showing 36 of ~574560 from 574555 documents
Chemotherapy of metastatic colon cancer in France: A population-based study
2021
International audience; Aims: to describe, using data from a cancer registry in a well-defined French population, the therapeutic strategies and survival of patients with metastatic colon cancer (mCC).Methods: all patients with synchronous mCC diagnosed within the 2005-2014 period recorded in the digestive cancers registry of Burgundy were included.Results: 1286 mCC patients were included (57% male), of which 34.5% did not receive any antitumor treatment. Both, advanced age (≥75 years) and the Charlson comorbidity score ≥2 were significantly associated with the absence of antitumor treatment. Among the patients treated with chemotherapy, 59 and 33% received at least two and three lines, res…
Relationship between emotional coping and depressive symptomatology
2021
IntroductionFrom the life cycle perspective, the aging is described as the strengthening of adaptive resources and the capacity for recovery or compensation for losses. These skills are grounded in the coping strategies that individuals apply in order to effectively adapt to diverse situations. Emotion-focused, passive coping strategies are considered to be maladaptive in the long term. These strategies are associated with affective disorders, being these phenomena of great impact in older adults.ObjectivesVerify if there is a relationship between emotion-focused coping strategies and depressive symptomsMethodsThe sample was composed of 418 healthy older adults, aged between 60 and 89 years…
Affinity Sensors for the Diagnosis of COVID-19
2021
The coronavirus disease 2019 (COVID-19) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was proclaimed a global pandemic in March 2020. Reducing the dissemination rate, in particular by tracking the infected people and their contacts, is the main instrument against infection spreading. Therefore, the creation and implementation of fast, reliable and responsive methods suitable for the diagnosis of COVID-19 are required. These needs can be fulfilled using affinity sensors, which differ in applied detection methods and markers that are generating analytical signals. Recently, nucleic acid hybridization, antigen-antibody interaction, and change of reactive oxyge…
Formación del profesorado de educación física en el uso de aplicaciones tecnológicas
2021
La inclusión de las Tecnologías de la Información y Comunicación (TIC) en el ámbito educativo precisa de un profesorado con un nivel de competencia digital (CD) suficiente para enseñar al alumnado dicha tecnología. Paradójicamente, en la literatura existe una tendencia emergente por el estudio de la CD, mientras que el uso específico de las herramientas tecnológicas se está dejando de lado, especialmente en el campo de la educación física (EF). Por ello, el objetivo del presente trabajo fue valorar el empleo real de las aplicaciones educativas por parte del futuro profesorado de EF. Para ello, se aplicó el cuestionario CUTDEF (Cuestionario sobre conocimiento y uso de las TIC por los y las d…
167P Chemotherapy-induced neutropenia and treatment efficacy in advanced non-small cell lung cancer (aNSCLC): A pooled analysis of 6 randomized trials
2021
Procoagulant activities of skeletal muscle and cardiac myosins require both myosin protein and myosin-associated anionic phospholipids
2021
Scales Used to Assess Stress Level and Mental Health During the Covid 19 Pandemic: Systematic Review
2021
At the end of December 2019, the world became aware of the existence of a new virus that was in the city of Wuhan...
Noise fiber lasers
2021
In this paper, we present a brief review of the noise operation mode of fiber lasers. These lasers were studied recently by collaborative group that includes researchers, professors, and Ph.D. students from the Centro de Investigaciones en Optica, A.C. (Leon, Guanajuato, Mexico) and from the Universidad de Valencia (Valencia, Spain). Meanwhile, the pioneer works in this topic important for understanding the physics behind fiber lasers’ operation and for practical applications were done with the active participation of Dr. Evgeny Kuzin from the Instituto Nacional de Astrofisica, Optica y Electronica (Puebla, Mexico) and Dr. Georgina Beltrán-Pérez from the Benemérita Universidad Autónoma de P…
Long-term effects of the home literacy environment on reading development: Familial risk for dyslexia as a moderator.
2021
This study aimed to gain better understanding of the associations between literacy activities at home and long-term language and literacy development. We extended the home literacy environment (HLE) model of Sénéchal and LeFevre (Child Development [2002], Vol. 73, pp. 445–460) by including repeated assessments of shared reading, oral language, and reading comprehension development, including examination of familial risk for dyslexia as a moderator, and following development over time from ages 2 to 15 years. Of the 198 Finnish participants, 106 have familial risk for dyslexia due to parental dyslexia. Our path models include development in vocabulary (2–5.5 years), emerging literacy (5.5 ye…
Role of Adenosine Receptors in Rare Neurodegenerative Diseases with Motor Symptoms
2021
: The approval of istradefylline, an adenosine 2A receptor (A2AR) antagonist, as an addon treatment in adult patients with Parkinson’s disease by the Food and Drug Administration (FDA) and European Medicines Agency (EMA), is the latest proof of the importance of the adenosinergic system in the nervous system. Adenosine is an endogenous purine nucleoside with a role as a modulator of both neurotransmission and the inflammatory response. As such, the expression pattern of the 4 adenosine receptors (A1R, A2AR, A2BR and A3R) and the extracellular adenosine levels have attracted great interest in the pathogenesis and possible treatment of rare neurodegenerative diseases with motor symptoms. The…
Balance del año 2020 y nuevos propósitos de 2021 para abordar los objetivos propuestos en el Plan Estratégico 2020-2022 de la Revista Española de Nut…
2021
La predicción del fracaso empresarial de las cooperativas españolas. Aplicación del Algoritmo Extreme Gradient Boosting
2021
El objetivo del estudio realizado es mostrar la utilidad de la metodología Extreme Gradient Boosting (XGBoost), basada en el aprendizaje automático, en la predicción del fracaso empresarial, particularmente en el ámbito de las empresas cooperativas. Para ello, se ha estimado un modelo a partir de una muestra de cooperativas pertenecientes a diversos sectores, que ha permitido identificar que estas empresas presentan una menor propensión al fracaso cuando alcanzan mayores índices de solvencia y rentabilidad y menor endeudamiento. De acuerdo con los resultados, el modelo estimado XGBoost obtiene una capacidad predictiva del 100% en la muestra de entrenamiento y de un 86% en una muestra de com…
Controlling the Formation of Sodium/Black Phosphorus IntercalationCompounds Towards High Sodium Content
2021
The solid-state synthesis of pure sodium-black phosphorus intercalation compounds (Na-BPICs) has been optimized in bulk for two stoichiometric ratios. Specifically, in-situ X-Ray diffraction (XRD) allowed the precise identification of the optimal temperature range for the formation of Na-BPICs: 94°C–96°C. Moreover, as the undesired formation of Na3P takes place at this very same range, we succeeded in introducing a new synthetic route based on a fast-thermal ball milling implementation that results in the bulk production of BPIC without Na3P in 9 out of 10 cases. Finally, by combining XRD, Raman spectroscopy, and DFT calculations we developed a new structural model for Na-based BPICs showin…
false
2021
The hydrophobic tails of aliphatic primary alcohols do insert into the hydrophobic core of a lipid bilayer. Thereby, they disrupt hydrophobic interactions between the lipid molecules, resulting in a decreased lipid order, i.e., an increased membrane fluidity. While aromatic alcohols, such as 2-phenylethanol, also insert into lipid bilayers and disturb the membrane organization, the impact of aromatic alcohols on the structure of biological membranes, as well as the potential physiological implication of membrane incorporation has only been studied to a limited extent. Although diverse targets are discussed to be causing the bacteriostatic and bactericidal activity of 2-phenylethanol, it is …
Generations of Stateless People: Many Years of The Rohingya’s Personal Security at Risk and the Support of the EU
2021
The Rohingya is an ethnic-religious Muslim minority that has struggled with serious human rights violations for decades. Indian migration to Burma, stimulated by British colonial rule, is pointed to as the main cause of the Muslim-Buddhist conflict. Although Indians in Burma currently constitute a fraction of the population (2.3%), resentment remained. The aim of the article is to analyze the threats to many aspects of the personal security of the Rohingya population. It is one of the most populous groups of stateless persons in the world; moreover, since the 1960s, this ethnic group has experienced oppression on a huge scale: from restrictions related to work and movement as well as diffic…
Abacavir Increases Purinergic P2X7 Receptor Activation by ATP: Does a Pro-inflammatory Synergism Underlie Its Cardiovascular Toxicity?
2021
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The first COVID-19 lockdown reveals an ambivalent relation of French parents with food pleasure: the struggle to find a balance
2021
International audience; In France, a first COVID-19 lockdown took place from March-May 2020. Using an online survey including three open-ended questions, this study explored parents' experiences regarding changes in their family's eating behaviors during this lockdown. French parents (n = 498, 71% mothers) of young children were invited to describe which food-related changes they (1) perceived as positive during the lockdown, (2) perceived as negative, and (3) would like to maintain after the lockdown. A thematic analysis revealed that parents appreciated the choice of more local, fresh and high-quality foods, the time to prepare foods (homemade dishes, new recipes) and cooking and eating w…
Online Non-linear Topology Identification from Graph-connected Time Series
2021
Estimating the unknown causal dependencies among graph-connected time series plays an important role in many applications, such as sensor network analysis, signal processing over cyber-physical systems, and finance engineering. Inference of such causal dependencies, often know as topology identification, is not well studied for non-linear non-stationary systems, and most of the existing methods are batch-based which are not capable of handling streaming sensor signals. In this paper, we propose an online kernel-based algorithm for topology estimation of non-linear vector autoregressive time series by solving a sparse online optimization framework using the composite objective mirror descent…
The effectiveness of alkaline water on oily and acne-prone skin: a case report
2021
Background: Skin lesions and excess sebum on the surface of epidermis occur mainly among people suffering from acne vulgaris. Scientists are constantly searching for cosmetic procedures that, can not only complement dermatological treatment and decrease sebum production, but also increase patients’ quality of lives. Aim of the study: To evaluate the effectiveness of alkaline water in the treatment oily skin and acne vulgaris in a 21-year-old woman. Case report: A 21- year-old female reported problems with too high a sebum level and skin eruptions like blackheads, whiteheads, and pustules. The sebum level was measured and the global acne severity scale (GAGS) score was used to check the amou…
Implantable Sensors Based on Gold Nanoparticles for Continuous Long-Term Concentration Monitoring in the Body.
2021
Implantable sensors continuously transmit information on vital values or biomarker concentrations in bodily fluids, enabling physicians to survey disease progression and monitor therapeutic success. However, currently available technologies still face difficulties with long-term operation and transferability to different analytes. We show the potential of a generalizable platform based on gold nanoparticles embedded in a hydrogel for long-term implanted biosensing. Using optical imaging and an intelligent sensor/reference-design, we assess the tissue concentration of kanamycin in anesthetized rats by interrogating our implanted sensor noninvasively through the skin. Combining a tissue-integ…
Fear of COVID-19, Risk Perception and Stress Level in Polish Nurses During COVID-19 Outbreak
2021
Introduction. The outbreak of COVID-19 disease causes severe stress in health care workers, especially nurses.Nurses are at high risk of contracting the disease, as well as an increased risk of developing mental health symptomssuch as fear, anxiety and work-related stress.Aim. The aim of the study was to determine the relationship between fear of COVID-19, risk perception, perceivedthreat and stress in Polish nurses during COVID-19 outbreak.Material and Methods. 106 nurses participated in the study. Perceived Stress Scale (PSS-10), Fear of COVID-19 Scale(FOC-6), Risk of Contracting COVID-19 Scale and Perceived Threat of COVID-19 Scale were used in the study.Results. It has been shown that p…
Implementation of internal marketing in hotels – a case study of the Opole market
2021
This study assesses the extent to which Opole hotels rely on internal marketing. The assessment is based on results of a case study, analysis of documents, a diagnostic survey and logical analysis and construction. A questionnaire survey conducted in 12 hotels, accounting for about 92% of all hotels in Opole, was used to produce descriptive statistics of hotel characteristics. Most hotels evaluated in this study already use internal marketing. The most common marketing tools include training sessions, communication and information support, and active assistance provided by managers or owners to their employees. The main factors influencing the implementation of internal marketing in Opole h…
Evaluation of balance and fall risk in geriatric ward patients.
2021
Background. The physical changes inherent to aging can reduce autonomy and functional independence, which may directly or indirectly lead to falls. Aim of the study. The aim of this study was to assess the risk of falls in patients over 75 years of age. Materials and methods. Fifty elderly patients were examined. The subjects were divided into the three age groups: 75–79, 80–84 and 85–90 years old. The Berg Balance Scale was used to assess the risk of falls related to the balance skills. Results. The average Berg Balance Scale score in the 75–79 age group was 37.6 points; for 80–84, 33.53 points; and for 85–90, 27.81 points. The difference between the youngest and oldest age group was stati…
Review: Kagan, Olga, Carreira, Maria M., & Hitchins Chik, Claire (Eds.). (2017). The Routledge handbook of heritage language education: From inno…
2021
The Routledge Handbook of Heritage Language Education successfully contextualizes heritage language education initiatives across a wide range of languages and geographical settings. It comprises an impressive range of studies that cover all levels of education and show the institutionalization process of heritage language education initiatives. The book is recommended reading for researchers, scholars, educators, language planners, and practitioners.
Sociability in Virtual Reality
2021
This study investigates sociability in the context of immersive Virtual Reality (VR). A Design Science Research process was applied, and three iterative development versions of a VR application were studied. Sociability around the technology was investigated with two theoretical perspectives: social presence and social interactions. The results of qualitative interviews and observations as well as a quantitative experiment are combined to make a proposal for four design principles enhancing the beneficial sociability of VR systems. These principles address the importance of ease-of-use and personalization in the activation of a customer, customer empowerment and emancipation through familia…
false
2021
Students with poor reading skills and reading difficulties (RDs) are at elevated risk for bullying involvement in elementary school, but it is not known whether they are at risk also later in adolescence. This study investigated the longitudinal interplay between reading skills (fluency and comprehension), victimization, and bullying across the transition from elementary to middle school, controlling for externalizing and internalizing problems. The sample consists of 1,824 students (47.3% girls, T1 mean age was 12 years 9 months) from 150 Grade 6 classrooms, whose reading fluency and comprehension, self-reported victimization and bullying, and self-reported externalizing and internalizing …
Maternal and paternal feeding practices: links with child eating behaviors and effects of couples' concordant/discordant practices
2021
International audience; Past research has mainly focused on mothers' feeding practices. This study aimed to study (1) gender differences in parental feeding practices, and (2) the impact of couples' concordant/discordant food parenting practices on child eating behaviors. To do so, both parents of 105 French children aged 2.01-6.51 years (51.4% boys, Mage= 3.88 years, SD=1.40) filled in a survey with items from validated questionnaires. Results showed that fathers and mothers had similar perceptions about their child's eating behaviors (Pearson correlations between 0.34 and 0.78; M=0.60), despite fathers taking significantly fewer meals with their child than mothers. Fathers reported using …
Estigmatización de la obesidad: un problema a erradicar
2021
El modelo organizativo de la Economía del Bien Común y su comparación con otros enfoques de la sostenibilidad
2021
Son cada vez más las empresas que están adoptando la sostenibilidad como un enfoque estratégico que garantiza la supervivencia a largo plazo. Más allá de la Responsabilidad Social (RS), se impone un modelo empresarial basado en la triple dimensión económica, social y ambiental, que de acuerdo con el enfoque de la creación de valor compartido de Porter y Kramer, incluya la RS dentro del corazón de la estrategia de la empresa. El modelo de la Economía del Bien Común (EBC), que nace en el centro de Europa en el año 2010 de la mano del profesor de la Universidad de Viena Christian Felber, propone una herramienta, el Balance del Bien Común (BBC), que puede facilitar la implantación de la Sosteni…
Biomimetic G-quartet compounds
2021
A cyclic peptide significantly improves thyroid function, thyrotropin-receptor antibodies and orbital mucine /collagen content in a long-term Graves’…
2021
BALB/c mice which received long-term immunizations of adenovirus (Ad) expressing thyrotropin receptor A-subunits (TSHR) developed stable Graves' disease (GD). TSHR-derived cyclic peptide 19 (P19) was identified as effective therapy in this model.In Ad-TSHR mice, we investigated shorter disease intervals up to 4 months for histological alterations of the orbits, fine tuning of anti-TSHR antibodies (Ab) and free thyroxine (fT4) hormone levels by using novel detection methods in an independent laboratory. Therapy (0.3 mg/kg P19 or vehicle) was given intravenously after the fourth Ad-TSHR immunization (week 11) and continued until week 19.Thyrotropin binding inhibitory immunoglobulins (TBII, br…
Du goût des protéines végétales au comportement des consommateurs : quelles méthodes d'étude pour quels enjeux ?
2021
National audience
The Nature of Soft Excess in ESO 362-G18 Revealed by XMM-Newton and NuSTAR Spectroscopy
2021
We present a detailed spectral analysis of the joint XMM-Newton and NuSTAR observations of the active galactic nuclei (AGN) in the Seyfert 1.5 Galaxy ESO 362-G18. The broadband ($0.3\mbox{--}79$ keV) spectrum shows the presence of a power-law continuum with a soft excess below $2$ keV, iron K$\alpha$ emission ($\sim 6.4$ keV), and a Compton hump (peaking at $\sim 20$ keV). We find that the soft excess can be modeled by two different possible scenarios: a warm ($kT_\mathrm{e}\sim0.2$ keV) and optically thick ($\tau\sim34$) Comptonizing corona; or with relativistically-blurred reflection off a high-density ($\log{[n_\mathrm{e}/\mathrm{cm}^{-3}]}>18.3$) inner disk. These two models cannot be e…
Implications of the identity position for dual career construction: Gendering the pathways to (Dis)continuation
2021
Objectives To examine how gender functions in the narrative construction of dual career styles, and how these styles impact the (dis)continuation of a dual career pathway. Design Longitudinal qualitative study. Method Life story interviews with 18 talented Finnish athletes (10 cis women, 8 cis men) at four points in time – when they averaged 16, 17, 19, and 20 years of age – followed by an integrative narrative-discursive analysis. Results (a) contrapuntal style was gender-typically female; (b) monophonic style was gender-typically male; and (c) dissonant style was an important pathway to dual career discontinuation through which gender ideologies impacted the emergent adults with different…
The nonlinear optical loop mirror: soliton and noise-like pulse emission in a figure-eight fiber laser
2021
In this article, a symmetrical nonlinear optical loop mirror (NOLM) exhibiting a polarization-dependent transmission is evaluated to generate optical pulse emission in a figure-eight fiber laser in the soliton and noise-like pulse (NLP) regimes. The NOLM structure relies on a 50:50 fiber coupler, a loop with highly twisted single-mode optical fiber and a quarter-wave retarder (QWR) to break the polarization asymmetry. The pulse operation regime is determined by properly adjusting the NOLM low-power transmission, which is easily realized by the rotation of the QWR angle. Soliton pulses of 1.48 ps pulse duration and peak power of 18 W were observed with a peak to peak separation of 1.25 µs, c…
Krajowa Rada Narodowa i Polski Komitet Wyzwolenia Narodowego w państwie prawa. Stanowiska doktryny
2021
<p>The establishment of the communist regime in Poland in 1944 is a current subject of reflection in the doctrine and practice of legislation and judiciary. There has been no uniform position on these events, which means that the then sanctioned political and normative order continues to produce controversial assessments and, above all, certain legal effects. This results from the fact that the new people’s power, empowered by force, and not by legal or social basis, has given itself the competence to establish a normative order. The lack of legitimacy for the rightful rule and legislative activity, in principle – from the point of view of the idea of the rule of law – undermines the …