Search results for "Variations"

Sun-Earth System Interaction studies over Vietnam: an international cooperative project

2006

International audience; During many past decades, scientists from various countries have studied separately the atmospheric motions in the lower atmosphere, in the Earth's magnetic field, in the magnetospheric currents, etc. All of these separate studies lead today to the global study of the Sun and Earth connections, and as a consequence, new scientific programs (IHY- International Heliophysical Year, CAWSES- Climate and Weather in the Sun-Earth System) are defined, in order to assume this new challenge. In the past, many scientists did not have the possibility to collect data at the same time in the various latitude and longitude sectors. Now, with the progress of geophysical sciences in …

Diferenciālvienādojumi un variāciju rēķini, 1. daļa

1937

Germline copy number variation in theYTHDC2gene: does it have a role in finding a novel potential molecular target involved in pancreatic adenocarcin…

2014

Abstract: Objective: The vast majority of pancreatic cancers occurs sporadically. The discovery of frequent variations in germline gene copy number can significantly influence the expression levels of genes that predispose to pancreatic adenocarcinoma. We prospectively investigated whether patients with sporadic pancreatic adenocarcinoma share specific gene copy number variations (CNVs) in their germline DNA. Patients and methods: DNA samples were analyzed from peripheral leukocytes from 72 patients with a diagnosis of sporadic pancreatic adenocarcinoma and from 60 controls using Affymetrix 500K array set. Multiplex ligation-dependent probe amplification (MLPA) assay was performed using a s…

The differential diagnoses of uterine leiomyomas and leiomyosarcomas using DNA and RNA sequencing.

2019

BACKGROUND: Although uterine leiomyomas and leiomyosarcomas are considered biologically unrelated tumors, they share morphologic and histologic characteristics that complicate their differential diagnosis. The long-term therapeutic option for leiomyoma is laparoscopic myomectomy with morcellation, particularly for patients who wish to preserve their fertility. However, because of the potential dissemination of undiagnosed or hidden leiomyosarcoma from morcellation, there is a need to develop a preoperative assessment of malignancy risk. OBJECTIVE: Through an integrated comparative genomic and transcriptomic analysis, we aim to identify differential genetic targets in leiomyomas vs leiomyosa…

A Computational Study on Temperature Variations in MRgFUS Treatments Using PRF Thermometry Techniques and Optical Probes

2021

Structural and metabolic imaging are fundamental for diagnosis, treatment and follow-up in oncology. Beyond the well-established diagnostic imaging applications, ultrasounds are currently emerging in the clinical practice as a noninvasive technology for therapy. Indeed, the sound waves can be used to increase the temperature inside the target solid tumors, leading to apoptosis or necrosis of neoplastic tissues. The Magnetic resonance-guided focused ultrasound surgery (MRgFUS) technology represents a valid application of this ultrasound property, mainly used in oncology and neurology. In this paper

Identification of New Genetic Clusters in Glioblastoma Multiforme: EGFR Status and ADD3 Losses Influence Prognosis

2020

Glioblastoma multiforme (GB) is one of the most aggressive tumors. Despite continuous efforts to improve its clinical management, there is still no strategy to avoid a rapid and fatal outcome. EGFR amplification is the most characteristic alteration of these tumors. Although effective therapy against it has not yet been found in GB, it may be central to classifying patients. We investigated somatic-copy number alterations (SCNA) by multiplex ligation-dependent probe amplification in a series of 137 GB, together with the detection of EGFRvIII and FISH analysis for EGFR amplification. Publicly available data from 604 patients were used as a validation cohort. We found statistical associations…

Seasonal variation in total phenolic content of Dictyopteris polypodioides (Dictyotaceae) and Cystoseira amentacea (Sargassaceae) from the Sicilian c…

2014

This study focuses on the differences in total phenolic content and its seasonal variations in two temperate brown algae, Cystoseira amentacea (C. Agardh) Bory and Dictyopteris polypodioides (A.P. De Candolle) J.V. Lamouroux, inhabiting respectively the infralittoral fringe and the upper infralittoral zone. Phenolic compounds are secondary metabolites, found in almost all brown algal orders, that function as defense against grazers, epiphytes and UV radiation. Total phenolic content was determined colorimetrically with the Folin-Ciocalteu reagent. Results showed significant differences in total phenol content between D. polypodioides and C. amentacea with higher values observed in the first…

Isolated bladder exstrophy associated with a de novo 0.9 Mb microduplication on chromosome 19p13.12

2012

BACKGROUND: The exstrophy-epispadias complex (BEEC) is a urogenital birth defect of varying severity. The causes of the BEEC are likely to be heterogeneous, with individual environmental or genetic risk factors still being largely unknown. In this study, we aimed to identify de novo causative copy number variations (CNVs) that contribute to the BEEC. METHODS: Array-based molecular karyotyping was performed to screen 110 individuals with BEEC. Promising CNVs were tested for de novo occurrence by investigating parental DNAs. Genes located in regions of rearrangements were prioritized through expression analysis in mice to be sequenced in the complete cohort, to identify high-penetrance mutati…

Additional evidence to support the role of the 20q13.33 region in susceptibility to autism

2012

Environmental and ontogenetic constraints on developmental stability in the spatangoid sea urchin Echinocardium (Echinoidea).

2006

13 pages; International audience; Spatangoid irregular sea urchins are detritivorous benthic organisms particularly prone to variations of environment, and their mode of growth and plate morphology make them an appropriate model to assess the effects of environmental variations. Two populations of Echinocardium flavescens were sampled in two sites of the Norwegian coast characterized by contrasted environmental conditions. Different morphological descriptors (plate areas, interlandmarks distances, overall size, and shape of the posterior ambulacra) were used to appraise interindividual variations, and fluctuating asymmetry. The comparisons were carried out using classical fluctuating asymme…