High Responders to Hypertrophic Strength Training Also Tend to Lose More Muscle Mass and Strength During Detraining Than Low Responders.

2021

Räntilä, A, Ahtiainen, JP, Avela, J, Restuccia, J, Kidgell, DJ, and Häkkinen, K. High responders to hypertrophic strength training also tend to lose more muscle mass and strength during detraining than low responders. J Strength Cond Res 35(6): 1500-1511, 2021-This study investigated differences in individual responses to muscle hypertrophy during strength training and detraining. Ten weeks of resistance training was followed by 6 weeks of detraining in men (n = 24). Bilateral leg press (LP) one-repetition maximum (1RM) and maximal electromyography (EMGs) of vastus lateralis (VL) and vastus medialis, maximal voluntary activation (VA), transcranial magnetic stimulation for corticospinal exci…

Hypericum perforatum L. prevents the acquisition of and promotes resilience against stress-induced reinstatement of the conditioned place preference …

2021

Abstract Cocaine use disorder is a serious problem worldwide, and there are no approved medications for its treatment. A novel approach to the treatment of drug addiction is the use of natural products, and, in this context, preclinical evidence suggests that Hypericum perforatum L. (Hypericum) is effective against alcohol and other substance use disorders. We hypothesised that Hypericum could also be useful as a treatment for cocaine use disorder, and so we set out to test its effectiveness in a mice model of cocaine addiction. In the first experiment we evaluated its effects on the acquisition of cocaine-induced conditioned place preference (CPP). Adult male mice were conditioned with coc…

Nosespace PTR-MS analysis with simutaneous TDS or TCATA sensory evaluation: Release and perception of the aroma of dark chocolates differing in senso…

2021

International audience; Perception of flavor is a dynamic process during which the concentration of aroma molecules at the olfactory epithelium varies with time as they are released progressively from the food in the mouth during consumption. However, how the various components combine to produce a sensory impression is still not completely understood. Real-time mass spectrometry (MS) techniques that measure aroma compounds directly in the nose (nosespace) aim at obtaining data patterns that are supposed to reflect the way aromas are released in real time during food consumption. These patterns are supposed to be representative of the retronasal stimuli perception. Real-time sensory methods…

false

2021

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent for the COVID-19 pandemic, which generated more than 1.82 million deaths in 2020 alone, in addition to 83.8 million infections. Currently, there is no antiviral medication to treat COVID-19. In the search for drug leads, marine-derived metabolites are reported here as prospective SARS-CoV-2 inhibitors. Two hundred and twenty-seven terpene natural products isolated from the biodiverse Red-Sea ecosystem were screened for inhibitor activity against the SARS-CoV-2 main protease (Mpro) using molecular docking and molecular dynamics (MD) simulations combined with molecular mechanics/generalized Born surface area b…

CAR-T therapy in solid transplant recipients with post-transplant lymphoproliferative disease: case report and literature review

2021

Patients with postransplant lymphoproliferative disease (PTLD) who are refractory to rituximab-based regimens have extremely poor prognosis. Data is lacking in the setting of solid organ transplantation (SOT)-related PTLD treated with chimeric antigen receptor T-cell (CAR-T) therapy. Moreover, limited information is available on the influence of concomitant immunosuppressive drugs on CAR-T function. Here, we describe the clinical outcome in one PTLD patient and propose a strategy for tailoring immunosuppressive treatment and organ monitoring in patients with kidney allografts after CAR-T infusion. This report also reviews the limited published data in the setting of SOT-related PTLD treated…

Bionanocomposite Blown Films: Insights on the Rheological and Mechanical Behavior.

2021

In this work, bionanocomposites based on two different types of biopolymers belonging to the MaterBi® family and containing two kinds of modified nanoclays were compounded in a twin-screw extruder and then subjected to a film blowing process, aiming at obtaining sustainable films potentially suitable for packaging applications. The preliminary characterization of the extruded bionanocomposites allowed establishing some correlations between the obtained morphology and the material rheological and mechanical behavior. More specifically, the morphological analysis showed that, regardless of the type of biopolymeric matrix, a homogeneous nanofiller dispersion was achieved

Unmanned aerial vehicle technology to assess the state of threatened biogenic formations: The vermetid reefs of mediterranean intertidal rocky coasts

2021

Abstract Vermetid bioconstructions are biogenic formations, built by sessile gastropod molluscs belonging to the family Vermetidae worldwide distributed, occurring in the intertidal and upper subtidal in the rocky shores. In the Mediterranean basin, they occur in complex and tridimensional structures that enhance the local biodiversity, allowing to qualify the structuring species as ecosystem engineers. Due to their ecological relevance and considerable extension along the coasts, we assessed their structural complexity using unmanned aerial vehicle (UAV) technology, as tool of littoral cartography analysis of these bioconstructions, and plaster hemispheres dissolution as a descriptor index…

Quantifying treatment effects when flexibly modeling individual change in a nonlinear mixed effects model

2021

A core task in analyzing randomized clinical trials based on longitudinal data is to find the best way to describe the change over time for each treatment arm. We review the implementation and estimation of a flexible piecewise Hierarchical Linear Model (HLM) to model change over time. The flexible piecewise HLM consists of two phases with differing rates of change. The breakpoints between these two phases, as well as the rates of change per phase are allowed to vary between treatment groups as well as individuals. While this approach may provide better model fit, how to quantify treatment diff erences over the longitudinal period is not clear. In this paper, we develop a procedure for summ…

Study of the Stability of Citrate Capped AgNPs in Several Environmental Water Matrices by Asymmetrical Flow Field Flow Fractionation

2021

Asymmetrical flow field-flow fractionation (AF4) coupled to UV-Vis and dynamic light scattering (DLS) detectors in series, was tested for stability studies of dispersions of citrate-capped silver nanoparticles (AgNPs) in several water matrices. The main goal is to provide knowledge to understand their possible behavior in the environment for short times since mixturing (up to 180 min). Ultrapure (UPW), bottled (BW1, BW2), tap (TW), transitional (TrW) and sea water (SW) matrices were assayed. Observations were compatible with the aggregation of AgNPs, a change in the plasmon band and a size growth with time were done. Fractograms showed different evolution fingerprints in the function of the…

Tilted precession bands in Nd135

2021

Two new excited bands built on the πh11/2 configuration have been identified in Nd135 in addition to the known πh11/2 band. The energy spectra of the excited bands and the available electromagnetic transition probabilities are in good agreement with theoretical results obtained using quasiparticle-plus-triaxial-rotor model calculations. The properties of the bands identify them as tilted precession bands instead of wobbling bands. Our results give a new insight into the interpretation of the low-lying bands in odd-A mass nuclei, and can stimulate future studies to address the nuclear triaxiality.

Spectroscopy of A=9 hyperlithium with the (e,e′K+) reaction

2021

University-wide, top-down curriculum reform at a Finnish university: perceptions of the academic staff

2021

This study examines academic staff’s perceptions of a university-wide, top-down curriculum reform in terms of the management of the reform, the support provided by the university’s administration, and the utilisation of the university’s guidelines. Differences between faculties are also scrutinised. The study was conducted at a multidisciplinary public research university in Finland using the survey method. The data (n = 394) consisted of academic staff’s responses to multiple-choice and open-ended questions. Correlation coefficients, exploratory factor analyses, and a one-way analysis of variance (ANOVA) were utilised to analyse the quantitative data. Responses to the open-ended questions …

Medieval Monastery Gardens in Iceland and Norway

2021

Gardening was an important part of the daily duties within several of the religious orders in Europe during the Middle Ages. The rule of Saint Benedict specified that the monastery should, if possible, contain a garden within itself, and before and above all things, special care should be taken of the sick, so that they may be served in very deed, as Christ himself. The cultivation of medicinal and utility plants was important to meet the material needs of the monastic institutions, but no physical garden has yet been found and excavated in either Scandinavia or Iceland. Especially the Cistercians were well known for being pioneer gardeners, but also other orders like the Benedictines and A…

Sagittal suture morphological variation in human archaeological populations

2021

Cranial sutures join the many bones of the skull. They are therefore points of weakness and consequently subjected to the many mechanical stresses affecting the cranium. However, the way in which this impacts their morphological complexity remains unclear. We examine the intrinsic and extrinsic mechanisms of human sagittal sutures by quantifying the morphology from 107 individuals from archaeological populations spanning the Mesolithic to Middle ages, using standardized two-dimensional photographs. Results show that the most important factor determining sutural complexity appears to be the position along the cranial vault from the junction with the coronal suture at its anterior-most point …

Time-in-range for monitoring glucose control: Is it time for a change?

2021

The HbA1c value has been the gold standard for evaluating glucose control for decades. However, it has limitations such as the lack of information on glycemic variability or the risk of hypoglycemia. The increasing use of continuous glucose monitoring has provided patients and healthcare professionals with a range of useful metrics for the management of diabetes. Among them, Time in Range (TIR) is a simple and intuitive metric that gives information regarding the quality of glucose control. It is defined as the time spent in an individual's target glucose range. TIR is strongly correlated with HbA1c, and it has been linked to the risk of developing microvascular and macrovascular complicati…

The effect of bias field on the dielectric response of Ba0.95Pb0.05TiO3+Со2О3

2021

The nature of the dielectric response in ferroelectric ceramics Ba0.95Pb0.05TiO3+Со2О3 (BPTC) under the influence of a constant bias field EB in the phase transition region is studied. It is found ...

Assessment of drainage network analysis methods to rank sediment yield hotspots

2021

This paper aims to test different methods used for assessing sediment yield indices to identify hotspots and rank sediment yield hotspots. This process includes the assessment of the entropy weight...

Mediated learning materials: visibility checks in telepresence robot mediated classroom interaction

2021

Videoconferencing is increasingly used in education as a way to support distance learning. This article contributes to the emerging interactional literature on video-mediated educational interaction by exploring how a telepresence robot is used to facilitate remote participation in university-level foreign language teaching. A telepresence robot differs from commonly used videoconferencing set-ups in that it allows mobility and remote camera control. A remote student can thus move a classroom-based robot from a distance in order to shift attention between people, objects and environmental structures during classroom activities. Using multimodal conversation analysis, we focus on how partici…

Barrier effects on the spatial distribution of Xylella fastidiosa in Alicante, Spain

2021

AbstractSpatial models often assume isotropy and stationarity, implying that spatial dependence is direction invariant and uniform throughout the study area. However, these assumptions are violated when dispersal barriers are present in the form of geographical features or disease control interventions. Despite this, the issue of non-stationarity has been little explored in the context of plant health. The objective of this study was to evaluate the influence of different barriers in the distribution of the quarantine plant pathogenic bacterium Xylella fastidiosa in the demarcated area in Alicante, Spain. Occurrence data from the official surveys in 2018 were analyzed with four spatial Baye…

Magnetic Nanoparticle-Based Hyperthermia Mediates Drug Delivery and Impairs the Tumorigenic Capacity of Quiescent Colorectal Cancer Stem Cells

2021

Cancer stem cells (CSCs) are the tumor cell subpopulation responsible for resistance to chemotherapy, tumor recurrence, and metastasis. An efficient therapy must act on low proliferating quiescent-CSCs (q-CSCs). We here investigate the effect of magnetic hyperthermia (MHT) in combination with local chemotherapy as a dual therapy to inhibit patient-derived colorectal qCR-CSCs. We apply iron oxide nanocubes as MHT heat mediators, coated with a thermoresponsive polymer (TR-Cubes) and loaded with DOXO (TR-DOXO) as a chemotherapeutic agent. The thermoresponsive polymer releases DOXO only at a temperature above 44 °C. In colony-forming assays, the cells exposed to TR-Cubes with MHT reveal that qC…

The impact of life stage and pigment source on the evolution of novel warning signal traits

2021

Our understanding of how novel warning color traits evolve in natural populations is largely based on studies of reproductive stages and organisms with endogenously produced pigmentation. In these systems, genetic drift is often required for novel alleles to overcome strong purifying selection stemming from frequency-dependent predation and positive assortative mating. Here, we integrate data from field surveys, predation experiments, population genomics, and phenotypic correlations to explain the origin and maintenance of geographic variation in a diet-based larval pigmentation trait in the redheaded pine sawfly (Neodiprion lecontei), a pine-feeding hymenopteran. Although our experiments c…

Next-Generation Sequencing Identifies Potential Actionable Targets in Paediatric Sarcomas

2021

Background: Bone and soft-tissue sarcomas represent 13% of all paediatric malignancies. International contributions to introduce next-generation sequencing (NGS) approaches into clinical application are currently developing. We present the results from the Precision Medicine program for children with sarcomas at a reference centre. Results: Samples of 70 paediatric sarcomas were processed for histopathological analysis, reverse transcriptase polymerase chain reaction (RT-PCR) and next-generation sequencing (NGS) with a consensus gene panel. Pathogenic alterations were reported and, if existing, targeted recommendations were translated to the clinic. Seventy paediatric patients with sarcomas…

Studying ideology and discourse as knowledge, power and material practices

2021

The notion of ideology plays a crucial role in the social sciences in general and discourse studies in particular because it helps us conceptualize, problematize and understand the complex relation...

1uti

2021

'Love comes first, and it is ahead of any different political partisanism': How political polarizations compare to other forms of discrimination in B…

2021

Background: Affective polarization and stigma toward individuals with schizophrenia and toward immigrants in Argentina are not new despite its importance and dissemination. However, no research has been conducted taking into consideration political partisanship and attitudes toward these groups. Aims: Political polarization and attitudes toward socialization across party lines are studied in conjunction with attitudes toward immigrants and toward individuals with schizophrenia. Method: Individuals from Buenos Aires ( n = 712) were surveyed for their political partisanship and their attitudes toward Peruvian and Bolivian immigrants, people with schizophrenia and partisans from the opposing p…

Advances in spatial economic data analysis: methods and applications

2021

Spatial economic studies traditionally exploit areal data at the regional or sub-regional level. More recently, scholars have started to exploit spatial data of a different nature and, at the same time, extend the fields of application in economics. Specifically, this special issue contributes to the spatial economic literature by providing empirical evidence on a wide range of phenomena (socio-economic deprivation, land price volatility, electoral competition, real estate market, firm survival and tourism economics) and exploiting data at the municipality, firm, house and even individual level. At the same time, it tackles some of the methodological issues faced by the above-mentioned anal…

New national and regional bryophyte records, 66

2021

a The Natural History Museum, Cromwell Road, London, SW7 5BD, UK; b Department of Plant and Animal Production, Munzur University, Vocational School of Tunceli, Tunceli, Turkey; c International School of Advanced Studies, University of Camerino, Camerino (MC), Italy; d Grupo de Investigación Biología para la Conservación, Universidad Pedagógica y Tecnológica de Colombia, Colombia; e Botanical Survey of India, Central National Herbarium, Howrah, India; f Botanical Garden-Institute, Russian Academy of Science, Vladivostok, Russia; g Viale Rovereto, Trento, Italy; h Department of Botany, Kherson State University, Kherson, Ukraine; i Kherson Branch of Admiral Makarov University, Kherson, Ukraine…

The Republican Nature of Modern Democracy: Implications on Educational Policy

2021

This study offers a theoretical context for reading political education literature. Comparing the two classical cultural exemplars (Latin/Greek) we build our working framework upon the firm distinction between Republican and Democratic ideals and we suggest that the current political culture is shaped into the Republican mold. Setting these findings as our conceptual framework, we scrutinize the 2018's democratic education proposal of the Council of Europe, which although represents modern Republican states, it rather employs concepts¿participation, living-together, ethical competencies¿ extracted from the Democratic exemplar. Finally, we assess the effectiveness of our framework and the co…

false

2021

Centaurothamnus maximus (family Asteraceae), is a leafy shrub indigenous to the southwestern Arabian Peninsula. With a paucity of phytochemical data on this species, we set out to chemically characterize the plant. From the aerial parts, two newly identified guaianolides were isolated: 3β-hydroxy-4α(acetoxy)-4β(hydroxymethyl)-8α-(4-hydroxy methacrylate)-1αH,5αH, 6αH-gual-10(14),11(13)-dien-6,12-olide (1) and 15-descarboxy picrolide A (2). Seven previously reported compounds were also isolated: 3β, 4α, 8α-trihydroxy-4-(hydroxymethyl)-lαH, 5αH, 6βH, 7αH-guai-10(14),11(13)-dien-6,12-olide (3), chlorohyssopifolin B (4), cynaropikrin (5), hydroxyjanerin (6), chlorojanerin (7), isorhamnetin (8), …

How paradoxical is ‘paradoxical’ outcome? : Different pathways and implications

2021

The present special issue includes single and multiple case studies which report on the phenomenon of ‘paradoxical’ outcomes in psychotherapy, operationalized as discordant outcome assessments within the same case. In an attempt to find ground for my published response, I endeavored to juxtaposition the cases from the different studies, and by doing that gain an overview of the contributions and arguments. As a result of that exercise, I suggest three different types of paradoxical outcome with different pathways and implications. Discussing the concept of ‘illusory mental health’ as a possible explanation for paradoxical outcome, I suggest that self-ratings within a nonclinical range, give…

The transformation of the Ministries of Foreign Affairs in the Baltic countries

2021

This article analyses the transformation of the Ministries of Foreign Affairs (MFA) and the nature of changes in the Baltic countries (Estonia, Latvia, and Lithuania). By applying Brian Hocking’s a...

Guarding the borders of the Norwegian welfare state. How NAV employees decide on social assistance for unemployed Polish migrants

2021

In this article, I focus on social relations and institutional logics to explore how street-level bureaucrats in the Norwegian Labour and Welfare Administration (NAV) assess unemployed Polish migra...

Operating in alternative photography: agency through prolonged photographic acts

2021

The popularisation of digital photography has widened the gap between mainstream photography and alternative photographic processes. Analyses of the so-called post-photographic era have largely ign...

Concepts, causes and consequences of trust in news media – a literature review and framework

2021

Research on trust in media is on the rise. However, communication scholars have addressed related concepts (e.g. media credibility) for decades, and these concepts have often been used interchangea...

Policy vs. reality: intimate contact in Nazi-occupied Latvia

2021

To better understand the contradictions between regulations and reality on consensual relations between German soldiers and Latvian women, this article investigates the development of Nazi sexual p...

An evolutionary Haar-Rado type theorem

2021

AbstractIn this paper, we study variational solutions to parabolic equations of the type $$\partial _t u - \mathrm {div}_x (D_\xi f(Du)) + D_ug(x,u) = 0$$ ∂ t u - div x ( D ξ f ( D u ) ) + D u g ( x , u ) = 0 , where u attains time-independent boundary values $$u_0$$ u 0 on the parabolic boundary and f, g fulfill convexity assumptions. We establish a Haar-Rado type theorem: If the boundary values $$u_0$$ u 0 admit a modulus of continuity $$\omega $$ ω and the estimate $$|u(x,t)-u_0(\gamma )| \le \omega (|x-\gamma |)$$ | u ( x , t ) - u 0 ( γ ) | ≤ ω ( | x - γ | ) holds, then u admits the same modulus of continuity in the spatial variable.