Search results for "P3"
showing 10 items of 786 documents
Determinants of inter-regional migration in the Baltic countries
2003
We show that Estonia, Latvia and Lithuania despite small geographical size feature considerable and persistent regional disparities. Registered migration rates have declined dramatically since the last years of Soviet era, yet they are high by international standards. Evidence from regional inflows and outflows in Latvia and from Estonian labour force survey is used to show that regional unemployment and especially wage differentials, as well as demographic factors, have a significant impact both on gross and net migration flows. Age and education effects are consistent with predictions of the human capital model of migration. Unemployed persons, as well as commuters between regions, are si…
Langerhans cells are negative regulators of the anti-Leishmania response
2011
Langerhans cells suppress the immune response to low-dose Leishmania major infection in part by inducing regulatory T cells.
Verso l’«inesplorato fondo dell’io». De Roberto e la psicologia fin de siècle
2021
Il saggio mira ad analizzare le modalità con cui Federico De Roberto rappresenta e indaga il «fondo dell’incosciente», sulla scia delle acquisizioni della scienza e della psicologia coeve. A interessare lo scrittore non sono esclusivamente le dinamiche dell’ereditarietà, bensì i meccanismi occulti della psiche. I personaggi derobertiani sono agiti da impulsi irrazionali e involontari, che non riescono a governare ma che ne determinano i comportamenti. Inoltre, in anticipo sul Modernismo, De Roberto ritiene che qualsiasi raffigurazione verosimile del reale risulti sempre parziale, perché filtrata attraverso la lente deformante della soggettività. Nel trattato L’Amore. Fisiologia - Psicologia…
HSP27 controls GATA-1 protein level during erythroid cell differentiation.
2010
AbstractHeat shock protein 27 (HSP27) is a chaperone whose cellular expression increases in response to various stresses and protects the cell either by inhibiting apoptotic cell death or by promoting the ubiquitination and proteasomal degradation of specific proteins. Here, we show that globin transcription factor 1 (GATA-1) is a client protein of HSP27. In 2 models of erythroid differentiation; that is, in the human erythroleukemia cell line, K562 induced to differentiate into erythroid cells on hemin exposure and CD34+ human cells ex vivo driven to erythroid differentiation in liquid culture, depletion of HSP27 provokes an accumulation of GATA-1 and impairs terminal maturation. More spec…
Mapping wordnets from the perspective of inter-lingual equivalence
2017
Mapping wordnets from the perspective of inter-lingual equivalence This paper explores inter-lingual equivalence from the perspective of linking two large lexico-semantic databases, namely the Princeton WordNet of English and the plWordnet ( pl. Slowosiec ) of Polish. Wordnets are built as networks of lexico-semantic relations between words and their meanings, and constitute a type of monolingual dictionary cum thesaurus. The development of wordnets for different languages has given rise to many wordnet linking projects (e.g. EuroWordNet, Vossen, 2002). Regardless of a linking method used, these projects require defining rules for establishing equivalence links between wordnet building bloc…
The exceptional nature of the first person in natural story processing and the transfer of egocentricity
2018
Human language enables us to externalise self-internal information (e.g. emotions or beliefs that are not readily accessible to others). Thus, language bridges the gap between the self and the other (e.g. Frith and Frith, 2010) in a way that possibly no other communication system can provide. In many languages, the difference between the self and others is directly reflected in the distinction between first (“I”), second (“you”) and third person (“he, she”) marking. In the present study, we compared ERPs to first, second and third person pronouns during the comprehension of an audio-book version of The Little Prince. Our results revealed a strong P300 response following first person pronoun…
TRANSLATING A FAVELA MUSICAL: VINICIUS DE MORAES’ ORFEU DA CONCEIÇÃO IN GERMAN
2022
Zusammenfassung Vinicius de Moraes’ Musiktheaterstück Orfeu da Conceição. Tragédia carioca em três atos (1954) kann sowohl als Klassiker brasilianischer Literatur als auch als Weltliteratur betrachtet werden. Vinicius verknüpft den griechischen Stoff mit afrobrasilianischer Kultur, Musikstücken, die später zu Bossa Nova-Klassiker wurden und inszeniert einen schwarzen Orpheus auf einem Favelahügel in Rio de Janeiro. Das Stück wurde zwar mehrfach verfilmt, aber kaum übersetzt. Der Beitrag möchte ein paar Herausforderungen für die Übersetzung ins Deutsche skizzieren. Vor allem für die Vermittlung afrobrasilianischer Kultur müssen Strategien entwickelt werden. Erstens soll es um das semantische…
Genetic signature consistent with selection against the CYP3A4*1B allele in non-African populations.
2005
Cytochrome P450 3A enzymes (CYP3A) play a major role in the metabolism of steroid hormones, drugs and other chemicals, including many carcinogens. The individually variable CYP3A expression, which remains mostly unexplained, has been suggested to affect clinical phenotypes. We investigated the CYP3A locus in five ethnic groups. The degree of linkage disequilibrium (LD) differed among ethnic groups, but the most common alleles of the conserved LD regions were remarkably similar. Non-African haplotypes are few; for example, only four haplotypes account for 80% of common European Caucasian alleles. Large LD blocks of high frequencies were suggestive of selection. Accordingly, European Caucasia…
Pharmacogenetic Study of ABCB1 and CYP3A5 Genes During the First Year Following Heart Transplantation Regarding Tacrolimus or Cyclosporine Levels
2011
Pharmacogenetics explains part of the interindividual variability in drug responses. Many published works about the effects of single nucleotide polymorphisms (SNPs) on immunosuppressive drug blood levels present contradictory results. We evaluated the SNPs in ABCB1 (glycoprotein P) and CYP3A5 (metabolic enzyme) genes, seeking correlate them with tacrolimus or cyclosporine levels during the first year after heart transplantation. One blood sample was obtained from each of 41 patients: 26 treated with cyclosporine and 15 with tacrolimus. We characterize the SNPs rs1045642, 1128503, 2032582, 2235013, 2235033, 2229109, 3213619, 9282564 in ABCB1 and rs10264272, 776746 in CYP3A5 genes using the …
Gram-positive bacteria on grass pollen exhibit adjuvant activity inducing inflammatory T cell responses.
2011
BACKGROUND: Recently, it has been established that pollen grains contain Th2-enhancing activities besides allergens. OBJECTIVE: The aim of this study was to analyse whether pollen carry additional adjuvant factors like microbes and what immunological effects they may exert. METHODS: Timothy pollen grains were collected and disseminated on agar plates, and the growing microorganisms were cultivated and defined. Furthermore, the immunologic effects of microbial products on DC and T cell responses were analysed. RESULTS: A complex mixture of bacteria and moulds was detected on grass pollen. Besides Gram-negative bacteria that are known to favour Th1-directed immune responses, moulds were ident…