showing 36 of ~574560 from 574555 documents
Pathological Findings in COVID-19 as a Tool to Define SARS-CoV-2 Pathogenesis. A Systematic Review
2021
Introduction: The World Health Organization declared the COVID-19 pandemic in March 2020. COVID-19 still represents a worldwide health emergency, which causesa severe disease that has led to the death of many patients. The pathophysiological mechanism of SARS-CoV-2 determining the tissue damage is not clear and autopsycan be auseful tool to improve the knowledge of this infection and, thus, it can help achieve a timely diagnosis and develop an appropriate therapy. This is an overview of the main post-mortem findings reporting data on the infection effects on several organs.Methods: A systematic literature search was conducted in the PubMed database searching for articles from 1 January to A…
Integrated use of unmanned aerial vehicle photogrammetry and terrestrial laser scanning to support archaeological analysis: The Acropolis of Selinunt…
2021
Southwestern Sicily is an area of infrequent seismic activity; however, some studies carried out in the archaeological Selinunte site suggest that, between the fourth century BC and the early Middle Ages, probably at least two earthquakes strucked this area with enough energy to damage and cause the collapse and kinematics of much of the architecture of Selinunte. Take into account that, in 2008, a noninvasive archaeological prospection and traditional data gathering methods along the Acropolis north fortifications were carried out. Following these first studies, after about 10 years, a new geophysical campaign was carried out. This second campaign benefited from the application of modern t…
Permanently Online—Always Stressed Out? The Effects of Permanent Connectedness on Stress Experiences
2021
Abstract Concerns have been expressed that permanent online connectedness might negatively affect media user’s stress levels. Most research has focused on negative effects of specific media usage patterns, such as media multitasking or communication load. In contrast, users’ cognitive orientation toward online content and communication has rarely been investigated. Against this backdrop, we examined whether this cognitive orientation (i.e., online vigilance with its three dimensions salience, reactibility, monitoring) is related to perceived stress at different timescales (person, day, and situation level), while accounting for the effects of multitasking and communication load. Results acr…
Under pressure: phenotypic divergence and convergence associated with microhabitat adaptations in Triatominae
2021
AbstractBackgroundTriatomine bugs, the vectors of Chagas disease, associate with vertebrate hosts in highly diverse ecotopes. When these blood-sucking bugs adapt to new microhabitats, their phenotypes may change. Although understanding phenotypic variation is key to the study of adaptive evolution and central to phenotype-based taxonomy, the drivers of phenotypic change and diversity in triatomines remain poorly understood.Methods/FindingsWe combined a detailed phenotypic appraisal (including morphology and morphometrics) with mitochondrialcytband nuclear ITS2 DNA-sequence analyses to studyRhodnius ecuadoriensispopulations from across the species’ range. We found three major, naked-eye phen…
Study on consumer preferences for quality attributes of fig fruit after storage at room temperature
2021
Fig (Ficus carica L.) is a nutritious fruit, rich in fiber, potassium, calcium, and iron. It is an important source of vitamins, amino acids, antioxidants and phenolic compounds that contribute to a healthy diet. In addition to Asian countries, fig is cultivated in the Mediterranean basin, where quality fruit has been produced since ancient times. Sicily in southern Italy traditionally cultivated ‘San Giovanni’ figs, but fig consumption has decreased. This cultivar is very interesting for its intrinsic qualities and its appreciation after storage by consumers could help its commercialization. The objective of this study is to know consumer preferences for quality attributes of ‘San Giovanni…
Metric equivalences of Heintze groups and applications to classifications in low dimension
2021
We approach the quasi-isometric classification questions on Lie groups by considering low dimensional cases and isometries alongside quasi-isometries. First, we present some new results related to quasi-isometries between Heintze groups. Then we will see how these results together with the existing tools related to isometries can be applied to groups of dimension 4 and 5 in particular. Thus we take steps towards determining all the equivalence classes of groups up to isometry and quasi-isometry. We completely solve the classification up to isometry for simply connected solvable groups in dimension 4, and for the subclass of groups of polynomial growth in dimension 5.
Advanced teleoperation and control system for industrial robots based on augmented virtuality and haptic feedback
2021
[EN] There are some industrial tasks that are still mainly performed manually by human workers due to their complexity, which is the case of surface treatment operations (such as sanding, deburring, finishing, grinding, polishing, etc.) used to repair defects. This work develops an advanced teleoperation and control system for industrial robots in order to assist the human operator to perform the mentioned tasks. On the one hand, the controlled robotic system provides strength and accuracy, holding the tool, keeping the right tool orientation and guaranteeing a smooth approach to the workpiece. On the other hand, the advanced teleoperation provides security and comfort to the user when perf…
Cognitive reappraisal and self-compassion as emotion regulation strategies for parents during COVID-19: An online randomized controlled trial
2021
Objective Parenting during pandemic restrictions places extreme demands on everyday family life, leading to increased stress levels for parents and distressed parent-child interactions. This RCT aimed to investigate whether cognitive reappraisal and self-compassion are helpful emotion regulation (ER) strategies to reduce individual and parental stress during the COVID-19 pandemic. Method An online intervention for parents was developed focusing on the application of ER strategies to pandemic requirements of families. A sample of 265 parents were randomly assigned to either cognitive reappraisal (CR; n = 88), self-compassion (SC; n = 90) or wait-list control (WLC; n = 87) group. Intervention…
Re-definition and supporting evidence toward Fanconi Anemia as a mitochondrial disease: Prospects for new design in clinical management
2021
Fanconi anemia (FA) has been investigated since early studies based on two definitions, namely defective DNA repair and proinflammatory condition. The former definition has built up the grounds for FA diagnosis as excess sensitivity of patients' cells to xenobiotics as diepoxybutane and mitomycin C, resulting in typical chromosomal abnormalities. Another line of studies has related FA phenotype to a prooxidant state, as detected by both in vitro and ex vivo studies. The discovery that the FA group G (FANCG) protein is found in mitochondria (Mukhopadhyay et al., 2006) has been followed by an extensive line of studies providing evidence for multiple links between other FA gene products and mi…
COVID-SCORE Spain: public perceptions of key government COVID-19 control measures
2021
Abstract Background Spain was initially one of the countries most affected by the coronavirus disease 2019 (COVID-19) pandemic. In June 2020, the COVID-SCORE-10 study reported that the Spanish public’s perception of their government’s response to the pandemic was low. This study examines these perceptions in greater detail. Methods We employed an ordered logistic regression analysis using COVID-SCORE-10 data to examine the Spanish public’s perception of 10 key aspects of their government’s COVID-19 control measures. These included support for daily needs, mental and general health services, communication, information and coordination, which were examined by gender, age, education level, hav…
Role of the Non-Canonical RNAi Pathway in the Antifungal Resistance and Virulence of Mucorales
2021
Mucorales are the causal agents for the lethal disease known as mucormycosis. Mortality rates of mucormycosis can reach up to 90%, due to the mucoralean antifungal drug resistance and the lack of effective therapies. A concerning urgency among the medical and scientific community claims to find targets for the development of new treatments. Here, we reviewed different studies describing the role and machinery of a novel non-canonical RNAi pathway (NCRIP) only conserved in Mucorales. Its non-canonical features are the independence of Dicer and Argonaute proteins. Conversely, NCRIP relies on RNA-dependent RNA Polymerases (RdRP) and an atypical ribonuclease III (RNase III). NCRIP regulates the…
What robots want? Hearing the inner voice of a robot.
2021
Summary The inner speech is thoroughly studied in humans, and it represents an interdisciplinary research issue involving psychology, neuroscience, and pedagogy. A few papers only, mostly theoretical, analyze the role of inner speech in robots. The present study investigates the potential of the robot's inner speech while cooperating with human partners. A cognitive architecture is designed and integrated with standard robot routines into a complex framework. Two threads of interaction are discussed by setting the robot operations with and without inner speech. Thanks to the robotic self-dialog, the partner can easily trace the robot's processes. Moreover, the robot can better solve conflic…
Active biopackaging produced from by‐products and waste from food and marine industries
2021
The agro‐food industry cannot today do without packaging to preserve and above all market its products. Plastic materials coming mainly from petrochemicals have taken a predominant place in the food packaging sector. They have become indispensable in many sectors, from fresh to frozen products, from meat and dairy products to fruit and vegetables or almost‐ready meals. Plastics are cheap, their lightness reduces transport costs, and their convenience is fundamental for out‐of‐home catering. However, plastics pose serious end‐of‐life issues. The development of materials that are more respectful of the consumer and the environment has become a major issue. In addition, the agro‐food industrie…
Influence of the type of reciprocating motion on the cyclic fatigue resistance of reciprocating files in a dynamic model
2021
Abstract Background The aim of this study was to compare the influence of two novel reciprocating movements on the cyclic fatigue resistance of endodontic reciprocating files. Methods 30 Procodile® (Komet Medical, Lemgo, Germany) files were selected in this study and distributed according to the following study groups depending on the movements to be performed: ReFlex Dynamic (n = 10), ReFlex Smart (n = 10) and Reciproc (n = 10) reciprocating movement. These files were fixed to a specific dynamic cyclic fatigue device designed and manufactured by 3D impression to simulate the pecking motion performed by the operator. The time to failure and the number of cycles of in-and-out of the endodont…
Children at risk for dyslexia show deficient left-hemispheric memory representations for new spoken word forms
2021
Developmental dyslexia is a specific learning disorder with impairments in reading and spelling acquisition. Apart from literacy problems, dyslexics show inefficient speech encoding and deficient novel word learning, with underlying problems in phonological processing and learning. These problems have been suggested to be related to deficient specialization of the left hemisphere for language processing. To examine this possibility, we tracked with magnetoencephalography (MEG) the activation of the bilateral temporal cortices during formation of neural memory traces for new spoken word forms in 7–8-year-old children with high familial dyslexia risk and in controls. The at-risk children impr…
Phospholylmethano P-chirogenic-phosphine-borane as P-(η2-BH3)-chelating ligands of rhodium (I): Synthesis, characterization and asymmetric hydrogenat…
2021
International audience; The stereoselective synthesis of new phospholylmethano P-chirogenic-phosphine-borane was achieved by P-C bond formation of the bridge, using electrophilic or nucleophilic P*-building blocks. These P1CH2P2*.BH3 ligands behaved as chelating (κ1-P1)-(η2-BH3) entities towards the cationic rhodium(I) centre. The resulting chiral rhodium complexes were tested in asymmetric rhodium catalyzed hydrogenation of methyl 2-(acetamido)acrylate.
The Impact of the Introduction of Innovative REDS Scale for the Evaluation of Central Tunnelled Catheter (CTC) Exit Site on Infection Prevention in L…
2021
Central tunneled catheter (CTC)-related infections are a leading cause of a catheter loss, thus being the source of significant morbidity and mortality. The study aims at evaluating the impact of the implementation of the innovative redness, edema, discharge and tenderness, symptoms (REDS) scale (devised by the authors) for the description of the tunnel condition on the frequency of infection in long-term catheter users. The same cohort of the 40 patients was observed for 4 years altogether: 2 years before and 2 years after REDS application. The results, as well as follow-up evaluation of participants, were compared. The 2-year cumulative incidence of the CTC exit site infection (ESI) dropp…
Genetic Determinants in a Critical Domain of NS5A Correlate with Hepatocellular Carcinoma in Cirrhotic Patients Infected with HCV Genotype 1b
2021
HCV is an important cause of hepatocellular carcinoma (HCC). HCV NS5A domain-1 interacts with cellular proteins inducing pro-oncogenic pathways. Thus, we explore genetic variations in NS5A domain-1 and their association with HCC, by analyzing 188 NS5A sequences from HCV genotype-1b infected DAA-naïve cirrhotic patients: 34 with HCC and 154 without HCC. Specific NS5A mutations significantly correlate with HCC: S3T (8.8% vs. 1.3%, p = 0.01), T122M (8.8% vs. 0.0%, p <
Identifying Past and Current Trends in Technology Education in Finland
2021
Technology education makes a unique contribution to the development of all young people by providing them a wide range of knowledge and skills. It has a role in shaping future debates and discourses by developing students’ technological literacy and by raising awareness of various dimensions of technology. In order to understand technology education in Finnish basic education, it is necessary to consider it within the subject of craft, particularly the domain of technical craft activities. However, the role of technology education has been and still is undefined in Finland. Thus, we need strategic planning and research in order to develop the necessary procedures and operations to achieve i…
Does enterprise social media use promote employee creativity and well-being?
2021
Abstract Despite the increased use of Enterprise Social Media (ESM) worldwide, its adverse impact on firms’ employees, such as exhaustion, has not been researched sufficiently. This is a critical gap in the literature since employees’ well-being is crucial to maintaining their productivity. The current study addresses this gap by examining whether interruption overload and psychological transition affect the relationship of employees’ socio-instrumental use of ESM with ESM-related exhaustion and employee creativity, respectively. We utilized the Conservation of Resources (COR) theory to conceptualize the mediation effect of interruption overload and psychological transition on the hypothesi…
Multi-Antenna Covert Communication With Jamming in the Presence of a Mobile Warden
2021
Covert communication can hide the information transmission process from the warden to prevent adversarial eavesdropping. However, it becomes challenging when the warden can move. In this paper, we propose a covert communication scheme against a mobile warden, which maximizes the connectivity throughput between a multi-antenna transmitter and a full-duplex jamming receiver with the covert outage probability (COP) limit. First, we analyze the monotonicity of the COP to obtain the optimal location the warden can move. Then, under this worst situation, we optimize the transmission rate, the transmit power and the jamming power of covert communication to maximize the connection throughput. This …
The Role of p53 Signaling in Colorectal Cancer.
2021
Simple Summary The transcription factor p53 is a crucial tumor suppressor that regulates diverse cellular responses to protect against cancer development. Deactivating p53 signaling either by altering p53 regulators or by p53 mutations occurs frequently in human colorectal carcinoma (CRC). Forty-three percent of CRCs harbor p53 mutations that reduce wild-type p53 tumor suppressor activity and often provide neo-morphic functions, which contribute to tumorigenesis. In this review, we summarize wild-type p53 signaling, how it can be deregulated in CRC, and the functional and phenotypical effects of p53 mutations. We also discuss current therapeutic strategies of targeting p53. Abstract The tra…
Performance assessment of water companies: A metafrontier approach accounting for quality of service and group heterogeneities
2021
Abstract The assessment of water companies’ efficiency, productivity and quality of service is part of the process to set water tariffs and therefore, is relevant for regulators and customers. However, the water industry involves several heterogeneous water companies. Following a pioneering approach, this study estimates productivity change and its drivers considering the non-homogeneous nature of the water companies and incorporating quality of service variables as undesirable outputs. In doing so, the metafrontier Malmquist Luenberger productivity index was estimated for a sample of English and Welsh water and sewerage companies (WaSCs) and water only companies (WoCs) over the years 2001–…
Induction of stress resistance and extension of lifespan in Chaenorhabditis elegans serotonin-receptor knockout strains by withanolide A
2021
Abstract Introduction Approximately 300 million people worldwide suffer from depression. The COVID-19 crisis may dramatically increase these numbers. Severe side effects and resistance development limit the use of standard antidepressants. The steroidal lactone withanolide A (WA) from Withania somnifera may be a promising alternative. Caenorhabditis elegans was used as model to explore WA's anti-depressive and anti-stress potential. Methods C. elegans wildtype (N2) and deficient strains (AQ866, DA1814, DA2100, DA2109 and MT9772) were used to assess oxidative, osmotic or heat stress as measured by generation of reactive oxygen species (ROS), determination of lifespan, and mRNA expression of …
Mutations associated with pyrethroid resistance in Varroa mite, a parasite of honey bees, are widespread across the United States.
2021
BACKGROUND Managed honey bees are key pollinators of many crops and play an essential role in the United States food production. For more than ten years, beekeepers in the United States have been reporting high rates of colony losses. One of the drivers of these losses is the parasitic mite Varroa destructor. Maintaining healthy honey bee colonies in the United States is dependent on a successful control of this mite. The pyrethroid tau-fluvalinate (Apistan®) was among the first synthetic varroacides registered in the United States. With over 20 years of use, mites resistant to Apistan® have emerged, and so it is unsurprising that treatment failures have been reported. Resistance to tau-flu…
Vote choices of left-authoritarians: Misperceived congruence and issue salience
2021
Abstract Often lacking parties with a corresponding profile, citizens with economically left and culturally authoritarian, or nationalist, policy orientations face a trade-off between congruence on economic and on cultural issues. How such left-authoritarian voters resolve this trade-off depends on which issues are more salient to them, previous research argues. We extend this line of research by considering the role of (mis-)perceived party positions. Using a survey in the context of the 2017 German election, we show how perceived congruence and issue importance interactively shape the left-authoritarian vote. Our findings indicate that many left-authoritarians vote for a party simply beca…
Special Issue on Signal Processing and Machine Learning for Biomedical Data
2021
This Special Issue is focused on advanced techniques in signal processing, analysis, modelling, and classification, applied to a variety of medical diagnostic problems. Biomedical data play a fundamental role in many fields of research and clinical practice. Very often the complexity of these data and their large volume makes it necessary to develop advanced analysis techniques and systems. Furthermore, the introduction of new techniques and methodologies for diagnostic purposes, especially in the field of medical imaging, requires new signal processing and machine learning methods. The recent progress in machine learning techniques, and in particular deep learning, revolutionized various f…
Complex Rating Curves for Sharp Crested Orifices and Rectangular or Triangular Weirs under Unsteady Flow Conditions
2021
The importance of discharge measurements is fully acknowledged in many research fields, mostly in hydrology. Numerous measurement devices and various overflow structures have been proposed for discharge measurements; however, their use is based on calibrated simple stage discharge relationships that may cause significant errors when unsteady flow conditions occur. This issue is quite common because of rainfall and runoff temporal variability that inhibits the achievement of the steady state. Although this issue has already been experimentally investigated, it seems that a physically based line of approach has not been attempted before. In this paper, unsteady stage discharge relationships o…
How to do things with signs. The formulation of directives on signs in public spaces
2021
Abstract This paper analyzes signs and written messages aimed at regulating people's behavior in public spaces. Based on a collection of more than 700 verbal and pictographic signs, the paper focuses on how the formulation of the directives reflect and construct the authors' deontic authority, how they account for the social legitimacy of the directive and how they seek to evoke the addressee's goodwill and cooperativeness. The analysis shows that the author's entitlement to perform the directive may be grounded in references to institutional authority, or that it may be manifested in the linguistic or pictographic expression itself, such as use of imperative mode, exclamation marks, or thr…
Multimessenger Binary Mergers Containing Neutron Stars: Gravitational Waves, Jets, and γ-Ray Bursts
2021
Neutron stars (NSs) are extraordinary not only because they are the densest form of matter in the visible Universe but also because they can generate magnetic fields ten orders of magnitude larger than those currently constructed on earth. The combination of extreme gravity with the enormous electromagnetic (EM) fields gives rise to spectacular phenomena like those observed on August 2017 with the merger of a binary neutron star system, an event that generated a gravitational wave (GW) signal, a short γ-ray burst (sGRB), and a kilonova. This event serves as the highlight so far of the era of multimessenger astronomy. In this review, we present the current state of our theoretical understand…
Credit and financial markets in the Iberian Peninsula at the end of the Middle Ages. Historiographic production and recent developments
2021
El artículo examina la trayectoria de los estudios sobre el crédito y los mercados financieros en la Península Ibérica a finales de la Edad Media, desde los primeros trabajos sobre la usura y el préstamo a interés, fundamentalmente judío, en la primera mitad del siglo XX, hasta las líneas de investigación más recientes, que se ramifican en diversas direcciones, desde el marco teórico, doctrinal y legal del mercado del crédito y el estudio de los diferentes instrumentos financieros –préstamo a interés, crédito comercial y bancario, crédito a largo plazo en forma de censales y censos consignativos– a la deuda pública y el crédito privado, especialmente el crédito rural. Todos estos estudios m…
Su Dante. Un accenno dagli studi di Romano Guardini
2021
In occasione del centenario in onore del Nostro, sommo poeta Dante, il testo si presenta come un accenno dagli Studi Danteschi di Romano Guardini. Ripercorrendo il viaggio nei tre regni dell’aldilà l’autore ne ricorda gli incontri salienti, mostrando al lettore l’esaustiva corrispondenza fra l’interiorità del protagonista e l’esteriorità dei paesaggi attraversati. Un breve rinvio ai più ricchi volumi XIX/1 e XIX/2 dell’Opera Omnia guardiniana.
Patterns of Psychological Responses among the Public during the Early Phase of COVID-19: A Cross-Regional Analysis
2021
This study aimed to compare the mediation of psychological flexibility, prosociality and coping in the impacts of illness perceptions toward COVID-19 on mental health among seven regions. Convenience sampled online survey was conducted between April and June 2020 from 9130 citizens in 21 countries. Illness perceptions toward COVID-19, psychological flexibility, prosociality, coping and mental health, socio-demographics, lockdown-related variables and COVID-19 status were assessed. Results showed that psychological flexibility was the only significant mediator in the relationship between illness perceptions toward COVID-19 and mental health across all regions (all ps = 0.001–0.021). Seeking …