MYC dosage compensation is mediated by miRNA-transcription factor interactions in aneuploid cancer

2021

SummaryWe hypothesize that dosage compensation of critical genes arises from systems-level properties for cancer cells to withstand the negative effects of aneuploidy. We identified several candidate genes in cancer multi-omics data and developed a biocomputational platform to construct a mathematical model of their interaction network with miRNAs and transcription factors, where the property of dosage compensation emerged for MYC and was dependent on the kinetic parameters of its feedback interactions with three micro-RNAs. These circuits were experimentally validated with a novel genetic tug-of-war technique by overexpressing an exogenous MYC leading to over-expression of the three microR…

Invasive Aliens in Italy: Enumeration, History, Biology and Their Impact

2021

Italy includes two large islands, Sardinia and Sicily, and a peninsula separated from the European continent by the Alpine Arch. At national level ISPRA (Instituto Superiore per la Protezione e la Ricerca Ambientale, Higher Institute for Environmental protection and research) is the instrument of the Ministry of Environment and for the Protection of the Territory and the Sea to carry out its mission, including the study, monitoring, and control of invasive alien species. Universities, Scientific Societies, and ONGs play a vital role in basic research. The interest in the study of alien plants is of a theoretical nature, as regards the migrations of living beings and interactions with native…

Always in crisis, always a solution? : The Nordic model as a political and scholarly concept

2021

While campaigning for the 2016 US Democratic Party presidential nomination, Senator Bernie Sanders invoked the Nordic countries as a model for future politics. In a debate, he declared, ‘I think we should look to countries like Denmark, like Sweden and Norway, and learn from what they have accomplished for their working people.’1 Hailing the Nordic countries, especially Denmark, as an example of ‘democratic socialism’,2 Sanders’s vision engendered a heated debate, with political opponents critiquing the implied political agenda, the prime minister of Denmark protesting the idea of Denmark as a socialist country, and journalists and pundits presenting corrective views of the economic and soc…

Convolutional Regression Tsetlin Machine: An Interpretable Approach to Convolutional Regression

2021

The Convolutional Tsetlin Machine (CTM), a variant of Tsetlin Machine (TM), represents patterns as straightforward AND-rules, to address the high computational complexity and the lack of interpretability of Convolutional Neural Networks (CNNs). CTM has shown competitive performance on MNIST, Fashion-MNIST, and Kuzushiji-MNIST pattern classification benchmarks, both in terms of accuracy and memory footprint. In this paper, we propose the Convolutional Regression Tsetlin Machine (C-RTM) that extends the CTM to support continuous output problems in image analysis. C-RTM identifies patterns in images using the convolution operation as in the CTM and then maps the identified patterns into a real…

Senso, ritmo, multimodalità. Uno studio comparativo dei processi traduttivi nelle lingue dei segni (LIS e LSF)

2021

La presente tesi di dottorato analizza i processi traduttivi nelle lingue segnate, indagando la maniera di (re-)enunciare il senso in traduzione. La riflessione si costruisce come dialogo fra la linguistica delle lingue segnate e la traduttologia, a partire da presupposti teorici comuni a entrambe le discipline benché differentemente declinati, come il concetto di oralità. Lo studio, che intende definirsi come non assimilazionista (così come auspicato da C. Cuxac), tiene conto delle peculiarità proprie delle lingue segnate, fra cui le caratteristiche di multimodalità e multilinearità, e analizza le lingue dei segni sulla base del modèle sémiologique. Considerando la prospettiva dell’embodie…

A deep study of the high–energy transient sky

2021

This is an open access article. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds t…

Small Extracellular Vesicles Secreted by Region-specific Astrocytes Ameliorate the Mitochondrial Function in a Cellular Model of Parkinson’s Disease

2021

AbstractExtracellular vesicles (EVs) are emerging as powerful players in cell-to-cell communication both in health and diseased brain. In Parkinson’s disease (PD) – characterized by selective dopaminergic (DAergic) neuron death in ventral midbrain (VMB) and degeneration of DAergic terminals in striatum (STR) – astrocytes (AS) exert dual harmful/protective functions. When activated by chemokine CCL3, AS promote a robust DAergic neuroprotection both in cellular and pre-clinical models of PD, with mechanisms not fully elucidated. Here we used a combination of techniques to characterize AS-EVs derived from VMB and STR, and investigated their potential to exert neuroprotection. First, we show th…

AGE DIFFERENCES IN THE ACUTE STRESS EFFECTS ON DECLARATIVE MEMORY PERFORMANCE

2021

"In the last decades, there has been a growing interest in knowing the effects of acute stress on memory performance, particularly declarative memory. Research on this topic suggests that age is a crucial individual factor to consider in the stress-memory link. However, most of the evidence has been obtained from studies conducted in young people and, surprisingly, studies in older people are scarce. Thus, our aim was to investigate the age differences in the acute stress effects on declarative memory performance. To do this, we directly compared the effects of a psychosocial acute stressor (i.e. Trier Social Stress Test) on learning, consolidation and memory retrieval performance in two ag…

Coronary CT angiography: a guide to examination, interpretation, and clinical indications

2021

Introduction: The introduction of Cardiac Computed Tomography (CCT) has changed the paradigm in the field of diagnostic cardiovascular medicine. CCT is the primary tool in the assessment of suspected Coronary Artery Disease (CAD) and should be followed by functional assessment when needed to stratify disease and to plan potential interventional or surgical therapy. Areas Covered: We provided the current state of the knowledge on the main aspects of technique of examination, image interpretation and clinical indications. We have focused our attention on the basic routine applications and activities. Expert Opinion: The primary role of CCT in suspected CAD will progressively become the standa…

More or less equality? : Facts, debates, and policies related to the Nordic model

2021

The topic of income inequality has become a new nexus of research among historians and social scientists recently.1 Piketty (2014) has famously argued: Inequality is shaped by the way economic, social, and political actors view what is just and what is not, as well as by the relative power of those actors and the collective choices that result. It is the joint product of all relevant actors combined. Given that redistribution is a core element of the Nordic model and understood as key to the development of social trust and cohesion, all debates about social and cultural polarization are also debates about economic inequalities and the possible policy choices related to those issues. Moreove…

Editorial: Environmental enrichment as a treatment? Epigenetic mechanisms, challenges and limitations

2021

Confirmatory factor analysis and psychometric properties of the Emotion Regulation Questionnaire in participants with personality disorders

2021

Emotional dysregulation is a key symptom in participants with personality disorders. The Emotional Regulation Questionnaire (ERQ) has been studied with nonclinical samples; however, it is necessary to confirm the factorial structure of the ERQ in participants with personality disorders. The aims of the present study were to confirm the factorial structure of the Spanish version of the ERQ and analyse its psychometric properties as well as the association between the ERQ and the Borderline Symptoms List (BSL-23) and the Difficulties in Emotion Regulation Scale (DERS). The overall sample was composed of 250 patients with personality disorders, of whom 195 met the criteria for borderline perso…

Discursive framing and organizational venues: mechanisms of artificial intelligence policy adoption

2021

The purpose of this article is twofold: to theoretically assess ideational and organizational explanatory factors in the adoption of artificial intelligence policies; and to examine the extent to which the European Union has managed to facilitate a coordinated artificial intelligence policy in the Nordic countries. The study utilizes a mixed-methods approach based on systematic web searching, systematic policy document analysis and key informant semi-structured interviews. The study finds that the European Union has utilized framing-based strategies to set an agenda for a coordinated European artificial intelligence policy. Moreover, the strategy has affected member-state artificial intell…

Bortezomib Induces Anti–Multiple Myeloma Immune Response Mediated by cGAS/STING Pathway Activation

2021

Abstract The proteasome inhibitor bortezomib induces apoptosis in multiple myeloma cells and has transformed patient outcome. Using in vitro as well as in vivo immunodeficient and immunocompetent murine multiple myeloma models, we here show that bortezomib also triggers immunogenic cell death (ICD), characterized by exposure of calreticulin on dying multiple myeloma cells, phagocytosis of tumor cells by dendritic cells, and induction of multiple myeloma–specific immunity. We identify a bortezomib-triggered specific ICD gene signature associated with better outcome in two independent cohorts of patients with multiple myeloma. Importantly, bortezomib stimulates multiple myeloma cell immunogen…

Crystal structure of BaCa(CO3)2 alstonite carbonate and its phase stability upon compression

2021

Authors thank the financial support from the Spanish Ministerio de Ciencia, Innovación y Universidades (MICINN) and the Agencia Estatal de Investigación under projects MALTA Consolider Ingenio 2010 network (MAT2015-71070- REDC) and PGC2018-097520-A-I00 (cofinanced by EU FEDER funds) and from the Generalitat Valenciana under project PROMETEO/2018/123. D.S.-P. and A.O.R. acknowledge the financial support of the Spanish MINECO for RyC-2014-15643 and RyC-2016-20301 Ramón y Cajal grants, respectively. C.P. acknowledges the financial support from the Spanish Ministerio de Economia y Competitividad (MINECO project FIS2017-83295-P). Authors also thank Dr. Nicolescu and the Mineralogy and Meteoritic…

A Case for Raising the Camera: A Driving Simulator Test of Camera-Monitor Systems

2021

Objective This experiment provides a first-of-its-kind driving-simulator study to investigate the feasibility of camera-monitor systems (CMS) with displaced side-mounted cameras in sedans. Background Among the increasing number of studies investigating the replacement of side-mounted rearview mirrors with CMS, the placement of side-mounted cameras has been largely neglected. Moreover, user preferences with respect to camera placement have not been validated in a driving simulator. Past research merely has shown that the vertical camera position can affect distance perception. Method In a driving simulator experiment, we investigated the effects of rearward camera placement on driver accepta…

Papers and Boards

2021

WNT2 activation through proximal germline deletion predisposes to small intestinal neuroendocrine tumors and intestinal adenocarcinomas

2021

Abstract Many hereditary cancer syndromes are associated with an increased risk of small and large intestinal adenocarcinomas. However, conditions bearing a high risk to both adenocarcinomas and neuroendocrine tumors are yet to be described. We studied a family with 16 individuals in four generations affected by a wide spectrum of intestinal tumors, including hyperplastic polyps, adenomas, small intestinal neuroendocrine tumors, and colorectal and small intestinal adenocarcinomas. To assess the genetic susceptibility and understand the novel phenotype, we utilized multiple molecular methods, including whole genome sequencing, RNA sequencing, single cell sequencing, RNA in situ hybridization…

Validity, reliability, and sensitivity to motor impairment severity of a multi-touch app designed to assess hand mobility, coordination, and function…

2021

[EN] Background: The assessment of upper-limb motor impairments after stroke is usually performed using clinical scales and tests, which may lack accuracy and specificity and be biased. Although some instruments exist that are capable of evaluating hand functions and grasping during functional tasks, hand mobility and dexterity are generally either not specifically considered during clinical assessments or these examinations lack accuracy. This study aimed to determine the convergent validity, reliability, and sensitivity to impairment severity after a stroke of a dedicated, multi-touch app, named the Hand Assessment Test. Methods: The hand mobility, coordination, and function of 88 individ…

Redox Regulation of Metabolic Syndrome: From Biochemical Mechanisms to Nutritional Interventions.

2021

According to its “harmonized” definition, metabolic syndrome (MetS) is described as a cluster of metabolic factors that increases the risk of cardiovascular diseases, diabetes (DM) and associated morbidities such as dementia [...]

Diastereoselectivity of the Addition of Propargylic Magnesium Reagents to Fluorinated Aromatic Sulfinyl Imines.

2021

The addition of propargylmagnesium bromide to fluorinated aromatic sulfinyl imines gave homopropargyl amines with total regio- and diastereoselection. Complete reversal of diastereoselectivity can be achieved in some cases using coordinating (THF) or noncoordinating (DCM) solvents. Substituted propargylic magnesium reagents have been also tested toward fluorinated aryl sulfinyl imines affording chiral homoallenyl amines with good yields and selectivity control. DFT calculations helped to rationalize the origin of the experimental regio- and diastereoselectivities observed in each case.

Antoni Biosca i Bas (ed.), «La "Descendentia regum Sicilie" de Pau Rossell», València, Universitat de València / Universitat d'Alacant, col. «Fonts H…

2021

Ressenya sobre el llibre d'Antoni Biosca i Bas (ed.), La Descendentia regum Sicilie de Pau Rossell, València, Universitat de València / Universitat d’Alacant, col. «Fonts Històriques Valencianes», 73, 2019, 159 p., ISBN 978-84-9134-424-7. 

Thermo-Hydraulic Modelling and Experimental Validation of an Electro-Hydraulic Compact Drive

2021

Electro-hydraulic compact drives (ECDs) are an emerging technology for linear actuation in a wide range of applications. Especially within the low power range of 5–10 kW, the plug-and-play capability, good energy efficiency and small space requirements of ECDs render this technology a promising alternative to replace conventional valve-controlled linear drive solutions. In this power range, ECDs generally rely on passive cooling to keep oil and system temperatures within the tolerated range. When expanding the application range to larger power classes, passive cooling may not be sufficient. Research investigating the thermal behaviour of ECDs is limited but indeed required for a successful …

Human values and retirement experiences: A longitudinal analysis of Norwegian data.

2021

Motivational factors, such as one’s value system, may affect how people cope with the opportunities and challenges of retirement. This article explores the moderating roles of Schwartz’s four basic values (self-enhancement, self-transcendence, openness to change, and conservation) on the magnitude and duration of retirement effects on life satisfaction between two waves (2007 and 2017) of the Norwegian Life course, Ageing and Generation (NorLAG) study. Fixed-effect regression analyses are run separately for men and women to account for gender differences in the attachments and identities tied to work and non-work domains. Retirement is not a uniform experience, and findings show that retire…

Humanism and criticism in T. S. Eliot and Carles Riba

2021

T. S. Eliot i Carles Riba són dos autors amb moltes similituds: tots dos van viure aproxi­madament durant la mateixa època (la primera meitat del segle XX), tots dos van destacar com a poetes i com a crítics, i tots dos van escriure sobre temes literaris semblants, com, per exemple, l’humanisme, i sobre diversos autors de la literatura europea, com Dante, Goethe i Baudelaire. Però les seves diferents circumstàncies biogràfiques i els diferents contextos literaris, socials i polítics van condicionar la seva concepció de l’humanisme i la seva interpretació d’alguns dels principals escriptors de la cultura occidental. L’objectiu d’aquest article és fer un exercici de literatura com­parada per …

Josep Vicent Garcia Sebastià, «Les construccions de temps transcorregut en el català de l’edat moderna i contemporània (s. XVI-XX)», València/Barcelo…

2021

Ressenya sobre el llibre de Josep Vicent Garcia Sebastià, Les construccions de temps transcorregut en el català de l’edat moderna i contemporània (s. XVI-XX), València/Barcelona, Institut Interuniversitari de Filologia Valenciana / Publicacions de l’Abadia de Montserrat, 2019, col. «Biblioteca Sanchis Guarner», 90, 202 p., ISBN: 978-84-9191-155-9. 

Sobre alguns participis actius amb verbs de moviment

2021

L’objectiu d’aquest estudi és analitzar les estructures formades a partir de la combinació d’un participi amb un verb de moviment, en casos com venir plorat de casa. L’interès d’aquestes dades rau en el fet que els participis que descrivim no són actius (plorat, tossit), però adquireixen una lectura activa en combinar-se amb verbs de desplaçament (venir, sortir, arribar). Al llarg de l’article recopilem i descrivim les dades que segueixen aquesta configuració i mirem d’esbossar alguns apunts per a una possible anàlisi formal. D’una banda, seguint la proposta d’Armstrong (2017), defensem que verbs com plorar o tossir permeten la formació d’un participi actiu resultatiu perquè tenen un object…

Eulàlia Miralles & Pep Valsalobre (eds.), Joan Pujol, «Els poemes de Lepant», Barcelona, Barcino, col. «Biblioteca Barcino», 2019, 192 p.

2021

Ressenya sobre el llibre d'Eulàlia Miralles & Pep Valsalobre (eds.), Joan Pujol, Els poemes de Lepant, Barcelona, Barcino, col. «Biblioteca Barcino», 2019, 192 p., ISBN: 978-84-7226-841-8.

Are byline biases an issue of the past? The effect of author’s gender and emotion norm prescriptions on the evaluation of news articles on gender equ…

2021

When female journalists write about issues of gender equality, they often become the target of incivility and their work is devaluated. Research has investigated such devaluations based on journalists’ gender under the scope of byline biases, analysing if it matters to readers whether a news piece is authored by a male or female journalist. In this paper, we set out to study if gender byline biases occur when journalists write about gender equality. As gender attributions become particularly salient through the presentation of gendered emotion norms, we also inquire in how it matters for readers’ interest in reading such an article and the attributed credibility of the author when an artic…

Locus of control, personality and depression symptoms in cancer: Testing a moderated mediation model.

2021

OBJECTIVE To investigate the mediator role of locus of control on the relationship between the Big Five personality traits and the manifestation of depression symptoms in cancer outpatients. METHOD Participants consisted of 220 cancer outpatients (138 women and 82 men), evaluated individually at the hospital waiting room. The measures applied were as follows: The NEO-Five Factor Inventory (NEO-FFI), Multidimensional Health Locus of Control (MHLC) Scale and Hospital Anxiety and Depression Scale (HADS). RESULTS The factor structure of NEO-FFI was reexamined. A moderated mediation model was found for the powerful others external locus of control (LOC), depression symptoms and extraversion and …

L’estètica emocional de la transformació: una revisitació barroca de la Faula d’Apol·lo i Dafne

2021

The well-known Sonnet XIII by Garcilaso de la Vega «A Dafne ya los brazos le crecían» was to establish the disconsolate figure of Apollo, pining for the loss of Daphne, as the literary paradigm of the pangs of love —at least in Renaissance literature in the Iberian peninsula. Thus, a century later, Francesc Fontanella revisited the Garcilaso sonnet and carried out a profoundly Baroque re-reading. The Catalan text ‘transforms’ the symmetry and order in which the Spanish sonnet describes the metamorphosis of the nymph into an inseparable amalgam between the old way of being and the new reality, between the human and the plant, and freezes the figure in mutation: neither the original form nor …

ID4 Is Required for Normal Ependymal Cell Development

2021

Ependymal cells are radial glia-derived multiciliated cells lining the lateral ventricles of the brain and spinal cord. Correct development and coordinated cilia beating is essential for proper cerebrospinal fluid (CSF) flow and neurogenesis modulation. Dysfunctions of ependymal cells were associated with transcription factor deregulation. Here we provide evidence that the transcriptional regulator ID4 is involved in ependymal cell development and maturation. We observed that Id4-deficient mice display altered ventricular cell cytoarchitecture, decreased ependymal cell number and enlarged ventricles. In addition, absence of ID4 during embryonic development resulted in decreased ependymal ce…

Pilar Godayol, «Feminismes i traducció (1965-1990)», Lleida, Punctum, 2020, col. «Visions», 10, 240 p.

2021

Ressenya sobre el llibre de Pilar Godayol, Feminismes i traducció (1965-1990), Lleida, Punctum, 2020, col. «Visions», 10, 240 p., ISBN: 978-84-120749-2-5.

Joan Vergés Gifra, Francesco Ardolino, Marta Nadal Brunès (eds.), «Maria Aurèlia Capmany. Escriptora i pensadora», Girona, Documenta Universitaria, 2…

2021

Ressenya sobre el llibre de Joan Vergés Gifra, Francesco Ardolino, Marta Nadal Brunès (eds.), Maria Aurèlia Capmany. Escriptora i pensadora, Girona, Documenta Universitaria, 2019, 306 p., ISBN: 978-84-9984-496-1.

Fernando Ramallo, Estibaliz Amorrortu & Maite Puigdevall (eds.), «Neoha¬blantes de lenguas minorizadas en el Estado español», Madrid / Frankfurt …

2021

Ressenya sobre el llibre de Fernando Ramallo, Estibaliz Amorrortu & Maite Puigdevall (eds.), Neoha­blantes de lenguas minorizadas en el Estado español, Madrid / Frankfurt am Main, Iberoamericana/Vervuert, 2019, 195 p., ISBN: 978-84-9192-086-1 (Iberoamericana) / 978-3-96456-882-3 (Vervuert).

El enaltecimiento de los delitos previstos en el art. 510 CP a la luz de la última jurisprudencia constitucional

2021

espanolEl articulo 510 CP, en los apartados 1 c) y 2 d), tipifica el enaltecimiento y otras declaraciones de apoyo al genocidio y a los demas delitos cometidos contra grupos o sus miembros por motivos de intolerancia. Para castigar estas conductas se precisa tan solo el favorecimiento de un clima de violencia, hostilidad, odio o discriminacion, e incluso en el segundo precepto bastan esas expresiones, de modo que si se promueve ese clima se agrava la pena. Sin embargo, en los ultimos anos el Tribunal Constitucional ha aplicado la STC 235/2007 al enaltecimiento y justificacion de los delitos de terrorismo o de sus autores, del articulo 578.1 CP, al entender que constituyen “discurso del odio…