showing 36 of ~574560 from 574555 documents
Predicting the age at natural menopause in middle-aged women
2021
Objective To predict the age at natural menopause (ANM). Methods Cox models with time-dependent covariates were utilized for ANM prediction using longitudinal data from 47 to 55-year-old women (n = 279) participating in the Estrogenic Regulation of Muscle Apoptosis study. The ANM was assessed retrospectively for 105 women using bleeding diaries. The predictors were chosen from the set of 32 covariates by using the lasso regression (model 1). Another easy-to-access model (model 2) was created by using a subset of 16 self-reported covariates. The predictive performance was quantified with c-indices and by studying the means and standard deviations of absolute errors (MAE ± SD) between the pre…
Polymorphism of praseodymium orthovanadate under high pressure
2021
Zircon-type $\mathrm{PrV}{\mathrm{O}}_{4}$ has been studied at high pressures and room temperature by means of synchrotron powder x-ray diffraction. At room temperature, we observed the previously known zircon-to-monazite phase transition at 5.5(4) GPa and a second phase transition from monazite to a monoclinic structure at 12.7(8) GPa, which we identified as a $\mathrm{PbW}{\mathrm{O}}_{4}$-III-type phase. This conclusion is supported by our ab initio calculations, which also predict a scheelite-type phase to be stable at high pressure. Motivated by this finding, we subjected zircon-type $\mathrm{PrV}{\mathrm{O}}_{4}$ samples to high pressure (7 GPa) and temperature (600, 800, and 1000 \if…
Musculoskeletal Responses to Exercise Plus Nutrition in Men with Prostate Cancer on Androgen Deprivation: A 12-Month RCT
2021
PURPOSE Androgen deprivation therapy (ADT) for prostate cancer has multiple adverse effects on musculoskeletal health. This 12-month randomized controlled trial aimed to assess the effects of multicomponent exercise training combined with whey protein, calcium and vitamin D supplementation on bone mineral density (BMD), structure and strength, body composition, muscle strength, and physical function in ADT-treated men. METHODS Seventy ADT-treated men were randomized to exercise plus supplementation (Ex + Suppl; n = 34) or usual care (control; n = 36). Ex + Suppl involved thrice weekly progressive resistance training plus weight-bearing impact exercise with daily multinutrient supplementatio…
Herpes vegetans of the vulva.
2021
A global occurrence database of the Atlantic blue crab Callinectes sapidus
2021
The Atlantic blue crab Callinectes sapidus is a portunid native to the western Atlantic, from New England to Uruguay. The species was introduced in Europe in 1901 where it has become invasive; additionally, a significant northward expansion has been emphasized in its native range. Here we present a harmonized global compilation of C. sapidus occurrences from native and non-native distribution ranges derived from online databases (GBIF, BISON, OBIS, and iNaturalist) as well as from unpublished and published sources. The dataset consists of 40,388 geo-referenced occurrences, 39,824 from native and 564 from non-native ranges, recorded in 53 countries. The implementation of quality controls imp…
Physiological and oral parameters contribute prediction of retronasal aroma release in an elderly cohort.
2021
International audience; Malnutrition is a serious problem in the elderly while understanding flavour perception could be a tool for controlling appetite or food choices. To increase our knowledge, we characterised the health and oral physiology (oral volume, swallowing tongue force, number of teeth and salivary flow rate, protein content and antioxidant capacity) of a cohort of 54 community-dwelling French elderly as well as their individual retronasal release of five aroma compounds (2-pentanone, 2-nonanone, 2,3-hexanedione, octanal and linalool) by proton-transfer-reaction mass spectrometry (PTR-MS). In general, large variability across participants was observed in both oral physiological…
Correlation of high-field and zero- to ultralow-field NMR properties using 2D spectroscopy
2021
The field of zero- to ultralow-field (ZULF) nuclear magnetic resonance (NMR) is currently experiencing a rapid growth, owing to the progress in optical magnetometry, and also attractive features of ZULF NMR, such as low hardware cost and excellent spectral resolution achieved under ZULF conditions. In this work, an approach is proposed and demonstrated for simultaneous acquisition of ZULF-NMR spectra of individual 13C-containing isotopomers of chemical compounds in a complex mixture. The method makes use of fast field cycling, so that the spin evolution takes place at ZULF conditions, whereas signal detection is performed in a high-field NMR spectrometer. This method has excellent sensitivi…
Desigualdad social y toma de decisiones en los comunales: El gobierno del mayor canal de riego de España (la Acequia Real del Júcar, Valencia) en el …
2021
espanolHacia 1850 la Acequia Real del Jucar era el mayor sistema comunitario de riego de Espana y se caracterizaba por la fuerte desigualdad social entre los regantes. El articulo analiza los cambios que experimentaron las instituciones para su gobierno en una etapa de profundas transformaciones sociales y politicas en la sociedad espanola, la segunda mitad del siglo XIX. Los organos de gobierno del canal estaban sujetos a una organizacion de tipo jerarquico que comprendia dos grandes niveles: por una parte, estaba la direccion del conjunto del sistema, en la que solo una reducida elite de terratenientes podia intervenir; por otra, habia organos de gestion local que administraban las sucesi…
Nesting of the Spotless Starling, <em>Sturnus unicolor</em>, on the island of Favignana (Aegadian Islands, Sicily)
2021
The presence of the Spotless Starling in Sicily was reported for the first time at the beginning of the XIX century, although the first nests for the province of Trapani are reported almost at the end of the XX century. As a breeder, the Spotless Starling remained absent from all the circumsicilian islands until the first report for the island of Pantelleria, in 2012. In 2020, the nest of Spotless Starling was observed on the island of Favignana, within a hole on an antenna. The couple fed the chicks with Ligia italica crustacean isopod of the family Ligiidae. The nesting on the island of Favignana confirms the continuous expansion of the species in Sicily.
Les plaies de la Grande Guerre dans la Berliner Illustrirte Zeitung, un imaginaire de papier sous la République de Weimar
2021
International audience; Auch nach dem Waffenstillstand wird der Erste Weltkrieg in der Berliner Illustrirten Zeitung (BIZ)-einem der ersten illustrierten Massenblätter-weiter thematisiert. Bei der Untersuchung dieses mediatisierten Krieges wird der Frage nachgegangen, was diese Bilderwelt über die fortschrittlichen Erwartungen, Ängste und Hoffnungen in der Weimarer Republik aussagt. Dabei geht hervor, dass die BIZ nach der anfänglichen Bekundung eines gewissen Wohlwollens gegenüber den ehemaligen Feinden zu Beginn des Jahres 1919 bald in einen bitteren Ton umschlägt, als die Friedensbedingungen bekannt gegeben werden. Diese enttäuschten Hoffnungen haben die kulturelle Demobilisierung der BI…
Measurement of the Fluctuations in the Number of Muons in Extensive Air Showers with the Pierre Auger Observatory
2021
The successful installation, commissioning, and operation of the Pierre Auger Observatory would not have been possible without the strong commitment and effort from the technical and administrative staff in Malargue. We are very grateful to the following agencies and organizations for financial support: Argentina-Comision Nacional de Energia Atomica, Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT), Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Gobierno de la Provincia de Mendoza, Municipalidad de Malargue, NDM Holdings and Valle Las Lenas; in gratitude for their continuing cooperation over land access; Australia-the Australian Research Council; Brazil…
Metabolomics of the tryptophan-kynurenine degradation pathway and risk of atrial fibrillation and heart failure: potential modification effect of Med…
2021
BACKGROUND: The tryptophan–kynurenine pathway is linked to inflammation. We hypothesize that metabolites implicated in this pathway may be associated with the risk of heart failure (HF) or atrial fibrillation (AF) in a population at high risk of cardiovascular disease. OBJECTIVES: We aimed to prospectively analyze the associations of kynurenine-related metabolites with the risk of HF and AF and to analyze a potential effect modification by the randomized interventions of the PREDIMED (Prevención con Dieta Mediterránea) trial with Mediterranean diet (MedDiet). METHODS: Two case–control studies nested within the PREDIMED trial were designed. We selected 324 incident HF cases and 502 incident …
Keberlanjutan Agroindustri Pala Fakfak : a Sistematic Literature Review (SLR)
2021
Salah satu tanaman perkebunan yang menjadi komoditi unggulan Provinsi Papua Barat adalah adalah tanaman pala yang dominan tumbuh di Kabupaten Fakfak. Potensi pengembangan pala Fakfak menjadi produk agroindustry yang bernilai jual tinggi dan keberlanjutannya menjadi hal yang penting. Oleh karena itu penelitian ini bertujuan mengkaji keberlanjutan agroindustry pala Fakfak berdasarkan empat indikator yaitu ketersediaan bahan baku pala Fakfak, perubahan preferensi konsumen terhadap produk turunan pala Fakfak, karakteristik pesaing dalam agroindustry pala Fakfak dan sumberdaya manusia yang mengolah pala Fakfak. Metode yang digunakan adalah Systematic Literature Review dengan PRISMA (Preferred Re…
Hsp60 quantification in human gastric mucosa shows differences between pathologies with various degrees of proliferation and malignancy grade
2021
Background: Stomach diseases are an important sector of gastroenterology, including proliferative benign
Estructura del Test de Dependencia a los Videojuegos, relación con el juego, diferencias sexuales y tipologías de dependencia al juego en una muestra…
2021
Structure of the Video Game Dependence Test, relationship with playing, sex differences and typology of gambling dependence in a Colombian sampleAbstract: The objective of this study was to analyze the factorial structure and psychometric properties of the Video Game Dependence Test (TDV; Cholíz & Marco, 2011) in a Colombian sample, its ability to predict weekly game time, as well as differences by sex. The TDV was completed by a sample of 738 participants aged from 16 to 38 years. The factorial structure of the TDV was composed of these factors: impulsive gambling, compulsive gambling, and associated problems, constituting excellent predictors of weekly gambling time. Finally, we found…
Estimation of Personalized Minimal Purkinje Systems From Human Electro-Anatomical Maps
2021
The Purkinje system is a heart structure responsible for transmitting electrical impulses through the ventricles in a fast and coordinated way to trigger mechanical contraction. Estimating a patient-specific compatible Purkinje Network from an electro-anatomical map is a challenging task, that could help to improve models for electrophysiology simulations or provide aid in therapy planning, such as radiofrequency ablation. In this study, we present a methodology to inversely estimate a Purkinje network from a patient's electro-anatomical map. First, we carry out a simulation study to assess the accuracy of the method for different synthetic Purkinje network morphologies and myocardial junct…
Supported Web-Based Acceptance and Commitment Therapy for Older Family Caregivers (CareACT) Compared to Usual Care
2021
Objectives: The objective of the present study was to investigate whether an acceptance and commitment therapy (ACT)-based web-intervention (Group 1, CareACT), or a standardized rehabilitation in a rehabilitation center (Group 2) was effective in enhancing the psychological well-being of family caregivers aged 60 and over compared to support provided by voluntary caregiver associations (Group 3). Methods: Altogether, 149 family caregivers participated in this quasi-experimental study. Primary outcome measure was depression. Secondary outcomes included anxiety, sense of coherence, quality of life, psychological flexibility, experiential avoidance, and thought suppression. The questionnaires …
Los modelos de enseñanza de los problemas de aligación en las enciclopedias escolares españolas
2021
Los problemas de aligación forman parte de las matemáticas desde épocas antiguas. Actualmente, han perdido interés educativo, aunque siguen presentes en los temas de álgebra y en la vida diaria. En este trabajo, presentamos el modelo de enseñanza de estos problemas en las enciclopedias escolares que estuvieron vigentes desde los años veinte hasta los años setenta del pasado siglo. Para poder caracterizar el modelo de enseñanza nos fijamos en los aspectos contextuales, los estructurales, los procedimentales y los organizativos de los problemas de aligación. Realizamos una clasificación de los tipos de problemas, de los contextos utilizados, de los métodos de resolución que se utilizaban y có…
INNOVATIVE PERFORMANCE AND INNOVATION SYSTEM OF LATVIA
2021
The research andanalysis of strengths and weaknesses of national innovation system is extremelyimportant to successful and efficient innovation support policymaking.Innovation support policies should take into consideration all specifies ofnational innovation system in the country, not being one-size-fits-all. Untilnow, little analysis on the Latvian innovation system was made. The paper aimsto show Latvian innovative performance and to propose factors forwell-functioning innovation system of Latvia. This research gives apossibility to researchers and policy-makers to investigate the mismatchbetween policies and problems and identify policy gaps. KEY WORDS: innovativeperformance, innovation…
Using the r package spatstat to assess inhibitory effects of microregional hypoxia on the infiltration of cancers of the head and neck region by cyto…
2021
Simple Summary Progress in the field of in situ proteomics allows for the simultaneous detection of multiple biomarkers within one cancer tissue specimen. As a result, biological hypotheses previously only assessable ex vivo can now be studied in human cancer tissue. However, methods for objective analysis have so far been lacking behind. In this study, we established a free, objective, and entirely open-source-based method for the analysis of multiplexed immunofluorescence specimens. This will gain further importance with the availability of more advanced multiplexing methods in the future. Abstract (1) Background: The immune system has physiological antitumor activity, which is partially …
Toward a Comprehensive Dam Monitoring: On-Site and Remote-Retrieved Forcing Factors and Resulting Displacements (GNSS and PS–InSAR)
2021
Many factors can influence the displacements of a dam, including water level variability and environmental temperatures, in addition to the dam composition. In this work, optical-based classification, thermal diachronic analysis, and a quasi-PS (Persistent Scatter) Interferometric SAR technique have been applied to determine both forcing factors and resulting displacements of the crest of the Castello dam (South Italy) over a one-year time period. The dataset includes Sentinel-1A images acquired in Interferometric Wide swath mode using the Terrain Observation with Progressive Scans SAR (TOPSAR); Landsat 8 Thermal Infrared Sensor (TIRS) thermal images, and Global Navigation Satellite System …
Salt partitioning in ionized, thermo-responsive hydrogels: perspective to water desalination
2021
Charged hydrogels are capable of swelling in aqueous salt solutions, whereby part of the salt ions is repelled due to the presence of fixed charged groups inside the hydrogel. This effect creates a concentration gradient between the absorbed solution and the surrounding fluid known as salt partitioning, offering a potential for these materials to be employed to desalinate saltwater. If the charged hydrogels are thermo-sensitive as well, then the purer, absorbed solution can be recovered by shrinking the hydrogels upon temperature change. To tailor that potential in water-purification and desalination applications, the main parameters influencing the salt partitioning, the deswelling of the …
Can visualization alleviate dichotomous thinking? Effects of visual representations on the cliff effect
2021
Common reporting styles for statistical results in scientific articles, such as $p$ p -values and confidence intervals (CI), have been reported to be prone to dichotomous interpretations, especially with respect to the null hypothesis significance testing framework. For example when the $p$ p -value is small enough or the CIs of the mean effects of a studied drug and a placebo are not overlapping, scientists tend to claim significant differences while often disregarding the magnitudes and absolute differences in the effect sizes. This type of reasoning has been shown to be potentially harmful to science. Techniques relying on the visual estimation of the strength of evidence have been recom…
Direct assessment of the sensitivity drift of SQM sensors installed outdoors
2021
Long-term monitoring of the evolution of the artificial night sky brightness is a key tool for developing science-informed public policies and assessing the efficacy of light pollution mitigation measures. Detecting the underlying artificial brightness trend is a challenging task, since the typical night sky brightness signal shows a large variability with characteristic time scales ranging from seconds to years. In order to effectively isolate the weak signature of the effect of interest, determining the potential long term drifts of the radiance sensing systems is crucial. If these drifts can be adequately characterized, the raw measurements could be easily corrected for them and transfor…
BVP ir skolinimo elgsena : empiriniai Baltijos šalių ekonomikos požymiai
2021
Darnus ekonominis vystymasis remiasi stabilia ir palankia verslo aplinka, kuri skatina organizacijų konkurencingumą. Komerciniai bankai palengvina kapitalo judėjimą iš mažiau efektyvių ekonomikos sektorių į labiau konkurencingas ekonomikos šakas. Šio tyrimo tikslas – išanalizuoti Baltijos šalių BVP dinamiką 2005-2010 metais ir patikrinti BVP koreliavimą su vietinių komercinių bankų išduotų paskolų verslui skaičiumi. Tyrimo rezultatai parodė, kad yra požymių, jog egzistuoja abipusė priklausomybė tarp BVP veiksnių ir išduotų paskolų, tai savo ruožtu sudaro pagrindą formuoti pasiūlymus, kaip gaivinti Baltijos šalių ekonomiką. Šešiose pramonės šakose atliktas Granger BVP ir skolinimo priežastin…
Keskeiset keinot luontokadon pysäyttämiseksi
2021
Sanna Marinin hallitus on sitoutunut luonnon monimuotoisuuden tilan parantamiseen ja luontokadon pysäyttämiseen. Lupaus on äärimmäisen tärkeä. Luonnon ekosysteemien heikennys uhkaa elintärkeiden eko-systeemipalveluiden tuotantoa sekä ihmisten terveyttä, hyvinvointia ja turvallisuutta. Maailman talousfoorumi on nostanut luontokadon viiden vakavimman ihmiskuntaa uhkaavan riskin joukkoon. Myös Suomen luontotyyppien ja lajiston uhanalaisuustilanne on hälyttävä. Hallituksen kehysriihessä päätetään hallitusohjelman toteuttamisesta ja lunastetaan vuoden 2019 eduskuntavaalien lupaukset luonto- ja ilmastotoimista. Myös EU:n uusi biodiversiteettistrategia velvoittaa Suomea panostamaan luonnonsuojeluu…
ALTERNATIVE MODELS FOR REGIONAL AIRPORTS IN LATVIA
2021
Regional airports play a significant role inpromotion of connectivity and regional development. This is one of reasons whyairports are treated as public assets and in 77 % cases (airportsproviding scheduled air transport services) owned and operated by public sectorin the EU. 71 % of these publicairports have corporatized airport operators. Latviahas threepublic civil aviation airports planned for scheduled flights until 2015: Riga InternationalAirport as well as Liepaja Airportand Ventspils Airport (Kurzeme planning region). Latviacurrently has decentralised operational model of airports. Riga InternationalAirport is owned by state and operatedby a joint stock company.Regional airports are…
Molecular Mechanisms of the Blockage of Glioblastoma Motility
2021
Glioblastoma (GBM) is the most common and lethal brain tumor. GBM has a remarkable degree of motility and is able to infiltrate the healthy brain. In order to perform a rationale-based drug-repositioning study, we have used known inhibitors of two small Rho GTPases, Rac1 and Cdc42, which are upregulated in GBM and are involved in the signaling processes underlying the orchestration of the cytoskeleton and cellular motility. The selected inhibitors (R-ketorolac and ML141 for Cdc42 and R-ketorolac and EHT 1864 for Rac1) have been successfully employed to reduce the infiltration propensity of GBM in live cell imaging studies. Complementarily, all-atom simulations have elucidated the molecular …
Influence of Menstrual Cycle or Hormonal Contraceptive Phase on Energy Intake and Metabolic Hormones—A Pilot Study
2021
Sex hormones are suggested to influence energy intake (EI) and metabolic hormones. This study investigated the influence of menstrual cycle (MC) and hormonal contraceptive (HC) cycle phases on EI, energy availability (EA), and metabolic hormones in recreational athletes (eumenorrheic, NHC = 15 and monophasic HC-users, CHC = 9). In addition, 72-h dietary and training logs were collected in addition to blood samples, which were analyzed for 17β-estradiol (E2), progesterone (P4), leptin, total ghrelin, insulin, and tri-iodothyronine (T3). Measurements were completed at four time-points (phases): Bleeding, mid-follicular (FP)/active 1, ovulation (OVU)/active 2, mid-luteal (LP)/inactive in NHC/C…
Oral microbiome in Proliferative Verrucous Leukoplakia exhibits loss of diversity and enrichment of pathogens.
2021
Abstract Objectives Oral microbiome plays an important role in oral diseases. Among them, proliferative verrucous leucoplakia (PVL) is an uncommon form of progressive multifocal leukoplakia with a worryingly rate of malignant transformation. Here, we aimed to characterize the oral microbiome of PVL patients and compare it with those of healthy controls. Material and methods Oral biopsies from ten PVL patients and five healthy individuals were obtained and used to compare their microbial communities. The sequence of the V3-V4 region of 16S rRNA gene was used as the taxonomic basis to estimate and analyze the composition and diversity of bacterial populations present in the samples. Results O…
QUANTITATIVE ANALYSIS OF SPATIAL INDICATORS IN THE CASE OF VARYING ADMINISTRATIVE BOUNDARIES
2021
The aim of the research is to develop methods that would allow comparingthe statistical parameters of Latviaat differing administrative divisions, thereby solvingthe problems that arise in the case of discrepancy of borders. As part of thework, the developed method was implemented in order to assess the suitabilityof the created tool for mathematical analysis of statistical parameters on Latvia. Theterritory examined in the work is Latvia; the discrepancy of borderswas examined by comparing the parish borders of 1935 with the parishes of 2000.Therefore it was necessary to create a transfer matrix in order to link theadministrative borders of both periods. The transfer matrix was prepared in…
Intravitreal Dexamethasone Implant for Postoperative Macular Oedema Secondary to Vitrectomy for Epiretinal Membrane and Retinal Detachment: A Systema…
2021
Purpose. To evaluate the efficacy of intravitreal dexamethasone implant (DEX) for the treatment of macular oedema secondary to vitrectomy for epiretinal membrane (ERM) and retinal detachment (RD) by conducting a systematic review with meta-analysis of published studies. Methods. Studies reporting clinical outcomes of DEX use for the treatment of macular oedema secondary to ERM and RD vitrectomy were searched on PubMed and Embase databases. The primary outcome was best-corrected visual acuity (BCVA) change between baseline and post-DEX treatment, reported as mean difference (MD) with 95% confidence interval (CI). Mean central macular thickness (CMT) change was assessed as a secondary outcome…
Microtomographic reconstruction of mandibular defects treated with xenografts and collagen-based membranes:a pre-clinical minipig model
2021
Background The goal of this study was to evaluate hard tissue response following guided bone regeneration using commercially available bovine bone grafts and collagen membranes; bilayer collagen membrane and porcine pericardium-based membrane, by means of a non-destructive three-dimensional (3D) computerized volumetric analysis following microtomography reconstruction. Material and Methods Bone regenerative properties of various bovine bone graft materials were evaluated in the Göttingen minipig model. Two standardized intraosseous defects (15mm x 8mm x 8mm) were created bilaterally of the mandible of eighteen animals (n=72 defects). Groups were nested within the same subject and randomly d…
The War Diaries of Hélène Berr and Etty Hillesum: Jewish Women in Occupied Paris and Amsterdam, 1941–1944
2021
International audience
Study on the opinions of university teachers in the Region of Murcia on the training of active methods
2021
La formación del profesorado universitario supone el principal vehículo de cambio y mejora educativa en el marco del Espacio Europeo de Educación Superior (EEES). Sin embargo, existen una serie de factores que pueden impedir su formación y, por tanto, su repercusión en los estudiantes y en la sociedad. En este sentido, este trabajo describe las posibles dificultades que pueden surgir respecto de variables tales como: los años de experiencia docente, edad, género, área del conocimiento en la que imparten docencia, figura profesional o formación universitaria recibida. Para ello, se desarrolló un cuestionario ad hoc que fue aplicado a 501 docentes universitarios. Los resultados mostraron que …
Managing the Historical Agricultural Landscape in the Sicilian Anthropocene Context. The Landscape of the Valley of the Temples as a Time Capsule
2021
The debate over whether we are entering the Anthropocene Epoch focuses on the unequal consumption of the Earth system’s resources at the expense of nature’s regenerative abilities. To find a new point of balance with nature, it is useful to look back in time to understand how the so-called “Great Acceleration”—the surge in the consumption of the planet’s resources—hastened the arrival of the Anthropocene. Some particular places—for various reasons—survived the Great Acceleration and, as time capsules, have preserved more or less intact some landscape features that have disappeared elsewhere. How can we enhance these living archives that have come down to us? Through the analysis of the case…