Insights into the evolutionary history of the subfamily orthotrichoideae (Orthotrichaceae, Bryophyta): new and former supra-specific taxa so far obsc…

2021

Mosses of the subfamily Orthotrichoideae represent one of the main components of the cryptogam epiphytic communities in temperate areas. During the last two decades, this taxonomical group has undergone an extensive revision that has led to its rearrangement at the generic level. However, their phylogenetic relationships and inferences on the evolutionary patterns that have driven the present diversity have little advanced. In this study, we present a dated molecular phylogenetic reconstruction at the subfamily level, including 130 samples that represent the 12 genera currently recognized within the subfamily, and the analysis of four molecular markers: ITS2, rps4, trnG, and trnL-F. We also…

Bleeding events in Polish cardiology wards: the results of a 2-week survey

2021

Temporal Binding in Multisensory and Motor-Sensory Contexts: Toward a Unified Model

2021

Our senses receive a manifold of sensory signals at any given moment in our daily lives. For a coherent and unified representation of information and precise motor control, our brain needs to temporally bind the signals emanating from a common causal event and segregate others. Traditionally, different mechanisms were proposed for the temporal binding phenomenon in multisensory and motor-sensory contexts. This paper reviews the literature on the temporal binding phenomenon in both multisensory and motor-sensory contexts and suggests future research directions for advancing the field. Moreover, by critically evaluating the recent literature, this paper suggests that common computational prin…

Compétences sociales et civiques chez les jeunes "NEET" vulnérables

2021

International audience

Pullout Force and Inlet Oscillation in Telescopic Carbon Nanotubes: A Quantum Study

2021

The noncovalent interaction energy as a function of the core extension in double-walled carbon nanotubes (DWCNT) was accurately calculated in the frame of density functional theory, considering dis...

Ultrasound as a Promising Tool for the Green Extraction of Specialized Metabolites from Some Culinary Spices

2021

Spices are a popular food of plant origin, rich in various phytochemicals and recognized for their numerous properties. The aim of the study was to evaluate the antioxidant and antimicrobial activity, as well as the content of specialized metabolites, of aqueous extracts of three spice species––garlic (Allium sativum L.), ginger (Zingiber officinalle L.) and turmeric (Curcuma longa L.)––prepared by green extraction methods. Ultrasound treatment increased the chromaticity parameter b value of turmeric and ginger extracts, thus indicating a higher yellow color predominantly due to curcuminoids characteristic of these species. Ultrasound-assisted extraction significantly increased the content …

J-PARC E07: Systematic Study of Double Strangeness System with Hybrid Emulsion Method

2021

Hybridization, ecogeographical displacement and the emergence of new lineages – A genotyping‐by‐sequencing and ecological niche and species distribut…

2021

Ecogeographical displacement of homoploid hybrid lineages from their parents is well documented and considered an important mechanism to achieve reproductive isolation. In this study, we investigated the origin of the flowering plant species Sempervivum tectorum in the Massif Central (France) through homoploid hybridization between lineages of the species from the Rhine Gorge area (Germany) and the Pyrenees (France). We used genotyping-by-sequencing genetic data as evidence for the hybrid origin of the Massif Central lineage, and WorldClim climatic data and soil pH and soil temperature data collected by us for ecological niche and species distribution modelling. We could show that the Massi…

Heart Rate Variability Monitoring during Interferential Current Application in the Lower Back Area: A Cross-Sectional Study

2021

Vasovagal reactions may occur occasionally during electrical stimulation using interferential current (IFC). The purpose of this study was to examine variations in autonomic activity during the application of IFC in asymptomatic participants by analysis of their heart rate variability (HRV). Seventy-three male volunteers were randomly assigned to a placebo group (n = 36

A Computational Study on Temperature Variations in MRgFUS Treatments Using PRF Thermometry Techniques and Optical Probes

2021

Structural and metabolic imaging are fundamental for diagnosis, treatment and follow-up in oncology. Beyond the well-established diagnostic imaging applications, ultrasounds are currently emerging in the clinical practice as a noninvasive technology for therapy. Indeed, the sound waves can be used to increase the temperature inside the target solid tumors, leading to apoptosis or necrosis of neoplastic tissues. The Magnetic resonance-guided focused ultrasound surgery (MRgFUS) technology represents a valid application of this ultrasound property, mainly used in oncology and neurology. In this paper

Teachers' Survey on Emergency Remote Teaching Experience during Spring 2020 (COVID-19)

2021

Latvian Council of Science State Research Program “Covid-19 mitigation” project “Life with COVID-19: Evaluation of overcoming the coronavirus crisis in Latvia and recommendations for societal resilience in the future” No. VPP-COVID-2020/1-0013 Emergency Remote Teaching Questionnaire for Latvian Teachers of Comprehensive Schools during Spring 2020 (COVID-19 "First wave"). Participated 1543 teachers from all regions of Latvia.

Nitrogen Hydrate Cage Occupancy and Bulk Modulus Inferred from Density Functional Theory-Derived Cell Parameters

2021

International audience; Gas clathrate hydrate solid materials, ubiquitous in nature as found either on the ocean floor, permafrost on the Earth, or in extraterrestrial planets and comets, are also technologically relevant, for example, in energy storage or carbon dioxide sequestration. Nitrogen hydrate, in particular, is of great interest as a promoter of the kinetics of the methane replacement reaction by carbon dioxide in natural gas hydrates. This hydrate may also appear in the chemistry of planets wherever nitrogen constitutes the majority of the atmosphere. A fine understanding of the stability of this hydrate under various thermodynamic conditions is thus of utmost importance to asses…

Bottomonium precision tests from full lattice QCD: Hyperfine splitting, ϒ leptonic width, and b quark contribution to e+e−→hadrons

2021

We calculate the mass difference between the $\mathrm{\ensuremath{\Upsilon}}$ and ${\ensuremath{\eta}}_{b}$ and the $\mathrm{\ensuremath{\Upsilon}}$ leptonic width from lattice QCD using the highly improved staggered quark formalism for the $b$ quark and including $u$, $d$, $s$ and $c$ quarks in the sea. We have results for lattices with lattice spacing as low as 0.03 fm and multiple heavy quark masses, enabling us to map out the heavy quark mass dependence and determine values at the $b$ quark mass. Our results are ${M}_{\mathrm{\ensuremath{\Upsilon}}}\ensuremath{-}{M}_{{\ensuremath{\eta}}_{b}}=57.5(2.3)(1.0)\text{ }\text{ }\mathrm{MeV}$ (where the second uncertainty comes from neglect of …

Norma de reconocimiento, convención y obligación. Aquello que Shapiro todavía puede aprender de los errores de Hart

2021

Shapiro works out a version of legal positivism taking as its starting point Hart’s practice theory of law. Some serious limits of Hart’s practice theory of norms concern the conception of legal obligation and normativity of law. In this paper I analyze the limits of Hart’s conception of legal normativity and I appraise whether the planning theory of law indicates the correct direction for overcoming them. To anticipate the conclusion, my effort is to show that Shapiro replicates Hart’s mistakes on this subject-matters. The paper is divided in three main sections. First, I will present briefly a critical reconstruction of Hart’s conception of normativity, reconstruction which is partially d…

Radiomics and radiogenomics in head and neck squamous cell carcinoma: Potential contribution to patient management and challenges

2021

Abstract The application of imaging biomarkers in oncology is still in its infancy, but with the expansion of radiomics and radiogenomics a revolution is expected in this field. This may be of special interest in head and neck cancer, since it can promote precision medicine and personalization of treatment by overcoming several intrinsic obstacles in this pathology. Our goal is to provide the medical oncologist with the basis to approach these disciplines and appreciate their main uses in clinical research and clinical practice in the medium term. Aligned with this objective we analyzed the most relevant studies in the field, also highlighting novel opportunities and current challenges.

Hydrogen Dark Fermentation for Degradation of Solid andLiquid Food Waste

2021

The constant increase in the amount of food waste accumulating in landfills and discharged into the water reservoirs causes environment pollution and threatens human health. Solid and liquid food wastes include fruit, vegetable, and meat residues, alcohol bard, and sewage from various food enterprises. These products contain high concentrations of biodegradable organic compounds and represent an inexpensive and renewable substrate for the hydrogen fermentation. The goal of the work was to study the efficiency of hydrogen obtaining and decomposition of solid and liquid food waste via fermentation by granular microbial preparation (GMP). The application of GMP improved the efficiency of the d…

Ingéniérie de formation et éducation à la santé en milieu sportif

2021

International audience

Amyloid-Beta Induces Different Expression Pattern of Tissue Transglutaminase and Its Isoforms on Olfactory Ensheathing Cells: Modulatory Effect of In…

2021

Abstract Alzhèimer Disease (AD) is characterized by protein aggregates in the brain, including amyloid-beta (Aβ), a substrate for tissue transglutaminase (TG2). We assessed the effect of full native peptide of Aβ (1–42), the fragments (25–35 and 35–25) on TG2 expression and its isoforms (Long and Short) on mouse Olfactory Ensheathing Cells (OECs). The levels of cytoskeletal proteins, Vimentin and Glial Fibrillary Acid Protein, were also studied. The effect of the pre-treatment with Indicaxanthin on cell viability, total Reactive Oxygen Species, superoxide anion and apoptotic pathway activation was assessed. Since Nestin is co-expressed in pluripotent stem cells with cyclin D1, their levels …

Evaluating objective measures of impairment to trunk strength and control for cross-country sit skiing

2021

AbstractIn Paralympic cross-country sit skiing, athlete classification is performed by an expert panel, so it may be affected by subjectivity. An evidence-based classification is required, in which objective measures of impairment must be identified. The purposes of this study were: (i) to evaluate the reliability of 5 trunk strength measures and 18 trunk control measures developed for the purposes of classification; (ii) to rank the objective measures, according to the largest effects on performance. Using a new testing device, 14 elite sit-skiers performed two upright seated press tests and one simulated poling test to evaluate trunk strength. They were also subjected to unpredictable bal…

Multiscale Simulations of SARS-CoV-2 3CL Protease Inhibition with Aldehyde Derivatives. Role of Protein and Inhibitor Conformational Changes in the R…

2021

We here investigate the mechanism of SARS-CoV-2 3CL protease inhibition by one of the most promising families of inhibitors, those containing an aldehyde group as a warhead. These compounds are covalent inhibitors that inactivate the protease, forming a stable hemithioacetal complex. Inhibitor 11a is a potent inhibitor that has been already tested in vitro and in animals. Using a combination of classical and QM/MM simulations, we determined the binding mode of the inhibitor into the active site and the preferred rotameric state of the catalytic histidine. In the noncovalent complex, the aldehyde group is accommodated into the oxyanion hole formed by the NH main-chain groups of residues 143 …

Cardiovascular risk factors and the impact on prognosis in patients with chronic kidney disease secondary to autosomal dominant polycystic kidney dis…

2021

Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent hereditary renal disease. There is an increased rate of cardiovascular disease (CVD) in ADPKD. In this study, we evaluate the prevalence of cardiovascular risk factors, the achievement rates for treatment goals and cardiovascular events (CVE) in ADPKD and their relations with asymptomatic CVD in CKD from other etiologies (CKDoe) and controls. Methods: We evaluated 2445 CKD patients (2010–2012). The information collected was: clinical, anthropometric and analytical parameters, treatments and CVD evaluation (intima-media thickness (IMT), atheromatous plaque presence and ankle-brachial index (ABI)). Laborator…

Measurement of light-by-light scattering and search for axion-like particles with 2.2 nb−1 of Pb+Pb data with the ATLAS detector

2021

We thank CERN for the very successful operation of the LHC, as well as the support staff from our institutions without whom ATLAS could not be operated efficiently. We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; ANID, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS and CEA-DRF/IRFU, France; SRNSFG, Georgia; BMBF, HGF and MPG, Germany; GSRT, Greece; RGC and Hong Kong SAR, China; ISF and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Mor…

Novel hybrid polymer composites with graphene and MXene nano-reinforcements: computational analysis

2021

This paper presents a computational analysis on the mechanical and damage behavior of novel hybrid polymer composites with graphene and MXene nano-reinforcements targeted for flexible electronics and advanced high-strength structural applications with additional functions, such as real-time monitoring of structural integrity. Geometrical models of three-dimensional representative volume elements of various configurations were generated, and a computational model based on the micromechanical finite element method was developed and solved using an explicit dynamic solver. The influence of the geometrical orientation, aspect ratio, and volume fractions of the inclusions, as well as the interfa…

Mesothelial cyst of the round ligament of the uterus A case report of a rare condition

2021

Le cisti mesoteliali del legamento rotondo sono una rara causa di tumefazione inguinale nelle donne, la loro eziopatogenesi rimare poco chiara e i casi riportati in letteratura sono scarsi. Inoltre, quest’ultime sono raramente prese in considerazione nella diagnosi differenziale delle tumefazioni della regione inguinale nelle pazienti di sesso femminile, ragion per cui sono spesso identificate solo in corso di esplorazione chirurgica e correttamente diagnosticate solo dopo esame istopatologico. Una donna di 57 anni (BMI 37 kg / m2) si è presentato nel nostro dipartimento con una massa inguinale sinistra, con storia di 2 mesi, che causava disagio locale e peggioramento progressivo del dolore…

Atribución de la guarda del menor a un tercero distinto de los progenitores

2021

Este trabajo pretende dar respuesta a los diferentes interrogantes que plantea la posibilidad que prevé el Código Civil de que la guarda de un menor pueda ser atribuida a un tercero distinto de sus progenitores dentro del proceso de ruptura matrimonial. Entre dichos interrogantes se encuentran la naturaleza jurídica de este tipo de guarda, los sujetos legitimados para acordarla, el supuesto de hecho que debe concurrir para que proceda su establecimiento, los momentos en los que puede adoptarse, su duración, los sujetos en los que puede recaer y su contenido concreto. The purpose of this paper is to answer the various questions raised by the possibility provided for in the Civil Code that th…

¿Qué es el síndrome cardiometabólico?

2021

Las enfermedades cardiovasculares son la primera causa de mortalidad prematura en Europa. El síndrome metabólico o cardiometabólico es una asociación de factores de riesgo cardiovascular relacionados por un nexo fisiopatológico común, posiblemente la resistencia a la insulina.

Long term outcomes of fissurectomy and anoplasty for chronic anterior anal fissure without hypertonia: low recurrences and continence conservation

2021

Aetiopathogenesis of Chronic Anal Anterior Fissure (CAAF) remains poorly understood. Some anatomical, clinical and functional features suggest that pathophysiology may be linked to a reduced anal canal pressure. LIS appear illogical as a treatment for CAAF and the employ of techniques aiming to save the integrity of the sphincterial system appears more sensible. The aim of this study was to evaluate 5 years results of fissurectomy and anoplasty with cutaneous V-Y advancement flap in patients affected by CAAF without IAS hypertonia.We enrolled 20 women, affected by idiopathic and non-recurrent CAAF without hypertonic IAS. All patients were followed up for 5 years after surgery with evaluatio…

Rapid Weight Loss Habits before a Competition in Sambo Athletes

2021

Background: Like other combat sports, sambo has competition rules that divide athletes into categories based on gender, age and weight. Athletes in combat sports often resort to rapid weight loss (RWL) methods to be more competitive in lower weight categories and gain an advantage against lighter, smaller and weaker competitors. The aim of this study was to examine the methodology implemented by two different sambo age categories, junior and senior athletes, in order to attain RWL. Methods: The sample consisted of 103 male sambo elite athletes (seniors/juniors: age 28.5 ± 4.3/18.9 ± 0.8

Genetic analysis of familial Alzheimer’s disease, primary lateral sclerosis and paroxysmal kinesigenic dyskinesia: a tool to uncover common mechanist…

2021

Tesis doctoral 270 p. figuras y tablas

Reflexiones sobre las ciudades, la pobreza, la política y sus límites y la delincuencia en los espacios vulnerables.

2021

Resumen Este articulo presenta una reflexion sobre la actuacion de las politicas para las ciudades y la presencia de las actividades delictivas en los espacios vulnerables urbanos. En este sentido, se construyo una linea de argumentacion que involucra conceptos vinculados a las ciudades, a las desigualdades, a la segregacion espacial, a la pobreza y a la vulnerabilidad urbana, asi como al papel de las politicas para las ciudades y al contexto propicio a la emergencia de la actividad delictiva en los espacios vulnerables. Las bases de las conclusiones obtenidas parten de la concepcion de Bauman orientada a la centralidad del consumo y a la busqueda por reconocimiento en medio del ejercicio d…

Increased RNA virus population diversity improves adaptability

2021

The replication machinery of most RNA viruses lacks proofreading mechanisms. As a result, RNA virus populations harbor a large amount of genetic diversity that confers them the ability to rapidly adapt to changes in their environment. In this work, we investigate whether further increasing the initial population diversity of a model RNA virus can improve adaptation to a single selection pressure, thermal inactivation. For this, we experimentally increased the diversity of coxsackievirus B3 (CVB3) populations across the capsid region. We then compared the ability of these high diversity CVB3 populations to achieve resistance to thermal inactivation relative to standard CVB3 populations in an…

Etäkonferenssikuulumisia kotitoimistolta

2021

On ( p ( x ),  q ( x ))‐Laplace equations in ℝN without Ambrosetti‐Rabinowitz condition

2021

In the present work, we consider a (p(x), q(x))-elliptic equation describing the behavior of a double-phase anisotropic problem which has relevance in electrorheological fluid applications. The analysis leads to the existence of weak (nonnegative) solutions in the special case of potential terms with critical frequency and a superlinear reaction term. In order to prove the existence result, we combine critical point theory of mountain pass type with related topological and variational methods. Basically, the approach is variational, but we do not impose any Ambrosetti-Rabinowitz type condition for the superlinearity of the reaction. More specifically, we apply the Euler-Lagrange functional …

Digital datafication of education

2021

Tässä kriittisessä esseessä luon yleiskatsauksen koulutuksen digitaalisen datafikaation erilaisiin muotoihin ja merkityksiin erityisesti kotimaisessa kontekstissa. Esseessä käyn läpi datafikaation suhdetta muihin koulutusta ohjaaviin trendeihin, erityisesti digitalisaatioon, oppimiskeskeisyyteen ja tulosvastuullisuuteen. Lisäksi tarkastelen datan ja datan diskursiivisen tuottamisen välistä epäsuhtaa, josta jatkan koulun dataintensiivisten käytäntöjen kautta tapahtuvan jatkuvan datankeruun luonnollistumisen tarkasteluun. Viimeisessä temaattisessa osiossa jäsennän elinikäisen oppimisen ideologian ja datafikaation välistä suhdetta. Esseen lopuksi esitän monilukutaidon pedagogiikkaan tukeutuen …

The digital transnational linguistic landscape of wine discourses. A comparative discourse analysis of three European (wine) regions.

2021

International audience; [Context] Wine is a bio-cultural product (Bach 2017: 123; 2018: Part 2), which constitutes regional identities throughout Europe, and especially in Germany and France. This is particularly noticeable in regions where wine routes cross landscapes combining the experience of traditional winemaking with (daily) wine enjoyment and tourism. A marketing concept such as enotourism is (sure) the most notable manifestation of this shared interest. In Burgundy, Alsace, and Rhineland-Palatinate such socio-economic infrastructures are remarkable. From a sociolinguistic perspective, this is relevant to evaluate how phenomenal objects such as landscape are integrated into the comm…

Foxp3 and gata3 polymorphisms, vitamin d3 and multiple sclerosis

2021

Background: Regulatory T cells (Tregs) alterations have been implicated in the pathogenesis of Multiple Sclerosis (MS). Recently, a crucial role of the X-Linked Forkhead Box P3 (FoxP3) for the development and the stability of Tregs has emerged, and FOXP3 gene polymorphisms have been associated with the susceptibility to autoimmune diseases. The expression of Foxp3 in Tregs is regulated by the transcription factor GATA binding-protein 3 (GATA3) and vitamin D3. The aim of this retrospective case-control study was to investigate the potential association between FOXP3 and GATA3 genetic variants, Vitamin D3, and MS risk. Methods: We analyzed two polymorphisms in the FOXP3 gene (rs3761547 and rs…