6533b835fe1ef96bd129ecf1
RESEARCH PRODUCT
Associations between dietary polyphenols and type 2 diabetes in a cross-sectional analysis of the PREDIMED-Plus Trial: role of body mass index and sex
Dora RomagueraLucas Tojal SierraLucas Tojal-sierraLeyre Notario-barandiaranJacqueline ÁLvarez-pérezJacqueline ÁLvarez-pérezÁNgel M. Alonso-gómezÁNgel M. Alonso-gómezDolores CorellaDolores CorellaNerea Becerra-tomásJosep A. TurJosep A. TurZenaida Vázquez-ruizZenaida Vázquez-ruizJordi Salas-salvadóItziar AbeteItziar AbeteItziar AbeteJosé Manuel Santos LozanoFrancisco J. TinahonesFrancisco J. TinahonesFrancisco Javier Basterra-gortariFrancisco Javier Basterra-gortariJosé Carlos Fernández-garcíaJosé Carlos Fernández-garcíaJadwiga KoniecznaJulia WärnbergJulia WärnbergJessica Pérez LópezAndrés Díaz-lópezRaul Martinez-lacruzRaul Martinez-lacruzRamon EstruchRamon EstruchAlfredo GeaAlfredo GeaPilar Matía-martínFacundo Vitelli-storelliJosé LapetraAnai Moreno-rodriguezAnai Moreno-rodriguezAna Galera-cusíAna Galera-cusíXavier PintóXavier PintóJosé V. SorlíJosé V. SorlíOlga CastañerRosa M. Lamuela-raventósRosa M. Lamuela-raventósSara Castro-barqueroSara Castro-barqueroJose Lopez-mirandaJose Lopez-mirandaMiguel Delgado-rodríguezMiguel Delgado-rodríguezEmilio RosEmilio RosMontserrat FitóAnna Tresserra-rimbauConcepción Pastor-poloAlba GaldonÁLvaro HernáezÁLvaro HernáezLidia DaimielKarla-alejandra Pérez-vegaJesús VioqueAlicia JulibertAlicia JulibertNancy BabioMiguel Ruiz-canelaMiguel Ruiz-canelaLaura García-molinaLaura García-molinaLluis Serra-majemLluis Serra-majemMaría Rubín-garcíaJosep VidalJosep VidalJosé Alfredo MartínezAina M. Galmes-panadessubject
0301 basic medicinePhysiologyCross-sectional studyClinical BiochemistryHydroxycinnamic acidsType 2 diabetesOverweightBiochemistry0302 clinical medicinepreventionFlavonoidesmetabolitesrisk2. Zero hungereducation.field_of_studyDiabetisDiabetes1. No poverty3. Good healthObesitatDietamedicine.symptommanagementHydroxybenzoic acidHydroxybenzoic acidsPhenolic acidsPopulationmen030209 endocrinology & metabolismArticleLignansCatechins2 cohorts03 medical and health sciencesEnvironmental healthcatechins diet flavonoids hydroxybenzoic acids hydroxycinnamic acids lignans obesity phenolic acids proanthocyanidinsmedicineProanthocyanidinsObesityeducationMolecular BiologyFlavonoids030109 nutrition & dieteticsbusiness.industrylcsh:RM1-950biomarkersnutritional and metabolic diseasesCell Biologymedicine.diseaseObesityDietlcsh:Therapeutics. PharmacologyMetabolic syndromebusinessBody mass indexdescription
Overweight and obesity are important risk factors for type 2 diabetes (T2D). Moving towards healthier diets, namely, diets rich in bioactive compounds, could decrease the odds of suffering T2D. However, those individuals with high body mass index (BMI) may have altered absorption or metabolism of some nutrients and dietary components, including polyphenols. Therefore, we aimed to assess whether high intakes of some classes of polyphenols are associated with T2D in a population with metabolic syndrome and how these associations depend on BMI and sex. This baseline cross-sectional analysis includes 6633 participants from the PREDIMED-Plus trial. Polyphenol intakes were calculated from food frequency questionnaires (FFQ). Cox regression models with constant time at risk and robust variance estimators were used to estimate the prevalence ratios (PRs) for polyphenol intake and T2D prevalence using the lowest quartile as the reference group. Analyses were stratified by sex and BMI groups (overweight and obese) to evaluate potential effect modification. Catechins, proanthocyanidins, hydroxybenzoic acids, and lignans were inversely associated with T2D. Hydroxycinnamic acids were directly related in men. These associations were different depending on sex and BMI, that is, women and overweight obtained stronger inverse associations.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-11-08 |