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Flavour retention and release from protein solutions
2006
International audience; This paper briefly presents the main results obtained up to now on protein–flavour binding and release in relation with flavour perception. Among the food proteins, β-lactoglobulin is the most extensively studied for its binding properties, which involve both hydrophobic and hydrogen binding. Recent developments using molecular modelling and Quantitative Structure–Activity Relationship confirmed the existence of two different binding sites for flavour compounds on β-lactoglobulin. During the aroma release process in the mouth, not only free aroma compounds are released but also those reversibly bound by the protein, pointing out the fact that flavour perception is on…
New insights into the pharmacology of the short-chain free fatty acid receptors 2 and 3
2011
Metabolic diseases, such as diabetes, dyslipidemia or obesity, are more and more weighing on public health expenses in developed countries. Despite active research, these widespread diseases remain difficult to handle. Promising new therapeutic strategies against metabolic diseases include the development of drugs targeting the free fatty acid receptors, as key players in metabolism homeostasis. In this context, the current PhD thesis focuses on the study of two G protein-coupled receptors, namely the short-chain free fatty acid receptors 2 (FFA2) and 3 (FFA3). First, we investigated the expression of the two receptors of interest in a variety of cell types. Then, in order to study the phar…
Arbuscular mycorrhizal fungi, partners of the rhizostabilization proccess of an orphan mining site
2012
International audience
Das Bleigewicht aus dem Hofareal der Fürstin von Vix auf dem Hochplateau des Mont Lassois.
2021
Das Bleigewicht aus dem Hofareal der Fürstin von VixDer Mont Lassois bei Vix, Dép. Côte d’Or, zählt neben der Heuneburg zu den am besten erforschten Fürstensitzen imfrühkeltischen Westhallstattkreis. 1953 wurde das späthallstattzeitliche Fürstinnengrab von Vix entdeckt. Im Rahmendes deutsch-französischen Forschungsprojektes »Keltische Fürstensitze westlich des Rheins« (1991-1997) und desfranzösischen PCR-Projektes (Projet collectif de recherche) »Vix et son environnement« (seit 2002) mit Beteiligungder Universitäten Dijon, Kiel, Wien und Zürich wurden die Altgrabungen (1930-1974) wieder aufgenommen. Bei derUntersuchung des späthallstattzeitlichen Hofareals der Fürstin von Vix auf dem Hochpl…
L'abrogation du délit de consultation habituelle de sites internet terroristes par le Conseil constitutionnel
2017
International audience; Conseil constitutionnel, 10 février 2017, n° 2016-611-QPC, AJ pénal 2017. 237, obs. J. Alix ; Dalloz IP/IT 2017. 289, obs. M. Quéméner
Rational backbone redesign of a fructosyl peptide oxidase to widen its active site access tunnel
2020
Fructosyl peptide oxidases (FPOXs) are enzymes currently used in enzymatic assays to measure the concentration of glycated hemoglobin and albumin in blood samples, which serve as biomarkers of diabetes. However, since FPOX are unable to work directly on glycated proteins, current enzymatic assays are based on a preliminary proteolytic digestion of the target proteins. Herein, to improve the speed and costs of the enzymatic assays for diabetes testing, we applied a rational design approach to engineer a novel enzyme with a wider access tunnel to the catalytic site, using a combination of Rosetta design and molecular dynamics simulations. Our final design, L3_35A, shows a significantly wider …
Comparison of the generation II with IV heterogeneous Ziegler-Natta catalysts used in propylene polymerizations
1998
An unsupported TiCl3-based catalyst (generation II), modified with n-butyl ether and AlEt2Cl3, was compared with a MgCl2/dibutyl phthalate/AlEt3/cyclohexylmethyldimethoxysilane catalyst system (generation IV) in propylene polymerizations. The latter (magnesium-supported) was fund to be more than 20 times as active as the former and more stereospecific, but to yield PP with a lower molecular weight (Table 2). The kinetics of the polymerizations studied with either of the catalyst, and involving the determination of concentrations of active sites [C0*] and elementary reaction rate constants (Table 4) based on earlier kinetic models, showed the C0*-values in the magnesium-supported catalyst to…
Effects of density, species interactions, and environmental stochasticity on the dynamics of British bird communities
2022
Our knowledge of the factors affecting species abundances is mainly based on time-series analyses of a few well-studied species at single or few localities, but we know little about whether results from such analyses can be extrapolated to the community level. We apply a joint species distribution model to long-term time-series data on British bird communities to examine the relative contribution of intra- and interspecific density dependence at different spatial scales, as well as the influence of environmental stochasticity, to spatiotemporal interspecific variation in abundance. Intraspecific density dependence has the major structuring effect on these bird communities. In addition, envi…
Aviokompāniju reklāmu raksturojums sociālo tīklu tīmekļa vietnēs Facebook un Twitter
2018
Reklāma ir profesionālā diskursa žanrs, kas tiek izmantots komunikācijai ar sabiedrību. Mūsdienās internets un sociālo tīklu tīmekļa vietnes tiek bieži izmantotas reklāmas nolūkos. Šī pētījuma mērķis bija analizēt lingvistiskās un paralingvistiskās iezīmes sociālo tīklu tīmekļa vietnēs Facebook un Twitter publicētajās aviokompāniju reklāmās. Pētījums tika balstīts uz Kuka (Cook, 1992) piedāvāto diskursa analīzes modeli, kas ietver teksta un konteksta analīzi. Pētījuma rezultāti parādīja, ka šo reklāmu tekstos izmantotā valoda ir vienkārša un lasītājam draudzīga, kas ir panākts, pārsvarā izmantojot vienkāršus teikumus, kā arī lietojot kontrakcijas un saīsinājumus. Tā arī imitē sarunu ar lasī…
Biochemical and structural features of a novel cyclodextrinase from cow rumen metagenome.
2007
A novel enzyme, RA.04, belonging to the alpha-amylase family was obtained after expression of metagenomic DNA from rumen fluid (Ferrer et al.: Environ. Microbiol. 2005, 7, 1996-2010). The purified RA.04 has a tetrameric structure (280 kDa) and exhibited maximum activity (5000 U/mg protein) at 70 degrees C and was active within an unusually broad pH range from 5.5 to 9.0. It maintained 80% activity at pH 5.0 and 9.5 and 75 degrees C. The enzyme hydrolyzed alpha-D-(1,4) bonds 13-fold faster than alpha-D-(1,6) bonds to yield maltose and glucose as the main products, and it exhibited transglycosylation activity. Its preferred substrates, in the descending order, were maltooligosaccharides (C3-C…