showing 36 of ~574560 from 574555 documents
Students' abilities to evaluate the credibility of online texts: The role of internet‐specific epistemic justifications
2021
Previous evaluation studies have rarely used authentic online texts and investigated upper secondary school students' use of evaluation criteria and deep reasoning. The associations between internet-specific epistemic justifications for knowing and credibility evaluation of online texts are not yet fully understood among adolescents. This study investigated upper secondary school students' (N = 372) abilities to evaluate self-selected authentic online texts and the role of internet-specific epistemic justifications in students' evaluation performance when solving a health-related information problem. Students selected three texts with Google Custom Search Engine and evaluated their credibil…
Cost-efficient QFA Algorithm for Quantum Computers
2021
The study of quantum finite automata (QFAs) is one of the possible approaches in exploring quantum computers with finite memory. Despite being one of the most restricted models, Moore-Crutchfield quantum finite automaton (MCQFA) is proven to be exponentially more succinct than classical finite automata models in recognizing certain languages such as $\mathtt{MOD}_p = \{ a^{j} \mid j \equiv 0 \mod p\}$, where $p$ is a prime number. In this paper, we present a modified MCQFA algorithm for the language $\mathtt{MOD}_p$, the operators of which are selected based on the basis gates on the available real quantum computers. As a consequence, we obtain shorter quantum programs using fewer basis gat…
Negative Impact of Citral on Susceptibility of Pseudomonas aeruginosa to Antibiotics
2021
Essential oils (EOs) or their components are widely used by inhalation or nebulization to fight mild respiratory bacterial infections. However, their interaction with antibiotics is poorly known. In this study we evaluated the effects of citral, the main component of lemongrass oil, on in vitro susceptibility of Pseudomonas aeruginosa to antibiotics. Exposure of strain PA14 to subinhibitory concentrations of citral increased expression of operons encoding the multidrug efflux systems MexEF-OprN and MexXY/OprM, and bacterial resistance to anti-pseudomonal antibiotics including imipenem (twofold), gentamicin (eightfold), tobramycin (eightfold), ciprofloxacin (twofold), and colistin (≥128-fold…
Quasi-soliton spatial autoguidé en milieu non lineaire quadratique
2021
International audience; Nous démontrons ici des phénomènes d'autoguidage optique existant dans les milieux à non-linéarités quadratiques. En plus de la formation puis disparition d'un phénomène auto confiné, nous observons des effets de commutation ultrarapide et de démultiplication spatiale, ainsi qu'une restructuration temporelle suivie d'élargissements spectraux.
Propagation non-linéaire de champs partiellement incohérents mais avec une cohérence mutuelle contrôlée
2021
National audience
Clinical evaluation of bempedoic acid for the treatment of hyperlipidaemia.
2021
Bempedoic acid (BA) is a novel first-in-class oral lipid-lowering therapy. BA has been approved by the European Medicinal Agency and Food and Drug Administration and has been commercialised throughout Europe since the end of 2020 as an add-on therapy in patients at high/very-high cardiovascular risk that are not at LDL-C goals with current lipid-lowering treatments. Recently, Italian lipid management experts gathered to discuss several open questions on BA characteristics and BArelated practical clinical issues. The panel permitted collection of its opinions in a ten Q&A format. Aim: The aim of this viewpoint is to discuss and answer several open questions on BA characteristics and BA-r…
Nimbolide inhibits 2D and 3D prostate cancer cells migration, affects microtubules and angiogenesis and suppresses B-RAF/p.ERK-mediated in vivo tumor…
2021
Abstract Background Prostate cancer (PCa) is the most prominent malignancy among men worldwide. PCa cells have a high tendency to metastasize to various distant organs, and this activity is the main cause of PCa mortality. Nimbolide is a promising phytochemical constituent of neem Azadirachta indica (Meliaceae). Previous studies showed that nimbolide exhibited potent anticancer activity however, its role against PCa tumorigenesis has not been fully elucidated. Purpose Our work aims to explore the role of nimbolide in regulating the essential tumor-associated processes involved in the metastatic cascade in PCa cells. Study design Cytotoxicity assay, wound healing and spheroid invasion assays…
Le réexamen des lois de bioéthique, pour quel monde commun ?
2021
International audience; C omment une société fait-elle le point sur ce qui, pour elle, compte au point qu'elle ne saurait, en ces matières, transiger ? Peut-elle seulement, se regardant vivre et évoluer, instaurer de temps à autre, dans le flux et la vitesse, des stases pour se livrer à un auto-examen ? N'est-ce d'ailleurs pas cela l'éthique, dans la bioéthique : offrir collectivement le scrupule de la pause au coeur de la trépidation des courses à l'innovation ? Elle peut le faire en imagination, de façon prospective, en se projetant dans le temps. La récente réinitialisation d'un Haut-Commissariat au Plan servira une telle entreprise. Elle peut le faire à travers un travail de mémoire, co…
Génération de doublets d’impulsions picosecondes à très haut débit
2021
National audience
La tache d’Arago temporelle en optique fibrée non-linéaire
2021
National audience
Source optique à très haut débit basée sur la compression non-linéaire de besselons optiques
2021
National audience; Nous démontrons la génération expérimentale de trains d’impulsions ultrabrèves à des taux de répétition allant de 28 à 112 GHz. Notre approche se base sur la compression non-linéaire de besselons dans une fibre optique hautement non-linéaire à dispersion normale. Les impulsions obtenues atteignent des durées subpicosecondes.
Assessing the influence of the amount of reachable habitat on genetic structure using landscape and genetic graphs.
2021
Genetic structure, i.e. intra-population genetic diversity and inter-population genetic differentiation, is influenced by the amount and spatial configuration of habitat. Measuring the amount of reachable habitat (ARH) makes it possible to describe habitat patterns by considering intra-patch and inter-patch connectivity, dispersal capacities and matrix resistance. Complementary ARH metrics computed under various resistance scenarios are expected to reflect both drift and gene flow influence on genetic structure. Using an empirical genetic dataset concerning the large marsh grasshopper (Stethophyma grossum), we tested whether ARH metrics are good predictors of genetic structure. We further i…
false
2021
We report the assembly and annotation of the complete mitochondrial genome of the warningly-coloured wood tiger moth (Arctia plantaginis) and investigate its phylogenetic position within Arctiinae. The A.plantaginis mitogenome is 15,479 bp long with 13 protein-coding genes, 22 transfer RNAs, 2 ribosomal RNA genes, and an A + T-rich region (D-loop). The phylogenetic analyses based on 13 protein-coding genes showed A.plantaginis clustering within a clade of species with white wings and yellow or red bodies. This result can be useful in understanding the evolution of coloration in Arctiid moths.
Using Machine Learning to Characterize Atrial Fibrotic Substrate From Intracardiac Signals With a Hybrid in silico and in vivo Dataset
2021
[EN] In patients with atrial fibrillation, intracardiac electrogram signal amplitude is known to decrease with increased structural tissue remodeling, referred to as fibrosis. In addition to the isolation of the pulmonary veins, fibrotic sites are considered a suitable target for catheter ablation. However, it remains an open challenge to find fibrotic areas and to differentiate their density and transmurality. This study aims to identify the volume fraction and transmurality of fibrosis in the atrial substrate. Simulated cardiac electrograms, combined with a generalized model of clinical noise, reproduce clinically measured signals. Our hybrid dataset approach combines in silico and clinic…
Autonomous 3D geometry reconstruction through robot-manipulated optical sensors
2021
Abstract Many industrial sectors face increasing production demands and need to reduce costs, without compromising the quality. Whereas mass production relies on well-established protocols, small production facilities with small lot sizes struggle to update their highly changeable production at reasonable costs. The use of robotics and automation has grown significantly in recent years, but extremely versatile robotic manipulators are still not commonly used in small factories. Beside of the investments required to enable efficient and profitable use of robot technology, the efforts needed to program robots are only economically viable in case of large lot sizes. Generating robot programs f…
Non-adiabatic control in NxN integrated photonic switch
2021
National audience
false
2021
Parvoviruses are small single-stranded (ss) DNA viruses, which replicate in the nucleoplasm and affect both the structure and function of the nucleus. The nuclear stage of the parvovirus life cycle starts at the nuclear entry of incoming capsids and culminates in the successful passage of progeny capsids out of the nucleus. In this review, we will present past, current, and future microscopy and biochemical techniques and demonstrate their potential in revealing the dynamics and molecular interactions in the intranuclear processes of parvovirus infection. In particular, a number of advanced techniques will be presented for the detection of infection-induced changes, such as DNA modification…
Psychologische Herausforderungen bei Erwachsenen mit Typ-1-Diabetes
2021
ZusammenfassungMenschen mit Typ-1-Diabetes müssen immer wieder verschiedene Anpassungsleistungen erbringen, um ihre Erkrankung und deren Therapie in den Alltag integrieren zu können. Gelingt dies nicht, können daraus Probleme beim Selbstmanagement der Krankheit resultieren. Doch trotz strukturierter Schulungsprogramme und leitliniengerechter, individuell zugeschnittener Therapieempfehlungen leben einige Menschen mit Typ-1-Diabetes mit chronisch erhöhten Blutzuckerwerten. Dabei scheint der Diabetes-Distress als Reaktion auf die erlebten Herausforderungen eine wichtige Rolle zu spielen und im Zusammenhang mit Problemen bei der glykämischen Kontrolle wie auch einer Therapievermeidung zu stehen…
A Highly Luminescent Nitrogen-Doped Nanographene as an Acid- and Metal-Sensitive Fluorophore for Optical Imaging.
2021
Dibenzo[hi,st]ovalene (DBOV) has excellent photophysical properties, including strong fluorescence and high ambient stability. Moreover, the optical blinking properties of DBOV have enabled optical super-resolution single-molecule localization microscopy with an imaging resolution beyond the diffraction limit. Various organic and inorganic fluorescent probes have been developed for super-resolution imaging, but those sensitive to pH and/or metal ions have remained elusive. Here, we report a diaza-derivative of DBOV (N-DBOV), synthesized in eight steps with a total yield of 15%. Nitrogen (N)-bearing zigzag edges were formed through oxidative cyclization of amino groups in the last step. UV-v…
Le dioxyde de titane pour la photonique
2021
National audience
PANI-Based Wearable Electrochemical Sensor for pH Sweat Monitoring
2021
Nowadays, we are assisting in the exceptional growth in research relating to the development of wearable devices for sweat analysis. Sweat is a biofluid that contains useful health information and allows a non-invasive, continuous and comfortable collection. For this reason, it is an excellent biofluid for the detection of different analytes. In this work, electrochemical sensors based on polyaniline thin films deposited on the flexible substrate polyethylene terephthalate coated with indium tin oxide were studied. Polyaniline thin films were abstained by the potentiostatic deposition technique, applying a potential of +2 V vs. SCE for 90 s. To improve the sensor performance, the electronic…
Découvrir la polarisation à partir de l’application en ligne Emanim
2021
National audience
Lethal and behavioural effects of a green insecticide against an invasive polyphagous fruit fly pest and its safety to mammals
2021
Abstract Plant essential oil-based insecticides, with special reference to those that may be obtained from largely available biomasses, represent a valuable tool for Integrated Pest Management. However, the sublethal effects and the potential effects on aggressive insect traits of these green insecticides are understudied. Herein, the lethal and sub-lethal effects of the carlina oxide, constituting more than 97% of the whole Carlina acaulis (Asteraceae) root essential oil (EO), were determined against an invasive polyphagous tephritid pest, Ceratitis capitata (medfly). The carlina oxide was formulated in a mucilaginous solution containing carboxymethylcellulose sodium salt, sucrose, and hyd…
Propagation non-linéaire dans les fibres optiques par réseaux de neurones artificiels
2021
National audience; Nous mettons en œuvre différents réseaux de neurones artificiels pour prédire l’évolution des profils temporels et spectraux d’intensité après propagation dans une fibre optique en présence de non-linéarité forte. Le problème inverse est également considéré.
Le light painting pour éclairer une classe de primaire
2021
National audience
“Good translating is very hard work”
2021
Abstract Upon immigrating to New Zealand in 1937, Austrian-born philosopher of science Karl Raimund Popper lived and worked in the English-speaking world, where he published his major works in English. Life events forced him to engage in various forms of self-translation around the same time that he began earnestly working on translating Presocratic philosophical fragments into English. While he rejected language wholesale as an object of philosophical reflection, translation became an exception, a privileged occasion for philosophical reflection on language. This article reads Popper’s thoughts on translation in the context of previously unpublished correspondence between Popper and potent…
Is a National Court Competent to Introduce a Disclaimer into a Trade Mark Registration? The Latvian Supreme Court Finally Says ‘No’
2021
Abstract It was a longstanding practice of Latvian courts to acknowledge their competence to introduce a disclaimer into a challenged trade mark registration. This had come to be considered as settled court practice. However, the Latvian Supreme Court recently decided to withdraw this practice and explicitly admitted a change of approach concerning the competence of Latvian national courts to introduce a disclaimer into a trade mark registration. In this way, the Latvian Supreme Court finally abolished a disputable practice in the Latvian courts, having formerly allowed themselves to introduce a disclaimer which could – by way of a misunderstanding of trade mark law – be introduced by a cou…
Inclusion of a suite of weathering tracers in the cGENIE Earth system model-muffin release v.0.9.23
2021
Abstract. The metals strontium (Sr), lithium (Li), osmium (Os) and calcium (Ca), together with their isotopes, are important tracers of weathering and volcanism – primary processes which shape the long-term cycling of carbon and other biogeochemically important elements at the Earth's surface. Traditionally, because of their long residence times in the ocean, isotopic shifts in these four elements observed in the geologic record are almost exclusively interpreted with the aid of isotope-mixing, tracer-specific box models. However, such models may lack a mechanistic description of the links between the cycling of the four metals to other geochemically relevant elements, particularly carbon, …
Professionals' Views on the Comparatively Low Prevalence of Intimate Partner Violence Against Women in Spain.
2021
The aim of this study was to understand the reasons why Spain has one of the lowest prevalence rates of intimate partner violence against women (IPVAW) in the European Union. Using a qualitative and inductive research approach, a total of five focus groups ( n = 19) and 10 unstructured interviews with key informants were conducted. Three main categories were identified as possible explanations of the relatively low prevalence of IPVAW in Spain: law and policy, social awareness, and cultural patterns. Lessons learned and implications to improve future macrolevel intervention and prevention strategies are discussed.
Parenté et organisation sociale chez les Wayùu. Retour sur la question
2021
Dans cet article, l’auteur revient sur certaines questions concernant le domaine de la parenté et de l’organisation sociale des Wayùu de la péninsule de La Guajira, dans la zone frontalière du nord de la Colombie et du Venezuela. Prenant pour point de départ le désaccord entre Goulet et Saler sur l’existence de catégories et de groupes de lignages et sur la place de ceux-ci dans le monde social des Wayùu, il opte pour le point de vue de Saler, à savoir que ces catégories peuvent être considérées non seulement dans les mythes au sujet de l’origine de la société wayùu, mais aussi dans les différents concepts qui réfèrent à l’ancestralité utérine commune d’un groupe de gens apparentés, ainsi q…
Curation by the Living Dead: Exploring the Legacy of Norwegian Museums' Colonial Collections
2021
ABSTRACT While the history of Norwegian museum acquisitions and collection formation has long been a topic of research, the extent to which colonial structures are still embedded in various Norwegian collecting institutions is seldom addressed. In this paper, we discuss the legacy of colonial collections in Norway through two case studies; Inge Heiberg’s collection of Congo ethnographica in various exhibitions at the University of Oslo’s Museum of Cultural History from the early 1900s to the present; and the Norwegian Kon-Tiki Museum’s initiative to repatriate human remains and other material excavated by Thor Heyerdahl on Rapa Nui in the 1950s. Presenting two cases that have been promoted …
Epistatic interactions between pterin and carotenoid genes modulate intra-morph color variation in a lizard.
2021
Color polymorphisms have become a major topic in evolutionary biology and substantial efforts have been devoted to the understanding of the mechanisms responsible for originating such colorful systems. Within-morph continuous variation, on the other hand, has been neglected in most of the studies. Here, we combine spectrophotometric/visual modeling and genetic data to study the mechanisms promoting continuous variation within categorical color morphs of Podarcis muralis. Our results suggest that intra-morph variability in the pterin-based orange morph is greater compared to white and yellow morphs. We also show that continuous variation within the orange morph is partially discriminable by …
false
2021
Background: Since there is no standardized and effective treatment for advanced uveal melanoma (UM), the prognosis is dismal once metastases develop. Due to the availability of immune checkpoint blockade (ICB) in the real-world setting, the prognosis of metastatic UM has improved. However, it is unclear how the presence of hepatic and extrahepatic metastasis impacts the response and survival after ICB. Methods: A total of 178 patients with metastatic UM treated with ICB were included in this analysis. Patients were recruited from German skin cancer centers and the German national skin cancer registry (ADOReg). To investigate the impact of hepatic metastasis, two cohorts were compared: patie…
Covalent Organic Frameworks for the detection of CO
2021
International audience; Every year in the world, carbon monoxide (CO) is responsible for thousands of intoxications and hundreds of deaths. The detection (CO) at few ppm levels is thus a critical point for the control of the air quality. Corrole belongs to the family of porphyrinoids which is largely used for sensing applications [1]. We have shown that cobalt metallocorroles are able to bind carbon monoxide in the axial position with a high affinity even in the presence of nitrogen and dioxygen, the two main components of the atmosphere [2]. We have recently prepared sensing devices for low CO detection level (sub-ppm) using cobalt corroles deposited as films on a Surface Acoustic Wave dev…
Safety Related Behaviors and Law Adherence of Shared E-Scooter Riders in Germany
2021
Shared e-scooters, whose supply and coverage keeps increasing in many cities around the globe, are rapidly changing mobility in urban road environments. As rising injury rates have been observed alongside this new form of mobility, researchers are investigating potential factors that relate to safe/unsafe e-scooter use. In Germany, e-scooter sharing platforms were only recently permitted in the middle of 2019, and their number has increased steadily since then. The aim of this study was to assess key factors that relate to their safe use, through a direct observation of e-scooters conducted at three observation sites around Berlin. Helmet use, dual use, type of infrastructure use, and trave…
Electrochemistry of Mono- and Bis-CN Ligated Cobalt Corroles
2021
International audience; The electrochemical properties of numerous transition metal corroles have been examined under a variety of<br>solution condition with special emphasis being placed on the innocent or non-innocent nature of the corrole<br>macrocycle. This property, as well as the half-wave potentials and sites of electron transfers, are known to be<br>strongly influenced by the type of central metal ion and degree of axial coordination, namely 4, 5 or 6-coordinate.<br>The redox potentials of metallocorroles are also dependent upon the solvent and inductive, resonance or steric<br>effects dictated by peripheral substituents at the meso or β-pyrrole positions of the corrole li…