showing 36 of ~574560 from 574555 documents
Monitoring Reversible Tight Junction Modulation with a Current-Driven Organic Electrochemical Transistor
2021
Rethinking Learning Design in IT Education During a Pandemic
2021
Maintaining high-quality teaching and learning in the times of a pandemic poses a huge challenge to education systems. To scaffold adequate practices in our courses during the pandemic, more advanced, and fine-grained “learning design” is needed than providing the learning objectives and learning materials of the course and defining the deliverables and assignments. In this paper, we leverage on our experience with putting into practice different learning designs and technologies, in various information technology (IT) contexts and discuss how IT educators can further reflect on the learning design of their courses and scaffold fully remote or blended learning approaches to accommodate thei…
Monetary policy and the redistribution of net worth in the U.S
2021
The view that expansionary monetary policy can exacerbate both income and wealth inequality by increasing asset prices has become increasingly popular. The aim of this paper is to study the distributive effects of monetary policy on wealth inequality. In the first part of this research, we develop a simple framework based on accounting identity to examine the redistributive repercussions of changes in monetary policy on net worth through different channels. Based on this framework, in the second part of the paper, we show empirical evidence concerning the effects of monetary policy on wealth inequality in the US. To derive this, we combined macro and micro data, and proceeded in two steps. …
IPSIM-Cirsium, a Qualitative Expert-Based Model to Predict Infestations of Cirsium arvense
2021
Throughout Europe, Cirsium arvense is the most problematic perennial weed in arable crops, whether managed under organic or conventional agriculture. Non-chemical control methods are limited with partial efficacy. Knowledge is missing on their effect across a wide gradient of cropping systems and pedoclimates. To achieve effective Cirsium arvense management ensuring crop productivity while limiting the reliance of cropping systems on herbicide, expert-based models are needed to gather knowledge on the effect of individual levers and their interactions in order to (i) design and assess finely tuned combinations of farming practices in different pedoclimates and (ii) support decisions for Cir…
Muscle Function Differences between Patients with Bulbar and Spinal Onset Amyotrophic Lateral Sclerosis. Does It Depend on Peripheral Glucose?
2021
Background: One of the pathogenic mechanisms of ALS disease is perturbed energy metabolism particularly glucose metabolism. Given the substantial difference in the severity and the prognosis of the disease, depending on whether it has a bulbar or spinal onset, the aim of the study was to determine metabolic differences between both types of ALS, as well as the possible relationship with muscle function. Materials and Methods: A descriptive, analytical, quantitative, and transversal study was carried out in hospitals and Primary Care centers in the region of Valencia, Spain. Fasting glucose and alkaline phosphatase (AP) levels in venous blood, muscle percentage, fat percentage, muscle streng…
false
2021
Abstract. Lignin oxidation products (LOPs) are widely used as vegetation proxies in climate archives, such as sediment and peat cores. The total LOP concentration, Σ 8, provides information on the abundance of vegetation, while the ratios C / V and S / V of the different LOP groups also provide information on the type of vegetation. Recently, LOP analysis has been successfully applied to speleothem archives. However, there are many open questions concerning the transport and microbial degradation of LOPs on their way from the soil into the cave system. These processes could potentially alter the original source-dependent LOP signals, in particular the C / V and S / V ratios, and thus compli…
Lernkulturen und Persönlichkeit
2021
Digitale Medien sind in der modernen Bildungslandschaft stetiger Hoffnungsträger für die Aufhebung der Bildungsungleichheit. Im Fokus der 2010er Jahre standen Massive Open Online Courses (MOOCs), die spätestens seit dem grossen MOOC-Hype 2012 kontinuierlich und in stetig wechselnder Gestalt als Optimierungen der Hochschulbildung gehandelt werden und selbst in den vergangenen sieben Jahren zahlreiche Veränderungen durchlaufen haben. MOOCs haben in der deutschen Hochschulbildung zu kontroversen Diskussionen geführt, bisweilen nehmen MOOCs an deutschen Hochschulen jedoch keinen besonderen Stellenwert ein. Dabei gäbees durchaus Potenziale zur Weiterentwicklung (und damit auch Optimierung) der H…
Lagrangian matches between observations from aircraft, lidar and radar in a warm conveyor belt crossing orography
2021
Warm conveyor belts (WCBs) are important airstreams in extratropical cyclones, often leading to the formation of intense precipitation and the amplification of upper-level ridges. This study presents a case study that involves aircraft, lidar and radar observations in a WCB ascending from western Europe towards the Baltic Sea during the Hydrological Cycle in the Mediterranean Experiment (HyMeX) and T-NAWDEX-Falcon in October 2012, a preparatory campaign for the THORPEX North Atlantic Waveguide and Downstream Impact Experiment (T-NAWDEX). Trajectories were used to link different observations along the WCB, that is, to establish so-called Lagrangian matches between observations. To this aim, …
Prise en compte des sols pour l’évaluation du potentiel de production d’une légumineuse d’intérêt : le pois
2021
National audience; Dans le contexte actuel de changements climatiques et de pression croissance sur les ressources, le modèle de production agricole est remis en cause et se pose donc le défi d’une production de protéines plus autonome, performante et durable. Le projet PSDR 4 ProSys a pour objectif de développer la production des protéines végétales dans les systèmes de culture de la région Bourgogne-Franche-Comté (BFC), via notamment l’intégration des légumineuses. Un des résultats de l’axe 1 du projet est l’acquisition de références régionales sur le potentiel de production actuel et en contexte de changement climatique, sur une légumineuse d’intérêt : le pois. Le modèle de culture de po…
Toward a link between brain plasticity and satiety
2021
International audience
Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin.
2021
Abstract Background Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent and represents a growing challenge in terms of prevention and treatment. A minority of affected patients develops inflammation, subsequently fibrosis, cirrhosis and hepatocellular carcinoma (HCC). HCC is a leading cause of cancer-related death. An increased number of senescent cells correlate with age-related tissue degeneration during NAFLD-induced HCC. Senolytics are promising agents that target selectively senescent cells. Previous studies showed that whereas a combination of the senolytic drugs dasatinib and quercetin (D + Q) reduced NAFLD in mice, D + Q lacked efficacy in removing doxorubicin-induced…
Housing tenure of young people through a multilevel strategy: differences according to living arrangements
2021
In this study, we identify and analyse the key determinants of the housing tenure regime and residential independence of young adults in Spain. We use a multilevel strategy that allows us to take i...
Rapid neural encoding of the contrast between native and nonnative speech in the alpha band
2021
AbstractMore than half of the world’s population is multilingual, yet it is not known how the human brain encodes the perception of native vs. nonnative speech. To find out, we asked German native speakers to detect the onset of native and nonnative (English and Turkish) vowels in a roving standard stimulation. Using EEG, we show that nonnativeness is robustly registered by an increase in phase coherence in the alpha band (8-12 Hz), beginning as early as ∼100 ms after stimulus onset and lasting more than 200 ms. The alpha band effect is speech-specific, successfully predicts the response speed advantage of nonnative speech, and grants ∼90% decoding accuracy in distinguishing native vs. nonn…
L’expérience de consommation : et après ?
2021
Workshop en ligne; National audience
Les organes de la copropriété
2021
International audience
The temperature dependence of ice-nucleating particle concentrations affects the radiative properties of tropical convective cloud systems
2021
Convective cloud systems in the maritime tropics play a critical role in global climate, but accurately representing aerosol interactions within these clouds persists as a major challenge for weather and climate modelling. We quantify the effect of ice-nucleating particles (INPs) on the radiative properties of a complex tropical Atlantic deep convective cloud field using a regional model with an advanced double-moment microphysics scheme. Our results show that the domain-mean daylight outgoing radiation varies by up to 18 W m−2 depending on the chosen INP parameterisation. The key distinction between different INP parameterisations is the temperature dependence of ice formation, which alter…
false
2021
Brain homeostasis is the dynamic equilibrium whereby physiological parameters are kept actively within a specific range. The homeostatic range is not fixed and may change throughout the individual's lifespan, or may be transiently modified in the presence of severe perturbations. The endocannabinoid system has emerged as a safeguard of homeostasis, e.g., it modulates neurotransmission and protects neurons from prolonged or excessively strong activation. We used genetically engineered mouse lines that lack the cannabinoid type-1 receptor (CB1) either in dorsal telencephalic glutamatergic or in forebrain GABAergic neurons to create new allostatic states, resulting from alterations in the exci…
Les médias et nos assiettes : l’esprit critique, un ingrédient clé
2021
International audience
Les régimes dérogatoires, in Copropriétés: les nouvelles règles, sous la dir. de J. Lafond, à paraître
2021
International audience
Hospital Contacts for Psychiatric Disorders in Parents of Children With Cancer in Denmark
2021
Abstract Background Having a child diagnosed with cancer is a devastating experience that may affect parents’ mental health. We aimed to assess the risk of hospital contacts for psychiatric disorders in parents of children with cancer. Methods We conducted a nationwide population-based cohort study using Danish registry data. Parents of children diagnosed with cancer between 1982 and 2014 (n = 6689 mothers, n = 5509 fathers) were matched with comparison parents of cancer-free children (n = 67 544 mothers, n = 55 756 fathers). We used Cox proportional hazards models to estimate the risk of hospital contacts for any psychiatric disorder and specific disorders. Cox models were also used to inv…
An assessment of COVID-19’s impact on Finnish University Leadership
2021
This article maps the management actions that Finnish universities have taken during the COVID-19 pandemic and studies how managers in Finnish higher education coped during the crisis and how they feel about it. The article uses action mapping and a survey that was administered to top- and mid-level managers at Finnish universities, and the findings highlight the importance of collegial coordination and maintenance work abilities among managers. publishedVersion Peer reviewed
Participation et empowerment vont-ils de pair dans l’expérience-client ? Une grille de lecture à partir des concepts de soi
2021
Workshop en ligne; National audience
Experimental investigation of effect of printing direction and surface roughness on the mechanical properties of AlSi10Mg-alloy produced by selective…
2021
The additive manufacturing has initially gained popularity for production of non-loadbearing parts and components or in the fields where the material strength and ductility are less important such as modelling and rapid prototyping. But as the technology develops, availability of metal additive manufacturing naturally dictates the desire to use the produced components in load-bearing parts. This requires not-only a thorough documentation on the mechanical properties but also additional and independent research to learn the expected level of variation of the mechanical properties and what factors affect them. The presented paper investigates strength, ductility, hardness, and microstructure …
Inférence de la résistance du paysage au flux de gènes à l'aide de modèles gravitaires intégrant des variables intra-populationnelles
2021
International audience; Modéliser les mouvements de dispersion nécessite d'associer aux éléments paysagers des valeurs de coût caractérisant leur résistance aux déplacements. En landscape genetics, l'inférence de ces valeurs se fait à partir de mesures de différenciation génétique entre populations. Bien que l'hétérogénéité spatiale des tailles de populations puisse aussi influencer de façon significative la différenciation génétique, les variables intra-populationnelles sont rarement prises en compte dans ce type d'inférence. Nous avons étudié à quel point la prise en compte de ces variables pouvait améliorer l'inférence des coûts. Pour cela, nous avons simulé des flux de gènes entre 60 po…
Competencia digital ciudadana: análisis de tendencias en el ámbito educativo
2021
La competencia digital ciudadana se ha ido integrando en los procesos formativos de manera desigual, a pesar de la existencia de marcos internacionales que promueven su inclusión en los diferentes sistemas educativos. Este estudio trata de aproximarse al fenómeno desde una perspectiva bibliométrica y bibliográfica. Por un lado, se explora la producción científica en términos cuantitativos, a partir del análisis de los 87 artículos seleccionados de las bases de datos Scopus y Web of Science, analizando cuestiones como el número de autores o de citas. Por otro lado, se analiza el contenido de las 47 publicaciones disponibles en abierto, abordando cuestiones como la etapa educativa, los partic…
The diversification of the northern temperate woody flora – A case study of the Elm family (Ulmaceae) based on phylogenomic and paleobotanical eviden…
2021
Ovarian steroids and cancer: news on the breast, questions on the reproductive tract
2021
The association between steroid hormones and cancer has been a primary research focus for many years. Reproductive hormones are of particular interest given the fact that several highly prevalent c...
Young Scottish National Party Members and National Identity
2021
International audience
Pressure and Thermally Induced Spin Crossover in a 2D Iron(II) Coordination Polymer {Fe[bipy(ttr)2]}n
2021
Using magnetic measurements and UV -visible spectroscopy we have studied the pressure influence on the spin crossover (SCO) properties of the 2D Fe (II) coordination polymer formulated {Fe[bipy(ttr) 2 ]} n . At variable temperature and fixed pressure, we have measured the magnetic property of this compound. Under different pressures and at room temperature, the visible spectroscopy has been observed. The magnetic experiment displays a two-step spin crossover behavior under pressure. The visible spectroscopic measurements at room temperature show a spin crossover with an asymmetric hysteresis at 0.4GPa.
Secondary Structure-Driven Self-Assembly of Thiol-Reactive Polypept(o)ides
2021
Secondary structure formation differentiates polypeptides from most of the other synthetic polymers, and the transitions from random coils to rod-like α-helices or β-sheets represent an additional parameter to direct self-assembly and the morphology of nanostructures. We investigated the influence of distinct secondary structures on the self-assembly of reactive amphiphilic polypept(o)ides. The individual morphologies can be preserved by core cross-linking via chemoselective disulfide bond formation. A series of thiol-responsive copolymers of racemic polysarcosine-block-poly(S-ethylsulfonyl-dl-cysteine) (pSar-b-p(dl)Cys), enantiopure polysarcosine-block-poly(S-ethylsulfonyl-l-cysteine) (pSa…
Una asociación peculiar de fusulinas en las calizas de Tanes, sección de Campo de Caso (Pensilvánico, Moscoviense superior; zona Cantábrica, España)
2021
The Campo de Caso section (eastern part of the Cantabrian Zone, NW Spain) exposes a middle to upper Moscovian (Middle Pennsylvanian) succession, up to 3500-m thick, consisting of marine shelfal and deltaic siliciclastic and shale deposits with numerous intercalated fossiliferous limestones. A limestone outcropping in the upper part of this section, close to the village of Tanes, has yielded a fusuline assemblage composed of species of the genera Eostaffella, Pseudonovella, Ozawainella, Pseudostaffella, Neostaffella, Schubertella, Fusiella, Taitzehoella, Fusulinella, Beedeina and Putrella . The specific composition of these genera, considered as a whole, indicates an early to mid- Myachkov…
50 Shades of Green: Insights into Personal Values and Worldviews as Drivers of Green Purchasing Intention, Behaviour, and Experience
2021
Despite the booming interest in determinants of green (i.e., sustainable) consumption, the psychological factors that influence pro-environmental consumption patterns are not yet fully understood. To answer this call, we developed and analysed a model that offers an integrative approach to sustainable consumption patterns by addressing the full palette of consumers’ personal value orientations. Specifically, we linked consumers’ egoistic, altruistic, and biospheric values at the personal level to pro-environmental purchasing intentions, behaviours, and experiences. Furthermore, we examined whether implicit beliefs about the balance between humanity and nature (i.e., worldviews) moderate the…
Wie adaptiv ist Sprachförderung für Kinder mit Deutsch als Zweitsprache?
2021
Abstract This paper focuses on the definition, operationalization and empirical investigation of adaptivity in the context of language training. We discuss a study that aimed at answering the question whether kindergarten teachers adapt their language to the specific needs of children with German as a second language in language training situations. Specifically, we investigated whether teachers use subordinate clauses and specific language training techniques to present or elicit subordinate clauses more frequently when working with children who had not yet acquired subordinate clauses than teachers supporting children who already had. Fifteen teachers were videotaped during language suppo…
Redefining outcomes in immune TTP: an international working group consensus report
2021
Abstract Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a potentially fatal thrombotic microangiopathy caused by autoantibody-mediated severe deficiency of ADAMTS13. Standardized definitions of response, exacerbation, remission, and relapse were initially proposed in 2003 and modified by the International Working Group for TTP in 2017. These definitions, which have been widely used in clinical practice and research, are based primarily on the platelet count and are benchmarked against the timing of discontinuation of therapeutic plasma exchange (TPE). They do not incorporate ADAMTS13 activity or the temporizing effects on the platelet count of caplacizumab, a novel anti–von W…
false
2021
Abstract. Warm conveyor belts (WCBs) are important airstreams in extratropical cyclones, often leading to the formation of intense precipitation and the amplification of upper-level ridges. This study presents a case study that involves aircraft, lidar and radar observations in a WCB ascending from western Europe towards the Baltic Sea during the Hydrological Cycle in the Mediterranean Experiment (HyMeX) and T-NAWDEX-Falcon in October 2012, a preparatory campaign for the THORPEX North Atlantic Waveguide and Downstream Impact Experiment (T-NAWDEX). Trajectories were used to link different observations along the WCB, that is, to establish so-called Lagrangian matches between observations. To …
Copropriété : les nouvelles règles
2021
National audience