Conventional and semi-automatic histopathological analysis of tumor cell content for multigene sequencing of lung adenocarcinoma

2021

BACKGROUND: Targeted genetic profiling of tissue samples is paramount to detect druggable genetic aberrations in patients with non-squamous non-small cell lung cancer (NSCLC). Accurate upfront estimation of tumor cell content (TCC) is a crucial pre-analytical step for reliable testing and to avoid false-negative results. As of now, TCC is usually estimated on hematoxylin-eosin (H&E) stained tissue sections by a pathologist, a methodology that may be prone to substantial intra- and interobserver variability. Here we the investigate suitability of digital pathology for TCC estimation in a clinical setting by evaluating the concordance between semi-automatic and conventional TCC quantification…

Monitoring Occurrence of Liver-Related Events and Survival by Transient Elastography in Patients With Nonalcoholic Fatty Liver Disease and Compensate…

2021

[Background & Aims] Patients with advanced fibrosis related to nonalcoholic fatty liver disease (NAFLD) are at risk of developing hepatic and extrahepatic complications. We investigated whether, in a large cohort of patients with NAFLD and compensated advanced chronic liver disease, baseline liver stiffness measurements (LSMs) and their changes can be used to identify patients at risk for liver-related and extrahepatic events.

Impact of prompt gamma emission of 44Sc on quantification in preclinical and clinical PET systems

2021

Abstract 44Sc is an increasingly investigated positron emitter for use in positron emission tomography (PET) imaging. However, 44Sc is a non-pure positron emitter, since prompt photons are co-emitted during the decay process. This study investigates coincidence energy spectra of 44Sc and its impact on PET quantification on a preclinical and clinical PET system in comparison with 18F. The raw data of the coincidence events revealed characteristic differences comparing the photon energy distribution of 44Sc and 18F. Due to prompt gamma emission of 44Sc, activity recovery is underestimated on PET systems. However, clinical PET imaging of 44Sc with acceptable quantitative accuracy appears feasi…

‘Dry’ electrochemistry: A non-invasive approach to the characterization of archaeological iron objects

2021

A methodology for monitoring the corrosion state of archaeological iron objects using ‘dry’ open circuit potential (OCP) measurements is described. Application of this technique to a set of objects from La Bastida de les Alcusses archaeological site (Moixent, València, Spain), dating back to the 4th century BCE, reveals significant differences depending on the conservation state. The transient OCP responses (which last between a few seconds and 10–15 min) were superimposed with much shorter (less than one second) intense features. Fil: Doménech Carbó, Antonio. Universidad de Valencia; España Fil: Peiró Ronda, María Amparo. Museu de Prehistòria de València; España Fil: Vives Ferrándiz, Jaime…

La prospettiva sociologica sulla balbuzie

2021

Reflection on the effects of language disorders, such as stuttering.

Solvent-tuned ultrasonic synthesis of 2D coordination polymer nanostructures and flakes

2021

Highlights • Combined ultrasound and solvent assisted synthesis of 2D coordination polymers. • Role of interstitial solvent molecules in the delamination of 2D-CPs. • Influence of the sonication time in delamination and nanostructuration processes. • Morphological and supramolecular transformations in 2D-CPs.

Corrigendum: Wired for motherhood: induction of maternal care but not maternal aggression in virgin female CD1 mice

2021

The relationship between age and fitness profiles in elite male ice hockey players

2021

Background: The present study investigated relationships between age, body composition and performance in elite male ice hockey players.Methods: 199 players performed off-ice tests (countermovement jump height (CMJ) and body composition) and on-ice tests (5-10-5 Pro Agility test, 30-m sprint test and the maximal Yo-Yo Intermittent Recovery Ice Hockey test (Yo-Yo IR1-IHMAX) for assessment of aerobic capacity.Results: No overall correlations between age and performance were present except small-moderate positive associations between age and body-and muscle mass (r=0.24-0.30, ≤0.05). The youngest age group (YOU; 18-21 years) were 4-9% lighter than all other age groups and possessed 7% less mus…

Mal-logement des personnes âgées en France : des situations marginales à l’habitat inadapté

2021

numéro « Vieillissement, marginalité urbaine et mal-logement »; International audience

The evolution of COVID-19: A discontinuous approach.

2021

The evolution of the COVID-19 disease is monitored on the basis of the daily number of infected patients and the daily number of deaths provided from national health agencies. The variation of such parameters with time parallels that described for the growth/decay of historic transportation systems revealing the appearance of discontinuities. The evolution of the pandemic disease is represented in terms of two nominally equivalent formulations: a logistic model with sharp changes in its rate parameters, and in topological terms resulting in 2nd order phase transitions in the infected patients/time space.

Pre-training inter-rater reliability of clinical instruments in an international psychosis research project.

2021

International audience

Substrate Selectivity of Coumarin Derivatives by Human CYP1 Enzymes: In Vitro Enzyme Kinetics and In Silico Modeling

2021

Of the three enzymes in the human cytochrome P450 family 1, CYP1A2 is an important enzyme mediating metabolism of xenobiotics including drugs in the liver, while CYP1A1 and CYP1B1 are expressed in extrahepatic tissues. Currently used CYP substrates, such as 7-ethoxycoumarin and 7-ethoxyresorufin, are oxidized by all individual CYP1 forms. The main aim of this study was to find profluorescent coumarin substrates that are more selective for the individual CYP1 forms. Eleven 3-phenylcoumarin derivatives were synthetized, their enzyme kinetic parameters were determined, and their interactions in the active sites of CYP1 enzymes were analyzed by docking and molecular dynamic simulations. All cou…

Chemically Fueled Block Copolymer Self‐Assembly into Transient Nanoreactors**

2021

In chemically fueled supramolecular materials, molecular self-assembly is coupled to a fuel-driven chemical reaction cycle. The fuel-dependence makes the material dynamic and endows it with exciting properties like adaptivity and autonomy. In contrast to the large work on the self-assembly of small molecules, we herein designed a diblock copolymer, which self assembles into transient micelles when coupled to a fuel-driven chemical reaction cycle. Moreover, we used these transient block copolymer micelles to locally increase the concentration of hydrophobic reagents and thereby function as a transient nanoreactor.

Obstetrics outcomes after complete and partial molar pregnancy: Review of the literature and meta-analysis.

2021

The hydatidiform mole is a rare gynecological disease rising from the trophoblastic. Post-molar pregnancies have an extremely variable course, varying from repeated abortions, stillbirths, preterm births, live births, or recurring in further molar pregnancies. Literature on obstetric outcomes following molar pregnancy is poor, often including monocentric studies, and with data collected from national databases. This review and meta-analysis aim to analyze the obstetric outcomes after conservative management of complete (CHM) and partial (PHM) molar pregnancies. The meta-analysis was performed following the Meta-analysis Of Observational Studies in Epidemiology (MOOSE) and the preferred repo…

Childhood Sports Participation Is Associated With Health-Related Quality of Life in Young Men: A Retrospective Cross-Sectional Study

2021

The aim of the study was to examine whether sports participation (SP), engagement in competitive sports (CS) and the type of sport undertaken at the age of 12 are associated with the physical and the mental components of health-related quality of life (HRQoL) in young adulthood. The data were collected using questionnaires prior to a compulsory military refresher training course in Finland. The sample consisted of 784 men (mean age 26 years). HRQoL was measured with RAND 36 and childhood sports participation with a series of questions. Data were analysed with logistic regression. Higher frequency of SP, participation in district level CS, performing team, endurance or extreme sports and pla…

Jealousy due to social media? A systematic literature review and framework of social media-induced jealousy

2021

Purpose The association between social media and jealousy is an aspect of the dark side of social media that has garnered significant attention in the past decade. However, the understanding of this association is fragmented and needs to be assimilated to provide scholars with an overview of the current boundaries of knowledge in this area. This systematic literature review (SLR) aims to fulfill this need. Design/methodology/approach The authors undertake an SLR to assimilate the current knowledge regarding the association between social media and jealousy, and they examine the phenomenon of social media-induced jealousy (SoMJ). Forty-five empirical studies are curated and analyzed using st…

Affinity Sensors for the Diagnosis of COVID-19

2021

The coronavirus disease 2019 (COVID-19) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was proclaimed a global pandemic in March 2020. Reducing the dissemination rate, in particular by tracking the infected people and their contacts, is the main instrument against infection spreading. Therefore, the creation and implementation of fast, reliable and responsive methods suitable for the diagnosis of COVID-19 are required. These needs can be fulfilled using affinity sensors, which differ in applied detection methods and markers that are generating analytical signals. Recently, nucleic acid hybridization, antigen-antibody interaction, and change of reactive oxyge…

Induction of Regulatory T Cells in Leishmania major‒Infected BALB/c Mice Does Not Require Langerin+ Dendritic Cells

2021

Disposal Behavior of Used Masks during the COVID-19 Pandemic in the Moroccan Community: Potential Environmental Impact.

2021

The spread of coronavirus disease-2019 (COVID-19) levied on the Moroccan authorities to increase their mask production capacity, which reached up to 12 million facemask units produced per day. This increase in personal protective equipment (PPE) production and consumption is an efficient tool to address the spread of COVID-19. However, this results in more plastic and microplastic debris being added into the land and marine environments, which will harm the ecosystem, wildlife, and public health. Such a situation needs deep individual behavior observation and tracking, as well as an assessment of the potential environmental impact of this new type of waste. For this reason, we assessed the …

Editorial for Special Issue “Yeast in Winemaking”

2021

Yeast in winemaking was first studied for its role in alcoholic fermentation, and has led to the publication of a huge amount of scientific articles [...]

Automation Inner Speech as an Anthropomorphic Feature Affecting Human Trust: Current Issues and Future Directions

2021

This paper aims to discuss the possible role of inner speech in influencing trust in human–automation interaction. Inner speech is an everyday covert inner monolog or dialog with oneself, which is essential for human psychological life and functioning as it is linked to self-regulation and self-awareness. Recently, in the field of machine consciousness, computational models using different forms of robot speech have been developed that make it possible to implement inner speech in robots. As is discussed, robot inner speech could be a new feature affecting human trust by increasing robot transparency and anthropomorphism.

253. La pandemia y el Geoforo Iberoamericano en 2020

2021

La pandemia de la COVID-19, que nos afecta desde los primeros meses de 2020, ha modificado nuestras costumbres y rutinas. Y también la manera de relacionarnos en los medios escolares y universitarios. Desde el Geoforo Iberoamericano sobre Educación, Geografía y Sociedad hemos considerado que se abría una oportunidad para re-pensar los problemas sociales y ambientales que condicionan nuestra cotidianidad. Desde el estudio de situaciones particulares hemos querido definir los problemas intelectuales que sean susceptibles de ser trabajados en las aulas. Esta consideración es fruto de la evolución que venimos manteniendo desde 2008 y que se valoró en el Coloquio de 2019 en Bogotá, del cual tamb…

false

2021

Abstract In an ever-evolving technological landscape that challenges teaching professionals' digital competence, this study complements previous studies by providing an overall picture of teaching professionals' digital competence. We employed regression models on two large-scale assessment data sets on teachers from 11 countries—namely, the Teaching and Learning International Survey (TALIS; n = 50,800) and the Programme for the International Assessment of Adult Competencies (PIAAC; n = 2590)—to investigate through the theoretical lens of digital competence how teaching professionals' skills, attitudes and knowledge distribute and relate, and how they are associated with personal and contex…

Impact of COVID-19 on hand surgery in Italy: A comparison between the Northern and the Southern regions

2021

The aims of this study were to evaluate the impact of the COVID-19 pandemic on emergency and elective hand surgery in four Italian regions that had either a high (Lombardy and Piemonte) or a low (Sicilia and Puglia) COVID-19 case load to discuss problems and to elaborate strategies to improve treatment pathways. A panel of hand surgeons from these different regions compared and discussed data from the centers they work in. The COVID-19 pandemic had an enormous impact on both elective and emergency surgery in Italy, not only in highly affected regions but also – and paradoxically even at a higher extent – in regions with a low COVID-19 case load. A durable and flexible redesign of hand surge…

Influence of the anisotropy of sisal fibers on the mechanical properties of high performance unidirectional biocomposite lamina and micromechanical m…

2021

Abstract High performance biocomposites reinforced by sisal fibers, are between the most promising materials that could be used in various fields, from automotive to civil constructions, thanks to their good mechanical performance, as well as to the low cost and the great availability of the fiber. Nevertheless, at present their practical use is prevented by the limited knowledge of their mechanical performance. The results of the present study have shown that the intimate fibrillar structure of the sisal fiber is associated with a high anisotropy involving not only the elastic parameters, but also the damage processes with typical fiber splitting phenomena, that influence noticeably the bi…

Histological findings of osteonecrosis spotted prior to tooth extractions. Should we consider tooth extraction still the main trigger event?

2021

Osteonecrosis of the jaw (ONJ) is an adverse drug reaction described as the progressive destruction and death of bone that affects the mandible and maxilla of patients exposed to the treatment with medications known to increase the risk of disease, in the absence of a previous radiation treatment. Tooth extraction often precedes the manifestation of ONJ; indeed, it is sometimes called trigger event and it have also been considered as risk factors for the onset of ONJ. As a consequence, some of the guidelines recommend avoiding tooth extractions in patients at risk of ONJ; however, a growing body of evidence indicates that dental/periodontal infection prior to extraction, rather than dental …

Cancer: New Needs, New Models. Is It Time for a Community Oncologist? Another Brick in the Wall

2021

Simple Summary Community care activity in the oncology field does not exist. This unmet need contrasts with the increasing number of patients with a previous diagnosis of cancer. Abstract Over the last few decades, thanks to early detection, effective drugs, and personalized treatments, the natural history of cancer has radically changed. Thanks to these advances, we have observed how survival of cancer patients has increased, becoming an ever more important goal in cancer care. Effective clinical governance of survivorship care is essential to ensure a successful transition between active and post-treatment life, identifying optimization of healthcare outcomes and quality of life for patie…

Biological and chemical characterization of new isolated halophilic microorganisms from saltern ponds of Trapani, Sicily

2021

Abstract Halophilic microorganisms inhabiting hypersaline environments such as salt lakes, Dead Sea, or salt evaporation ponds, have acquired specific cell adaptation to grow within stressful conditions. In this study, we isolated heterotrophic and autotrophic microorganisms from several saltern ponds located at the Natural Reserve “Saline di Trapani e Paceco”, Sicily, Italy. The aim of the study was to investigate the biotechnological potential of new microbial strains from saltern ponds, by capturing their biological and chemical diversity. After the isolation and identification of the sampled strains, their growth capacity was determined under low and high salinity conditions. The metabo…

Editorial for Special Issue “Bioactive Oxadiazoles”

2021

Oxadiazoles are electron-poor, five-membered aromatic heterocycles containing one oxygen and two nitrogen atoms [...]

Hospitalizations for Stroke in France During the COVID-19 Pandemic Before, During, and After the National Lockdown.

2021

Background and Purpose: In France, the entire population was put under a total lockdown from March 17 to May 11, 2020 during the peak of the coronavirus disease 2019 (COVID-19) pandemic. Whether the lockdown had consequences on the management of medical emergencies such as stroke and transient ischemic attack (TIA) has yet to be fully evaluated. This article describes hospitalization rates for acute stroke in 2 French regions that experienced contrasting rates of COVID-19 infection, before, during, and after the nationwide lockdown (January to June 2020). Methods: All patients admitted for acute stroke/TIA into all public and private hospitals of the 2 study regions were included. Data wer…

Temperature Variation Enables the Design of Biobased Block Copolymers via One‐Step Anionic Copolymerization

2021

A one-pot approach for the preparation of diblock copolymers consisting of polystyrene and polymyrcene blocks is described via a temperature-induced block copolymer (BCP) formation strategy. A monomer mixture of styrene and myrcene is employed. The unreactive nature of myrcene in a polar solvent (tetrahydrofuran) at -78 °C enables the sole formation of active polystyrene macroinitiators, while an increase of the temperature (-38 °C to room temperature) leads to poly(styrene-block-myrcene) formation due to polymerization of myrcene. Well-defined BCPs featuring molar masses in the range of 44-117.2 kg mol-1 with dispersities, Ð, of 1.09-1.21, and polymyrcene volume fractions of 30-64% are acc…

Cognitive benefits of exercise interventions: an fMRI activation likelihood estimation meta-analysis.

2021

Despite a growing number of functional MRI studies reporting exercise-induced changes during cognitive processing, a systematic determination of the underlying neurobiological pathways is currently lacking. To this end, our neuroimaging meta-analysis included 20 studies and investigated the influence of physical exercise on cognition-related functional brain activation. The overall meta-analysis encompassing all experiments revealed physical exercise-induced changes in the left parietal lobe during cognitive processing. Subgroup analysis further revealed that in the younger-age group (< 35 years old) physical exercise induced more widespread changes in the right hemisphere, whereas in th…

mRNA-Based Vaccines

2021

Increases in the world’s population and population density promote the spread of emerging pathogens. Vaccines are the most cost-effective means of preventing this spread. Traditional methods used to identify and produce new vaccines are not adequate, in most instances, to ensure global protection. New technologies are urgently needed to expedite large scale vaccine development. mRNA-based vaccines promise to meet this need. mRNA-based vaccines exhibit a number of potential advantages relative to conventional vaccines, namely they (1) involve neither infectious elements nor a risk of stable integration into the host cell genome; (2) generate humoral and cell-mediated immunity; (3) are well-t…

COMPAS : une application innovante pour soutenir la communication centrée sur la personne entre les personnes âgées atteintes de démence et leur proc…

2021

Introduction Les personnes atteintes de demence (PAD) developpent des troubles de la communication qui impactent la relation avec l’aidant ce qui contribue a l’isolement de l’un et a l’epuisement de l’autre. Objectifs L’objectif est de valider COMmunication Proche-Aidants (COMPAs) en contexte de soins de longue duree. Cette application favorise les interactions grâce a du contenu audiovisuel personnalise permettant une communication centree sur la personne. Patients et methodes 17 aides-soignants ont utilise quotidiennement COMPAs aupres de 39 beneficiaires atteints de troubles neurocognitifs majeurs pendant huit semaines. L’etude mesure les effets de COMPAs sur la communication, la qualite…

Un Parco nella Sicilia più nascosta

2021

Le aree interne della Sicilia sono caratterizzate, oltre che dalle tipiche crisi delle aree marginali, da altri fattori peculiari quali una costante arretratezza tecnologica e uno disfattismo di gattopardesca memoria. Esse sono anche però il luogo ove lo sviluppo locale potrebbe riportare i suoi migliori esiti, trasformandole da luoghi del sottosviluppo in luoghi di rinnovata e viva identità. Ciò in virtù dalla immensa potenzialità che luoghi naturali come i Parchi possiedono intrinsecamente per avviare uno sviluppo sostenibile che riesca a mantenere le componenti identitarie e paesaggistiche di un luogo e al contempo risollevarne le sorti. Il caso studio, ivi presentato, riguarda il Parco …

Les habitudes alimentaires des familles françaises pendant le confinement lié au COVID-19 : (comment) ont-elles changé ?

2021

La pandemie liee au COVID-19 a conduit la France a imposer un confinement strict, affectant les habitudes des familles dans de nombreux domaines Cette etude visait a evaluer les changements possibles dans les comportements alimentaires des enfants, les pratiques educatives parentales en matiere d'alimentation et les motivations d'achat des aliments, pendant le confinement par rapport a la periode avant confinement Pendant le confinement, les parents de 498 enfants âges de 3 a 12 ans (238 garcons ;M = 7,32 ;ET = 2,27) ont repondu a une enquete nationale en ligne comprenant les items issus de questionnaires valides (ex CEDQ, CEBQ, HomeSTEAD) Ils ont decrit leur situation et celle de l'enfant …