showing 36 of ~574560 from 574555 documents
Broadband Multi-wavelength Properties of M87 during the 2017 Event Horizon Telescope Campaign
2021
Full list of authors: EHT MWL Science Working Group; Algaba, J. C.; Anczarski, J.; Asada, K.; Baloković, M.; Chandra, S.; Cui, Y. -Z.; Falcone, A. D.; Giroletti, M.; Goddi, C.; Hada, K.; Haggard, D.; Jorstad, S.; Kaur, A.; Kawashima, T.; Keating, G.; Kim, J. -Y.; Kino, M.; Komossa, S.; Kravchenko, E. V.; Krichbaum, T. P.; Lee, S. -S.; Lu, R. -S.; Lucchini, M.; Markoff, S.; Neilsen, J.; Nowak, M. A.; Park, J.; Principe, G.; Ramakrishnan, V.; Reynolds, M. T.; Sasada, M.; Savchenko, S. S.; Williamson, K. E.; Event Horizon Telescope Collaboration; Akiyama, Kazunori; Alberdi, Antxon; Alef, Walter; Anantua, Richard; Azulay, Rebecca; Baczko, Anne-Kathrin; Ball, David; Barrett, John; Bintley, Dan; …
ACTUAL PROBLEMS OF ENTERPRISES’ MARKETING MANAGEMENT
2021
The purpose of this paper is to provide an overview of the most current problems and issues in marketing management. As all enterprises deal with various difficulties in their business planning, implementation and control, these issues and problems have to be recognized, dealt with, and solved. Most of the business strains will have a lot to do with diverse marketing aspects, as marketing is the main link between enterprises and their markets and customers; strategically mappedand implemented marketing helps to create competitive advantage and pave the way for success, but different problems can endanger firms’ marketing process, thus in today’s volatile business environment marketing execu…
LC‐ESI / HRMS analysis of glucosinolates, oxylipins and phenols in Italian rocket salad ( Diplotaxis erucoides subsp. erucoides (L.) DC .) and evalua…
2021
BACKGROUND This study investigated the chemical profile and biological activity of Diplotaxis erucoides subsp. erucoides (L.) DC. (Brassicaceae) collected in Sicily (Italy). RESULTS Liquid chromatography coupled with electrospray ionization and high-resolution mass spectrometry (LC-ESI/HRMS) analysis of the ethanol extract revealed the presence of 42 compounds - glucosinolates, hydroxycinnamic acids, flavonoids, and oxylipins. The extract was tested for its antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic) acid (ABTS), ferric reducing ability power (FRAP), and β-carotene bleaching tests. Promising protection from lipid peroxida…
Municipal Climate Change Adaptation GOVERNANCE in Latvia: ApproachING Cross-sectorial and Multi–instrumental understanding
2021
Climate change adaptation being one of today’s main challenges on global agenda do affect people worldwide, but even though most decisions regarding climate change governance are made at the international or national level, the implementation of these decisions in most cases takes place at the local level. Municipal climate change adaptation research project in Latvia was carried out with special emphases on main stakeholder understanding, preparedness and communication factors using several complementary research methods – case study research in Salacgriva coastal municipality, sociological surveys with both Salacgriva town households / inhabitants (home visits / questionnaires) and also n…
Melatonin Targets Metabolism in Head and Neck Cancer Cells by Regulating Mitochondrial Structure and Function.
2021
This study was funded by grants from the Ministerio de Economia, Industria y Competitividad y por el Fondo de Desarrollo Regional FEDER, Spain nº SAF2013-49019, SAF2017-85903-P, and from the Consejería de Innovación, Ciencia y Empresa, Junta de Andalucía (P07- CTS- 03135, P10- CTS- 5784, and CTS- 101), Spain. J.F. and L.M. have FPU fellowships from the Ministerio de Educación Cultura y Deporte, Spain. C.R.S. was a schorlarship holder from the Plan Propio de Investigación of the University of Granada.
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2021
Retinoblastoma and other eye tumors in childhood are rare diseases. Many eye tumors are the first signs of a genetic tumor predisposition syndrome and the affected children carry a higher risk of developing other cancers later in life. Clinical and genetic data of all children with eye tumors diagnosed between 2013–2018 in Germany and Austria were collected in a multicenter prospective observational study. In five years, 300 children were recruited into the study: 287 with retinoblastoma, 7 uveal melanoma, 3 ciliary body medulloepithelioma, 2 retinal astrocytoma, 1 meningioma of the optic nerve extending into the eye. Heritable retinoblastoma was diagnosed in 44% of children with retinoblas…
A Hybrid Strategic Oscillation with Path Relinking Algorithm for the Multiobjective k-Balanced Center Location Problem
2021
This paper presents a hybridization of Strategic Oscillation with Path Relinking to provide a set of high-quality nondominated solutions for the Multiobjective k-Balanced Center Location problem. The considered location problem seeks to locate k out of m facilities in order to serve n demand points, minimizing the maximum distance between any demand point and its closest facility while balancing the workload among the facilities. An extensive computational experimentation is carried out to compare the performance of our proposal, including the best method found in the state-of-the-art as well as traditional multiobjective evolutionary algorithms.
Loomis-Whitney inequalities in Heisenberg groups
2021
This note concerns Loomis-Whitney inequalities in Heisenberg groups $\mathbb{H}^n$: $$|K| \lesssim \prod_{j=1}^{2n}|\pi_j(K)|^{\frac{n+1}{n(2n+1)}}, \qquad K \subset \mathbb{H}^n.$$ Here $\pi_{j}$, $j=1,\ldots,2n$, are the vertical Heisenberg projections to the hyperplanes $\{x_j=0\}$, respectively, and $|\cdot|$ refers to a natural Haar measure on either $\mathbb{H}^n$, or one of the hyperplanes. The Loomis-Whitney inequality in the first Heisenberg group $\mathbb{H}^1$ is a direct consequence of known $L^p$ improving properties of the standard Radon transform in $\mathbb{R}^2$. In this note, we show how the Loomis-Whitney inequalities in higher dimensional Heisenberg groups can be deduced…
Blood Vessel Detection Algorithm for Tissue Engineering and Quantitative Histology.
2021
AbstractImmunohistochemistry for vascular network analysis plays a fundamental role in basic science, translational research and clinical practice. However, identifying vascularization in histological tissue images is time consuming and markedly depends on the operator’s experience. In this study, we present “blood vessel detection—BVD”, an automatic algorithm for quantitative analysis of blood vessels in immunohistochemical images. BVD is based on extraction and analysis of low-level image features and spatial filtering techniques, which do not require a training phase. BVD algorithm performance was comparatively evaluated on histological sections from three different in vivo experiments. …
COMMUTING PATTERNS IN RIGA AGGLOMERATION: EVIDENCE FROM A SURVEY ANALYSIS OF YOUTH
2021
In the last ten years the evident changes of settlement patterns through suburban growth near to capital city of Latvia occurred. Increase of distance between home and routine activity places as well as changes of public transport and rapid increase of car ownership initiated significant changes in commuting patterns of inhabitants living outside of Riga. Although the commuting from suburban area to Riga is recently broadly studied, however these researches focused primarily on able-bodied population leaving behind school-age children and young people. The aim of this study is to analyse commuting patterns of young people aged 12 to 17 moving from outskirts of Riga to school located in Riga…
An Ecological Study to Investigate Links Between Atmospheric Pollutants From Farming and SARS-CoV-2 Mortality
2021
AbstractExposure to atmospheric particulate matter and nitrogen dioxide has been linked to SARS-CoV-2 infection and death. We hypothesized that an interaction between SARS-CoV-2 infection and exposure to farming-related atmospheric pollutants worsens the effect of SARS-CoV-2 on mortality. Our objective was investigate this hypothesis by performing an ecological study in five Italian Regions (Piedmont, Lombardy, Veneto, Emilia-Romagna and Sicily) linking all-cause mortality, by province (administrative entities within regions), to atmospheric particulate matter (PM2.5and PM10) nitrous oxide (N2O), ammonia (NH3) and methane (CH4) mainly produced by agricultural activities. Study outcome was c…
La blogosfera como herramienta de evaluación formativa y compartida en la Educación Superior
2021
La experiencia desarrollada es una innovación docente a partir de la creación de blogs educativos o edublogs diseñada para facilitar la interacción y la construcción de un aprendizaje significativo, además de estrategias de seguimiento y evaluación formativa entre iguales. UV-SFPIE_PID20-1353630 The experience developed is a teaching innovation based on the creation of educational blogs or edublogs designed to facilitate interaction and the construction of meaningful learning, as well as training follow-up and evaluation strategies among peers.
Effects of tumor mutation burden on the antigen presentation pathway
2021
AbstractTumor mutation burden (TMB) is used to select patients to receive immune checkpoint inhibitors (ICIs) but has mixed predictive capabilities. We hypothesized that inactivation of antigen presenting genes (APGs) that result from increased TMBs would result in inherent resistance to ICIs. We observed that somatic mutations in APGs were associated with increasing TMBs across 9,418 tumor samples of 33 different histological subtypes. In adenocarcinomas of the lung, ITGAX and CD1B were some of the most commonly mutated APGs. In 62 patients with non-small cell lung cancers treated with a PD-1 inhibitor in second or later lines of therapy, there was an association of increased TMB with muta…
Preliminary reference intervals of Glycated Albumin in healthy Caucasian pregnant women
2021
Abstract Background and aims Glycated albumin (GA) could represent a useful biomarker in pregnant women for diagnosing and monitoring gestational diabetes mellitus (GDM). The establishment of reference intervals (RI) is mandatory before assessing its clinical usefulness. The RIs of GA in healthy pregnant women are not well defined. The aim of the current study was to establish the RI in a cohort consisting of Caucasian pregnant women without overt diabetes mellitus or gestational diabetes mellitus. Methods The study included 183 healthy pregnant women. GA was measured on plasma by an enzymatic method (quantILab Glycated Albumin, IL Werfen, Germany). The RI was calculated by the non-parametr…
LA RILEVANZA IVA DELLE PRESTAZIONI DI DISTACCO DI PERSONALE ALLA LUCE DELLA GIURISPRUDENZA DELLA CORTE DI GIUSTIZIA EUROPEA
2021
LO STUDIO ESAMINA LA RILEVANZA AI FINI DELL'IMPOSTA SUL VALORE AGGIUNTO DELLE PRESTAZIONI DI DISTACCO DI PERSONALE TENENDO CONTO DELLA RECENTE ED INNOVATIVA SENTENZA DELLA CORTE DI GIUSTIZIA DELL'UNIONE EUROPEA DELL'11 MARZO 2020 NELLA CAUSA C-94/19 E PARTENDO DALLA NORMATIVA IITALIANA DI CUI ALL'ART. 8, C. 35, DELLA L. N.67/1988.
Validation of tumour-free distance as novel prognostic marker in early-stage cervical cancer: a retrospective, single-centre, cohort study
2021
Background: The aim of the present study was to assess the prognostic value of tumour-free distance (TFD), defined as the minimum distance of uninvolved stroma between the tumour and peri-cervical stromal ring, in early-stage cervical cancer. Methods: Patients with pathologic FIGO 2009 stage IA1–IIA2 cervical cancer, treated by primary radical surgical treatment between 01/2000 and 11/2019, were retrospectively included. Adjuvant treatment was administered according to the presence of previously established pathologic risk factors. TFD was measured histologically on the hysterectomy specimen. Pre-operative TFD measured at MRI-scan from a cohort of patients was reviewed and compared with pat…
Magnetoencephalography Responses to Unpredictable and Predictable Rare Somatosensory Stimuli in Healthy Adult Humans
2021
Mismatch brain responses to unpredicted rare stimuli are suggested to be a neural indicator of prediction error, but this has rarely been studied in the somatosensory modality. Here, we investigated how the brain responds to unpredictable and predictable rare events. Magnetoencephalography responses were measured in adults frequently presented with somatosensory stimuli (FRE) that were occasionally replaced by two consecutively presented rare stimuli [unpredictable rare stimulus (UR) and predictable rare stimulus (PR); p = 0.1 for each]. The FRE and PR were electrical stimulations administered to either the little finger or the forefinger in a counterbalanced manner between the two conditio…
Search for the rare semi-leptonic decay $J/\psi\to D^{-}e^{+}\nu_{e}+c.c.$
2021
Using $10.1\times10^{9}$ $J/\psi$ events produced by the Beijing Electron Positron Collider (BEPCII) at a center-of-mass energy $\sqrt{s}=3.097~\rm{GeV}$ and collected with the BESIII detector, we present a search for the rare semi-leptonic decay $J/\psi\to D^{-}e^{+}\nu_{e}+c.c.$. No excess of signal above background is observed, and an upper limit on the branching fraction $\mathcal{B}(J/\psi\to D^{-}e^{+}\nu_{e}+c.c.)<7.1\times10^{-8}$ is obtained at $90\%$ confidence level. This is an improvement of more than two orders of magnitude over the previous best limit.
Nitroenynes as Electrophiles in Organocatalysis and their Application in the Synthesis of Chiral Heterocycles
2021
Nitroenynes are an interesting electrophile in asymmetric organocatalysis, due to the versatility of the functional groups present in its structure. This review covers the organocatalytic examples using this electrophile and its application for the synthesis of chiral heterocycles.
The Nordic Paradox. Professionals’ Discussions about Gender Equality and Intimate Partner Violence against Women in Sweden
2021
Intimate partner violence against women (IPVAW) is a global public health issue often assumed to be associated with gender inequality. The so-called Nordic Paradox, the apparently contradictory co-existence of high levels of IPVAW and of gender equality in Nordic countries, has not been adequately explained. This study explores discussions about how this apparent paradox can be understood among 30 IPVAW professionals working in southern Sweden, through a thematic analysis of focus groups and individual and paired interviews. The analysis highlights complexities of gender (in)equality and its links with IPVAW in Sweden, of relevance for the addressing and prevention of IPVAW.
Preliminary evaluation of biopolymers production by mixed microbial culture from citrus wastewater in a MBR system using respirometric techniques
2021
Abstract This preliminary study was aimed at evaluating the feasibility to produce biopolymers (BP) from citrus wastewater by mixed microbial culture in an anaerobic/aerobic membrane bioreactor (A/O-MBR). The activated sludge of the A/O-MBR was successfully enriched in microorganisms having a good capacity in producing intracellular biopolymers. The production of BP was found to be about 0.55 mgCOD mgCOD−1 using pure acetate at a concentration of 1000 mgCOD L−1. When using fermented wastewater, the conversion of acetate into BP product was 0.56 mgCOD mgCOD−1 in the test performed with C/N equal to 1000:1, whereas it was only 0.12 mgCOD mgCOD−1 in the test with C/N of 100:5. The results achi…
Only Females Oviposit: Chemical Discrimination of Adult Stink Bug Sex by the Egg Parasitoid Trissolcus japonicus
2021
Egg parasitoids foraging for suitable hosts scattered in the environment rely mainly on chemical cues. Elucidating the chemical ecology of natural enemies is important in the development of effective and successful strategies for conservation biological control. In this context, the host cuticular hydrocarbons, which are exploited by several species of egg parasitoids as contact kairomones, could be used to retain them by providing information about the presence and the sex of adults of the target species: sex is important because only females of the host species lay the eggs that can be subsequently utilized for parasitoid reproduction. However, the chemical basis of host sex discriminatio…
Bioprospecting of Beneficial Bacteria Traits Associated With Tomato Root in Greenhouse Environment Reveals That Sampling Sites Impact More Than the R…
2021
Tomato is subject to several diseases that affect both field- and greenhouse-grown crops. To select cost-effective potential biocontrol agents, we used laboratory throughput screening to identify bacterial strains with versatile characteristics suitable for multipurpose uses. The natural diversity of tomato root–associated bacterial communities was bioprospected under a real-world environment represented by an intensive tomato cultivation area characterized by extraseasonal productions in the greenhouse. Approximately 400 tomato root–associated bacterial isolates, in majority Gram-negative bacteria, were isolated from three compartments: the soil close to the root surface (rhizosphere, R), …
Therapeutic Vaccination of Hematopoietic Cell Transplantation Recipients Improves Protective CD8 T-Cell Immunotherapy of Cytomegalovirus Infection
2021
Reactivation of latent cytomegalovirus (CMV) endangers the therapeutic success of hematopoietic cell transplantation (HCT) in tumor patients due to cytopathogenic virus spread that leads to organ manifestations of CMV disease, to interstitial pneumonia in particular. In cases of virus variants that are refractory to standard antiviral pharmacotherapy, immunotherapy by adoptive cell transfer (ACT) of virus-specific CD8+ T cells is the last resort to bridge the “protection gap” between hematoablative conditioning for HCT and endogenous reconstitution of antiviral immunity. We have used the well-established mouse model of CD8+ T-cell immunotherapy by ACT in a setting of experimental HCT and mu…
GRAd-COV2, a gorilla adenovirus based candidate vaccine against COVID-19, is safe and immunogenic in young and older adults
2021
AbstractSafe and effective vaccines against coronavirus disease 2019 (COVID-19) are urgently needed to control the ongoing pandemic. Although impressive progress has been made with several COVID-19 vaccines already approved, it is clear that those developed so far cannot meet the global vaccine demand. We have developed a COVID-19 vaccine based on a replication-defective gorilla adenovirus expressing the stabilized pre-fusion SARS-CoV-2 Spike protein, named GRAd-COV2. We aimed to assess the safety and immunogenicity of a single-dose regimen of this vaccine in healthy younger and older adults to select the appropriate dose for each age group. To this purpose, a phase 1, dose-escalation, open…
Six-Step Gram Scale Synthesis of the HIV Integrase Inhibitor Dolutegravir Sodium
2021
A short and practical synthesis for preparing the active pharmaceutical ingredient dolutegravir sodium was investigated. The convergent strategy developed herein starts from 3-(R)-amino-1- butanol and builds up the BC ring system in 76% isolated yield over four steps. Ring A was constructed by a one-pot 1,4-addition to diethyl-(2E/Z)-2-(ethoxymethylidene)-3-oxobutandioate and subsequent MgBr2·OEt2-mediated regioselective cyclization. Amide formation with 2,4- difluorobenzylamine was either performed from the carboxylic acid or through aminolysis of the corresponding ester precursor. Final salt formation afforded dolutegravir sodium in 48–51% isolated yield (HPLC-purity: 99.7–99.9%) over six…
Characteristics of cellulose fibers from Opuntia ficus indica cladodes and its use as reinforcement for PET based composites
2021
With the aim of valorizing the unexplored Moroccan resources, Opuntia ficus indica (OFI) cladodes were proposed as a renewable source for the production of cellulose. In this work, cellulose microf...
Prevention of school conflict in a Mexican primary school from an integrative and restorative perspective
2021
The objective of this study was to evaluate the perception of different educational agents regarding the application of a conflict prevention programme through restorative practices. Eighteen teach...
Scientific power in the Spanish press during the Pandemic : a portrait of new leaders while explaining its risk
2021
This work is based on the mediatisation of society theory, which establishes more attached importance and the presence of the mass media as mediators in various social processes, as well as on Production Studies, that analyse creative skills to draw an audience, to apply these theories to the media representation of the COVID-19 pandemic. The objective is to analyse how the generalist media have represented male/female scientists, who have become social benchmarks during the first COVID-19 wave in Spain. Our initial hypothesis considers that the purpose of the mediatisation of scientific discourse was to contribute answers to, and to keep society calm, in an uncertainty context. By content …
On the typology of motion events in Aymara
2021
This paper investigates the lexicalization pattern of motion events in Aymara, an Andean language spoken in Bolivia, Peru, and Chile. After providing a description of the morphosyntax of translational motion events, this study aims at a preliminary typological classification of Aymara within the framework of Talmy’s typology (Talmy 2000). With this purpose, three diagnostic tests have been used to determine the basic framing-typology of motion events. These tests consider i) the size of manner-of-motion lexicon and, more broadly, the degree of manner salience, ii) the complex-path constructions and the use of ‘plus-ground’ clauses, iii) the expression of boundary-crossing. The results of th…
Vesti la Giubba! Indumentaria, apariencia y comhunicación en la entrada triunfal de Alfonso el Magnánimo en Nápoles (1443)
2021
espanolLa entrada triunfal de Alfonso el Magnanimo en Napoles el 26 de febrero de 1443 es uno de esos momentos de la Historia que quedaron marcados para la posteridad, no solo por la importancia del hecho en si, sino por todo el despliegue de mensajes en clave simbolica que en ese acto se llegaron a emitir. Analizado por diversos autores desde diferentes puntos de vista, se ha abordado bastante menos hasta la fecha una interpretacion de los codigos implicitos en la indumentaria de quienes participaron en la ceremonia, que aqui se ha tratado de realizar en base a las variadas fuentes que la describieron y de los nuevos conocimientos que la historia del vestido pone hoy a nuestra disposicion …
MATLAB codes implementing the generalized cross-wavelet transform (GXWT) algorithm described in the paper "Analyzing multidimensional movement intera…
2021
MATLAB codes implementing the generalized cross-wavelet transform (GXWT) algorithm described in the paper "Analyzing multidimensional movement interaction with generalized cross-wavelet transform" (Toiviainen & Hartmann, 2021). Basic workflow for multivariate (time by channel) signals d1 and d2: [w1,f] = cwtensor(d1,FS,MINF,MAXF); [w2,f] = cwtensor(d2,FS,MINF,MAXF); [xs p1 p2] = getxwt(w1,w2); NOTE: cwtensor.m requires the Wavelet Toolbox for MATLAB.
An assessment of the hemorheological profile in patients with subclinical carotid atherosclerosis divided in relation to the number of cardiovascular…
2021
We present a cohort of 100 subjects [43 men and 57 women; median age 66.00(25)] who were tested using carotid ultrasound to identify subclinical carotid atherosclerosis (SCA). We have evaluated the behaviour of whole blood viscosity (WBV) at high (450 s–1) and low (0.51 s–1) shear rates, plasma viscosity (450–1), hematocrit and mean erythrocyte aggregation. When compared to normal control subjects, using the Mann-Whitney test, we observed in SCA patients a significant increase in WBV only. The results were substantial after having divided the SCA subjects according to the cardiovascular risk factors (CRFs) and the degree of insulin resistance; the research was performed using two surrogate …
A new tool for sepsis screening in the Emergency Department
2021
Abstract Objectives In this study, we developed and evaluated the diagnostic accuracy of the Sepsis Index for early sepsis screening in the Emergency Department (ED). Methods Sepsis Index is based on the combination of monocyte distribution width (MDW) and mean monocyte volume (MMV). Sepsis Index≥1 was selected to define sepsis. We tested its diagnostic accuracy in an ED population stratified in four groups: controls, Systemic Inflammatory Response Syndrome (SIRS), infection, and sepsis, according to Sepsis-2 criteria. Results Patients with sepsis displayed higher median Sepsis Index value than patients without sepsis. At the receiver operating characterictis (ROC) curve analysis for the pr…
Computational analysis of macrolides as SARS-CoV-2 main protease inhibitors: a pattern recognition study based on molecular topology and validated by…
2021
Since the outbreak of the current SARS-CoV-2 pandemic, much has been discussed about the effectiveness of treatments based on hydroxychloroquine combined with azithromycin or another macrolide. However, few articles have dealt with the possibility of using macrolides alone in treating the disease. In the present article, the authors' hypothesis centers on the possibility that macrolides are effective against SARS-CoV-2 by inhibiting the virus protease. In support of this hypothesis, significant results are collected by following an in silico strategy based on a combination of molecular topology and docking. The results are in accordance with recent clinical data generated during the pandemi…
Decoupling lattice and magnetic instabilities in frustrated CuMnO$_2$
2021
The $A$MnO$_{2}$ delafossites ($A$=Na, Cu), are model frustrated antiferromagnets, with triangular layers of Mn$^{3+}$~spins. At low temperatures ($T_{N}$=65 K), a $C2/m \rightarrow P\overline{1}$ transition is found in CuMnO$_2$, which breaks frustration and establishes magnetic order. In contrast to this clean transition, $A$=Na only shows short-range distortions at $T_N$. Here we report a systematic crystallographic, spectroscopic, and theoretical investigation of CuMnO$_2$. We show that, even in stoichiometric samples, non-zero anisotropic Cu displacements co-exist with magnetic order. Using X-ray/neutron diffraction and Raman scattering, we show that high pressures acts to decouple the…