Search results for "PATHOLOGY"

Mesenchymal Stem Cells Provide Better Results Than Hematopoietic Precursors for the Treatment of Myocardial Infarction

2010

Objectives The purpose of this study was to compare the ability of human CD34(+) hematopoietic stem cells and bone marrow mesenchymal stem cells (MSC) to treat myocardial infarction (MI) in a model of permanent left descendent coronary artery (LDA) ligation in nude rats. Background Transplantation of human CD34(+) cells and MSC has been proved to be effective in treating MI, but no comparative studies have been performed to elucidate which treatment prevents left ventricular (LV) remodelling more efficiently. Methods Human bone marrow MSC or freshly isolated CD34(+) cells from umbilical cord blood were injected intramyocardially in infarcted nude rats. Cardiac function was analyzed by echoc…

Approximators and mitigators in Chilean Spanish: the case of 'como' and 'como que'

2019

espanolEn el presente trabajo se realiza un analisis del uso de los aproximadores como y como que en el espanol de Chile y la vinculacion de su valor semantico aproximador con la atenuacion pragmatica. Diversos son los trabajos que han otorgado al marcador como un valor aproximativo (Mihatsch, 2009, 2010; Jorgensen y Stenstrom 2009; Jorgensen, 2011; Holmvik, 2011; Kornfeld, 2013; Kern, 2014; Jimenez y Flores-Ferran, 2018) y tambien un valor atenuador (Briz, 1998; Jorgensen, 2011; Holmvik, 2011; Kornfeld, 2013, Panussis, 2016; Mondaca, 2017; Panussis y San Martin, 2017). Asi, el objetivo es analizar la relacion que existe entre la aproximacion semantica y la atenuacion pragmatica por medio d…

Impact du climat sur la santé : modélisation régionale des poussières pour les épidémies de méningites au Sahel.

2014

6 pages; International audience; Les épidémies des méningites bactériennes constituent encore à l’heure actuelle un problème de santé publiquemajeur en Afrique de l’Ouest. Chaque année, au coeur de la saison sèche (de janvier à mars), 25 000 à 250 000 cas sontenregistrés par l’Organisation Mondiale de la Santé (OMS) dans la zone latitudinale 10-15°N, plus communément appelée« ceinture de la méningite ». L’importance des facteurs sociétaux dans l’expansion des épidémies est indéniable. Cependant,une série d’études récentes a permis de mettre en lumière le rôle important du climat. Ainsi, l’intensité des épidémies sembleliée à des conditions de circulation atmosphérique spécifiques quelques m…

A genomic reappraisal of symbiotic function in the aphid/Buchnera symbiosis: reduced transporter sets and variable membrane organisations.

2011

International audience; Buchnera aphidicola is an obligate symbiotic bacterium that sustains the physiology of aphids by complementing their exclusive phloem sap diet. In this study, we reappraised the transport function of different Buchnera strains, from the aphids Acyrthosiphon pisum, Schizaphis graminum, Baizongia pistaciae and Cinara cedri, using the re-annotation of their transmembrane proteins coupled with an exploration of their metabolic networks. Although metabolic analyses revealed high interdependencies between the host and the bacteria, we demonstrate here that transport in Buchnera is assured by low transporter diversity, when compared to free-living bacteria, being mostly bas…

The patterned ways of interlinking linguistic and multimodal elements in visually oriented communities

2019

This paper attends to languaging in the context of visually oriented communities of sign language users through the concept of chaining. I define chaining as the patterned, routine ways of interlin...

Cardiolipin content controls mitochondrial coupling and energetic efficiency in muscle

2020

Decreasing mitochondrial energy-production efficiency in skeletal muscle can confer protection against diet-induced obesity.

The utility of SATB2 immunohistochemical expression in distinguishing between osteosarcomas and their malignant bone tumor mimickers, such as Ewing s…

2016

SATB2 is commonly expressed in osteosarcomas. Although apparently being a valuable diagnostic marker for differentiating between small cell osteosarcoma (SCO) and other small round cell tumors of bone, for instance Ewing sarcoma family of tumors (ESFT), it has not been tested in a large series of ESFT and chondrosarcomas so far. We studied the immunohistochemical expression of SATB2 in 42 osteosarcomas, 31 chondrosarcomas, and 371 genetically confirmed ESFT. SATB2 positivity was detected in 90.4% of osteosarcomas, 87.5% of SCO, 91.3% of osteoblastic osteosarcomas, and in all chondroblastic and parosteal osteosarcomas. The osteoblastic and SCO subtypes expressed SATB2 more intensely than oth…

2016

Background Contractile myofibroblasts (MFs) accumulate in the joint capsules of patients suffering from posttraumatic joint stiffness. MF activation is controlled by a complex local network of growth factors and cytokines, ending in the increased production of extracellular matrix components followed by soft tissue contracture. Despite the tremendous growth of knowledge in this field, inconsistencies remain in practice and prevention.

The role of osteoprotegerin in the crosstalk between vessels and bone: Its potential utility as a marker of cardiometabolic diseases

2018

International audience; Among the numerous molecules that are being studied for their potential utility as biomarkers of cardiovascular diseases, much interest has been shown in the superfamily of tumor necrosis factor (TNF) receptors. Members of this family include osteoprotegerin (OPG) and its ligands, which are receptor activators of nuclear factor κB ligand (RANKL) and TNF-related apoptosis-inducing ligand (TRAIL). These signals may be expressed and regulated, and their functions could be involved in several physiological and pathological processes. The relationship between bone regulatory proteins and vascular biology has attracted attention, and it has been suggested that OPG may medi…

miR-7 Restores Phenotypes in Myotonic Dystrophy Muscle Cells by Repressing Hyperactivated Autophagy

2019

International audience; Unstable CTG expansions in the 3' UTR of the DMPK gene are responsible for myotonic dystrophy type 1 (DM1) condition. Muscle dysfunction is one of the main contributors to DM1 mortality and morbidity. Pathways by which mutant DMPK trigger muscle defects, however, are not fully understood. We previously reported that miR-7 was downregulated in a DM1 Drosophila model and in biopsies from patients. Here, using DM1 and normal muscle cells, we investigated whether miR-7 contributes to the muscle phenotype by studying the consequences of replenishing or blocking miR-7, respectively. Restoration of miR-7 with agomiR-7 was sufficient to rescue DM1 myoblast fusion defects and…