showing 36 of ~574560 from 574555 documents
More or less equality?
2021
ID4 Is Required for Normal Ependymal Cell Development
2021
Ependymal cells are radial glia-derived multiciliated cells lining the lateral ventricles of the brain and spinal cord. Correct development and coordinated cilia beating is essential for proper cerebrospinal fluid (CSF) flow and neurogenesis modulation. Dysfunctions of ependymal cells were associated with transcription factor deregulation. Here we provide evidence that the transcriptional regulator ID4 is involved in ependymal cell development and maturation. We observed that Id4-deficient mice display altered ventricular cell cytoarchitecture, decreased ependymal cell number and enlarged ventricles. In addition, absence of ID4 during embryonic development resulted in decreased ependymal ce…
Dividend Policy and Managerial Overconfidence: French Evidence
2021
This paper examines the impact of managerial overconfidence on dividend policy.The literature has identified two strands of reasoning. Deshmukh et al. (2013) argue that overconfident managers with relatively high investment needs perceive external funds as more costly than internal financing. This leads them to pay out lower dividends. Conversely, Wu and Liu (2011) claim that overconfident CEOs expect higher future cash flows and are prone to pay out higher dividends. We study a sample of 120 French firms for the period 2000–2015. Our results provide evidence that CEOs’ overconfidence plays a decisive role in explaining the dividend policy of French firms. Managerial overconfidence exerts a…
El enaltecimiento de los delitos previstos en el art. 510 CP a la luz de la última jurisprudencia constitucional
2021
espanolEl articulo 510 CP, en los apartados 1 c) y 2 d), tipifica el enaltecimiento y otras declaraciones de apoyo al genocidio y a los demas delitos cometidos contra grupos o sus miembros por motivos de intolerancia. Para castigar estas conductas se precisa tan solo el favorecimiento de un clima de violencia, hostilidad, odio o discriminacion, e incluso en el segundo precepto bastan esas expresiones, de modo que si se promueve ese clima se agrava la pena. Sin embargo, en los ultimos anos el Tribunal Constitucional ha aplicado la STC 235/2007 al enaltecimiento y justificacion de los delitos de terrorismo o de sus autores, del articulo 578.1 CP, al entender que constituyen “discurso del odio…
Joan Estelrich i el nou humanisme a l’Europa d’entreguerres
2021
Aquest article presenta alguns aspectes de l’activitat de Joan Estelrich a partir de dues iniciatives pertanyents, segons ell mateix, a un humanisme o nou humanisme en voga a l’Europa d’entreguerres. Com que el terme humanisme és polisèmic, i l’expressió nou humanisme és encara més ambigua, en primer lloc repassem breument el context històric per mirar d’evitar equívocs. Presentem seguidament el projecte de revista Humanitats (1929), concebuda com a òrgan de la Fundació Bernat Metge i com a plataforma de difusió de l’activitat classicista a Catalunya i a l’exterior, amb especial atenció a la contribució de Mario Meunier sobre l’esperit europeu i les humanitats. A partir de les intervencion…
Humanisme o humanitarisme? Fallida d’imponderables a l’entorn d’una discussió propedèutica entre Ramon Esquerra i Manuel Cruells
2021
Aquest article analitza l’intercanvi de parers entre els crítics Ramon Esquerra (1909-1938) i Manuel Cruells (1910-1988) sobre com calia entendre l’humanisme renaixentista. Partint d’aquí, se centra en el primer autor per examinar les implicacions derivades de l’acte de pensar la crisi d’entreguerres, la funció de l’intel·lectual i els processos culturals del passat des del context geogràfic i temporal del present. A la llum dels discursos d’alguns dels grans pensadors europeus del moment (Hazard, Berdiàiev, Benda, Maurois, etc.), Esquerra projecta des de la seva crítica literària una preocupació per l’esdevenidor de la civilització occidental davant l’ascens de les ideologies totalitariste…
Presentació del monogràfic «La crisi del nou humanisme a Catalunya, 1918-1936»
2021
Presentació del monogràfic «La crisi del nou humanisme a Catalunya, 1918-1936», coordinat per Xavier Pla i Francesc Montero.
Three solutions to mixed boundary value problem driven by p(z)-Laplace operator
2021
We prove the existence of at least three weak solutions to a mixed Dirichlet–Neumann boundary value problem for equations driven by the p(z)-Laplace operator in the principal part. Our approach is variational and use three critical points theorems.
Characteristics of SARS-CoV-2 variants of concern B.1.1.7, B.1.351 or P.1: data from seven EU/EEA countries, weeks 38/2020 to 10/2021
2021
COVID study groups - PORTUGAL: Portuguese Laboratory Network for the Diagnosis of COVID-19 and Public Health Department of the Health Administrative Regions, Physicians that provided data and samples from suspected cases and SARS-CoV-2 genetic characterization. INSA laboratory team for the diagnosis of SARS-CoV-2. Algarve Biomedical Center and Unilabs. We compared 19,207 cases of SARS-CoV-2 variant B.1.1.7/S gene target failure (SGTF), 436 B.1.351 and 352 P.1 to non-variant cases reported by seven European countries. COVID-19 cases with these variants had significantly higher adjusted odds ratios for hospitalisation (B.1.1.7/SGTF: 1.7, 95% confidence interval (CI): 1.0-2.9; B.1.351: 3.6, 95…
Mycorrhizal symbiosis primes the accumulation of antiherbivore compounds and enhances herbivore mortality in tomato
2021
Abstract Plant association with arbuscular mycorrhizal fungi (AMF) can increase their ability to overcome multiple stresses, but their impact on plant interactions with herbivorous insects is controversial. Here we show higher mortality of the leaf-chewer Spodoptera exigua when fed on tomato plants colonized by the AMF Funneliformis mosseae, evidencing mycorrhiza-induced resistance. In search of the underlying mechanisms, an untargeted metabolomic analysis through ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS) was performed. The results showed that mycorrhizal symbiosis had a very limited impact on the leaf metabolome in the absence of stress, but significantly m…
Mapping the Idea of Europe : Cultural Production of Border Imaginaries through Heritage
2021
In contrast to recent reinforcements of Europe's internal and external borders due to the refugee situation on the Mediterranean and the Covid-19 outbreak, talk of European borders has in the past decades focused on the freedom of mobility guaranteed by the Schengen treaty. In many senses, free intra-European mobility has become a recited truth in the EU discourse: a phrase that hides under its repetition the gap between its implied content and empirical realities of many of those who are affected by European borders’ exclusive tendencies. Through the concept of borderscape, this article focuses on the role that cultural products – especially maps exhibited at heritage sites – have in recit…
Els epítets dels artistes baixmedievals al servei dels poders reial i municipal
2021
Aquest article estudia els adjectius que van rebre els artistes que treballaren per al rei i per a les elits ciutadanes en els territoris de parla catalana durant els segles XIV i XV. En particular, se n’hi examinen dos: apte i subtil. Les notícies exhumades per uns altres especialistes fins al moment permeten comprendre’ls en el propi context documental. Ací es compara el seu significat amb uns altres exemples de la literatura baixmedieval de la Corona d’Aragó i es du a terme una aproximació històrica com a paraules que al·ludien a la perícia de l’artista i que van ser escollides amb una finalitat. Participaren i repercutiren, per tant, en la relació històrica de l’artista amb el client, …
false
2021
Intensified job demands (IJDs) originate in the general accelerated pace of society and ever-changing working conditions, which subject workers to increasing workloads and deadlines, constant planning and decision-making about one’s job and career, and the continual learning of new professional knowledge and skills. This study investigated how individual characteristics, namely negative and positive affectivity related to competence demands, and multitasking preference moderate the association between IJDs and cognitive stress symptoms among media workers (n = 833; 69% female, mean age 48 years). The results show that although IJDs were associated with higher cognitive stress symptoms at wo…
Stochastic Episodes of Latent Cytomegalovirus Transcription Drive CD8 T-Cell “Memory Inflation” and Avoid Immune Evasion
2021
Acute infection with murine cytomegalovirus (mCMV) is controlled by CD8+ T cells and develops into a state of latent infection, referred to as latency, which is defined by lifelong maintenance of viral genomes but absence of infectious virus in latently infected cell types. Latency is associated with an increase in numbers of viral epitope-specific CD8+ T cells over time, a phenomenon known as “memory inflation” (MI). The “inflationary” subset of CD8+ T cells has been phenotyped as KLRG1+CD62L- effector-memory T cells (iTEM). It is agreed upon that proliferation of iTEM requires repeated episodes of antigen presentation, which implies that antigen-encoding viral genes must be transcribed du…
Josep Vicent Garcia Sebastià, «Les construccions de temps transcorregut en el català de l’edat moderna i contemporània (s. XVI-XX)», València/Barcelo…
2021
Ressenya sobre el llibre de Josep Vicent Garcia Sebastià, Les construccions de temps transcorregut en el català de l’edat moderna i contemporània (s. XVI-XX), València/Barcelona, Institut Interuniversitari de Filologia Valenciana / Publicacions de l’Abadia de Montserrat, 2019, col. «Biblioteca Sanchis Guarner», 90, 202 p., ISBN: 978-84-9191-155-9.
The Elusive Structure of Magadiite, Solved by 3D Electron Diffraction and Model Building
2021
In addition to a great swelling ability, layered silicates also allow the functionalization of their interlayer region to form various robust green materials that are used as CO2 adsorbents, drug c...
Direct image-guided retroperitoneal approach and treatment of the pancreas by using natural orifice transluminal endoscopic surgery after EUS sugar-a…
2021
Are byline biases an issue of the past? The effect of author’s gender and emotion norm prescriptions on the evaluation of news articles on gender equ…
2021
When female journalists write about issues of gender equality, they often become the target of incivility and their work is devaluated. Research has investigated such devaluations based on journalists’ gender under the scope of byline biases, analysing if it matters to readers whether a news piece is authored by a male or female journalist. In this paper, we set out to study if gender byline biases occur when journalists write about gender equality. As gender attributions become particularly salient through the presentation of gendered emotion norms, we also inquire in how it matters for readers’ interest in reading such an article and the attributed credibility of the author when an artic…
Determination of isoniazid and pyridoxine in plasma sample of tuberculosis patients by micellar liquid chromatography
2021
It is no doubt Isoniazid is a powerful tuberculosis drug, but it might give rise to Vitamin B6 (Pyridoxine) deficiency. In this case, a usual treatment is the combined administration of Isoniazid and Pyridoxine. An easy-to-conduct procedure based on Micellar Liquid Chromatography has been developed to quantify Isoniazid and Pyridoxine in plasma from Tuberculosis patients. The sample was diluted in mobile phase, filtered and directly injected, thus avoiding extraction or purification steps. Both drugs were adequately resolved from the matrix and endogenous compounds using a mobile phase made up of 0.15 M sodium dodecyl sulfate – 8%(v/v) 1-butanol – 0.01 M phosphate buffer at pH 3, running at…
Alexithymia and Adult Attachment: Investigating the Mediating Role of Fear of Intimacy and Negative Mood Regulation Expectancies
2021
Literature suggests an association between alexithymia and insecure adult attachment, but the mediation factors involved in this relationship are under-investigated. The study was carried out to test the possible mediation roles of the fear of intimacy and negative mood regulation expectancies in explaining this relationship. A convenience sample of 258 Polish adults (mean age: 30; 45% male), completed self-reporting measures related to adult attachment (RAAS), alexithymia (TAS-20), fear of intimacy (FIS) and negative mood regulation expectancies (NMRE). The results showed that alexithymia directly and indirectly predicts insecure adult attachment. Alexithymia positively predicts the fear …
Zweig i el dimoni. Presències i absències de la recepció d'una figura europea a Catalunya
2021
Durant dècades, la figura i les obres de l’escriptor austríac Stefan Zweig (Viena, 1881 - Petròpolis, Brasil, 1942) van gaudir a Catalunya del benefici d’una popularitat inigualable. Més enllà dels elogis i de les crítiques, Zweig, que és indiscutiblement un dels escriptors més famosos del segle vint, va interessar i implicar escriptors, artistes, crítics, traductors, polítics, i tota mena d’agents culturals en una recepció crítica de la seva obra a Catalunya que està, encara, per estudiar exhaustivament i per interpretar adequadament.
 En aquest article, es proposa una primera interpretació de la recepció crítica de Zweig a Barcelona, la qual, per més anecdòtica, episòdica i tangenci…
La influència de l´humanisme catòlic anglès a Catalunya durant el període d´entreguerres:la contribució d´Hilaire Belloc
2021
L’estudi de la popularització a Catalunya del periodisme anglès d’arrel catòlica durant els anys vint i trenta s’ha centrat bàsicament sobre la figura de G. K. Chesterton. No obstant això, el seu gran amic, el polemista Hilaire Belloc, també va tenir una certa presència a Catalunya a través del contacte directe amb el país, la traducció dels seus articles i obres i la col·laboració en mitjans catalans. El fet que Belloc fos clarament un antimodern apologeta de la fe cristiana i l’ideòleg original d’un sistema polític i econòmic d’arrel medievalitzant anomenat distributisme, així com un notable historiador i autor de biografies, va dotar la seva figura d’un caràcter polièdric i d’un interès …
A numerical approach for the modelling of forming limits in hot incremental forming of AZ31 magnesium alloy
2021
AbstractMagnesium alloys, because of their good specific material strength, can be considered attractive by different industry fields, as the aerospace and the automotive one. However, their use is limited by the poor formability at room temperature. In this research, a numerical approach is proposed in order to determine an analytical expression of material formability in hot incremental forming processes. The numerical model was developed using the commercial software ABAQUS/Explicit. The Johnson-Cook material model was used, and the model was validated through experimental measurements carried out using the ARAMIS system. Different geometries were considered with temperature varying in a…
Challenging serve myths in doubles tennis
2021
Doubles tennis has received little interest from quantitative research to date. Coach-led anecdotes therefore abound. The aims of this study were therefore to evaluate the veracity of the following common anecdotes: (a) serving teams have an advantage regardless of the length of the point; (b) serving teams have a greater advantage with new balls; (c) regular teams perform better when serving than new teams and (d) serving teams decrease their performance during break points. Data from doubles hard-court and clay-court tennis were collated for 52 doubles teams during 2018 ATP tournaments. Results revealed that the advantage of serving teams was evident on the points lasting up to 4 shots. …
Hypersensitivity pneumonitis : Lessons from a randomized controlled trial in children
2021
Introduction Hypersensitivity pneumonitis (HP) in children is a severe interstitial lung disease and potentially, a chronic condition, if not treated appropriately. No evidence-based guidelines are available; in particular, the role of systemic glucocorticoid therapy is unclear. Methods The aim of this randomized, double-blind, placebo-controlled, parallel-group, multi-center, phase II trial in pediatric HP was to assess the outcome of HP in children after 6 months of treatment and to compare 3 months of treatment with oral prednisolone or placebo. Results After 1.5 years and the inclusion of only four children, we terminated the study prematurely. Two of the children randomized to predniso…
Dynamic clock generator and memory mass device using a quantum ring driven by three-color laser fields
2021
We study the behaviour and applications of a quantum ring (QR) under a three-color laser field. In particular we study the emission of harmonics and their temporal evolution through wavelets. These results suggest the use of QR for three important applications: (1) generation of single short pulses, (2) creation of a variable clock generator, (3) a memory mass device through the angular momentum acquired by the electron.
Elites and Culture: Social Profiles in the Cultivated Population
2021
Since the 1990s, the central references of the sociology of cultural practices have been the theoretical frameworks developed by Pierre Bourdieu and Richard A. Peterson around the concepts of distinction and omnivorousness. This article is based on these frameworks; it revises them together with those of Donnat and Lahire and postulates that the terms of cultural classification and especially those of the upper classes (distinguished and omnivorous) require revision. The article also claims that there are diverse socio-cultural profiles due to the fact that there is never a single logic of differentiation of tastes, and that the results of the present research demand a new conceptual frame…
RESCUE OF LRBA GENE EXPRESSION IN PRIMARY HUMAN FIBROBLASTS CHARACTERISED BY NONSENSE MUTATION c. 5047 (C>T).
2021
Primary immunodeficiencies (PIDs) are rare genetic diseases characterized by susceptibility to infections, increased risk of autoimmunity, hypogammaglobulinemia, and lymphoproliferative syndromes. PIDs are associated to genetic alterations in about 400 known genes, among which, mutations of the LRBA gene. LRBA gene encodes a widely expressed multi-domain protein with highly conserved BEACH domain, involved in regulation of endosomal trafficking, particularly endocytosis of ligand-activated receptors. It was reported that stop mutations affect this gene leading to the loss of the protein expression. Recently, we identified three Translational Readthrough Inducing Drug (TRID), that showed hig…
Direct Oral Anticoagulants versus Vitamin K Antagonists in Patients Aged 80 Years and Older.
2021
The effectiveness of direct oral anticoagulants (DOAC) is non-inferior to vitamin K antagonists (VKA) to treat atrial fibrillation and venous thromboembolism (VTE). In this cross-sectional study, we compared older persons taking DOACs to those taking VKAs. We included ambulatory individuals ≥80 years, affiliated to Mutualité Sociale Agricole of Burgundy, who were refunded for a medical prescription in September 2017. The demographic conditions, registered chronic diseases (RCD), and number and types of prescribed drugs were compared in the DOAC group and VKA group. Of the 3190 included individuals, 1279 (40%) were prescribed DOACs and 1911 (60%) VKAs. Individuals taking VKAs were older than…
Análisis de las políticas de seguridad ciudadana en El Salvador y su impacto en el incremento de la violencia
2021
Este artículo analiza las políticas de seguridad ciudadana que se han implementado en ElSalvador para combatir a las pandillas. El estudio hace un repaso por los cuatro distintosgobiernos que de 2003 a 2019 han intentado, sin éxito, reducir los altos niveles deviolencia. El artículo indaga en cómo estas políticas han permitido el fortalecimiento delas pandillas, el debilitamiento de la institucionalidad y, principalmente, elrecrudecimiento de la violencia expresada en la tasa de homicidios, que ha hecho de ElSalvador uno de los países más violentos del mundo. Por otra parte, también se hace unabreve exposición sobre el futuro de la política de seguridad ciudadana del gobierno de Nayib Buke…
Jordi M. Antolí Martínez, «Els verbs de percepció en català antic. Els verbs “veure”, “sentir”, “oir” i “entendre” en els segles XIII-XVI», Alacant/B…
2021
Ressenya sobre el llibre de Jordi M. Antolí Martínez, Els verbs de percepció en català antic. Els verbs veure, sentir, oir i entendre en els segles XIII-XVI, Alacant/Barcelona, Institut Interuniversitari de Filologia Valenciana / Publicacions de l’Abadia de Montserrat, 2017, 225 p., ISBN: 978-84-9883-882-4.
Història i trama: els casos clínics com a relats acadèmics
2021
Els casos clínics constitueixen un gènere propi dels professionals sanitaris, que els redacten i publiquen amb propòsits didàctics i de recerca. A diferència d’altres textos científics, es basen en l’experiència clínica d’un o pocs pacients, per la qual cosa adopten un caràcter narratiu i una sèrie de característiques que ens condueixen a considerar-los com a relats acadèmics. En aquest article mirem d’esbrinar si aquesta consideració és apropiada. Revisem la teoria de la narració per identificar l’element clau que defineix el relat respecte d’altres textos narratius: la trama o intriga. Comprovem la presència d’aquest element en un corpus de casos clínics escrits en català, anglès i castel…
Ageing via sexual perception is a by-product of male adaptive plasticity inDrosophila melanogaster
2021
ABSTRACTSensory perception of environmental cues can dramatically modulate ageing across distant taxa. For example, maleDrosophila melanogasterage faster if they perceive female cues but fail to mate (ageing via sexual perception). This finding has been a breakthrough for our understanding of the mechanisms of ageing, yet we ignore how and why such responses have evolved. Here, we usedD. melanogasterto ask whether ageing via sexual perception may be a by-product of plastic adaptive responses to female cues, and found that while long-term sexual perception leads to reproductive costs, short-term perception increases male lifetime reproductive success in a competitive environment. Simulations…
Ischemic Stroke With Atrial Fibrillation: Characteristics and Time Trends 2006 to 2017 in the Dijon Stroke Registry.
2021
Background and Purpose: Because of the aging population, an increase in the prevalence of atrial fibrillation (AF) is currently observed, thus leading to a rise in AF-related ischemic stroke (IS). We analyzed the current prevalence of AF among patients with IS, their characteristics, and temporal trends from 2006 to 2017 in the population-based Dijon Stroke Registry. Methods: We used data from the Dijon Stroke Registry, an ongoing population-based study that records all cases of acute stroke among residents of the city of Dijon. All patients with IS between 2006 and 2017 were included. Previous AF was defined if it was mentioned in the medical file before stroke and newly diagnosed AF if i…
The Exclusion of Women from Inheritance Rights: An Unresolved Issue?
2021
In Italy, the women's exclusion from the inheritance is the principle that structures the property system of the families in medieval and early modern age and the social and juridical organization of these centuries, until the XIX century. Despite its importance, the exclusion of the women has never been an autonomous historiographical issue, but it has been ignored to advantage of analysis centered on the dowry system: emphasis has been placed mainly on the property rights of the women instead of observing the marginalization of the female part of lineages respect to the family wealths. The essay addresses two issues: the way in which statutory and state laws rule women’s exclusion from in…
Spin-Wave Driven Bidirectional Domain Wall Motion in Kagome Antiferromagnets
2021
We predict a mechanism to controllably manipulate domain walls in kagome antiferromagnets via a single linearly polarized spin-wave source. We show by means of atomistic spin dynamics simulations of antiferromagnets with kagome structure that the speed and direction of the domain wall motion can be regulated by only tuning the frequency of the applied spin-wave. Starting from microscopics, we establish an effective action and derive the corresponding equations of motion for the spin-wave-driven domain wall. Our analytical calculations reveal that the coupling of two spin-wave modes inside the domain wall explains the frequency-dependent velocity of the spin texture. Such a highly tunable sp…