showing 36 of ~574560 from 574555 documents
Influence of interfering gases on a carbon monoxide differential sensor based on SAW devices functionalized with cobalt and copper corroles
2021
International audience; <!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves/> <w:TrackFormatting/> <w:HyphenationZone>21</w:HyphenationZone> <w:PunctuationKerning/> <w:ValidateAgainstSchemas/> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF/> <w:LidThemeOther>FR</w:LidThemeOther> <w:Compatibility> <w:BreakWrappedTables/> <w:SnapToGridInCell/> <w:WrapTextWithPunct/> <w:UseAsianBreakRules/> <w:DontGrowAutofit/> <w:SplitPgBreakAndParaMark/> <w:EnableOpenTypeKe…
Numerical and analytical analysis of a monopile-supported offshore wind turbine under ship impacts
2021
Abstract Offshore wind turbines in the vicinity of ship traffic are exposed to increased risks of ship collisions. To better understand the impact mechanism, this paper evaluates the dynamic responses of a monopile-supported wind turbine under ship impacts, using both numerical and analytical methods. The nonlinear finite element method is applied during the numerical simulations, and the wind load effects, soil conditions, and rigid and deformable ship bows are considered. The analytical approach, originally developed based on the energy method, is extended here to address the damping effects of monopile-supported wind turbines. In the case study, the impacts are studied between a 4600-ton…
Screening of potent phytochemical inhibitors against SARS-CoV-2 protease and its two Asian mutants
2021
Abstract Background COVID-19, declared a pandemic in March 2020 by the World Health Organization is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The virus has already killed more than 2.3 million people worldwide. Object The principal intent of this work was to investigate lead compounds by screening natural product library (NPASS) for possible treatment of COVID-19. Methods Pharmacophore features were used to screen a large database to get a small dataset for structure-based virtual screening of natural product compounds. In the structure-based screening, molecular docking was performed to find a potent inhibitor molecule against the main protease (Mpro) of SARS-…
Impact of prompt gamma emission of 44Sc on quantification in preclinical and clinical PET systems
2021
Abstract 44Sc is an increasingly investigated positron emitter for use in positron emission tomography (PET) imaging. However, 44Sc is a non-pure positron emitter, since prompt photons are co-emitted during the decay process. This study investigates coincidence energy spectra of 44Sc and its impact on PET quantification on a preclinical and clinical PET system in comparison with 18F. The raw data of the coincidence events revealed characteristic differences comparing the photon energy distribution of 44Sc and 18F. Due to prompt gamma emission of 44Sc, activity recovery is underestimated on PET systems. However, clinical PET imaging of 44Sc with acceptable quantitative accuracy appears feasi…
Noise-Induced Vascular Dysfunction, Oxidative Stress, and Inflammation Are Improved by Pharmacological Modulation of the NRF2/HO-1 Axis
2021
Vascular oxidative stress, inflammation, and subsequent endothelial dysfunction are consequences of traditional cardiovascular risk factors, all of which contribute to cardiovascular disease. Environmental stressors, such as traffic noise and air pollution, may also facilitate the development and progression of cardiovascular and metabolic diseases. In our previous studies, we investigated the influence of aircraft noise exposure on molecular mechanisms, identifying oxidative stress and inflammation as central players in mediating vascular function. The present study investigates the role of heme oxygenase-1 (HO-1) as an antioxidant response preventing vascular consequences following exposu…
Impact of Age and Comorbidity on Multimodal Management and Survival from Colorectal Cancer : A Population-Based Study
2021
This retrospective population-based study examined the impact of age and comorbidity burden on multimodal management and survival from colorectal cancer (CRC). From 2000 to 2015, 1479 consecutive patients, who underwent surgical resection for CRC, were reviewed for age-adjusted Charlson comorbidity index (ACCI) including 19 well-defined weighted comorbidities. The impact of ACCI on multimodal management and survival was compared between low (score 0–2), intermediate (score 3) and high ACCI (score ≥ 4) groups. Changes in treatment from 2000 to 2015 were seen next to a major increase of laparoscopic surgery, increased use of adjuvant chemotherapy and an intensified treatment of metastatic dis…
An Internet-based treatment for Flying Phobia using 360° images: Study protocol for a feasibility pilot study
2021
Background Flying Phobia (FP) is a prevalent disorder that can cause serious interference in a person's life. ICBT interventions have already shown their efficacy in several studies, but studies in the field of specific phobias are still scarce. Moreover, few studies have investigated the feasibility of using different types of images in exposure scenarios in ICBTs and no studies have been carried out on the role of sense of presence and reality judgement. The aim of the present study is to explore the feasibility of an ICBT for FP (NO-FEAR Airlines) using two types of images with different levels of immersion (still and navigable images). A secondary aim is to explore the potential effecti…
RNA-controlled nucleocytoplasmic shuttling of mRNA decay factors regulates mRNA synthesis and initiates a novel mRNA decay pathway
2021
AbstractmRNA level is controlled by factors that mediate both mRNA synthesis and decay, including the exonuclease Xrn1 - a major mRNA synthesis and decay factor. Here we show that nucleocytoplasmic shuttling of Xrn1 and of some of its associated mRNA decay factors plays a key role in determining both mRNA synthesis and decay. Shuttling is regulated by RNA-controlled binding of the karyopherin Kap120 to two nuclear localization sequences (NLSs) in Xrn1. The decaying RNA binds and masks NLS1, establishing a link between mRNA decay and Xrn1 shuttling. Mutations in the two NLSs, which prevent Xrn1 import, compromise transcription and, unexpectedly, also the cytoplasmic decay of ∼50% of the cell…
Pathological Findings in COVID-19 as a Tool to Define SARS-CoV-2 Pathogenesis. A Systematic Review
2021
Introduction: The World Health Organization declared the COVID-19 pandemic in March 2020. COVID-19 still represents a worldwide health emergency, which causesa severe disease that has led to the death of many patients. The pathophysiological mechanism of SARS-CoV-2 determining the tissue damage is not clear and autopsycan be auseful tool to improve the knowledge of this infection and, thus, it can help achieve a timely diagnosis and develop an appropriate therapy. This is an overview of the main post-mortem findings reporting data on the infection effects on several organs.Methods: A systematic literature search was conducted in the PubMed database searching for articles from 1 January to A…
Effectiveness and efficiency of a special program to reduce the bariatric surgery waiting list at a tertiary hospital
2021
Graphical abstract
Niche partitioning amongst northwestern Mediterranean cetaceans using stable isotopes
2021
Abstract Ten species of cetaceans coexist in the Mediterranean Sea, one of the richest seas in biodiversity and endemisms worldwide. The conservation status of Mediterranean cetaceans has been a concern for many years, particularly due to increasing anthropogenic threats such as global warming and overfishing. We established the stable isotopic niches of carbon, nitrogen, and sulphur for five species of cetaceans inhabiting the northwestern Mediterranean Sea to elucidate the mechanisms of coexistence. The fin whale exploited epipelagic habitats with a low trophic level; the bottlenose dolphin was mostly neritic and had a high trophic level; the Risso’s dolphin was oceanic and fed bathypelag…
Adhesion G protein-coupled receptor VLGR1/ADGRV1 regulates cell spreading and migration by mechanosensing at focal adhesions.
2021
Summary VLGR1 (very large G protein-coupled receptor-1) is by far the largest adhesion G protein-coupled receptor in humans. Homozygous pathologic variants of VLGR1 cause hereditary deaf blindness in Usher syndrome 2C and haploinsufficiency of VLGR1 is associated with epilepsy. However, its molecular function remains elusive. Herein, we used affinity proteomics to identify many components of focal adhesions (FAs) in the VLGR1 interactome. VLGR1 is localized in FAs and assembles in FA protein complexes in situ. Depletion or loss of VLGR1 decreases the number and length of FAs in hTERT-RPE1 cells and in astrocytes of Vlgr1 mutant mice. VLGR1 depletion reduces cell spread and migration kinetic…
The use of MAP for maintaining quality of ‘Bifara’ fig fruits
2021
Bifara is an old cultivar of Sicilians breba fig (Ficus carica L.). Several studies on market trends and consumer preferences show that fresh fruit is required to have a good visual appearance and to be without defects on the skin in order to be considered fresh and healthy. Breba fig is a climacteric fruit that ripens very rapidly, and therefore, once harvested, it must be kept under low temperature. To reduce the respiration rate of this fruit and increase its postharvest life, effectiveness of low temperature storage was studied on ‘Bifara’ fig fruit, either placed in Modified Atmosphere Packaging MAP (20 kPa O2 and 15 kPa CO2) bags and stored for 3, 5, 7, and 10 days at 5°C and 90% RH. …
Development of Magnetic Field-Assisted Single-Point Incremental Forming
2021
Single Point Incremental Forming (SPIF) has recently introduced the concept of material formability enhancement through localized deformation. Since material is processed by means of a pin tool attached to spindle, physical interference (especially in vertical direction) limits attainable shapes with the conventional process. The aim of the following work is to increase the variety of achievable geometries with SPIF through in-process magnetic field assistance. An innovative configuration managing SPIF tool movement using magnetic force is proposed. With this in mind, a magnet configuration was designed to generate a vertical load able to plastically deform a 0.5 mm thick AA1100 aluminum sh…
Photoelastic analysis of conventional and locking system for treatment of mandibular angle fractures with a single plate
2021
Made available in DSpace on 2021-06-25T10:28:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-04-01 Background: This photoelastic analysis evaluated stress distribution in different osteosynthesis systems, conventional and locking, used for treatment of mandibular angle fractures with a single plate. Material and Methods: Angle fractures were simulated in mandibles made of photoelastic resin. Following Champy’s method, plate osteosynthesis was performed. The samples were divided into five groups: Group 1, non-fractured mandible; Group 2, two screws were installed in each segment using a conventional system; Group 3, two screws were installed in each segment using a locking system; …
Self-control and need satisfaction in primetime: Television, social media, and friends can enhance regulatory resources via perceived autonomy and co…
2021
The relationship between self-control and media use is complicated. Loss of self-control capacity has been linked to generally higher levels of media use, which might represent self-regulatory failure, but could also be attempts at replenishing self-control. Indeed, self-determination theory proposes that satisfying intrinsic psychological needs (autonomy, competence, and relatedness), for example via media use, aids the recovery of self-control. In this 2-wave survey (N = 395), we examined the interplay of users’ self-control capacity and their perceived satisfaction of autonomy, competence, and relatedness needs via media use and alternative leisure activities. Satisfaction of intrinsic n…
Predictive Strength of Physical Education-Centered Physical Literacy Indicators on Physical Activity
2021
This study examined the predictive strength of selected physical education (PE)-centered physical literacy indicators on elementary school students’ accelerometer-measured moderate to vigorous intensity physical activity (PA). The study was a cross-sectional study with a sample of 450 Finnish children (M = 11.26 [0.32]; nfemales = 194; nmales = 256). Data on a set of predictor variables (motor competence, in-class PE moderate- to vigorous-intensity PA [MVPA], health-related fitness, and PE motivation and enjoyment) and total MVPA as a single outcome variable were collected. The entire model explained almost 30% of MVPA (R2adj = .298). Cardiorespiratory endurance (β = 0.42, 95% confidence in…
Recognition as Generative Movement. Axel Honneth between Structure of the Self and Second Nature
2021
Il lavoro affronta tematicamente il paradigma del riconoscimento di Axel Honneth attraverso quattro opere principali — Kampf um Anerkennung, Verdinglichung, Das Recht der Freiheit e Anerkennung. Lo scopo principale è quello di distillare i diversi concetti di riconoscimento messi in campo da Honneth, pur mantenendo l'analisi all'interno dell'orizzonte di matrice francofortese, con le sue necessarie implicazioni antropologiche e filosofico-sociali. A una prima parte storico-filosofica segue un ultimo capitolo in cui i diversi concetti di riconoscimento vengono confrontati con la proposta di Hegel, elaborata nella sezione sulla moralità nella Fenomenologia dello spirito. The work thematically…
A User-Centered Chatbot (Wakamola) to Collect Linked Data in Population Networks to Support Studies of Overweight and Obesity Causes: Design and Pilo…
2021
[EN] Background: Obesity and overweight are a serious health problem worldwide with multiple and connected causes. Simultaneously, chatbots are becoming increasingly popular as a way to interact with users in mobile health apps. Objective: This study reports the user-centered design and feasibility study of a chatbot to collect linked data to support the study of individual and social overweight and obesity causes in populations. Methods: We first studied the users' needs and gathered users' graphical preferences through an open survey on 52 wireframes designed by 150 design students; it also included questions about sociodemographics, diet and activity habits, the need for overweight and o…
Effects of the Educational Use of Music on 3- to 12-Year-Old Children’s Emotional Development: A Systematic Review
2021
Interest in the study of emotions in education has grown in recent years. Some of our modern challenges, such as constantly adapting to new scenarios or the need for team work have justified the introduction of emotional competence into educational systems, while diverse studies confirm the relationship between music and emotional intelligence, so that the former could be used as a tool to develop the latter. The aim of this work was to examine the evidence for positive effects of music on the emotions of 3- to 12-year-old children, to which end a systematic review was carried out. Two reviewers independently evaluated 424 studies that were identified in MEDLINE, Psycinfo, and CINAHL databa…
Induction of Regulatory T Cells in Leishmania major‒Infected BALB/c Mice Does Not Require Langerin+ Dendritic Cells
2021
Semantics of Voids within Data: Ignorance-Aware Machine Learning
2021
Operating with ignorance is an important concern of geographical information science when the objective is to discover knowledge from the imperfect spatial data. Data mining (driven by knowledge discovery tools) is about processing available (observed, known, and understood) samples of data aiming to build a model (e.g., a classifier) to handle data samples that are not yet observed, known, or understood. These tools traditionally take semantically labeled samples of the available data (known facts) as an input for learning. We want to challenge the indispensability of this approach, and we suggest considering the things the other way around. What if the task would be as follows: how to buil…
Children of migrants in French and Norwegian schools. A comparative analysis of educational attainment of second-generation students and reflections …
2021
International audience
Is there a need to widely prescribe antibiotics in patients hospitalized with COVID-19?
2021
Highlights • Antibiotics were a main part of COVID-19 treatments during the first epidemic peak. • Bacterial coinfections seem to be rare, especially if no ICU transfer needed. • We studied the place of antibiotics and the impact on prognosis of patients. • Antibiotics were prescribed if more severe infection and has no impact on prognosis. • We think that antibiotic therapy must be not widely prescribed.
Sex-Related Clinical Characteristics and Outcomes of Patients Undergoing Transcatheter Edge-to-Edge Repair for Secondary Mitral Regurgitation.
2021
OBJECTIVES The authors sought to assess sex-based differences in characteristics and outcomes of patients undergoing transcatheter edge-to-edge mitral valve repair (TMVR) for secondary mitral regurgitation (SMR). BACKGROUND Subgroup analysis from the COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart��Failure Patients with Functional Mitral Regurgitation) trial indicated potential sex-related differences in outcomes after TMVR. The impact of sex on results after TMVR in a real-world setting is unknown. METHODS The authors assessed clinical outcomes and echocardiographic parameters in women and men undergoing TMVR for SMR between 2008 and 2018 who were …
Relationship between exercise-induced muscle soreness, pain thresholds, and skin temperature in men and women.
2021
Abstract Infrared thermography (IRT) has gained popularity in sports medicine for determining whether changes in skin temperature relate to pain and muscle damage. Such a relationship would support IRT as a non-invasive method to monitor these physiological responses. However, the literature remains controversial. Here, we determine the relationship between exercise-induced muscle soreness (DOMS), pain, and skin temperature in men and women before and after exercise. Twenty-two physically active adults (10 men and 12 women) completed a squat exercise protocol to induce muscle damage. Skin temperature, DOMS, and pressure pain threshold (PPT) were assessed in the quadriceps pre, post-exercise…
Green Design of Novel Starch-Based Packaging Materials Sustaining Human and Environmental Health
2021
A critical overview of current approaches to the development of starch-containing packaging, integrating the principles of green chemistry (GC), green technology (GT) and green nanotechnology (GN) with those of green packaging (GP) to produce materials important for both us and the planet is given. First, as a relationship between GP and GC, the benefits of natural bioactive compounds are analyzed and the state-of-the-art is updated in terms of the starch packaging incorporating green chemicals that normally help us to maintain health, are environmentally friendly and are obtained via GC. Newer approaches are identified, such as the incorporation of vitamins or minerals into films and coati…
Validation of the Marathon Motivation Scale in Chile
2021
The objective of this work was to validate the Marathon Motivation Scale (MOMS) for its application in the Chilean context. The study used a non-experimental, descriptive and transversal design. The sample was non-probability and intentional and was composed of 250 subjects (143 male and 104 female) runners who participated in the International Marathon of Viña del Mar with an average age of 29.8 (TD = 10.1) years. For the analysis of the data, an exploratory factorial analysis was carried out with free parameters, another one with seven factors fixed to the theoretical dimensions and a confirmatory factorial analysis with the items corresponding to the MOMS model. The validity and reliabil…
The role of the brand in perceived service performance: Moderating effects and configurational approach in professional football
2021
Abstract This research aims to determine the effects of brand credibility and brand congruence on future intentions, perceived value, and spectators’ satisfaction among the fans of a first division football team by combining two complementary methodological approaches, lineal models (the PROCESS macro) and fuzzy set qualitative comparative analysis (fsQCA). The effects of brand credibility and brand congruence were tested in a sample of 536 fans of a first division Spanish football club aged from 18 to 70 (70.2% men). The results suggest direct, positive, and significant effects of brand congruence and brand credibility on perceived value and future intentions. In contrast, in predicting sp…
Permanently Online—Always Stressed Out? The Effects of Permanent Connectedness on Stress Experiences
2021
Abstract Concerns have been expressed that permanent online connectedness might negatively affect media user’s stress levels. Most research has focused on negative effects of specific media usage patterns, such as media multitasking or communication load. In contrast, users’ cognitive orientation toward online content and communication has rarely been investigated. Against this backdrop, we examined whether this cognitive orientation (i.e., online vigilance with its three dimensions salience, reactibility, monitoring) is related to perceived stress at different timescales (person, day, and situation level), while accounting for the effects of multitasking and communication load. Results acr…
Monitoring serologic response to single in ovo vaccination with an immune complex vaccine against infectious bursal disease in broilers
2021
Este artículo se encuentra disponible en la siguiente URL: https://www.sciencedirect.com/science/article/pii/S003257912100033X The infectious bursal disease (IBD) virus is one of the most resistant and prevalent virus worldwide in the poultry industry, being vaccination the main tool to control the disease. For this reason, consistent and uniform immunization of broiler flocks against IBD is necessary to avoid the disease spreading. The aim of this study was to apply and assess an epidemiologic mapping tool focused on the immunization by in ovo single broiler vaccination using an immune complex IBD vaccine. With this regard, 7,576 serum samples were collected from 603 broiler flocks raised …
The First Biography of Jesus: Genre and Meaning in Mark's Gospel, Helen K. Bond, Eerdmans, 2020 (ISBN 978‐0‐8028‐7460‐3), xiii + 317 pp., hb $43
2021
Towards a precision calculation of the effective number of neutrinos 𝖭_𝖾𝖿𝖿 in the Standard Model. Part II. Neutrino decoupling in the presence of…
2021
Abstract We present in this work a new calculation of the standard-model benchmark value for the effective number of neutrinos, Neff SM, that quantifies the cosmological neutrino-to-photon energy densities. The calculation takes into account neutrino flavour oscillations, finite-temperature effects in the quantum electrodynamics plasma to O(e3), where e is the elementary electric charge, and a full evaluation of the neutrino-neutrino collision integral. We provide furthermore a detailed assessment of the uncertainties in the benchmark Neff SM value, through testing the value's dependence on (i) optional approximate modelling of the weak collision integrals, (ii) measurement errors in the ph…
Linear, tripodal, macrocyclic: Ligand geometry and ORR activity of supported Pd(II) complexes
2021
Abstract The novel ligand H3L designed to spontaneously adsorb onto MWCNT via electron-deficient pyrimidine residues and bind metal cations is used to prepare an oxygen reduction reaction (ORR) cathode catalyst based on supported Pd(II) complexes. Herein we report the synthesis of the ligand, its solution behaviour (protonation constants, binding constants for the test cation Cu(II), UV evidence of Cu(II) and Pd(II) complexes formation) and ORR performances together with XPS and STEM characterization. Tripodal nature of the H3L ligand frame it in-between previously studied macrocyclic and linear open chain ligands, allowing to draw meaningful comparisons.
COVID-19 lockdown influence in the psychiatric emergencies: Drastic reduction and increase in severe mental disorders.
2021
Behavioral Restriction Determines Left Attentional Bias: Preliminary Evidences From COVID-19 Lockdown
2021
International audience; During the COVID-19 lockdown, individuals were forced to remain at home, hence severely limiting the interaction within environmental stimuli, reducing the cognitive load placed on spatial competences. The effects of the behavioral restriction on cognition have been little examined. The present study is aimed at analyzing the effects of lockdown on executive function prominently involved in adapting behavior to new environmental demands. We analyze non-verbal fluency abilities, as indirectly providing a measure of cognitive flexibility to react to spatial changes. Sixteen students (mean age 20.75; SD 1.34), evaluated before the start of the lockdown (T1) in a battery…