showing 36 of ~574560 from 574555 documents
The impact of life stage and pigment source on the evolution of novel warning signal traits
2021
Our understanding of how novel warning color traits evolve in natural populations is largely based on studies of reproductive stages and organisms with endogenously produced pigmentation. In these systems, genetic drift is often required for novel alleles to overcome strong purifying selection stemming from frequency-dependent predation and positive assortative mating. Here, we integrate data from field surveys, predation experiments, population genomics, and phenotypic correlations to explain the origin and maintenance of geographic variation in a diet-based larval pigmentation trait in the redheaded pine sawfly (Neodiprion lecontei), a pine-feeding hymenopteran. Although our experiments c…
Introduction: classroom discourse at the intersection of language education and materiality
2021
This special issue provides a collection of research that examines the relationships between classroom materials and discourse in various second language education contexts. Together, these studies...
'Love comes first, and it is ahead of any different political partisanism': How political polarizations compare to other forms of discrimination in B…
2021
Background: Affective polarization and stigma toward individuals with schizophrenia and toward immigrants in Argentina are not new despite its importance and dissemination. However, no research has been conducted taking into consideration political partisanship and attitudes toward these groups. Aims: Political polarization and attitudes toward socialization across party lines are studied in conjunction with attitudes toward immigrants and toward individuals with schizophrenia. Method: Individuals from Buenos Aires ( n = 712) were surveyed for their political partisanship and their attitudes toward Peruvian and Bolivian immigrants, people with schizophrenia and partisans from the opposing p…
Doing gender and sexuality intersectionally in multimodal social media practices
2021
The chapter focuses on how members in participatory cultures engage in everyday, informal, and interest-driven social and discursive practices primarily on social media but also in ways that relate to the material and physical contexts of their lives. We show how social actors operating in these sites construct gender and sexuality intersectionally and multimodally. We argue that gender and sexuality are always constructed at intersections with other identity categories. With respect to both digital and physical participatory activities, multisemioticity is, in turn, necessary as an analytic perspective: it allows the investigation of how participants routinely draw on and deploy a range of…
Introduction d'une nouvelle variable individuelle en persuasion publicitaire : quel(s) rôle(s) pour l'estime de soi-état ?
2021
National audience
Can business model innovation help SMEs in the food and beverage industry to respond to crises? Findings from a Swiss brewery during COVID-19
2021
PurposeThe purpose of this paper is to show how different business model innovations (BMIs) help small and medium-sized enterprises (SMEs) in the food and beverage industry to navigate turbulent and uncertain environments such as the coronavirus economic crisis (COVID-19).Design/methodology/approachThe paper adopts an in-depth case study approach and uses a dynamic business modeling (DBM) approach to analyze how a pioneer craft brewery in Switzerland implemented innovative actions undertaken during the COVID-19 pandemic.FindingsThe paper offers a novel framework describing three processes helping SMEs to implement innovations in their business model (BM) to respond in an effective way to cr…
Type I interferons as the potential mechanism linking mRNA COVID-19 vaccines to Bell's palsy
2021
Therapies - Sous presse. Epreuves corrigees par l'auteur. Disponible en ligne depuis le mardi 13 avril 2021
Variety of size and form of GRM2 bacterial microcompartment particles
2021
Bacterial microcompartments (BMCs) are bacterial organelles involved in enzymatic processes, such as carbon fixation, choline, ethanolamine and propanediol degradation, and others. Formed of a semi‐permeable protein shell and an enzymatic core, they can enhance enzyme performance and protect the cell from harmful intermediates. With the ability to encapsulate non‐native enzymes, BMCs show high potential for applied use. For this goal, a detailed look into shell form variability is significant to predict shell adaptability. Here we present four novel 3D cryo‐EM maps of recombinant Klebsiella pneumoniae GRM2 BMC shell particles with the resolution in range of 9 to 22 Å and nine novel 2D class…
Dataset related to article "Development and external validation of a clinical prediction model for functional impairment after intracranial tumor sur…
2021
Anonymised clinical database containing information (Age, sex, prior surgery, tumor histology and maximum diameter, expected major brain vessel or cranial nerve manipulation, resection in eloquent areas and the posterior fossa, and surgical approach were recorded) about patients of Fondazione IRCCS Istituto Besta analysed for the article “Development and external validation of a clinical prediction model for functional impairment after intracranial tumor surgery”
Derrames de la inversión extranjera directa y su efecto en las exportaciones: una aplicación empírica en un país emergente
2021
Este trabajo investiga, por primera vez en el caso colombiano, los efectos indirectos de los derrames de la inversión extranjera directa (IED) sobre las exportaciones de las empresas nacionales. A nivel empírico utilizamos una muestra de conveniencia formada por 32 empresas exportadoras, 14 filiales extranjeras y 18 empresas domésticas, las cuales mantuvieron continuidad en cerca de 60% del valor total de la oferta exportable nacional en el periodo de 2007 a 2016. Mediante el uso de un panel de datos con efectos fijos, demostramos que los efectos positivos de la entrada de IED sobre la exportación de las empresas locales se asocian más con mecanismos de reacción para la protección de sus me…
Association between Life Skills and Academic Performance in Adolescents in the Autonomous Community of Aragon (Spain).
2021
Background: Learning and socio-emotional development is promoted through the creation and nurturing of an optimal school climate. This study aims to analyze the relationship between life skills and academic performance in a large sample of adolescents from the autonomous community of Aragón (Spain). Methods: A cross-sectional study was conducted on the life skills and academic performance of a sample of 7th and 8th grade middle school students during the academic year 2018–2019. A sample of 43 middle schools were randomly selected
Protéines végétales : les consommateurs sont-ils prêts ?
2021
National audience
The psychometric measures to assess aggressive dimension following traumatic brain injury: A review.
2021
Abstract Background: higher level of aggression and antisocial behavior are frequent following head trauma, due to specific brain alterations. Many tests are used to assess this aspect. A descriptive review was conducted on the main tests used to detect the appearance of aggressive dimensions following traumatic brain injury. Review summary: we searched on PubMed and Web of Science databases and screening references of included studies and review articles for additional citations. From initial 723 publications, only 7 met our search criteria. Findings showed that various psychometric tools are used to assess aggressiveness and its subdomains, following head trauma. Conclusions: further inve…
Cornered: Intimate Relations in The Words upon the WIndow-Pane
2021
Supply Chain Collaboration in Craft Production: empirical evidences from the food and beverage industry
2021
This paper empirically analyzes collaborative relationships among craftsmen and their suppliers in the food and beverage industry. Despite the recent return to traditional manufacturing methods triggered by customers’ attention, the literature debate on supply chain collaboration, in this field, has received limited research attention. In particular, the paper aims at investigating information and knowledge sharing in craft production environments by addressing the following research questions: RQ1. What type of information and knowledge is shared? RQ2. What are the main antecedents that lead to exchange information and knowledge with suppliers? RQ3. What are the benefits? The qualitative c…
Identification of sub- μs isomeric states in the odd-odd nucleus Au178
2021
The neutron-deficient gold (Z=79) isotopes in the vicinity of the neutron midshell N=104 provide prolific examples of shape coexistence and isomerism at low excitation energy. They can be probed via a number of different experimental techniques. In this study, two new isomeric states with half-lives of 294(7) and 373(9) ns have been observed in the neutron-deficient odd-odd nuclide Au178 (N=99) in an experiment at the RITU gas-filled separator at JYFL, Jyvaskyla. This result was achieved due to the use of a segmented planar germanium detector with a high efficiency at low energies. By applying the recoil-decay tagging technique, they were assigned to decay to two different long-lived α-deca…
Complications of Botulinum toxin A: An update review.
2021
Cosmetic surgery procedures have increased manifolds all over the world owing to the ever-increasing demand of people to look beautiful and young. Injectable treatments like botulinum toxin are becoming more popular owing to their rapid, well-defined, and lasting results for the reduction of facial fine lines, wrinkles, and facial rejuvenation. These emerging treatments are quite safe but can have certain adverse effects. In this article, we have highlighted the complications and side effects of botulinum toxin based on the anatomical location. The possible causes and precautions to prevent these complications are also discussed. The search of literature included peer-reviewed articles incl…
Physical exercise and prevention of falls. Effects of a Pilates training method compared with a general physical activity program
2021
Introduction Falls are the leading cause of injury-related mortality and morbidity in the elderly. Physical activity plays a key role in the prevention of falls and stimulates postural control. The aim of this study was to compare a general physical activity program for the elderly with a Pilates program to evaluate the effects on balance and on reducing the risk of falling. Materials and methods Forty-six subjects were enrolled in this study, but only 41 were included in the study. The subjects were divided into 2 groups: Pilates group (P-G) and a group following a nonspecific program of physical activity (Pa-G). Each subject underwent the hand grip test, Berg balance scale test, and postu…
Le décolonialisme, c'est 50,4%
2021
International audience
The impact of cultural and creative industries on the wealth of countries, regions and municipalities
2021
[EN] This paper compares the total impact of cultural and creative industries (CCIs) on per capita income of countries, regions and municipalities. We estimate the total effects of CCIs in 78 developed and developing countries in 5 continents, in 275 European regions and in 518 municipalities in the European region of Valencia, using data obtained from multiple databases and nonparametric local linear least squares. The average effects of CCIs are positive in the three territorial scales, in both low- and high-income locations, and increase in conjunction with increases in development, with high and very high developed places showing greater impacts. CCIs are, thus, a powerful resource for …
Postural Sensorimotor Control on Anorectal Pressures and Pelvic Floor Muscle Tone and Strength: Effects of a Single 5P® LOGSURF Session. A Cross-Sect…
2021
Pelvic floor dysfunction (PFD) is a functional condition present most frequently in women. Despite pelvic floor muscle training being considered by the International Continence Society (ICS) as the first-line treatment in uncomplicated urinary incontinence, other more comprehensive postural methods as 5P® LOGSURF have emerged. This preliminary cross-sectional study explores the effects of a single 5P® LOGSURF session on pelvic floor muscle (PFM) tone and strength (MVC), resting anal tone, intrarectal pressure, and deep abdominal muscles activation. Thirty women were included (11 without PFD and 19 with PFD). Primary outcome measures were PFM tone, PFM MVC and resting anal tone and secondary…
Physically active play in the early years
2021
Babies have an inborn drive to be physically active, which serves as a necessary moderator for their development. Young children discover and learn new skills through movement, and this important bond between physical activity and development continues as children grow older. Babies are driven to be physically active, and this innate drive is a key aspect of development. Without this drive, babies would be content simply to have their basic needs met, such as feeding, hygiene, and interaction with another person. Consecutive learning moments create the foundation for overall development, and sensory stimulation and bodily movements combined with cognitive challenges form the basis for react…
Relative risk rather than absolute risk reduction should be preferred to sensitise the public to preventive actions.
2021
We thank Lawrence and colleagues1 for their interest in our work,2 about which they raised some comments as the need of expressing results in absolute rather than relative risks. As they appropriately mentioned in their correspondence, absolute risk is an important parameter for the estimation of the effect of an intervention and must sometimes be preferred to relative risk. However, when discussing with health professionals and policymakers, using absolute risk reductions, expressed as percentages, may incorrectly lead to an intervention being considered unnecessary. As example, what would be the point of reducing by 30% the occurrence of an event affecting 2% of the population? This is ex…
(±)- BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channe…
2021
Multitarget-directed ligands (MTDLs) are considered a promising therapeutic strategy to address the multifactorial nature of Alzheimer's disease (AD). Novel MTDLs have been designed as inhibitors of human acetylcholinesterases/butyrylcholinesterases, monoamine oxidase A/B, and glycogen synthase kinase 3β and as calcium channel antagonists via the Biginelli multicomponent reaction. Among these MTDLs, (±)-BIGI-3h was identified as a promising new hit compound showing in vitro balanced activities toward the aforementioned recognized AD targets. Additional in vitro studies demonstrated antioxidant effects and brain penetration, along with the ability to inhibit the aggregation of both τ protein…
Les appellations d'origine en jugement : quels usages pour quels territoires ?
2021
International audience
EU Cultural Security Law in an Educational Context
2021
Cultural security is a comprehensive notion that has gained much attention in the recent cultural heritage debates. In terms of the EU, it encapsulates cultural heritage destruction and protection in armed conflicts, post-war cultural heritage management, restitution, illicit traffic of cultural property, cultural diversity, and intercultural dialogue. The article aims to present how cultural security matters appear in the EU legal system and policy. The authors argue that cultural security is present in different policies regarding cultural property and the fight against illicit trafficking, as well as in EU external cultural relations. Digitization in the cultural sector constitutes a cha…
Quel avenir pour les appellations d'origine ? Histoire de la labellisation des produits des terroirs
2021
International audience
Identification of sub-μs isomeric states in the odd-odd nucleus 178Au
2021
The neutron-deficient gold (Z=79) isotopes in the vicinity of the neutron midshell N=104 provide prolific examples of shape coexistence and isomerism at low excitation energy. They can be probed via a number of different experimental techniques. In this study, two new isomeric states with half-lives of 294(7) and 373(9) ns have been observed in the neutron-deficient odd-odd nuclide 178Au (N=99) in an experiment at the RITU gas-filled separator at JYFL, Jyväskylä. This result was achieved due to the use of a segmented planar germanium detector with a high efficiency at low energies. By applying the recoil-decay tagging technique, they were assigned to decay to two different long-lived α-deca…
false
2021
Although it is widely accepted that cancer-derived extracellular vesicles (EVs) carry DNA cargo, the association of cell-free circulating DNA (cfDNA) and EVs in plasma of healthy humans remains elusive. Using a physiological exercise model, where EVs and cfDNA are synchronously released, we aimed to characterize the kinetics and localization of DNA associated with EVs. EVs were separated from human plasma using size exclusion chromatography or immuno-affinity capture for CD9+, CD63+, and CD81+ EVs. DNA was quantified with an ultra-sensitive qPCR assay targeting repetitive LINE elements, with or without DNase digestion. This model shows that a minute part of circulating cell-free DNA is asso…
Choice of CTO scores to predict procedural success in clinical practice. A comparison of 4 different CTO PCI scores in a comprehensive national regis…
2021
Background We aimed to compare the performance of the recent CASTLE score to J-CTO, CL and PROGRESS CTO scores in a comprehensive database of percutaneous coronary intervention of chronic total occlusion procedures. Methods Scores were calculated using raw data from 1,342 chronic total occlusion procedures included in REBECO Registry that includes learning and expert operators. Calibration, discrimination and reclassification were evaluated and compared. Results Mean score values were: CASTLE 1.60±1.10, J-CTO 2.15±1.24, PROGRESS 1.68±0.94 and CL 2.52±1.52 points. The overall percutaneous coronary intervention success rate was 77.8%. Calibration was good for CASTLE and CL, but not for J-CTO…
Function And Morphology Of The Urinary Bladder After Denervation
2021
Öz bulunamadı.
Overview of Prognostic Systems for Hepatocellular Carcinoma and ITA.LI.CA External Validation of MESH and CNLC Classifications
2021
Simple Summary This review proposes a comprehensive overview of the main prognostic systems for HCC classified as prognostic scores, staging systems, or combined systems. Prognostic systems for HCC are usually compared in terms of homogeneity, monotonicity of gradients, and discrimination ability. However, despite the great number of published studies comparing HCC prognostic systems, it is rather difficult to identify a system that could be universally accepted as the best prognostic scheme for all HCC patients encountered in clinical practice. In order to give a contribute in this topic, we conducted a study aimed at externally validate the MESH score and the CNLC classification using the…
Adhesion G protein-coupled receptor VLGR1/ADGRV1 regulates cell spreading and migration by mechanosensing at focal adhesions.
2021
Summary VLGR1 (very large G protein-coupled receptor-1) is by far the largest adhesion G protein-coupled receptor in humans. Homozygous pathologic variants of VLGR1 cause hereditary deaf blindness in Usher syndrome 2C and haploinsufficiency of VLGR1 is associated with epilepsy. However, its molecular function remains elusive. Herein, we used affinity proteomics to identify many components of focal adhesions (FAs) in the VLGR1 interactome. VLGR1 is localized in FAs and assembles in FA protein complexes in situ. Depletion or loss of VLGR1 decreases the number and length of FAs in hTERT-RPE1 cells and in astrocytes of Vlgr1 mutant mice. VLGR1 depletion reduces cell spread and migration kinetic…
The Inside Information Regime of the MAR andthe Rise of the ESG Era
2021
Abstract The rise in ESG investing has been characterized as an “investor revolution” and a manifestation of “social change”. The current coronavirus pandemic will arguably intensify the impact of such social change, with the “S” and “G” components of ESG, in particular, having been brought into sharper focus during the crisis. The issue of the extent to which ESG factors are (currently) of considerable importance – and, in particular, are likely to become even more so in the future – for the performance of share prices remains a highly controversial one in financial economics. However, where an empirically substantiated impact of ESG-related information on the prices of financial instrumen…
Predicting the Unknown and the Unknowable. Are Anthropometric Measures and Fitness Profile Associated with the Outcome of a Simulated CrossFit® Compe…
2021
The main objective of this research was to find associations between the outcome of a simulated CrossFit® competition, anthropometric measures, and standardized fitness tests. Ten experienced male CrossFit® athletes (age 28.8 ± 3.5 years
A paradigmatic autistic phenotype associated with loss of PCDH11Y and NLGN4Y genes
2021
Abstract Background Most studies relative to Y chromosome abnormalities are focused on the sexual developmental disorders. Recently, a few studies suggest that some genes located on Y chromosome may be related to different neurodevelopment disorders. Case presentation We report a child with sexual developmental disorder associated with a peculiar phenotype characterized by severe language impairment and autistic behaviour associated with a mosaicism [45,X(11)/46,XY(89)] and a partial deletion of the short and long arm of Y chromosome (del Yp11.31q11.23) that also involves the loss of both PCDH11Y and NLGN4Y genes. To our knowledge no study has ever reported the occurrence of the lack of bot…