Search results for "differentiation"
showing 10 items of 1605 documents
Advance booking across channels: The effects on dynamic pricing
2021
This research analyzes the effects of advance booking and channel type on hotel rates. While this relationship has been addressed in the literature, most studies take a partial approach by focusing only on one distribution channel or one destination. This study fills this gap by analyzing the price dynamics for four channels and multiple destinations. The data set consists of 39,363 bookings for 1085 hotels over 27 consecutive months. We used two-stage least squares to solve potential endogeneity issues, and the results proved that distribution channel, hotel type and hotel size have an influence on the effect of advance booking on hotel rates. Critical managerial implications are discussed…
Neuroprotective Potential of GDF11: Myth or Reality?
2019
In the brain, aging is accompanied by cellular and functional deficiencies that promote vulnerability to neurodegenerative disorders. In blood plasma from young and old animals, various factors such as growth differentiation factor 11 (GDF11), whose levels are elevated in young animals, have been identified. The blood concentrations of these factors appear to be inversely correlated with the age-related decline of neurogenesis. The identification of GDF11 as a “rejuvenating factor” opens up perspectives for the treatment of neurodegenerative diseases. As a pro-neurogenic and pro-angiogenic agent, GDF11 may constitute a basis for novel therapeutic strategies.
Experimental demonstration of fractional order differentiation using a long-period grating-based in-fiber modal interferometer
2016
In this work we demonstrate both, experimentally and theoretically, that a long-period grating-based in-fiber modal interferometer can perform an all-optical arbitrary-order fractional differentiation. Experimentally, we fractionally differentiated to the 0.5th order a secant hyperbolic-like pulse of 23 ps time width provided by a 1039.5 nm emission wavelength modelocked fiber laser, with a chirp parameter of −30. An analytical expression relating the fractional order of differentiation n with the characteristics of the modal interferometer was also derived, with the purpose to simplify the design procedure. The proposal was corroborated also numerically. This device may find applications i…
Human brain organoids assemble functionally integrated bilateral optic vesicles
2021
During embryogenesis, optic vesicles develop from the diencephalon via a multistep process of organogenesis. Using induced pluripotent stem cell (iPSC)-derived human brain organoids, we attempted to simplify the complexities and demonstrate formation of forebrain-associated bilateral optic vesicles, cellular diversity, and functionality. Around day 30, brain organoids attempt to assemble optic vesicles, which develop progressively as visible structures within 60 days. These optic vesicle-containing brain organoids (OVB-organoids) constitute a developing optic vesicle's cellular components, including primitive corneal epithelial and lens-like cells, retinal pigment epithelia, retinal progeni…
Pool choice in a vertical landscape: Tadpole‐rearing site flexibility in phytotelm‐breeding frogs
2021
Abstract Many species of Neotropical frogs have evolved to deposit their tadpoles in small water bodies inside plant structures called phytotelmata. These pools are small enough to exclude large predators but have limited nutrients and high desiccation risk. Here, we explore phytotelm use by three common Neotropical species: Osteocephalus oophagus, an arboreal frog that periodically feeds eggs to its tadpoles; Dendrobates tinctorius, a tadpole‐transporting poison frog with cannibalistic tadpoles; and Allobates femoralis, a terrestrial tadpole‐transporting poison frog with omnivorous tadpoles. We found that D. tinctorius occupies pools across the chemical and vertical gradient, whereas A. fe…
P2 receptors influence differentiation in human mesenchymal and ectomesenchymal stem cells
2010
In Human Retinoblastoma Y-79 Cells 3-aminobenzamide induces Differentiation
2006
Behavior of Human Osteoblast Cells Cultured on Titanium Discs in Relation to Surface Roughness and Presence of Melatonin
2017
The aim of this work was to observe the behavior of osteoblast cells cultured in vitro on titanium discs in relation to disc surface roughness and the addition of melatonin to the culture medium. MG63 osteoblast cells were cultivated on 120 Grade 5 Ti divided into three groups: Group E, treated with dual acid etch; Group EP, treated with dual acid etch and calcium phosphate; and Group M, machined. Surface roughness was examined under a laser scanning confocal microscope (CLSM) and scanning electron microscopy (SEM). The proliferation and morphology of cells were determined under fluorescence microscopy and SEM. Messenger ribonucleic acid (mRNA) of different genes related to osteoblastic dif…