Development of New Targeted Inulin Complex Nanoaggregates for siRNA Delivery in Antitumor Therapy.

2021

Here, a novel strategy of formulating efficient polymeric carriers based on the already described INU-IMI-DETA for gene material whose structural, functional, and biological properties can be modulated and improved was successfully investigated. In particular, two novel derivatives of INU-IMI-DETA graft copolymer were synthesized by chemical functionalisation with epidermal growth factor (EGF) or polyethylenglycol (PEG), named INU-IMI-DETA-EGF and INU-IMI-DETA-PEG, respectively, in order to improve the performance of already described “inulin complex nanoaggregates” (ICONs). The latter were thus prepared by appropriately mixing the two copolymers, by varying each component from 0 to 100 wt%…

Local Spectral Properties Under Conjugations

2021

AbstractIn this paper, we study some local spectral properties of operators having form JTJ, where J is a conjugation on a Hilbert space H and $$T\in L(H)$$ T ∈ L ( H ) . We also study the relationship between the quasi-nilpotent part of the adjoint $$T^*$$ T ∗ and the analytic core K(T) in the case of decomposable complex symmetric operators. In the last part we consider Weyl type theorems for triangular operator matrices for which one of the entries has form JTJ, or has form $$JT^*J$$ J T ∗ J . The theory is exemplified in some concrete cases.

Theological and Philosophical Responses to Syncretism. Beyond the Mirage of Pure Religion, edited by Patrik Fridlund and Mika Vähäkangas

2021

Parenting and adolescent adjustment: The mediational role of family self-esteem

2021

The present study analyzes the relationship between parental socialization practices, acceptance/involvement, and strictness/ imposition, and different indicators of adolescent adjustment, taking into account the role of family self-esteem. A sample of 848 Spanish adolescents (54.70% females) ranging in age from 14 to 18 years old (M = 16.11, SD = 1.10) participated in the study. A series of structural equations models (SEMs) were tested to examine the mediational role of family self-esteem in the relationship between parenting practices and the outcome variables that capture adolescent adjustment: emotional instability, antisocial behavior, and academic achievement. The influence of parent…

Impact of global warming on snow in ski areas: A case study using a regional climate simulation over the interior western United States

2021

AbstractA high-resolution (4 km) regional climate simulation conducted with the Weather Research and Forecast (WRF) model is used to investigate potential impacts of global warming on skiing conditions in the interior western United States (IWUS). Recent past and near-future climate conditions are compared. The past climate period is from November 1981 to October 2011. The future climate applies to a 30-year period centered on 2050. A pseudo global warming approach is used, with the driver re-analysis dataset perturbed by the CMIP5 ensemble mean model guidance. Using the 30-year retrospective simulation, a vertical adjustment technique is used to determine meteorological parameters in the c…

3-D attenuation image of fluid storage and tectonic interactions across the Pollino fault network

2021

SUMMARYThe Pollino range is a region of slow deformation where earthquakes generally nucleate on low-angle normal faults. Recent studies have mapped fault structures and identified fluid-related dynamics responsible for historical and recent seismicity in the area. Here, we apply the coda-normalization method at multiple frequencies and scales to image the 3-D P-wave attenuation (QP) properties of its slowly deforming fault network. The wide-scale average attenuation properties of the Pollino range are typical for a stable continental block, with a dependence of QP on frequency of $Q_\mathrm{ P}^{-1}=(0.0011\pm 0.0008) f^{(0.36\pm 0.32)}$. Using only waveforms comprised in the area of seism…

The histology of brain tumors for 67 331 children and 671 085 adults diagnosed in 60 countries during 2000-2014: a global, population-based study (CO…

2021

Abstract Background Global variations in survival for brain tumors are very wide when all histological types are considered together. Appraisal of international differences should be informed by the distribution of histology, but little is known beyond Europe and North America. Methods The source for the analysis was the CONCORD database, a program of global surveillance of cancer survival trends, which includes the tumor records of individual patients from more than 300 population-based cancer registries. We considered all patients aged 0-99 years who were diagnosed with a primary brain tumor during 2000-2014, whether malignant or nonmalignant. We presented the histology distribution of th…

La regulación de la guarda y custodia de los hijos en el entorno europeo

2021

Los distintos países europeos recogen figuras y reglas diversas para la determinación del modo en el que se va a organizar el cuidado de los hijos menores tras la ruptura de una pareja. Este trabajo presenta las normas previstas por los ordenamientos jurídicos de España, Italia, Francia, Inglaterra, Bélgica, Alemania y la República Checa; así como el régimen legal previsto en cada una de ellas para los supuestos de falta de acuerdo entre los progenitores. Different European countries contain diverse figures and rules to determine how childcare will be organized after a marital breakdown. This work presents the rules laid down by the legal systems of Spain, Italy, France, England, Belgium, G…

false

2021

Previous work showed that the beginning of a sound is more important for the perception of loudness than later parts. When a short silent gap of sufficient duration is inserted into a sound, this primacy effect reoccurs in the second sound part after the gap. The present study investigates whether this temporal weighting occurs independently for different frequency bands. Sounds consisting of two bandpass noises were presented in four different conditions: (1) a simultaneous gap in both bands, (2) a gap in only the lower frequency band, (3) a gap in only the higher frequency band, or (4) no gap. In all conditions, the temporal loudness weights showed a primacy effect at sound onset. For the…

Two stories, one fate: age-heaping and literacy in Spain, 1877-1930

2021

This study looks at human capital in Spain during the early stages of modern economic growth. In order to do so, we have assembled a new dataset on ageheaping and literacy in Spain for both men and women between 1877 and 1930 based on six population censuses with information for 49 provinces. Our results show that age-heaping was less prevalent during the second half of the 19th century than previously thought and did not decrease until the early twentieth century. By contrast, literacy increased throughout the whole period. Interestingly, age-heaping and illiteracy rates depict similar spatial patterns which confirm the stark differences in human capital within Spain. Lastly, we raise crit…

A realist approach to thematic analysis: making sense of qualitative data through experiential, inferential and dispositional themes

2021

Thematic analysis (TA) is the most widely used method for analysing qualitative data. Recent debates, highlighting the binary distinctions between reflexive TA grounded within the qualitative parad...

Nanoporous Gold‐Based Materials for Electrochemical Energy Storage and Conversion

2021

Observed teaching practices interpreted from the perspective of school-based teacher educators

2021

A teacher supervising the school practice of student teachers is regarded as an expert who sets an example of good teaching to future teachers and chooses teaching practices that support pupils’ co...

Human-Bat Interactions in Rural Southwestern Madagascar through a Biocultural Lens

2021

Human-bat interactions are common in rural areas across the tropics. Over 40 bat species occur in Madagascar, most of which are endemic. Forest loss is changing the distribution of bats throughout the island, with potential increases in both the abundance of synanthropic species and human-bat interactions. We set out to study knowledge of, interactions with, and attitudes towards bats in rural Madagascar, including reports of food and ethnomedicinal uses of bats, their cultural representations in folklore, and the existence of culturally enforced taboos in relation to them. We administered 108 surveys with open- and closed-ended questions with adults from the Tanala and Betsileo ethnic grou…

A Short Measure of Acceptability of Intimate Partner Violence Against Women: Development and Validation of the A-IPVAW-8 Scale

2021

Attitudes of acceptability of intimate partner violence against women (IPVAW) are considered one of the main risk factors of this type of violence. The aim of this study is to develop and validate a short version of the acceptability of IPVAW scale, the A-IPVAW-8, for large scale studies where space and time are limited. A panel of experts were asked to assess item content validity. Two samples were recruited to assemble an 8-item short version of the scale using automated test assembly, and to reassess the psychometric properties of the A-IPVAW-8 in an independent sample. Results showed that the A-IPVAW-8 had adequate internal consistency (α = .72-.76, ω = .73-.81), a stable one-factor la…

Reporting, interpretation, and extrapolation issues (SPIN) in abstracts of orthodontic meta-analyses published from 2000 to 2020

2021

Summary Aim To assess the prevalence of and identify factors associated with SPIN in abstracts of orthodontic meta-analyses. Materials and methods Electronic search was performed within the contents of five orthodontic journals and the Cochrane Database of Systematic Reviews (CDSR) to identify meta-analyses of studies involving humans, from 1 January 2000 until 31 August 2020. Inclusion of SPIN in the abstract of meta-analyses, defined as misleading reporting, misleading interpretation, and inappropriate extrapolation of the findings, was documented. Extent of SPIN and associations with journal and year of publication, type of study, number of authors, continent of authorship, methodologist…

Déterminisme génétique de la plasticité de la composition protéique des graines de légumineuses vis-à-vis de l'environnement : rôle du métabolisme du…

2021

The renewed interest in plant proteins has stimulated research aimed at developing markers to aid in the selection of legume varieties better adapted to nutritional needs. Among the traits to be improved and stabilized is the amino acid balance of seeds, the essential amino acids methionine and tryptophan being particularly under-represented in legume seeds. This thesis focuses on seed protein composition, which is a major determinant of the seed amino acid balance. The objective was to explore the genetic and environmental variability in this trait and to identify genes potentially involved in its plasticity when subjected to environmental stresses. In the first part of the thesis, the pro…

Lasten ja vanhusten toimijuus : diskurssianalyysi neljän puolueen eduskuntavaaliohjelmista

2021

Tutkimuksessa tarkasteltiin, miten lapsia ja vanhuksia kuvataan toimijuuden näkökulmasta neljän suurimman puolueen eduskuntavaaliohjelmissa. Tutkimusmenetelmänä hyödynnettiin kriittistä diskurssianalyysiä. Aineistosta oli tunnistettavissa kaksi toimijuuden diskurssia: passiivisen ja aktiivisen toimijuuden diskurssit, joissa molemmissa puhutaan lasten ja vanhusten toimijuudesta erityisesti palvelujärjestelmän kautta. Passiivisen toimijuuden diskurssissa erilaiset yhteiskunnalliset toimijat näyttäytyivät aktiivisina toimijoina lasten ja vanhusten sijaan. Aktiivisen toimijuuden puhe kietoutui palvelujärjestelmään, joka kuvautui keskeiseksi toimijuutta tuottavaksi tekijäksi. Lisäksi lasten toim…

El derecho como institución espontánea

2021

En este artículo trataremos de mostrar la viabilidad y con-veniencia de un orden jurídico descentralizado frente a una or-ganización monocéntrica que genere e imponga sus propios mandatos jurídicos.
 En la primera parte, comenzaremos con al análisis haye-kiano del orden espontáneo para explicar las distintas carac-terísticas y etapas que componen una institución. En la se-gunda, aplicaremos estas conclusiones al caso particular del derecho.
 Con este análisis podremos elaborar ciertas predicciones y explicaciones sobre la evolución política del Estado y pergeñar estrategias para lograr defender la libertad.
 Para Hayek las instituciones sociales «no sólo no han sido creadas p…

Efficacy and safety of two artificial saliva-based polymers containing 0.1% pilocarpine for treatment of xerostomia: A randomized clinical pilot tria…

2021

Background Topical agents are the mainstay in the treatment of xerostomia, a common complaint most frequently associated with salivary dysfunction. This study aimed to compared the efficacy and safety for xerostomia treatment of 2 artificial saliva preparations containing 0.1% pilocarpine, and, either sodium carboxymethylcellulose (SCMC), or, sodium polyacrylate (SPA). Material and Methods Thirty-one xerostomia patients were randomly allocated into either a SCMC-treated group (15 patients), or, a SPA-treated group (16 patients). The formulations were taken 0.5 ml, 4 times daily for 6 weeks and double-blinded assessed before and after treatments using Xerostomia Inventory (XI) and Clinical O…

Three-year (2017-2019) activity report of the Replantation Service for hand amputations in Poland

2021

W pracy przedstawiono podsumowanie działalności Serwisu Replantacyjnego dla amputacji rąk w Polsce w latach 2017-2019. W analizowanym okresie, do Serwisu zgłoszono 551 przypadków amputacji i innych rozległych urazów kończyn górnych, z czego 330 zaakceptowano do operacji, a w 221 przypadkach, z różnych powodów odmówiono przyjęcia. Wśród 330 przyjętych było 165 (50%) amputacji całkowitych, 131 (40%) prawie całkowitych i 34 (10%) inne, ciężkie, zagrażające utratą kończyny urazy. W przeważającej liczbie ofiarami byli mężczyźni w młodym i średnim wieku. Najwięcej było amputacji kilku palców i kciuków - 251 (76%), następnie amputacji na poziomie śródręcza - 30 (9%), przedramienia - 23 (7%) i nadg…

The crime of consumption of alcoholic beverages in the Somali Penal Code

2021

Somalia is a Muslim country whose criminal law has been based on the 1930 Italian penal code to which some changes have been made to try to adapt it to the local context. One of these changes has been to introduce the crime of consumption of alcoholic beverages, a crime that anyway could be committed only by local Somali people due to their religious belief. This chapter analyzes this part of the Somali penal code trying to highlight the issues arising from the text of the law. The analysis is compared to the regime existing in the other Muslim African countries to understand similarities and differences with the Somali regulation. A conclusion is then drawn up also in view of a possible fu…

Distance decay 2.0 – a global synthesis of taxonomic and functional turnover in ecological communities

2021

AbstractUnderstanding the variation in community composition and species abundances, i.e., β-diversity, is at the heart of community ecology. A common approach to examine β-diversity is to evaluate directional turnover in community composition by measuring the decay in the similarity among pairs of communities along spatial or environmental distances. We provide the first global synthesis of taxonomic and functional distance decay along spatial and environmental distance by analysing 149 datasets comprising different types of organisms and environments. We modelled an exponential distance decay for each dataset using generalized linear models and extracted r2 and slope to analyse the streng…

Thiopurine adherence: high prevalence with low impact in UC outcomes

2021

Introduction Thiopurines are used as maintenance therapy in patients with ulcerative colitis (UC). There are contradictory results regarding the relationship between adherence to treatment and risk of relapse. Objectives To quantify and evaluate the trends in thiopurines prescription rates, and to determine the impact and risk factors of non-adherence. Methods Analytical, observational and retrospective study of UC patients, on thiopurines, included in the ENEIDA single-center registry from October 2017 to October 2019. We included adult patients under clinical remission at the beginning of the study on thiopurines maintenance treatment for at least 6 months before recruitment. Adherence wa…

false

2021

An observational cross-sectional survey was planned to analyze the weekly workload reduction of German dentists during lockdown due to the global COVID-19 pandemic. Participants were predominantly members of the Free Association of German Dentists and filled in an online questionnaire. The questionnaire was sent to a total of 9416 dentists, with a response rate of 27.98% (n = 2635). Respondents were divided into seven macro areas by gross domestic product. Nearly two-thirds of dentists (65.16%) reported a reduction in their practice workload of more than 50% compared to the pre-pandemic period with statistically significant differences between German macro areas (p < 0.01). Weekly worklo…

The effects of cors network geometry and differential nrtk corrections on gnss solutions

2021

The widespread availability of Continuosly Operating Reference Station (CORS) all over the world, allows to improve more scientific and technical studies on the use of satellite positioning techniques. The aim of this paper is to understand the effects of a GNSS CORS network geometry and differential corrections on the solutions. The analysis is carried out using ten different network configurations, with different inter-distances between the stations within GNSMART Geo++ software. The coordinates of one control point placed on the top of the Department of Engineering (University of Palermo, Italy) have been used to perform several static positioning mode test within fourthy hours. Differen…

El derecho de abolorio: una institución aragonesa al servicio de la conservación del patrimonio familiar

2021

El presente trabajo tiene por objeto dar noticia del régimen jurídico y de la práctica jurisprudencial existente en materia de derecho de abolorio, un derecho familiar de adquisición preferente que rige en Derecho aragonés desde sus inicios y que tiene por finalidad evitar la salida de los inmuebles de su familia de origen por enajenación de su titular actual. The aim of this paper is to give an accurate account about regulation and the court's decisions on the Right of Abolorio, a Family Right of Preferential Acquisition prevailing in Aragonese civil law from the origins and is intended to prevent the alienation of properties in favour of individuals who are not membres of the family…

Retrospective clinical evaluation of root canal treatment with or without photodynamic therapy for necrotic teeth and teeth subjected to retreatment.

2021

PURPOSE To compare the effect of photodynamic therapy (PDT) as a procedure to complement root canal treatment (RCT), for both primary treatment and retreatment. METHODS This was a retrospective study based on analysis of clinical records. A total of 214 teeth that had undergone RCT on either a primary or retreatment basis, with or without complementary PDT, were evaluated. For 118 teeth that met the previously established inclusion criteria, the time until healing was evaluated. Complementarily, the need for application of calcium hydroxide (CaHy) between visits and the number of visits necessary for completing the treatment were assessed. Data were analyzed using the Mann-Whitney and χ2 te…

Multivariate Exploratory Comparative Analysis of LaLiga Teams: Principal Component Analysis

2021

The use of principal component analysis (PCA) provides information about the main characteristics of teams, based on a set of indicators, instead of displaying individualized information for each of these indicators. In this work we have considered reducing an extensive data matrix to improve interpretation, using PCA. Subsequently, with new components and with multiple linear regression, we have carried out a comparative analysis between the best and bottom teams of LaLiga. The sample consisted of the matches corresponding to the 2015/16, 2016/17 and 2017/18 seasons. The results showed that the best teams were characterized and differentiated from bottom teams in the realization of a great…

A thermoelastic theory with microtemperatures of type III

2021

In this paper, we use the Green-Naghdi theory of thermomechanics of continua to derive a nonlinear theory of thermoelasticity with microtemperatures of type III. This theory permits propagation of both thermal and microtemperatures waves at finite speeds with dissipation of energy. The equations of the linear theory are also obtained. With the help of the semigroup theory of linear operators we establish that the linear anisotropic problem is well posed and we study the asymptotic behavior of the solutions. Finally, we investigate the impossibility of the localization in time of solutions.

Civil Religion or Nationalism? The National Day Celebrations in Norway

2021

The Norwegian National Day (17 May, also referred to as Constitution Day) stands out as one of the most popular National Day celebrations in Europe. According to surveys, around seven out of every 10 Norwegians take part in a public celebration during this day. This means that the National Day potentially has an impact on the way people reflect upon national identity and its relationship to the Lutheran heritage. In this paper, I will focus on the role religion plays in the Norwegian National Day rituals. Researchers have described these rituals as both containing a significant religious element and being rather secularized. In this article, I discuss the extent to which the theoretical con…

Systematic analysis of specific and nonspecific auxin effects on endocytosis and trafficking.

2021

Abstract The phytohormone auxin and its directional transport through tissues are intensively studied. However, a mechanistic understanding of auxin-mediated feedback on endocytosis and polar distribution of PIN auxin transporters remains limited due to contradictory observations and interpretations. Here, we used state-of-the-art methods to reexamine the auxin effects on PIN endocytic trafficking. We used high auxin concentrations or longer treatments versus lower concentrations and shorter treatments of natural indole-3-acetic acid (IAA) and synthetic naphthalene acetic acid (NAA) auxins to distinguish between specific and nonspecific effects. Longer treatments of both auxins interfere wi…

EFFICIENT AND SECURE ALGORITHMS FOR MOBILE CROWDSENSING THROUGH PERSONAL SMART DEVICES.

2021

The success of the modern pervasive sensing strategies, such as the Social Sensing, strongly depends on the diffusion of smart mobile devices. Smartwatches, smart- phones, and tablets are devices capable of capturing and analyzing data about the user’s context, and can be exploited to infer high-level knowledge about the user himself, and/or the surrounding environment. In this sense, one of the most relevant applications of the Social Sensing paradigm concerns distributed Human Activity Recognition (HAR) in scenarios ranging from health care to urban mobility management, ambient intelligence, and assisted living. Even though some simple HAR techniques can be directly implemented on mo- bil…

Der Cliffhanger im Kolportageroman um 1900

2021

Some new species of Phaneroptera, Eulioptera and Scolocerca (Orthoptera Tettigoniidae: Phaneropterinae) from West Tropical Africa

2021

The author describes Phaneroptera abdita n. sp., characterized by only two apical spurs; two new species of Eulioptera, E. iolandae n. sp. with unarmed fore coxae, E. atypica n. sp., with atypical opaque tegmina; and Scolocerca thomasi n. sp., all from West Tropical Africa. In addition, he discusses on the probable only African distribution of Phaneroptera sparsa Stål, 1857, and transfers Dithela longicaudata Massa, 2017 to the genus Eulioptera Ragge, 1956. 

La créativité en Sciences de l’Éducation et de la formation - Pistes réflexives autour d'une notion en construction

2021

International audience