Lifestyle habits and depressive symptoms in Norwegian adolescents: a national cross-sectional study

2021

Abstract Background This study’s purpose was to examine the association between a broad range of lifestyle habits and depressive symptoms in Norwegian adolescents. Methods This study was based on national, self-reported, cross-sectional data from the Ungdata Surveys, conducted in 2017–2019. The target group comprised 244,250 adolescents (ages 13–19). Binominal logistic regression was used to analyse the association between lifestyle habits (physical activity, social media use, gaming, dietary habits, smoking, smokeless tobacco, alcohol intoxication) and depressive symptoms. The outcome measure was defined as a high level of depressive symptoms (≥80th percentile). Separate analyses were perf…

Continuous‐Flow Synthesis of High‐Quality Few‐Layer Antimonene Hexagons

2021

2D materials show outstanding properties that can bring many applications in different technological fields. However, their uses are still limited by production methods. In this context, antimonene is recently suggested as a new 2D material to fabricate different (opto)electronic devices, among other potential applications. This work focuses on optimizing the synthetic parameters to produce high-quality antimonene hexagons and their implementation in a large-scale manufacturing procedure. By means of a continuous-flow synthesis, few-layer antimonene hexagons with ultra-large lateral dimensions (up to several microns) and a few nanometers thick are isolated. The suitable chemical post-treatm…

Effects of a psychosocial intervention at one-year follow-up in a PREDIMED-plus sample with obesity and metabolic syndrome

2021

This study examines if overweight/obesity are related to higher impulsivity, food addiction and depressive symptoms, and if these variables could be modified after 1 year of a multimodal intervention (diet, physical activity, psychosocial support). 342 adults (55-75 years) with overweight/obesity and metabolic syndrome (MetS) from the PREDIMED-Plus Cognition study were randomized to the intervention or to the control group (lifestyle recommendations). Cognitive and psychopathological assessments were performed at baseline and after 1-year follow-up. At baseline, higher impulsivity was linked to higher food addiction and depressive symptoms, but not to body mass index (BMI). Food addiction n…

Comparative Analysis of Periodontal Pain According to the Type of Precision Orthodontic Appliances: Vestibular, Lingual and Aligners. A Prospective C…

2021

The objective of this prospective clinical study was to analyze the pain (intensity, location and type) that patients presented after the placement of different types of orthodontic appliances: conventional, low friction, lingual and aligners. The sample consisted of 120 patients divided into four groups: conventional (CON), low friction (LF), lingual (LO) and aligners (INV). The participants were given the Short-Form McGill Pain Questionnaire (Ortho-SF-MPQ), where they had to record the pain intensity (no pain, mild, moderate or intense) and the periodontal location at different time points, from the first 4 h to 7 days after the start of treatment. In all the study groups, the most freque…

Evaluación Docente y Mejora Profesional. Descubrir el Encanto de su Complicidad

2021

Actualmente, nos encontramos en un momento óptimo y crucial, lleno de complejidad y con unas grandes necesidades de progresar y mejorar tras los meses de pandemia vividos tras el COVID-19. Aunque España, es uno de los países en los que apenas se ha abordado la evaluación docente, ésta debería de ir caminando hacia una corriente vinculada con el desarrollo docente, a través de procesos autoevaluativos. La razón de ser de este articulo radica, a través de los comentarios que vamos a presentar, en tratar de despertar la complicidad entre la evaluación docente y su incidencia en la mejora y desarrollo tanto profesional como personal. Si el profesorado descubriera el encanto que conlleva hacer u…

Two relaxation times and thermal nonlinear waves along wires with lateral heat exchange

2021

Abstract We propose a model for studying several nonlinear waves for heat transport along a cylindrical system with lateral non-linear heat transfer to the environment. We consider relaxational equations, each with its own relaxation time, for longitudinal heat transfer and for lateral heat transfer across the wall. We consider two kinds of nonlinear lateral heat transport: radiative heat transport, and flux-limited heat transport. This work generalizes our previous studies in which the relaxation time for the lateral heat transfer was considered equal to that of the longitudinal heat flux. We explore the influence of both relaxation times on the propagation speed of linear and nonlinear wa…

tryparedoxin from trypanosoma brucei in complex with cft

2021

Does reviewing experience reduce disagreement in proposals evaluation? Insights from Marie Skłodowska-Curie and COST Actions

2021

Abstract We have limited understanding of why reviewers tend to strongly disagree when scoring the same research proposal. Thus far, research that explored disagreement has focused on the characteristics of the proposal or the applicants, while ignoring the characteristics of the reviewers themselves. This article aims to address this gap by exploring which reviewer characteristics most affect disagreement among reviewers. We present hypotheses regarding the effect of a reviewer’s level of experience in evaluating research proposals for a specific granting scheme, that is, scheme reviewing experience. We test our hypotheses by studying two of the most important research funding programmes i…

Psoriasis: Embarking a dynamic shift in the skin microbiota

2021

Recent interest has arisen regarding the role of microbiome and its composition in the pathogenesis of psoriasis. Numerous studies have shown that there are alterations in skin flora arrangement between normal individuals and psoriatic patients. Psoriasis exacerbation could be interconnected with epidermal or mucosal colonization with streptococci, Malassezia, Staphylococcus aureus, or Candida albicans. The role of cutaneous and gut microbiome in psoriasis pathogenesis has recently been studied in both human and animal models. In this review, we try to evaluate various pathogenic mechanisms linking the microbiota and psoriasis. The literature research included peer-reviewed articles which i…

Comorbidities impact and de-prescribing in elderly with HCV-related liver disease: analysis of a prospective cohort.

2021

AbstractManagement for HCV has undergone a notable change using direct-acting antiviral drugs (DAAs), which are safe and effective even in elderly. Here, we define impact of comorbidities, concomitant medication and drug–drug interactions in elder patients with HCV related disease before starting DAAs regimen. We analyzed data of 814 patients prospectively enrolled at our Unit within the web based model HCV Sicily Network. Out of 814, 590 were treated with DAAs and 414 of them were older than 65 years. We divided those 414 in two groups, one including 215 patients, aged between 65 and 74 years, and another with 199 patients, aged of 75 years and over. Charlson Comorbidity Index (CCI) was as…

A comprehensive use of ultrasound examination in infertility workup

2021

Considering the growing availability of ultrasound diagnostic methods in gynecology, its role in the infertility setting is increasing. In this review, we present an up-to-date ultrasound based diagnostic scheme in infertility workup comprising the evaluation of ovarian anatomy and function, uterine exploration, as well as tubal patency. The possibility of performing the vast majority of infertility diagnostics by ultrasound in the ambulatory settings is not only attractive and beneficial to patients, but also to health care system. Thus, it is vital for gynecologists to implement modern non-invasive ultrasound modalities in their everyday practice.

From Job Resources to Idea Implementation: A Moderated Sequential Mediation Model

2021

Considering the motivational path of the Job Demands-Resources (JD-R) model, this study investigates a multistep process by which contextual job resources might have an indirect effect on idea implementation. Among 187 shop floor employees of a manufacturing company, we found support for a model whereby job control has an indirect effect, over a 5-month time frame, on idea implementation through employee work engagement and personal initiative. In addition, we found that the indirect effect of job control on idea implementation is stronger when employees have a higher conformity orientation. Support was not found for the hypothesized indirect effect of coworker social support on idea imple…

Adoption of Green Environmental Practices in Small and Medium-Sized Enterprises: Entrepreneur and Business Policies Patterns in Romania

2021

Current research shows that SMEs’ social and environmental actions are fragmented and informal, and few have formal policies and intentions. At the same time, many SMEs are engaged with environmental policies, often not knowing it. Concurrently, there is a gap between the pro-environmental attitudes of the SMEs managers, who are often seen as the main drivers for the firm’s behavior, and the policies implemented in reality in their firms. To this end, our research’s objective is to explore pro-environmental behavior, both at the individual and firm level, to identify connections between these levels and measures but also with firm’s and managers’ demographics, based on a study of Romanian S…

The chaperone-like protein Cdc48 regulates ubiquitin-proteasome system in plants.

2021

The degradation of misfolded proteins is mainly mediated by the ubiquitin-proteasome system (UPS). UPS can be assisted by the protein Cdc48 but the relationship between UPS and Cdc48 in plants has been poorly investigated. Here, we analyzed the regulation of UPS by Cdc48 in tobacco thanks to two independent cell lines overexpressing Cdc48 constitutively and plant leaves overexpressing Cdc48 transiently. In the cell lines, the accumulation of ubiquitinated proteins was affected both quantitatively and qualitatively and the amount of proteasomal subunits was modified, while proteolytic activities were unchanged. Similarly, the over-expression of Cdc48 in planta impacted the accumulation of ub…

A Comparative Analysis of Multiple Biasing Techniques for $Q_{biased}$ Softmax Regression Algorithm

2021

Over the past many years the popularity of robotic workers has seen a tremendous surge. Several tasks which were previously considered insurmountable are able to be performed by robots efficiently, with much ease. This is mainly due to the advances made in the field of control systems and artificial intelligence in recent years. Lately, we have seen Reinforcement Learning (RL) capture the spotlight, in the field of robotics. Instead of explicitly specifying the solution of a particular task, RL enables the robot (agent) to explore its environment and through trial and error choose the appropriate response. In this paper, a comparative analysis of biasing techniques for the Q-biased softmax …

Dynamic Tuning of Viscoelastic Hydrogels with Carbonyl Iron Microparticles Reveals the Rapid Response of Cells to Three-Dimensional Substrate Mechani…

2021

Current methods to dynamically tune three-dimensional hydrogel mechanics require specific chemistries and substrates that make modest, slow, and often irreversible changes to their mechanical properties, exclude the use of protein-based scaffolds, or alter hydrogel microstructure and pore size. Here, we rapidly and reversibly alter the mechanical properties of hydrogels consisting of extracellular matrix proteins and proteoglycans by adding carbonyl iron microparticles (MP) and applying external magnetic fields. This approach drastically alters hydrogel mechanics: rheology reveals that application of a 4,000 Oe magnetic field to a 5 mg/mL collagen hydrogel containing 10 wt% MPs increases th…

DLPNO-MP2 second derivatives for the computation of polarizabilities and NMR shieldings

2021

We present a derivation and efficient implementation of the formally complete analytic second derivatives for the domain-based local pair natural orbital second order Møller–Plesset perturbation theory (MP2) method, applicable to electric or magnetic field-response properties but not yet to harmonic frequencies. We also discuss the occurrence and avoidance of numerical instability issues related to singular linear equation systems and near linear dependences in the projected atomic orbital domains. A series of benchmark calculations on medium-sized systems is performed to assess the effect of the local approximation on calculated nuclear magnetic resonance shieldings and the static dipole …

A Navigation and Augmented Reality System for Visually Impaired People

2021

In recent years, we have assisted with an impressive advance in augmented reality systems and computer vision algorithms, based on image processing and artificial intelligence. Thanks to these technologies, mainstream smartphones are able to estimate their own motion in 3D space with high accuracy. In this paper, we exploit such technologies to support the autonomous mobility of people with visual disabilities, identifying pre-defined virtual paths and providing context information, reducing the distance between the digital and real worlds. In particular, we present ARIANNA+, an extension of ARIANNA, a system explicitly designed for visually impaired people for indoor and outdoor localizati…

¿Entre el fiscal y el verdugo? Mateu Orfila i Rotger (1787–1853) y la toxicología del siglo XIX

2021

We have recently witnessed the rebirth of biographical writing in the history of science. Over the last few years, many publications have re-evaluated the role of biography in our field, correcting...

Agency, expertise and working life skills : Students’ conceptions of the generic competences required in the world of work

2021

Fundamental changes in working life highlight the demands on the co-operation between the educational sector and working life, that should contribute to students’ employability. In addition to discipline-specific expertise, the development of working life skills has received increasing attention when it comes to employment. Drawing on data from Finnish universities of applied sciences (n=5) and universities (n=3), this paper examines how students (n=380) value the generic competences needed in in the world of work. The study is based on European reforms of labour markets and educational structures. This paper adds to current discourses around employability by highlighting differences betwee…

Systematic study of SYBR green chromophore reveals major improvement with one heteroatom difference

2021

Five nucleic acid binding cyanine dyes were synthesized and their photophysical properties were evaluated. Changing a single heteroatom in the chromophore causes major differences both in brightness and photostability between the dyes. With such alteration, the brightness of the chromophore increased two-fold compared to the one found in SYBR Green I.

Imaging Trapped Ion Structures via Fluorescence Cross-Correlation Detection

2021

Cross-correlation signals are recorded from fluorescence photons scattered in free space off a trapped ion structure. The analysis of the signal allows for unambiguously revealing the spatial frequency, thus the distance, as well as the spatial alignment of the ions. For the case of two ions we obtain from the cross-correlations a spatial frequency ${f}_{\text{spatial}}=1490\ifmmode\pm\else\textpm\fi{}{2}_{\mathrm{stat}}\ifmmode\pm\else\textpm\fi{}{8}_{\mathrm{syst}}\text{ }\text{ }{\mathrm{rad}}^{\ensuremath{-}1}$, where the statistical uncertainty improves with the integrated number of correlation events as ${N}^{\ensuremath{-}0.51\ifmmode\pm\else\textpm\fi{}0.06}$. We independently deter…

Characterization of Food Packaging Films with Blackcurrant Fruit Waste as a Source of Antioxidant and Color Sensing Intelligent Material

2021

Chitosan and pectin films were enriched with blackcurrant pomace powder (10 and 20% (w/w)), as bio-based material, to minimize food production losses and to increase the functional properties of produced films aimed at food coatings and wrappers. Water vapor permeability of active films increased up to 25%, moisture content for 27% in pectin-based ones, but water solubility was not significantly modified. Mechanical properties (tensile strength, elongation at break and Young’s modulus) were mainly decreased due to the residual insoluble particles present in blackcurrant waste. FTIR analysis showed no significant changes between the film samples. The degradation temperatures, determined by D…

Author response: Genomic basis for drought resistance in European beech forests threatened by climate change

2021

Incidence and Clinical Implications of Autoimmune Thyroiditis in the Development of Acne in Young Patients

2021

Autoimmune thyroiditis (AIT) is on the rise among the population, and is frequently associated with patients with acne vulgaris, especially females aged between 18–55 years old. The connection between the two is not fully elucidated. In this study, 236 patients diagnosed with acne in the dermatological office of the private Pelican Hospital and in few private dermatological offices from Oradea, Romania, during January 2018–December 2020, aged between 12 and 55 years old, were endocrinologically investigated to determine AIT and its influence on the severity of the acne. The values for the thyroid antibodies and thyroid-stimulating hormone (TSH) were determined for all of the subjects. The f…

Treatment of embryonal tumors with multilayered rosettes with carboplatin/etoposide induction and high-dose chemotherapy within the prospective P-HIT…

2021

Abstract Background Embryonal tumors with multilayered rosettes (ETMR) are highly aggressive tumors occurring in early childhood. Published clinical data refer to retrospective, heterogeneously treated cohorts. Here, we describe the outcome of patients treated according to the prospective P-HIT trial and subsequent HIT2000-interim-registry. Patients and methods Age-stratified treatment included carboplatin/etoposide induction, tandem high-dose chemotherapy (“CARBO/ETO + HDCT”), and response-stratified radiotherapy. Patients with centrally reviewed neuropathological and molecularly confirmed diagnosis of ETMR recruited within the P-HIT trial (2001-2011; n = 19), the HIT2000-interim-registry …

Airborne Measurements of Contrail Ice Properties—Dependence on Temperature and Humidity

2021

The largest share in the climate impact of aviation results from cirrus clouds. Here, the dependence of microphysical contrail ice properties and extinction on temperature and humidity is investigated. Contrail measurements were performed at various altitudes during the 2018 ECLIF II/NDMAX campaign with the NASA DC-8 chasing the DLR A320. Ice number concentrations and contrail extinction coefficients are largest at altitudes near 9.5 km, typical for short- and medium-range air traffic. At higher altitudes near 11.5 km, low ambient water vapor concentrations lead to smaller contrail particle sizes and lower extinction coefficients. In addition, contrails were detected below 8.2 km near the S…

Enhanced Surface Ligands Reactivity of Metal Clusters by Bulky Ligands for Controlling Optical and Chiral Properties.

2021

Surface ligands play critical roles in determining the surface properties of metal clusters. However, modulating the properties and controlling the surface structure of clusters through surface‐capping agent displacement remain a challenge. In this work, a silver cluster, [Ag 14 (SPh(CF 3 ) 2 ) 12 (PPh 3 ) 4 (DMF) 4 ] ( Ag 14 ‐DMF , where HSPh(CF 3 ) 2 is 3,5‐bis(trifluoromethyl)benzenethiol, PPh 3 is triphenylphosphine and DMF is N,N‐Dimethylformamide), with weakly coordinated DMF ligands on the surface silver sites, was synthesized by using a mixed ligands strategy (bulky thiolates, phosphines and small solvents). The as‐prepared Ag 14 ‐DMF is a racemic mixture of chiral molecules. Owing …

Dose Estimation for the European Epidemiological Study on Pediatric Computed Tomography (EPI-CT).

2021

International audience; Within the European Epidemiological Study to Quantify Risks for Paediatric Computerized Tomography (EPI-CT study), a cohort was assembled comprising nearly one million children, adolescents and young adults who received over 1.4 million computed tomography (CT) examinations before 22 years of age in nine European countries from the late 1970s to 2014. Here we describe the methods used for, and the results of, organ dose estimations from CT scanning for the EPI-CT cohort members. Data on CT machine settings were obtained from national surveys, questionnaire data, and the Digital Imaging and Communications in Medicine (DICOM) headers of 437,249 individual CT scans. Exp…

Plywood Jig—A New Technique for Root Canal Curvature Measurement

2021

The successful outcome of endodontic treatment is dependent on complete cleaning, shaping as well as three dimensional obturation of the root canal system. A conventional radiograph is a two-dimensional replication of a three-dimensional object and does not provide any conclusive evidence for canal curvatures. An accurate knowledge of the tooth anatomy and curvature is essential to avoid procedural errors. 100 freshly extracted human teeth were used in this study. Digital images were obtained using the plywood JIG and Schneider’s technique. These images were analyzed using the VixWin Pro digital image analyzing software (Gendex system). Statistical analysis was done using paired t test. The…

Investigation of Phosphorylation-Induced Folding of an Intrinsically Disordered Protein by Coarse-Grained Molecular Dynamics

2021

Apart from being the most common mechanism of regulating protein function and transmitting signals throughout the cell, phosphorylation has an ability to induce disorder-to-order transition in an intrinsically disordered protein. In particular, it was shown that folding of the intrinsically disordered protein, eIF4E-binding protein isoform 2 (4E-BP2), can be induced by multisite phosphorylation. Here, the principles that govern the folding of phosphorylated 4E-BP2 (pT37pT46 4E-BP2(18–62)) are investigated by analyzing canonical and replica exchange molecular dynamics trajectories, generated with the coarse-grained united-residue force field, in terms of local and global motions and the time…

[2,5-Bis(dipropylamino)-4-(hydroxymethyl)phenyl]methanol

2021

The centrosymmetric title compound, C22H36N2O2, was prepared in five steps from diethyl succinate. The dipropylamino groups are almost orthogonal to the central phenylenedimethanol ring [dihedral angle = 87.62 (9)°]. In the crystal, the molecules are connected by O—H...N hydrogen bonds, forming (101) layers separated by the propyl chains.

Propolis-Based Nanofiber Patches to Repair Corneal Microbial Keratitis

2021

In this research, polyvinyl-alcohol (PVA)/gelatin (GEL)/propolis (Ps) biocompatible nanofiber patches were fabricated via electrospinning technique. The controlled release of Propolis, surface wettability behaviors, antimicrobial activities against the S. aureus and P. aeruginosa, and biocompatibility properties with the mesenchymal stem cells (MSCs) were investigated in detail. By adding 0.5, 1, and 3 wt.% GEL into the 13 wt.% PVA, the morphological and mechanical results suggested that 13 wt.% PVA/0.5 wt.% GEL patch can be an ideal matrix for 3 and 5 wt.% propolis addition. Morphological results revealed that the diameters of the electrospun nanofiber patches were increased with GEL (from…

"The Referee Plays to Be Insulted!": An Exploratory Qualitative Study on the Spanish Football Referees' Experiences of Aggression, Violence, and Copi…

2021

Referees are essential participants in the sport of football. They are responsible for enforcing the rules and achieving the necessary impartiality for the matches. Referees are often target of hostile reactions from fans, players, and coaches. However, few studies have focused on these experiences and the strategies they use to manage them. In order to fill this gap, a qualitative interview-based study was developed to explore the experiences of a group of football referees (four males and four females) on aggression, violence, and coping. A thematic analysis was developed combining inductive and deductive processes. Results indicated that the most frequent aggressions experienced were ver…

Novel therapeutical approaches to managing atherosclerotic risk

2021

Atherosclerosis is a multifactorial vascular disease that leads to inflammation and stiffening of the arteries and decreases their elasticity due to the accumulation of calcium, small dense Low Density Lipoproteins (sdLDL), inflammatory cells, and fibrotic material. A review of studies pertaining to cardiometabolic risk factors, lipids alterations, hypolipidemic agents, nutraceuticals, hypoglycaemic drugs, atherosclerosis, endothelial dysfunction, and inflammation was performed. There are several therapeutic strategies including Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) inhibitors, inclisiran, bempedoic acid, Glucagon-Like Peptide-1 Receptor agonists (GLP-1 RAs), and nutraceuticals t…

Comparison of Electromyographic Activity During Hip Extension Exercises Under Gravitational or Inertial Loading Conditions.

2021

Background: Hamstring injury prevention programs include strengthening, especially eccentric exercises using both gravitational and inertial loading. Inertial exercises are characterized by eccentric contractions of high intensity and velocity. This study aimed to analyze the muscular activation of the biceps femoris (BF), semitendinosus (ST), gluteus maximus (GM), and gracilis (GC) muscles during hip extension (HE) exercises performed under both gravitational and inertial loading conditions. Hypothesis: Inertial training would generate a greater activation of HE muscles than gravitational training. Study Design: Cross-sectional study. Level of Evidence: Level 4. Methods: Fifteen resistance…