showing 36 of ~574560 from 574555 documents
Danse et illustration : la marionnette et le masque de l’illustrateur
2021
International audience
Apoyo social de familia, profesorado y amigos, ajuste escolar y bienestar subjetivo en adolescentes peruanos
2021
espanolIntroduccion: La psicologia positiva ha senalado la importancia del bienestar subjetivo de los adolescentes, por ser un precursor del desarrollo positivo de los jovenes. La investigacion resalta la importancia del apoyo social percibido y el ajuste escolar como determinantes del bienestar adolescente. Por ello, este articulo tiene como finalidad analizar las relaciones de la percepcion de apoyo social (de familia, profesorado, amigos) con el bienestar subjetivo de los adolescentes, mediado por su ajuste escolar. Metodo: Participaron 1035 estudiantes peruanos de educacion secundaria, con edades entre 12 y 16 anos. Se probaron dos modelos teoricos con variables latentes, uno con mediac…
Electrocardiographic Imaging for Atrial Fibrillation: A Perspective From Computer Models and Animal Experiments to Clinical Value
2021
[EN] Electrocardiographic imaging (ECGI) is a technique to reconstruct non-invasively the electrical activity on the heart surface from body-surface potential recordings and geometric information of the torso and the heart. ECGI has shown scientific and clinical value when used to characterize and treat both atrial and ventricular arrhythmias. Regarding atrial fibrillation (AF), the characterization of the electrical propagation and the underlying substrate favoring AF is inherently more challenging than for ventricular arrhythmias, due to the progressive and heterogeneous nature of the disease and its manifestation, the small volume and wall thickness of the atria, and the relatively large…
The Role of Parliament in Sustainable Development Goals: A Case Study of Southeast Asia in International Parliamentary Forums
2021
Parliament has its role in supporting Sustainable Development Goals (SDG). SDG number 16 on peace, justice, and strong institution states one indicator of a legislative institution (for “responsive, inclusive, participatory and representative”, that the Inter-Parliamentary Union (IPU) commits to achieve. However, parliament must support the government in achieving all SDG programs as stated in Agenda 2030. What is the role of parliament in this and how to achieve it? This paper aims to show that the role of parliament in SDG is beyond the traditional legislative role of legislating, budgeting and overseeing the government, but more on representing people, meaning channeling people’s voice a…
Lièvre ou tortue ? Les accès anticipés au médicament à l'épreuve du dilemme entre précaution et « droit à l'espoir » des patients
2021
International audience
Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation
2021
AbstractPost-translational modifications (PTMs) have emerged as key modulators of protein phase separation and have been linked to protein aggregation in neurodegenerative disorders. The major aggregating protein in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), the RNA-binding protein TDP-43, is hyperphosphorylated in disease on several C-terminal serine residues, which is generally believed to promote TDP-43 aggregation. Here, we show that hyperphosphorylation by Casein kinase 1δ or C-terminal phosphomimetic mutations surprisingly reduce TDP-43 phase separation and aggregation and render TDP-43 condensates more liquid-like and dynamic. Multi-scale simulations revea…
Immunohistochemical markers for histopathological diagnosis and differentiation of acute cutaneous graft‐versus‐host disease
2021
Graft-versus-host disease (GvHD) is a major complication following stem-cell or solid-organ transplantation. Accurate diagnosis of cutaneous GvHD is challenging, given that drug eruptions and viral rashes may present with similar clinical/histological manifestations. Specific markers are not available. We performed the histological examination of biopsy samples from acute GvHD (aGvHD; n = 54), Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN; n = 27), maculopapular drug eruption (MDE; n = 26) and healthy controls (n = 26). Samples of aGvHD showed a decrease in Langerhans cells (LC, p = 0.0001) and an increase in macrophages (MΦ, p = 0.0001) compared to healthy skin. Compared to …
About the relevance of anion-π interactions in water.
2021
Anion-π interactions are emerging as exotic features with potential applications in chemistry. In the last years, their relevance in living systems has been outlined, and so far there is no concluding significant evidence recognized about the participation of anion-π interactions in water because anion-π sensors contain large aromatic hydrophobic surfaces with limited solubility. By transforming a neutral heterocycle (for example quinoline) into its corresponding salt (quinolinium), we have been able to overcome these solubility issues, and new cationic water-soluble fluorophores have been prepared. Herein, we used N-alkylated heterocycles as π-acidic surfaces to shed light on the nature of…
Serum leptin level as a diagnostic and prognostic marker in infectious diseases and sepsis: A comprehensive literature review.
2021
Abstract Background: Infections and sepsis are common causes of morbidity and mortality, with an increasing incidence worldwide. Leptin is involved in the inflammatory process and may modulate the cytokine production, immune cell proliferation and endothelial function. There are conflicting results regarding alterations of leptin levels in infectious diseases and the outcome from sepsis. The aim of the current article is to provide an overview of the medical literature on the correlations between variations of leptin levels and infectious diseases and sepsis. Methods: We performed an extensive literature search in PubMed and Google Scholar databases, using keywords to identify articles rela…
Healthcare Workers - Heroes and Villains in Covid-19 Pandemic. The Ethical Communication
2021
Jakość życia chorych na zaawansowanego raka trzustki
2021
Pancreatic cancer is one of the most common malignancies with poor prognosis and high mortality. Advanced-stage disease at diagnosis and the dominant clinical symptoms significantly deteriorate the quality of life. The paper presents an analysis of the results of quality of life studies in patients with locally advanced and metastatic pancreatic cancer, as well as the relationship between therapeutic decisions and quality of life indicators. It has been shown that the initial assessment of life quality can have prognostic value. Appropriate symptomatic treatment of patients with advanced pancreatic cancer improves the quality of life, increases the compliance and prolongs survival. The asse…
Experimental Constraint on Axionlike Particles over Seven Orders of Magnitude in Mass
2021
We use our recent electric dipole moment (EDM) measurement data to constrain the possibility that the HfF+ EDM oscillates in time due to interactions with candidate dark matter axionlike particles (ALPs). We employ a Bayesian analysis method which accounts for both the look-elsewhere effect and the uncertainties associated with stochastic density fluctuations in the ALP field. We find no evidence of an oscillating EDM over a range spanning from 27 nHz to 400 mHz, and we use this result to constrain the ALP-gluon coupling over the mass range 10-22-10-15 eV. This is the first laboratory constraint on the ALP-gluon coupling in the 10-17-10-15 eV range, and the first laboratory constraint to pr…
An “omic” approach towards molecular diagnosis of resistance to auxinic herbicides in Corn poppy (Papaver rhoeas)
2021
National audience; Papaver rhoeas (corn poppy) is a major, troublesome weed in winter crops. In conventionalagriculture, poppy control is essentially achieved through herbicide application. Followingintensive use of these substances, resistance has evolved in many poppy populations across itsrange in Europe. Among the herbicide modes of action concerned by resistance are auxinmimeticherbicides (HRAC group 4/O). Resistance to this mode of action has little beeninvestigated, and its determinants remain largely unknown. Literature data suggests that, whiletarget-site-based resistance exist, non-target-site-based resistance mechanisms may bepredominant. Target-site-based resistance to auxinic h…
Il neonato con gli occhi socchiusi. La displasia ectodermica legata al gene TP63
2021
An Italian female newborn presented with cleft palate, erythroderma, desquamations, skin erosions, ankyloblepharon filiforme adnatum, broad nasal root, short philtrum, thin vermillion border, maxillary hypoplasia, microstomia, microglossia, cupped ears, hypoplasia of the distal phalange of left index, widely spaced nipples and polythelia. The hallmarks of ankyloblepharon-ectodermal dysplasia-clefting syndrome (or Hay-Wells syndrome) as well as persistent scalp erosions led to exclude more frequent skin disorders like congenital ichthyosiform erythroderma or epidermolysis bullosa and to diagnose Hay-Wells syndrome by genetic analysis. Target sequencing of the tumour protein p63 (TP63) gene r…
Recherche de récepteurs de l’immunité des plantes et étude de l’impact de biostimulants sur leur expression et la résistance induite chez des organes…
2021
National audience; La stimulation des défenses immunitaires des plantes représente une stratégie durable deprotection des cultures qui pourrait permettre de réduire l’utilisation de pesticides chimiquesencore trop répandue en viticulture. Son principe réside en l’application, au contact des cellulesvégétales, de molécules élicitrices détectées comme des signaux de danger par la plante. Cessignaux de dangers peuvent être de différente nature et origine comme par exemple la chitine,un chito-oligosaccharide (COS) retrouvé dans les parois fongiques. Leur détection par desrécepteurs de l’immunité entraine une cascade de signalisation complexe, conduisant àl’activation de réactions de défense et …
Mental health of medical students belonging to sexual minorities: A focus on help-seeking behavior in an Italian multicenter survey
2021
The aim was to examine social, university, health-related differences among heterosexual and Sexual Minority Medical students (SM-Meds), and explore predictors of help-seeking behavior (i.e., current psychological support and hypothetical university counseling use). A multicenter cross-sectional study was conducted in Italy (2018). Questionnaires included socio-demographic items and Beck Depression Inventory-II (BDI-II). Chi-squared tests and multivariable regressions adjusted for BDI-II score were performed (sample size = 2513). SM-Meds were 13.9%. SM-Meds with depressive symptoms were 40.5%. Both considering overall and non-depressed students, SM-Meds exercised less and had worst relation…
Teaching in times of COVID-19: determinants of teachers' educational technology use
2021
We conduct a large and nationwide survey among German teachers to investigate the determinants of teachers' adaption to an increased use of educational technology during the COVID-19 school closure...
Évolution des pratiques et des performances technico-économiques et environnementales au sein du réseau de fermes DEPHY, filière Grandes Cultures
2021
National audience; Le réseau DEPHY génère des données uniques pour la production de connaissances génériquessur les systèmes agricoles peu consommateurs de pesticides. Des travaux récents ont valoriséla diversité des pratiques des agriculteurs DEPHY, décrites au moment de leur entrée dans leréseau, pour (i) identifier les caractéristiques techniques des stratégies de gestion associées à unfaible usage de pesticides, en tenant compte des spécificités du contexte de production dechaque ferme, et (ii) étudier le lien entre le niveau d’usage de pesticides et les performances deproductivité et de rentabilité économique. L’ambition de la thèse est d’analyser maintenant lesévolutions de pratiques …
Nutrition et protection de la vigne par la symbiose mycorhizienne à arbuscule
2021
National audience; La vigne, comme la majorité des espèces de plante d’intérêt agronomique, forme une symbiosemutualiste avec les Champignons Mycorhiziens à Arbuscules (CMA). En contrepartie deproduits issus de la photosynthèse, les CMA soutiennent leur(s) plante(s) hôte(s) dansl’acquisition de nutriments et la lutte contre leur(s) pathogène(s). En tant que biofertilisants, cessymbiontes obligatoires représentent une alternative de choix à l’égard des pratiques agricolesconventionnelles pour le développement d’une agriculture, et notamment d’une viticulturedurable. Les échanges entre les deux partenaires sont permis par la mise en place de structuresfongiques spécialisées appelées arbuscule…
Novel anti-GARP antibody DS-1055a augments anti-tumor immunity by depleting highly suppressive GARP+ regulatory T cells
2021
Abstract Regulatory T (Treg) cells, which are essential for maintaining self-tolerance, inhibit anti-tumor immunity, consequently hindering protective cancer immunosurveillance, and hampering effective anti-tumor immune responses in tumor-bearing hosts. Here, we show that depletion of Treg cells via targeting glycoprotein A repetitions predominant (GARP) induces effective anti-tumor immune responses. GARP was specifically expressed by highly suppressive Treg cells in the tumor microenvironment (TME) of multiple cancer types in humans. In the periphery, GARP was selectively induced in Treg cells, but not in effector T cells, by polyclonal stimulation. DS-1055a, a novel afucosylated anti-huma…
Interactions between Rainbow Trout Eyed Eggs and Flavobacterium spp. Using a Bath Challenge Model:Preliminary Evaluation of Bacteriophages as Pathoge…
2021
The microbial community surrounding fish eyed eggs can harbor pathogenic bacteria. In this study we focused on rainbow trout (Oncorhynchus mykiss) eyed eggs and the potential of bacteriophages against the pathogenic bacteria Flavobacterium psychrophilum and F. columnare. An infection bath method was first established, and the effects of singular phages on fish eggs was assessed (survival of eyed eggs, interaction of phages with eyed eggs). Subsequently, bacteria-challenged eyed eggs were exposed to phages to evaluate their effects in controlling the bacterial population. Culture-based methods were used to enumerate the number of bacteria and/or phages associated with eyed eggs and in the su…
Solution properties of the incompressible Euler system with rough path advection
2021
The present paper aims to establish the local well-posedness of Euler's fluid equations on geometric rough paths. In particular, we consider the Euler equations for the incompressible flow of an ideal fluid whose Lagrangian transport velocity possesses an additional rough-in-time, divergence-free vector field. In recent work, we have demonstrated that this system can be derived from Clebsch and Hamilton-Pontryagin variational principles that possess a perturbative geometric rough path Lie-advection constraint. In this paper, we prove the local well-posedness of the system in $L^2$-Sobolev spaces $H^m$ with integer regularity $m\ge \lfloor d/2\rfloor+2$ and establish a Beale-Kato-Majda (BKM)…
Chemical composition and source attribution of sub-micrometre aerosol particles in the summertime Arctic lower troposphere
2021
Aerosol particles impact the Arctic climate system both directly and indirectly by modifying cloud properties, yet our understanding of their vertical distribution, chemical composition, mixing state, and sources in the summertime Arctic is incomplete. In situ vertical observations of particle properties in the high Arctic combined with modelling analysis on source attribution are in short supply, particularly during summer. We thus use airborne measurements of aerosol particle composition to demonstrate the strong contrast between particle sources and composition within and above the summertime Arctic boundary layer. In situ measurements from two complementary aerosol mass spectrometers, t…
Atténuation des émissions par les sols du gaz à effet de serre N2O, grâce à l’utilisation d’additifs ou de microorganismes, tous d’origine naturelle
2021
National audience; Les sols agricoles sont la principale source du gaz à effet de serre (GES) N2O (protoxyded’azote). D’un point de vue environnemental ce gaz est impliqué à la fois dans l’effet de serreadditionnel et la destruction de la couche d’ozone stratosphérique. Le pouvoir de réchauffementglobal (PRG) du N2O sur une durée de 100 ans est 265 fois supérieur à celui du dioxyde decarbone (CO2). La durée de vie du protoxyde d’azote dans l’atmosphère est d’environ 120 ans.Ainsi, il apparait comme le 3ème gaz participant au réchauffement climatique d’origineanthropique, après le CO2 et le CH4. Les sols peuvent fonctionner comme source mais aussicomme puits de N2O, par l’intermédiaire de mé…
Acogimiento en familia extensa: perfil psicosocial de las familias y de los menores acogidos
2021
[EN] Extended family foster care family is the most frequent protective measure for minors in Spain. The objectives of the present study are to analyze the family profile according to different dimensions, knowing the state of psychosocial health care of minors in foster care and study the relationship between family and minor variables. The sample consisted of 101 families and 121 minors between 6 and 17 years old (M = 10.07; DT = 3.92), living in the province of Valencia. The evaluation was carried out through individual interviews with every family. Results show good functionality of families taking into account the family climate, the level of stress, the educational styles and the supp…
Comparison of Crop Trait Retrieval Strategies Using UAV-Based VNIR Hyperspectral Imaging.
2021
Hyperspectral cameras onboard unmanned aerial vehicles (UAVs) have recently emerged for monitoring crop traits at the sub-field scale. Different physical, statistical, and hybrid methods for crop trait retrieval have been developed. However, spectra collected from UAVs can be confounded by various issues, including illumination variation throughout the crop growing season, the effect of which on the retrieval performance is not well understood at present. In this study, four retrieval methods are compared, in terms of retrieving the leaf area index (LAI), fractional vegetation cover (fCover), and canopy chlorophyll content (CCC) of potato plants over an agricultural field for six dates duri…
Rainwater Interest in Urban Areas of E urope, the State of Art (1980–2016)
2021
Lateral Habenula 5-HT2C Receptor Function Is Altered by Acute and Chronic Nicotine Exposures
2021
Serotonin (5-HT) is important in some nicotine actions in the CNS. Among all the 5-HT receptors (5-HTRs), the 5-HT2CR has emerged as a promising drug target for smoking cessation. The 5-HT2CRs within the lateral habenula (LHb) may be crucial for nicotine addiction. Here we showed that after acute nicotine tartrate (2 mg/kg, i.p.) exposure, the 5-HT2CR agonist Ro 60-0175 (5–640 µg/kg, i.v.) increased the electrical activity of 42% of the LHb recorded neurons in vivo in rats. Conversely, after chronic nicotine treatment (6 mg/kg/day, i.p., for 14 days), Ro 60-0175 was incapable of affecting the LHb neuronal discharge. Moreover, acute nicotine exposure increased the 5-HT2CR-immunoreactive (IR)…
Sélection artificielle de communautés microbiennes : effet de la diversité génétique et rôle des interactions interspécifiques
2021
National audience; La sélection artificielle, à l'origine des espèces animales et végétales utilisées en agriculture, alongtemps été appliquée à l’échelle de l’individu. Il est possible de transposer cette procéduresur des holobiontes, communautés ou écosystèmes ; toutefois, cela ajoute un niveau decomplexité puisque le phénotype cible de la sélection résulte de la présence de plusieurs espèceset, potentiellement, de leurs interactions. L'ambition de ce projet est i) de déterminer si unediversité génétique microbienne élevée permet d'améliorer l'efficacité de la sélection artificiellede communautés microbiennes et ii) de déterminer si les interactions entre espèces sontimpliquées dans la mi…
Deciphering biotic interactions and their role in soil microbial community assembly
2021
National audience; Soil microbial communities play key roles in ecosystem functioning. Yet, little is known aboutthe importance of microbe-microbe interactions in soil microbial community assembly andfunctions. To address this knowledge gap, the objective of my thesis is to assess the role ofinteractions between micro-organisms in soil microbial communities. For this purpose, we willmanipulate the interactions between microorganisms within complex soil microbialcommunities by (i) removing different members of the soil community, (ii) adding microbialtaxa to the soil community and (iii) increasing the physical distance between members of thesoil community. How shifts in microbial interaction…
Neuromodulatory effect of interleukin 1β in the dorsal raphe nucleus on individual differences in aggression
2021
Heightened aggressive behavior is considered as one of the central symptoms of many neuropsychiatric disorders including autism, schizophrenia, and dementia. The consequences of aggression pose a heavy burden on patient’s families, clinicians, and the patients themselves. At the same time, we have limited treatment options for aggression and lack mechanistic insight into the causes of aggression needed to inform new efforts in drug discovery and development. Levels of proinflammatory cytokines in the periphery or cerebrospinal fluid were previously reported to correlate with aggressive traits in humans. However, it is still unknown whether cytokines affect brain circuits to modulate aggress…
Élaboration du premier référentiel territorial de la qualité microbiologique des sols afin de promouvoir la transition agroécologique
2021
National audience; Le sujet de thèse fait partie d’un projet de développement territorial, porté par Dijon Métropole,dont l’objectif est de développer un système alimentaire durable d’ici 2030 sur l’aire urbainede Dijon Métropole (3000 km2). Il s’inscrit dans l’une des actions du projet : l’action Sol Expertdont l’objectif est de développer un référentiel territorial de la qualité des sols afin de validerun diagnostic opérationnel pour accompagner la transition agroécologique. La question derecherche du sujet de thèse porte sur l’étude de l’effet des modes d’usage et des pratiquesassociées sur les communautés microbiennes telluriques et les services qu’elles fournissent.Des objectifs fondam…
Analyse des effets du paysage et des abondances régionales de bioagresseurs sur les niveaux d’usage phytosanitaires en grandes cultures et polycultur…
2021
National audience; L’utilisation massive de pesticides en agriculture engendre des problèmes environnementauxet sanitaires. Le plan Ecophyto II lancé en 2015 ambitionne une réduction de l’usage depesticides grâce d’une part à la généralisation et à l’optimisation des techniques identifiéescomme favorables à cette réduction et d’autre part à l’initiation de changements profonds dessystèmes de cultures et des filières. L’enjeu de la thèse est d’identifier des systèmes de culturesqui permettent de réduire la dépendance aux produits phytosanitaires mais aussi de biencomprendre les conditions de contextes paysagers et de pressions de bioagresseurs danslesquels ces systèmes sont performants. La d…
De Novo Genome Assembly of the Raccoon Dog (Nyctereutes Procyonoides)
2021
The raccoon dog, Nyctereutes procyonoides (NCBI Taxonomy ID: 34880, Figure 1a) belongs to the family Canidae, with foxes (genus Vulpes) being their closest relatives (Lindblad-Toh et al., 2005; Sun et al., 2019). Its original distribution in East Asia ranges from south-eastern Siberia to northern Vietnam and the Japanese islands. In the early 20th century, the raccoon dog was introduced into Western Russia for fur breeding and hunting purposes, which led to its widespread establishment in many European countries, Figure 1b. Together with the raccoon (Procyon lotor), it is now listed in Europe as an invasive species of Union concern (Regulation (EU) No. 1143/2014) and member states are requi…
La formation au numérique des enseignants du second degré en France : une approche exploratoire
2021
International audience
Pratiques pédagogiques en cours magistral, caractéristiques des enseignants et caractéristiques du contexte : une étude de liens
2021
International audience