addressed to the adaptation of new housing and urban needs, but it is obviously conditioned and/or "constrained" by the limitation of the building itself, in particular when its intrinsic characteristics must be preserved. The concept of "restriction" extends to its relationship with the site, the quality of its image, its living conditions. In this paper we focus on some aspects of the general framework of urban regeneration: the balance on the "urban question" and on the methodology of integrated planning; the connection between quality and urban …

P–074 Chromatin Maturity Index (CMI) in unfixed and live spermatozoa and Aniline Blue (AB) stained as an additional evaluation parameter in idiopathi…

2021

Abstract Study question To investigate whether idiopathic male infertility may be due to the presence of histones in motile spermatozoa using a modified AB staining protocol. Summary answer No correlation between CMI in live motile spermatozoa, DNA Fragmentation Index (DFI) and other conventional seminal parameters were found in male infertile patients. What is known already The AB stain discriminates between lysine-rich histones and arginine/cysteine-rich protamines. Transition from histones to protamines during spermatogenesis remodels chromatin packaging and abnormalities in the substitution of those proteins maybe interfere with seminal parameters and affect male infertility. The correl…

P-152 Sarcopenia in advanced colorectal cancer patients treated with trifluridine/tipiracil

2021

Pupils' Creative Self-Expression in Visual Art

2021

The study is devoted to the organization of the teaching/learning content of visual art and self-expression process in practice. The article, based on theory, explains creative self-expression in the context of pupil's meaningful learning, based on the new education policy and the developed guidelines in basic education. The individual experience of prospective primary school teachers and their understanding of self-expression in visual art has been clarified during the reflection and pedagogical observation in the study process in methods of teaching visual art which led to stating the research problem. The theoretical account offered in the article reveals pedagogical possibilities for pr…

Higgs-like spectator field as the origin of structure

2021

We show that the observed primordial perturbations can be entirely sourced by a light spectator scalar field with a quartic potential, akin to the Higgs boson, provided that the field is sufficiently displaced from vacuum during inflation. The framework relies on the indirect modulation of reheating, which is implemented without any direct coupling between the spectator field and the inflaton and does not require non-renormalisable interactions. The scenario gives rise to local non-Gaussianity with $f_{\rm NL}\simeq 5$ as the typical signal. As an example model where the indirect modulation mechanism is realised for the Higgs boson, we study the Standard Model extended with right-handed neu…

DISSIMMETRIA DI POTERE. SPAZIO PUBBLICO EGUALITARIO VS. SPAZIO PRIVATO AUTORITARIO

2021

In this article, Segreto deepens the birth of the Individual at the Polis time. The Role of the Kratos, the public space in the Demos of the Polis, the private sphere of Oikos, are analyzed in the light of the Gender differeence.

Abstract CT217: Phase I, first-in-human trial evaluating BI 1387446 (STING agonist) alone and in combination with ezabenlimab (BI 754091; anti-PD-1) …

2021

Abstract Background/Purpose Activation of the stimulator of interferon genes (STING) pathway in intratumoral immune cells leads to increased type I interferon production, promoting recruitment and priming of T-cells against tumor antigens and triggering anti-tumor activity. In patients with cancer, STING agonists have shown clinical activity, with effects increased when combined with an anti-programmed cell death [PD]-1 antibody. BI 1387446 potently and highly selectively activates the STING pathway; ezabenlimab (BI 754091) is a humanized IgG4 anti-PD-1 monoclonal antibody. Tumor regression and enhanced activity of anti-PD-1 therapy was observed after BI 1387446 administration in syngeneic …

Decoupling on the Wiener Space, Related Besov Spaces, and Applications to BSDEs

2021

We introduce a decoupling method on the Wiener space to define a wide class of anisotropic Besov spaces. The decoupling method is based on a general distributional approach and not restricted to the Wiener space. The class of Besov spaces we introduce contains the traditional isotropic Besov spaces obtained by the real interpolation method, but also new spaces that are designed to investigate backwards stochastic differential equations (BSDEs). As examples we discuss the Besov regularity (in the sense of our spaces) of forward diffusions and local times. It is shown that among our newly introduced Besov spaces there are spaces that characterize quantitative properties of directional derivat…

Study of phase composition, photocatalytic activity, and photoluminescence of TiO2 with Eu additive produced by the extraction-pyrolytic method

2021

The Institute of Solid State Physics, University of Latvia as the Center of Excellence has received funding from the H2020-WIDESPREAD-01-2016-2017-TeamingPhase2 under grant agreement No. 739508, project CAMART2. The work was also partially supported by the LZP grant 2020/2-0074. R. Burve has been supported by the project “Synthesis of nanostructured materials based on titanium dioxide and tin dioxide and investigation of their physicochemical properties” Nr. MP-2019/7, for strengthening scientific personnel capacity 2019/2020 at the Riga Technical University. Authors are grateful to Dr. K. Šmits for the microscopic measurements and SEM images.

PROPOSTA DI RIGENERAZIONE E GESTIONE DEGLI SPAZI PUBBLICI NELLA CITTÀ DI KOS, GRECIA

2021

The theme falls within the proposals of strategies, tools and forms of housing and urban regeneration and tackles the case of the city of Kos. There currently the recovery and the enhancement of public space in the city is being attempted, and specifically of those urban areas which have long suffered very strong exploitation pressure by private interests as a result of tourism.

The genre repertoires of Norwegian beauty and lifestyle influencers on YouTube

2021

Abstract YouTube represents an increasingly popular cultural phenomenon in the contemporary Norwegian media landscape. Since the inception of the digital video platform over 15 years ago, personal videoblogging has emerged as one of its dominant types of user-generated content. In this article, I draw from New Rhetoric genre theory and netnographic approaches to explore the beauty and lifestyle sphere on YouTube, in which several emergent genres are situated within a new media ecosystem. Through a qualitative content analysis of seven established Norwegian YouTube channels, a total of 17 individual genres were identified. Furthermore, I elaborate upon how informational, instructional, and c…

Cemiplimab for locally advanced and metastatic cutaneous squamous-cell carcinomas: Real-life experience from the French CAREPI study group

2021

Although cemiplimab has been approved for locally advanced (la) and metastatic (m) cutaneous squamous-cell carcinomas (CSCCs), its real-life value has not yet been demonstrated. An early-access program enrolled patients with la/mCSCCs to receive cemiplimab. Endpoints were best overall response rate (BOR), progression-free survival (PFS), overall survival (OS), duration of response (DOR) and safety. The 245 patients (mean age 77 years, 73% male, 49% prior systemic treatment, 24% immunocompromised, 27% Eastern Cooperative Oncology Group performance status (PS) ≥ 2) had laCSCCs (35%) or mCSCCs (65%). For the 240 recipients of ≥1 infusion(s), the BOR was 50.4% (complete, 21%

Administrative Coding in Electronic Health Care Record‐Based Research of NAFLD: An Expert Panel Consensus Statement

2021

BACKGROUND AND AIMS: Electronic health record (EHR)-based research allows the capture of large amounts of data, which is necessary in nonalcoholic fatty liver disease (NAFLD), where the risk of clinical liver outcomes is generally low. The lack of consensus on which International Classification of Disease (ICD) codes should be used as exposures and outcomes limits comparability and generalizability of results across studies. We aimed to establish consensus among a panel of experts on ICD codes that could become the reference standard and provide guidance around common methodological issues.APPROACH AND RESULTS: Researchers with an interest in EHR-based NAFLD research were invited to collect…

In vitro fertilization and andrology laboratories in 2030

2021

The in vitro fertilization and andrology laboratories are at the center of assisted reproductive technologies and the place where technicians and embryologists manipulate gametes and preimplantation-stage embryos with the goal of achieving the best embryo for transfer. Through the years, these laboratories have seen developments in technique, technology, and testing. The goal of this Views and Interviews series is to bring together the thought leaders in the field and envision what the laboratories will look like in the next 10 years.

Tears evoke the intention to offer social support: A systematic investigation of the interpersonal effects of emotional crying across 41 countries

2021

Tearful crying is a ubiquitous and likely uniquely human phenomenon. Scholars have argued that emotional tears serve an attachment function: Tears are thought to act as a social glue by evoking social support intentions. Initial experimental studies supported this proposition across several methodologies, but these were conducted almost exclusively on participants from North America and Europe, resulting in limited generalizability. This project examined the tears-social support intentions effect and possible mediating and moderating variables in a fully pre-registered study across 7007 participants (24,886 ratings) and 41 countries spanning all populated continents. Participants were prese…

Obtaining antioxidants and natural preservatives from food by-products through fermentation: A review

2021

Industrial food waste has potential for generating income from high-added-value compounds through fermentation. Solid-state fermentation is promising to obtain a high yield of bioactive compounds while requiring less water for the microorganism’s growth. A number of scientific studies evinced an increase in flavonoids or phenolics from fruit or vegetable waste and bioactive peptides from cereal processing residues and whey, a major waste of the dairy industry. Livestock, fish, or shellfish processing by-products (skin, viscera, fish scales, seabass colon, shrimp waste) also has the possibility of generating antioxidant peptides, hydrolysates, or compounds through fermentation. These bioacti…

Abstract 1847: Anti-GARP antibody DS-1055a augments antitumor immunity by depleting highly suppressive GARP+ regulatory T cells

2021

Abstract Immune checkpoint blockers (ICBs) have drastically changed the clinical care of cancer; however, the population of patients who can benefit is relatively small because of intrinsic or acquired resistance to immune therapy. To evade immune destruction, tumors exploit several distinct strategies including immunosuppressive cells such as regulatory T (Treg) cells. Treg cells, an essential component for maintaining self-tolerance, inhibit antitumor immunity, consequently hindering protective cancer immunosurveillance and hampering effective antitumor immune responses in tumor-bearing hosts. It is often reported that a high ratio of Treg cells to effector CD8+ T cells is associated with…

Novel Three-Phase Multilevel Inverter With Reduced Components for Low- and High-Voltage Applications

2021

In this article, a novel multilevel topology for three-phase applications, having three-level and hybrid N -level modular configurations, enabling low-, medium-, and high-voltage operations, is presented. The proposed topology has several attractive features, namely reduced component count, being capacitor-, inductor-, and diode-free, lowering cost, control-complexity, and size, and can operate in a wide range of voltages and powers. Selected simulation and experimental results are presented to verify the performance of the proposed topology. Further, the overall efficiency of the topology and loss distribution in switches are studied. Finally, the key features of the proposed topology in t…

La membership degli ordinariati per gli anglicani dopo la revisione delle Complementary Norms for Apostolic Constitution “Anglicanorum coetibus”.

2021

L’impianto normativo della cost. ap. Anglicanorum coetibus, ha subito ulteriori evoluzioni, per effetto della recente versione delle Norme complementari, emanate dalla Congregazione per la dottrina delle fede il 19 marzo 2019. Particolarmente rilevanti sono gli aggiustamenti riguardanti la composizione degli ordinariati personali per gli anglicani, il cui ambito risulta ora notevolmente ampliato, ben oltre il coetus dei soggetti provenienti dall’anglicanesimo. A tal proposito, il presente contributo si propone di valutare le molteplici implicazioni e ricadute sul piano teoretico della previsione di cui all’art.5 delle sopradette Norme, che nella sua nuova formulazione, consente non solo ai …

Il "Viaggio in inverno" di Franz Schubert

2021

Il testo descrive gli ultimi mesi della vita di Franz Schubert, soffermandosi sulla genesi, i contenuti e la struttura musicale e poetica del ciclo "Winterrreise". The text describes the last months of Franz Schubert's life, focusing on the genesis, contents and musical and poetic structure of the cycle "Winterrreise".

The role of hemostatic devices in neurosurgery. A systematic review.

2021

Hemostasis represents a fundamental step in every surgical procedure. During neurosurgical procedures, proper and robust hemostasis into confined spaces can significantly reduce the odds of perioperative complications. Over the decades, multiple methods have been applied, and several medical devices have been developed to promote and guarantee proper hemostasis. This study presents a systematic review of the most used intraoperative hemostatic methods and devices in neurosurgery. Insightful research was performed on the PubMed database according to the PRISMA guidelines. This comprehensive review of scientific literature represents a synoptic panel where the most used intraoperative hemosta…

Rendimiento de las pruebas complementarias en el estudio de pacientes con dolor abdominal crónico

2021

Resumen: Introducción: El dolor abdominal crónico (DAC) en la infancia es un motivo de consulta frecuente que afecta a la vida familiar, y en ocasiones precisa realización de pruebas complementarias. El objetivo fue realizar el análisis cualitativo, cuantitativo y económico de las pruebas que se solicitan. Pacientes y métodos: Estudio observacional, prospectivo y multicéntrico, incluyendo pacientes entre 4-15 años con DAC. Se diferenciaron 2 grupos: orgánico y funcional. Se recogieron las siguientes variables: clínicas, pruebas complementarias y su coste. Resultados: Se incluyeron 235 niños con DAC (edad media 9,7 ± 2,7 años). Un 79% resultaron trastornos funcionales y un 21% orgánicos. Cas…

A multi-proxy long-term ecological investigation into the development of a late Holocene calcareous spring-fed fen ecosystem (Raganu Mire) and boreal…

2021

Abstract The calcareous substrate of spring-fed fens makes them unique islands of biodiversity, hosting endangered, vulnerable, and protected vascular plants. Hence, spring-fed fens ecosystems require special conservation attention because many of them are destroyed (e.g. drained, forested) and it is extremely difficult or even impossible to restore the unique hydrogeological and geochemical conditions enabling their function. The long-term perspective of paleoecological studies allows indication of former wetland ecosystem states and provides understanding of their development over millennia. To examine the late Holocene dynamics of a calcareous spring-fed fen (Raganu Mire) ecosystem on th…

La Self-Efficacy del Docente Universitario in Situazione di Emergenza Covid-19

2021

Le convinzioni che i docenti universitari possiedono sulla propria Self-Efficacy influenzano non solo il loro modo di lavorare, ma soprattutto gli esiti di apprendimento e il senso di autoefficacia dei loro studenti. La percezione di autoefficacia dei docenti nella didattica a distanza assume un ruolo ancora più importante in situazione di emergenza Covid-19. Il presente contributo indaga tale costrutto in un campione di 50 docenti universitari dell’Università degli Studi di Palermo, rilevando l’eventuale incidenza di variabili quali le esperienze pregresse di insegnamento nell’ambito della didattica a distanza e l’autoefficacia nell’utilizzo di tecnologie didattiche. University teachers’ c…

11 and 15-month-old infants do not compensate immediately for energy variation, and no further adjustment occurs 12 or 24 hours later

2021

International audience; Previously, we demonstrated that, in the short term, infants undercompensated for the energy from a preload given 25 min before an ad libitum meal. However, although not consistent, there is evidence in young children that caloric adjustment may occur over longer periods. We investigated the extent to which further energy adjustment occurs up to 24 h after a single meal preceded by preloads of varying energy density (ED) in infants that are 11 and 15 months old. Short-term caloric adjustment was measured in 11- and 15-month-old infants through a preload paradigm meal in the laboratory. To assess their caloric adjustment over longer periods (12 and 24 h), we used 24 h…

Prognostic value of troponin I in atrial fibrillation

2021

To evaluate whether circulating cardiac troponin I (cTnI) levels are associated with worst outcomes in patients with atrial fibrillation (AF).Consecutive patients visiting the emergency room (ER) with a new episode of a previously diagnosed AF or a new diagnosis of AF during ER admission between January 1st, 2010 and December 31st, 2015, were enrolled in the study (n = 2617). After applying exclusion criteria and eliminating repeated episodes, 2013 patients were finally included. Of these, 1080 patients with at least one cTnI measurement in the ER were selected and classified into 4 groups according to cTnI quartiles: Q1 (n = 147) cTnI10 ng/L (Group 1); Q2 (n = 254): 10-19 ng/L (Group 2); Q…

Governance of global value chains after the Covid-19 pandemic: A new wave of regionalization?

2021

The disruption of the trade and investment activities of multinational enterprises as a consequence of the Covid-19 pandemic has reinvigorated the debate on the configuration of global value chains (GVCs) as well as the risks and challenges associated with offshoring. This article depicts how the pandemic might affect GVC configuration by driving a trend toward a more regional footprint in industries in which resilience and reliability are critical. Such a shift would create new opportunities for reshoring, and affect both the types of upgrading trajectories and the governance systems in value chains. The article also draws from the intersection of the global-strategy and value-chain field…