Reasons for low cervical cancer survival in new accession European Union countries: a EUROCARE-5 study.

Purpose: With better access to early diagnosis and appropriate treatment, cervical cancer (CC) burden decreased in several European countries. In Eastern European (EE) countries, which accessed European Union in 2004, CC survival was worse than in the rest of Europe. The present study investigates CC survival differences across five European regions, considering stage at diagnosis (local, regional and metastatic), morphology (mainly squamous versus glandular tumours) and patients’ age. Methods: We analysed 101,714 CC women diagnosed in 2000–2007 and followed-up to December 2008. Age-standardised 5-year relative survival (RS) and the excess risks of cancer death in the 5 years after diagnosi…

Search for Z0 decays to two leptons and a charged particle-antiparticle pair

Based on a sample equivalent to 365 000 hadronic Z0 decays, the search in DELPHI data for pairs of leptons accompanied by a pair of charged particles is described. A total of 11 events were found in the electron channel, 9 in the muon channel and 7 in the tau channel. Results on lepton pairs with a radiated photon are also presented. The data from all channels are compatible with the expectations from standard processes. However, one event was found in the tau channel with an unusually high mass of the charged particle pair.

Evidence for B$^{0}_{s}$ meson production in Z$^0$ decays

Seven unambiguous events out of a sample of 270 000 Z0 decays, contain in tile same jet a D(s) meson and a muon at large transverse momentum relative to the et axis. These events are direct evidence for B(s)0 meson production in hadronic Z0 decays. The production rate of these events, relative to all hadronic Z0 decays is ( 18 +/- 8) x 10(-5) this number including the relevant branching fractions of the B(s)0 and D(s). The value of the B(s)0 meson lifetime relative to the average B meson lifetime is measured to be 0.8 +/- 0.4.

Measurement of inclusive production of light meson resonances in hadronic decays of the Z0

A study of inclusive production of the meson resonances ρ0, K*0 (892), f{hook}0 (975) and f{hook}2 (1270) in hadronic decays of the Z0 is presented. The measured mean meson multiplicity per hadronic event is 0.83 ± 0.14 for the ρ0 0.64 ± 0.24 for the K*0 (892), 0.10 ± 0.04 for the f{hook}0 (975) in the momentum range p > 0.05pbeam (xp > 0.05) and 0.11 ± 0.05 for the f{hook}2 (1270) for xp > 0.1. These values and the corresponding differential cross sections ( 1 σhadr) dσ dxp for the vector mesons are in good agreement with the predictions of the JETSET 7.3 PS and HERWIG 5.4 models. The f{hook}2 (1270) production is overestimated by HERWIG but its xp-shape is correctly reproduced. T…

SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study

Abstract Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18–49, 50–69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results NNVs were more favourable in su…

A measurement of the tau lifetime

The tau lepton lifetime is measured using four different methods with the DELPHI detector. Three measurements using one prong decays are combined, accounting for correlations, resulting in tau(tau) = 298 +/- 7 (stat.) +/- 4 (syst.) fs while the decay length distribution of three prong decays gives tau(tau) = 298 +/- 13 (stat.) +/- 5 (syst.) fs. The combined result is tau(tau) = 298 +/- 7 fs. The ratio of the Fermi coupling constant from tau decay relative to that from muon decay is found to be 0.985 +/- 0.013, compatible with lepton universality.

Survival variations by country and age for lymphoid and myeloid malignancies in Europe 2000–2007: Results of EUROCARE-5 population-based study

BACKGROUND: Significant advances in the management of patients with lymphoid and myeloid malignancies entered clinical practice in the early 2000's. The EUROCARE-5 study database provides an opportunity to assess the impact of these changes at the population level by country in Europe. We provide survival estimates for clinically relevant haematological malignancies (HM), using the International Classification of Diseases for Oncology 3, by country, gender and age in Europe. METHODS: We estimated age-standardised relative survival using the complete cohort approach for 625, 000 adult patients diagnosed in 2000-2007 and followed up to 2008. Survival information was provided by 89 participati…

Survival in patients with primary liver cancer, gallbladder and extrahepatic biliary tract cancer and pancreatic cancer in Europe 1999- 2007: Results of EUROCARE-5

Abstract Background The EUROCARE study collects and analyses survival data from population-based cancer registries (CRs) in Europe in order to provide data on between-country differences in survival and time trends in survival. Methods This study analyses data on liver cancer, gallbladder and extrahepatic biliary tract cancers (“biliary tract cancers”), and pancreatic cancer diagnosed in 2000–2007 from 88 CRs in 29 countries. Relative survival (RS) was estimated overall, by region, sex, age and period of diagnosis using the complete approach. Time trends in 5-year RS over 1999–2007 were also analysed using the period approach. Results The prognosis of the studied cancers was poor. Age-stand…

The EUROCARE-5 study on cancer survival in Europe 1999-2007: Database, quality checks and statistical analysis methods

Abstract Background Since 25 years the EUROCARE study monitors the survival of cancer patients in Europe through centralised collection, quality check and statistical analysis of population-based cancer registries (CRs) data. The European population covered by the study increased remarkably in the latest round. The study design and statistical methods were also changed to improve timeliness and comparability of survival estimates. To interpret the EUROCARE-5 results on adult cancer patients better here we assess the impact of these changes on data quality and on survival comparisons. Methods In EUROCARE-5 the survival differences by area were studied applying the complete cohort approach to…

A measurement of the mean lifetimes of charged and neutral B-hadrons

The decays of B-hadrons have been reconstructed using the charged particles recorded in the DELPHI silicon microstrip detector. The sum of the charges of the secondaries determines the charge of the B-hadron parent. Some 232 114 multihadronic Z0 decays recorded during the 1991 run of LEP at centre-of-mass energies between 88.2 GeV and 94.2 GeV yield 253 B-hadron candidates with well-measured charge. From these the mean lifetimes of neutral and charged B-hadrons are found to be 1.44 +/- 0.21(stat.) +/- 0.14(syst.) ps and 1.56 +/- 0.19(stat.) +/- 0.13(syst.) ps respectively. The ratio of their lifetimes is 1.09(-0.23)+0.28 (Stat.) +/- 0.11 (syst.). Under some assumptions on the abundance and …

Italian cancer figures, report 2014: Prevalence and cure of cancer in Italy

This Report intends to estimate the total number of people still alive in 2010 after cancer diagnosis in Italy, regardless of the time since diagnosis, and to project these estimates to 2015. This study is also aimed to estimate the number of already cured cancer patients, whose mortality rates have become undistinguishable from that of the general population of the same age and sex.The study took advantage of the information from the AIRTUM database, which included 29 Cancer Registries (covering 21 million people, 35% of the Italian population). A total of 1,624,533 cancer cases diagnosed between 1976 and 2009 contributed to the study. For each registry, the observed prevalence was calcula…

Focal liver tumours characterization with contrast-specific modes and sulphur hexafluoride-filled microbubbles: analysis of diagnostic performance and confidence

Early outcomes and complications following cardiac surgery in patients testing positive for coronavirus disease 2019: An international cohort study

The outbreak of severe acute respiratory syndromecoronavirus-2, the cause of coronavirus disease 2019 (COVID-19) in December 2019 represented a global emergency accounting for more than 2.5 million deaths worldwide.1 It has had an unprecedented influence on cardiac surgery internationally, resulting in cautious delivery of surgery and restructuring of services.2 Understanding the influence of COVID-19 on patients after cardiac surgery is based on assumptions from other surgical specialties and single-center studies. The COVIDSurg Collaborative conducted a multicenter cohort study, including 1128 patients, across 235 hospitals, from 24 countries demonstrating perioperative COVID-19 infection…

Multiplicity fluctuations in hadronic final states from the decay of the Z0

An analysis of the fluctuations in the phase space distribution of hadrons produced in the decay of 78829 Z0 has been carried out, using the method of factorial moments. The high statistics collected by the DELPHI experiment at LEP during 1990 allowed studies of the event sample both globally and in intervals of p(t) and multiplicity, and for different jet topologies and for single jets. A large contribution to the factorial moments of the one-dimensional data on rapidity with respect to the event axis comes from hard gluons. Details of factorial moments in two and three dimensions are presented. Influences of resonance decays have been studied by Monte Carlo simulation: one-dimensional fac…

Changes in surgicaL behaviOrs dUring the CoviD-19 pandemic. The SICE CLOUD19 Study

Abstract Background The spread of the SARS-CoV2 virus, which causes COVID-19 disease, profoundly impacted the surgical community. Recommendations have been published to manage patients needing surgery during the COVID-19 pandemic. This survey, under the aegis of the Italian Society of Endoscopic Surgery, aims to analyze how Italian surgeons have changed their practice during the pandemic. Methods The authors designed an online survey that was circulated for completion to the Italian departments of general surgery registered in the Italian Ministry of Health database in December 2020. Questions were divided into three sections: hospital organization, screening policies, and safety profile of…

Classification of the hadronic decays of the Z$^0$ into b and c quark pairs using a neural network

A classifier based on a feed-forward neural network has been used for separating a sample of about 123 500 selected hadronic decays of the Z 0 , collected by DELPHI during 1991, into three classes according to the flavour of the original quark pair: u u +d d +s s (unresolved), c c and b b . The classification has been used to compute the partial widths of the Z 0 into b and c quark pairs. This gave Γ c c /Γ h = 0.151 ± 0.008 ( stat. ) ± 0.041 ( syst. ) , Γ b b /Γ h = 0.232±0.005 ( stat. )±0.017 ( syst. ) .

Comparison of European ICU patients in 2012 (ICON) versus 2002 (SOAP)

Purpose: To evaluate differences in the characteristics and outcomes of intensive care unit (ICU) patients over time. Methods: We reviewed all epidemiological data, including comorbidities, types and severity of organ failure, interventions, lengths of stay and outcome, for patients from the Sepsis Occurrence in Acutely ill Patients (SOAP) study, an observational study conducted in European intensive care units in 2002, and the Intensive Care Over Nations (ICON) audit, a survey of intensive care unit patients conducted in 2012. Results: We compared the 3147 patients from the SOAP study with the 4852 patients from the ICON audit admitted to intensive care units in the same countries as those…

Age and case mix-standardised survival for all cancer patients in Europe 1999-2007: Results of EUROCARE-5, a population-based study

Background: Overall survival after cancer is frequently used when assessing a health care service’s performance as a whole. It is mainly used by the public, politicians and the media, and is often dismissed by clinicians because of the heterogeneous mix of different cancers, risk factors and treatment modalities. Here we give survival details for all cancers combined in Europe, correlating it with economic variables to suggest reasons for differences. Methods: We computed age and cancer site case- mix standardised relative survival for all cancers combined (ACRS) for 29 countries participating in the EUROCARE-5 project with data on more than 7.5 million cancer cases from 87 population-based…

Urinary tract cancer survival in Europe 1999-2007: Results of the population-based study EUROCARE-5

Abstract Background This work presents relative survival estimates regarding urinary tract tumours among adult patients (age ⩾ 15 years) diagnosed in Europe. It reports on survival estimates of cases diagnosed in 2000–2007, and on survival time trends from 1999–2001 to 2005–2007. Methods Data on 677,340 adult urinary tract tumour patients, (429,154 cases of invasive and non-invasive bladder and 248,186 cases of invasive kidney cancers) diagnosed between 2000 and 2007 were provided by 86 population-based cancer registries from 29 European countries. The complete approach was used to estimate survival in 2000–2007; the period approach was used to estimate survival over time. Results The age-s…

Survival of male genital cancers (prostate, testis and penis) in Europe 1999-2007: Results from the EUROCARE-5 study

Abstract Background We provide updated estimates of survival and survival trends of male genital tumours (prostate, testicular and penis cancers), in Europe and across European areas. Methods The complete approach was used to obtain relative survival estimates for patients diagnosed in 2000–2007, and followed up through 2008 in 29 countries. Data came from 87 cancer registries (CRs) for prostate tumours and from 86 CRs for testis and penis tumours. Relative survival time trends in 1999–2007 were estimated by the period approach. Data came from 49 CRs in 25 countries. Results We analysed 1,021,275 male genital cancer cases. Five-year relative survival was high and decreased with increasing a…

Relationship between the Clinical Frailty Scale and short-term mortality in patients ≥ 80 years old acutely admitted to the ICU: a prospective cohort study.

Abstract Background The Clinical Frailty Scale (CFS) is frequently used to measure frailty in critically ill adults. There is wide variation in the approach to analysing the relationship between the CFS score and mortality after admission to the ICU. This study aimed to evaluate the influence of modelling approach on the association between the CFS score and short-term mortality and quantify the prognostic value of frailty in this context. Methods We analysed data from two multicentre prospective cohort studies which enrolled intensive care unit patients ≥ 80 years old in 26 countries. The primary outcome was mortality within 30-days from admission to the ICU. Logistic regression models for…

Quality analysis of population-based information on cancer stage at diagnosis across Europe, with presentation of stage-specific cancer survival estimates: A EUROCARE-5 study.

Abstract Background Cancer registries (CRs) are fundamental for estimating cancer burden, evaluating screening and monitoring health service performance. Stage at diagnosis—an essential information item collected by CRs—has been made available, for the first time, by CRs participating in EUROCARE-5. We analysed the quality of this information and estimated stage-specific survival across Europe for CRs with good data quality. Data and methods Sixty-two CRs sent stage (as TNM, condensed TNM or extent of disease) for 15 cancers diagnosed in 2000–2007. We assessed the quality, partly by comparing stage according to the three systems. We also developed procedures to reconstruct stage (categories…

Prevalence and correlates of QTc prolongation in Italian psychiatric care: cross-sectional multicentre study.

Aims.In recent years several warnings have been issued by regulatory authorities on the risk of electrocardiogram abnormalities in individuals exposed to psychotropic drugs. As a consequence of these warnings, monitoring of the QT interval corrected for heart rate (QTc) has become increasingly common. This study was conducted to measure the frequency of QTc prolongation in unselected psychiatric patients, and to document the associated factors using a cross-sectional approach.Method.The study was carried out in 35 Italian psychiatric services that are part of the STAR (Servizi Territoriali Associati per la Ricerca) Network, a research group established to produce scientific knowledge by col…

Survival of 86,690 patients with thyroid cancer: A population-based study in 29 European countries from EUROCARE-5

Background: Incidence rates of thyroid cancer (TC) increased in several countries during the last 30 years, while mortality rates remained unchanged, raising important questions for treatment and follow-up of TC patients. This study updates population-based estimates of relative survival (RS) after TC diagnosis in Europe by sex, country, age, period and histology.Methods: Data from 87 cancer registries in 29 countries were extracted from the EUROCARE-5 dataset. One-and 5-year RS were estimated using the cohort approach for 86,690 adult TC patients diagnosed in 2000-2007 and followed-up to 12/31/2008. RS trends in 1999-2007 and 10-year RS in 2005-2007 were estimated using the period approach…

Machine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: the COVIDSurg mortality score

The British journal of surgery 108(11), 1274-1292 (2021). doi:10.1093/bjs/znab183

Geographical variability in survival of European children with central nervous system tumours

Survival for childhood central nervous system (CNS) tumours varies across Europe, partly because of the difficulty of distinguishing malignant from non-malignant disease. This study examines bias in CNS tumours survival analysis to obtain the reliable and comparable survival figures. We analysed survival data for about 15, 000 children (age <15) diagnosed with CNS between 2000 and 2007, from 71 population- based cancer registries in 27 countries. We selected high- quality data based on registry- specific data quality indicators and recorded observed 1-year and 5-year survival by countries and CNS entity. We provided age- adjusted survival and used a Cox model to calculate the hazard ratios …

Assessment of the worldwide burden of critical illness: The Intensive Care Over Nations (ICON) audit

Item does not contain fulltext BACKGROUND: Global epidemiological data regarding outcomes for patients in intensive care units (ICUs) are scarce, but are important in understanding the worldwide burden of critical illness. We, therefore, did an international audit of ICU patients worldwide and assessed variations between hospitals and countries in terms of ICU mortality. METHODS: 730 participating centres in 84 countries prospectively collected data on all adult (>16 years) patients admitted to their ICU between May 8 and May 18, 2012, except those admitted for fewer than 24 h for routine postoperative monitoring. Participation was voluntary. Data were collected daily for a maximum of 28 da…