showing 36 of ~574560 from 574555 documents
The prevalence and characteristics of breakthrough cancer pain in patients receiving low doses of opioids for background pain
2021
Simple Summary The aim of this study was to assess the prevalence and characteristics of breakthrough cancer pain (BTcP) in patients receiving low doses of opioids for background pain. This prospective study showed that in this population, BTcP prevalence was 69.8%. Many patients did not achieve a sufficient level of satisfaction with BTcP medications, particularly with oral morphine. Data also suggest that better optimization of background analgesia, though apparently acceptable, may limit the number of BTcP episodes. Abstract The aim of this study was to assess the prevalence and characteristics of breakthrough cancer pain (BTcP) in patients receiving low doses of opioids for background p…
In vitro blood brain barrier exposure to mycotoxins and carotenoids pumpkin extract alters mitochondrial gene expression and oxidative stress.
2021
Abstract Food and feed are daily exposed to mycotoxin contamination which effects may be counteracted by antioxidants like carotenoids. Some mycotoxins as well as carotenoids penetrate the blood brain barrier (BBB) inducing alterations related to redox balance in the mitochondria. Therefore, the in vitro BBB model ECV304 was subcultured for 7 days and exposed to beauvericine, enniatins, ochratoxin A, zearalenone (100 nM each), individually and combined, and pumpkin extract (500 nM). Reactive oxygen species were measured by fluorescence using the dichlorofluorescein diacetate probe at 0 h, 2 h and 4 h. Intracellular ROS generation reported was condition dependent. RNA extraction was performe…
gg→HH : Combined uncertainties
2021
In this paper we discuss the combination of the usual renormalization and factorization scale uncertainties of Higgs-pair production via gluon fusion with the novel uncertainties originating from the scheme and scale choice of the virtual top mass. Moreover, we address the uncertainties related to the top-mass definition for different values of the trilinear Higgs coupling and their combination with the other uncertainties.
Experimental assessment of changes in bone fragment position using infraread diodes on saw bone models with a hexapod fixator
2021
Background: The purpose of this study was an experimental assessment of changes in bone fragment position in patients with non-union of the tibia treated with a hexapod fixator. Hypothesis: We hypothesized that the use of hexapod fixators leads to differences between the planned and actual position of bone fragments. Methods: The study was conducted in physical models of the hexapod fixator–bone fragment system. Bone fragment displacement was measured using the Optotrak Certus Motion Capture System. We assessed differences between the planned and actual position of bone fragments. Results: Assessment of bone fragment compression demonstrated a difference between the target and actual correc…
Oral Kaposi sarcoma development is associated with HIV viral load, CD4+ count and CD4+/CD8+ ratio.
2021
Background Kaposi’s sarcoma (KS) is an uncommon, multifocal and angioproliferative lesion, which demonstrates a poor prognosis. The aim of the present research was to explore the association of HIV viral load, CD4+ and CD8+ counts and the CD4+/CD8+ ratio on the risk of oral Kaposi’s sarcoma (KS) development. Material and Methods A total of 62 patients were retrieved from March 2008 to October 2020 from the files of two oral pathology centres. Clinical, laboratory and follow-up data were retrieved from their medical files. Poisson regression was used to explore the role of history of immunosuppression and its association with oral KS development. A P-value <0.05 was considered significant. R…
Resuscitative endovascular balloon occlusion of the aorta (REBOA) in patients with major trauma and uncontrolled haemorrhagic shock: a systematic rev…
2021
AbstractBackgroundMultiple studies regarding the use of Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) in patients with non-compressible torso injuries and uncontrolled haemorrhagic shock were recently published. To date, the clinical evidence of the efficacy of REBOA is still debated. We aimed to conduct a systematic review assessing the clinical efficacy and safety of REBOA in patients with major trauma and uncontrolled haemorrhagic shock.MethodsWe systematically searched MEDLINE (PubMed), EMBASE and CENTRAL up to June 2020. All randomized controlled trials and observational studies that investigated the use of REBOA compared to resuscitative thoracotomy (RT) with/witho…
Triangle singularity mechanism for the $pp \to \pi^+ d$ fusion reaction
2021
We develop a model for the $pp \to \pi^+ d$ reaction based on the $pp \to \Delta(1232) N$ transition followed by $\Delta(1232) \to \pi N'$ decay and posterior fusion of $N N'$ to give the deuteron. We show that the triangle diagram depicting this process develops a triangle singularity leading to a large cross section of this reaction compared to ordinary fusion reactions. The results of the calculation also show that the process is largely dominated by the $pp$ system in $L=2, S=0$, which transfers $J=2$ to the final $\pi^+ d$ system. This feature is shown to be well suited to provide $L=2,S=1$, $J^\mathrm{tot}=3$ for $np$ in the $np(I=0) \to \pi^- pp$ followed by $pp \to \pi^+ d$ reaction…
apuesta por un reconocimiento constitucional amplio del derecho al trabajo y a la seguridad social en Ecuador
2021
espanolLa integracion del derecho al trabajo en el constitucionalismo social de posguerra se caracterizo, entre otras cuestiones, por la incorporacion de la division del trabajo, diferenciando entre aquel remunerado, integrado en las normas constitucionales y sobre el que se asento en gran medida el reconocimiento de un amplio conjunto de derechos sociales; y el no remunerado, ausente del reconocimiento constitucional y normativo y condenado a la invisibilizacion y a ser acumulado sobre el anterior. Esta diferenciacion se fundamento, evidentemente, en la division sexual del trabajo integrada en la conjuncion del patriarcado con el sistema capitalista y recogida en las normas del constitucio…
false
2021
Background Vascular alterations induced by antineoplastic treatment might be considered as a possible underlying mechanism of increased cardiovascular sequelae in childhood cancer survivors (CCSs). We aimed to evaluate arterial stiffness among long‐term CCSs and to compare the data against a population‐based sample. Methods and Results Arterial stiffness was assessed by digital photoplethysmography (stiffness index; m/s) among 1002 participants of the CVSS (Cardiac and Vascular Late Sequelae in Long‐Term Survivors of Childhood Cancer) study, diagnosed with neoplasia (1980–1990) before an age of 15 years. A population‐based sample from the GHS (Gutenberg Health Study) (n=5252) was investiga…
Using the Updated EWGSOP2 Definition in Diagnosing Sarcopenia in Spanish Older Adults : Clinical Approach
2021
Recently the European Working Group on Sarcopenia in Older People (EWGSOP2) has updated diagnostic criteria for sarcopenia, which consist of one or more measures of muscle strength, muscle mass, and physical performance, plus an initial screening test called SARC-F. The main objective was to compare the number of cases of sarcopenia, using the different measurements and screening options. A cross-sectional study was conducted on Spanish older adults (n = 272, 72% women). Combining the different measures proposed by the steps described in the EWGSOP2 algorithm, 12 options were obtained (A–L). These options were studied in each of the three models: (1) using SARC-F as initial screening
THE CONE OF EXPERIENCE IN TEACHING MATHEMATICS SYNCHRONOUSLY AND ASYNCHRONOUSLY
2021
Teaching online is a new challenge for every single teacher. Mathematics in particular remains the school subject that requires special teaching tools. This article describes Edgar Dale’s «Cone of experience» and Bruner’s learning approaches for synchronous and asynchronous teaching in Mathematics. It also describes the most important tools that can be used for online teaching in a combination of both formats, asynchronous and synchronous. These teaching methods are described not only in terms of digital tools, but also in terms of Jerome Bruner’s theories on information processing.
A Comparison of Dyadic and Social Network Assessments of Peer Influence.
2021
The present study compares two methods for assessing peer influence: the longitudinal actor–partner interdependence model (L-APIM) and the longitudinal social network analysis (L-SNA) Model. The data were drawn from 1,995 (49% girls and 51% boys) third grade students ( Mage= 9.68 years). From this sample, L-APIM ( n = 206 indistinguishable dyads and n = 187 distinguishable dyads) and L-SNA ( n = 1,024 total network members) subsamples were created. Students completed peer nominations and objective assessments of mathematical reasoning in the spring of the third and fourth grades. Patterns of statistical significance differed across analyses. Stable distinguishable and indistinguishable L-AP…
Effects of a non-pharmacological approach for chronic pain management in patients with haemophilia: efficacy of cognitive-behavioural therapy associa…
2021
INTRODUCTION More than half of adult patients with severe haemophilia (PWH) suffer pain daily, with chronic pain (CP) in more than 15% of cases, thereby reducing their quality of life (QoL). However, there are no evidence-based therapeutic guidelines for pain management. AIM To evaluate the effectiveness of a combined protocol based on psychology and physiotherapy in the improvement of CP self-efficacy in PWH with CP. Secondary outcomes are changes in QoL, emotional status, pain and kinesiophobia. METHODS In this prospective controlled trial study, recruited patients were allocated either to an experimental group (EG, n = 10) or to a control group (CG, n = 9). EG received interventions over…
‘An apple a day’?: Psychiatrists, psychologists and psychotherapists report poor literacy for nutritional medicine: international survey spanning 52 …
2021
Nutritional interventions have beneficial effects on certain psychiatric disorder symptomatology and common physical health comorbidities. However, studies evaluating nutritional literacy in mental health professionals (MHP) are scarce. This study aimed to assess the across 52 countries. Surveys were distributed via colleagues and professional societies. Data were collected regarding self-reported general nutrition knowledge, nutrition education, learning opportunities, and the tendency to recommend food supplements or prescribe specific diets in clinical practice. In total, 1056 subjects participated in the study: 354 psychiatrists, 511 psychologists, 44 psychotherapists, and 147 MHPs in-t…
Reti sismiche urbane per monitoraggio sismico monitoraggio strutturale ed allerta precoce
2021
In questa tesi, viene effettuato un analisi preliminare in cui si mette in evidenza come l'italia sia un paese a rischio sismico, poichè possiede molti centri storici con strutture non progettate per eventi sismici di media entità. Si è prestato molta attenzione su quante vite umane vengono salvate dopo un terremoto catastrofico. L'analisi fa emergere come, è importante essere tempestivi nell'estrarre le persone rimaste sotto le macerie, poichè la percentuale di persone estratte vive si mantiene alta solo entro le 48 ore dall'evento. Dopo 96 ore questa percentule si attesta a 0. In eventi passati spesso i soccorsi sono arrivati con giorni di ritardo nelle zone più devastate. L'obbiettivo ch…
Brain Mapping-Aided SupraTotal Resection (SpTR) of Brain Tumors: The Role of Brain Connectivity
2021
Brain gliomas require a deep knowledge of their effects on brain connectivity. Understanding the complex relationship between tumor and functional brain is the preliminary and fundamental step for the subsequent surgery. The extent of resection (EOR) is an independent variable of surgical effectiveness and it correlates with the overall survival. Until now, great efforts have been made to achieve gross total resection (GTR) as the standard of care of brain tumor patients. However, high and low-grade gliomas have an infiltrative behavior and peritumoral white matter is often infiltrated by tumoral cells. According to these evidences, many efforts have been made to push the boundary of the re…
Repurposing of the Antiepileptic Drug Levetiracetam to Restrain Neuroendocrine Prostate Cancer and Inhibit Mast Cell Support to Adenocarcinoma
2021
A relevant fraction of castration-resistant prostate cancers (CRPC) evolve into fatal neuroendocrine (NEPC) tumors in resistance to androgen deprivation and/or inhibitors of androgen receptor pathway. Therefore, effective drugs against both CRPC and NEPC are needed. We have previously described a dual role of mast cells (MCs) in prostate cancer, being capable to promote adenocarcinoma but also to restrain NEPC. This finding suggests that a molecule targeting both MCs and NEPC cells could be effective against prostate cancer. Using an in silico drug repurposing approach, here we identify the antiepileptic drug levetiracetam as a potential candidate for this purpose. We found that the protein…
Morphological and Postural Changes in the Foot during Pregnancy and Puerperium: A Longitudinal Study
2021
The aim of this study is to observe the morphological and postural changes to the foot that take place during pregnancy and the puerperium. Method: In this descriptive, observational, longitudinal study, we analysed 23 pregnant women, with particular attention to morphological and postural aspects of the foot, at three time points during and after pregnancy: in weeks 9–13 of gestation, weeks 32–35 of gestation and weeks 4–6 after delivery. The parameters considered were changes in foot length, the Foot Posture Index (FPI) and the Hernández Corvo Index, which were analysed using a pedigraph and taking into account the Body Mass Index (BMI). The same procedure was conducted in each review. Re…
Climate Change: Negationism, Skepticism, and Misinformation
2021
Resumen: El objetivo de este artículo es examinar los principales lineamientos antagonistas sobre el cambio climático. Para ello, se ofrece una aproximación teórica a las narrativas y repertorios sustantivos que sostienen los fundamentos de la negación y se diferencia conceptualmente entre negacionistas, climatoescépticos y contrarios climáticos. Estos repertorios son la negación de las evidencias científicas, la negación económica y la negación política. Finalmente, se hace referencia a la difusión de información errónea y tóxica como estrategia organizada y deliberada. Como principal conclusión se abordan los emergentes programas de alfabetización climática para neutralizar la desinformac…
Constitucionalismo democrático e innovación constitucional en Ecuador
2021
Desde la activación del poder constituyente en la Constitución colombiana de 1991, diversas constituciones democráticas han supuesto cambios estructurales importantes en varios países latinoamericanos, tanto en la organización de los poderes públicos como en la legitimidad democrática del poder y la regeneración constitucional de los derechos. De entre estos nuevos textos constitucionales latinoamericanos destaca, por su originalidad y avances teóricos, la Constitución ecuatoriana de 2009: el primer caso de constitucionalismo de transición en el nuevo constitucionalismo latinoamericano. Estas constituciones, no obstante, se encuentran ante un problema de aplicación que dificulta su funcio…
Examining the predictors of prosocial behavior in young offenders and nonoffenders
2021
Research on young offenders has primarily focused on identifying predictors of the maladaptive, aggressive behavior; there is a scarcity of evidence on factors that relate to prosocial behavior in these adolescents. The current study examined the link from parenting, emotional instability, and prosocial reasoning to prosocial behavior, while also examining the mediating roles of empathic concern (EC) and perspective taking (PT) in a sample of Spanish adolescent offenders compared to a sample of nonoffenders. Participants were 440 adolescents: 220 young offenders residing in four Youth Detention Centres of Valencia (67.3% men) and 220 enrolled in public and private schools within the metrop…
Measurements of ν̅ μ and ν̅ μ + ν μ charged-current cross-sections without detected pions or protons on water and hydrocarbon at a mean anti-neutrino…
2021
Abstract We report measurements of the flux-integrated ν̅μ and ν̅μ + νμ charged-current cross-sections on water and hydrocarbon targets using the T2K anti-neutrino beam with a mean beam energy of 0.86 GeV. The signal is defined as the (anti-)neutrino charged-current interaction with one induced $\mu^\pm$ and no detected charged pion or proton. These measurements are performed using a new WAGASCI module recently added to the T2K setup in combination with the INGRID Proton Module. The phase space of muons is restricted to the high-detection efficiency region, $p_{\mu}&gt;400~{\rm MeV}/c$ and $\theta_{\mu}&lt;30^{\circ}$, in the laboratory frame. An absence of pions and protons in the …
Dual mixed-mode poly (vinylpyridine-co-methacrylic acid-co-ethylene glycol dimethacrylate)-based sorbent for acidic and basic drug extraction from or…
2021
Abstract In this study, a dual mixed-mode polymer sorbent was prepared via one-step thermally initiated polymerization of 4-vinylpyridine (VP), methacrylic acid (MAA) and ethylene glycol dimethacrylate (EGDMA) for the solid-phase extraction (SPE) of basic and acidic drugs. The use of VP and MAA as ionizable functional monomers allowed the tailoring of ion-exchange and hydrophobic features of the polymer. The obtained polymer was characterized by Fourier-transform infrared spectroscopy and scanning electron microscopy. Next, the retention behavior of dual mixed-mode polymer towards basic and acidic drugs was investigated. Moreover, the practical capability of this novel material was tested f…
Subdivisions of Ring Dupin Cyclides Using Bézier Curves with Mass Points
2021
Dupin cyclides are algebraic surfaces introduced for the first time in 1822 by the French mathematician Pierre-Charles Dupin. A Dupin cyclide can be defined as the envelope of a one-parameter family of oriented spheres, in two different ways. R. Martin is the first author who thought to use these surfaces in CAD/CAM and geometric modeling. The Minkowski-Lorentz space is a generalization of the space-time used in Einstein’s theory, equipped of the non-degenerate indefinite quadratic form $$Q_{M} ( \vec{u} ) = x^{2} + y^{2} + z^{2} - c^{2} t^{2}$$ where (x, y, z) are the spacial components of the vector $$ \vec{u}$$ and t is the time component of $$ \vec{u}$$ and c is the constant of the spee…
Challenges and advances for the treatment of renal cancer patients with brain metastases: From immunological background to upcoming clinical evidence…
2021
The introduction of checkpoint inhibitors (ICIs) in renal cell carcinoma (RCC) treatment landscape, resulted in improvements in overall survival (OS) in metastatic patients. Brain metastases (BMs) are a specific metastatic site of interest representing a predictive factor of poor prognosis. Patients with BMs were usually excluded from prospective clinical trials in the past. Despite recent evidence suggest the efficacy and safety of ICIs, the BMs treatment remains a challenge; the immunotherapy responsiveness seems to be multifactorial and dependent on several factors, such as the genetic intratumor heterogeneity and the immunosuppressive role of the brain tumor microenvironment. This revie…
revocación del mandato presidencial como instrumento de la ciudadanía en el Nuevo Constitucionalismo Latinoamericano
2021
espanolEl Nuevo Constitucionalismo Latinoamericano ha supuesto un cambio de paradigmas democraticos que han permitido la inclusion de instituciones de democracia directa como la del mandato presidencial, ofreciendo caracteristicas particulares en cuanto a la forma de entender esta institucion. Se realizara un analisis de las constituciones enmarcadas en este Nuevo Constitucionalismo que contemplan la del mandato presidencial para poder interpretar la intencion dada a esta institucion desde las premisas de esta nueva vertiente constitucional. Con una revision de las normas de desarrollo constitucional de la revocacion del mandato, asi como de los procesos de revocacion del mandato presidenci…
Anxiety and depression during the first wave of COVID-19 in Germany – results of repeated cross-sectional surveys
2021
Neoextractivism, or the birth of magical realism as world literature
2021
In recent years, literary criticism has shown increased interest towards the manner in which fiction depicts (neo)extractivism as a set of practices whereby large quantities of natural resources ar...
NOAA-AVHRR Orbital Drift Correction: Validating Methods Using MSG-SEVIRI Data as a Benchmark Dataset
2021
National Oceanic and Atmospheric Administration–Advanced Very High Resolution Radiometer (NOAA-AVHRR) data provides the possibility to build the longest Land Surface Temperature (LST) dataset to date, starting in 1981 up to the present. However, due to the orbital drift of the NOAA platforms, no LST dataset is available before 2000 and the arrival of newer platforms. Although numerous methods have been developed to correct this orbital drift effect on the LST, a lack of validation has prevented their application. This is the gap we bridge here by using the 15 min temporal resolution of Meteosat Second Generation–Spinning Enhanced Visible and Infra-Red Imager (MSG-SEVIRI) data to simulate dr…
The Role of Assumptions in Ohlson Model Performance: Lessons for Improving Equity-Value Modeling
2021
In this paper, we test whether the short-run econometric conditions for the basic assumptions of the Ohlson valuation model hold, and then we relate these results with the fulfillment of the short-run econometric conditions for this model to be effective. Better future modeling motivated us to analyze to what extent the assumptions involved in this seminal model are not good enough approximations to solve the firm valuation problem, causing poor model performance. The model is based on the well-known dividend discount model and the residual income valuation model, and it adds a linear information model, which is a time series model by nature. Therefore, we adopt the time series approach. In…
On the origin of BAG(3) and its consequences for an expansion of BAG3's role in protein homeostasis
2021
The B-cell CLL 2-associated athanogene (BAG) protein family in general and BAG3, in particular, are pivotal elements of cellular protein homeostasis, with BAG3 playing a major role in macroautophagy. In particular, in the contexts of senescence and degeneration, BAG3 has exhibited an essential role often related to its capabilities to organize and remove aggregated proteins. Exciting studies in different species ranging from human, murine, zebrafish, and plant samples have delivered vital insights into BAG3s' (and other BAG proteins') functions and their regulations. However, so far no studies have addressed neither BAG3's evolution nor its phylogenetic position in the BAG family.
Le pouvoir royal (1814-1848). A la recherche du quatrième pouvoir ?
2021
This work sheds light on the representations of royal power that confronted each other until 1848 to fulfil the programme of reconciliation of the "two France" wanted by Louis XVIII. They are divided between the desire to return to the Ancien Régime and the attempt to renew the royal function. Opposed to the ultraroyalists, the supporters of this original path wished to consecrate liberal constitutionalism by resorting to an unexpected expedient, the power of the King, which had to be remodelled. As with Constant and Dunoyer, it was a question of creating a fourth power with its own essence and a new mission: to watch over the institutions. This regulating or preserving power produced a pas…
Observation of $e^{+}e^{-}\rightarrow\eta\psi(2S)$ at center-of-mass energies from 4.236 to 4.600 GeV
2021
Using a total of $5.25~{\rm fb}^{-1}$ of $e^{+}e^{-}$ collision data with center-of-mass energies from 4.236 to 4.600 GeV, we report the first observation of the process $e^{+}e^{-}\to \eta\psi(2S)$ with a statistical significance of $5\sigma$. The data sets were collected by the BESIII detector operating at the BEPCII storage ring. We measure the yield of events integrated over center-of-mass energies and also present the energy dependence of the measured cross section.
COVID-19 and oral lesions, short communication and review
2021
Background The COVID-19 disease first appeared in December 2019 in Wuhan, China. The World Health Organization (WHO) declared the pandemic in March 2020, with 40 million cases and a million deaths in October 2020. COVID-19 also includes manifestations on the skin and mucous mucosal membrane. Objective: To evaluate the prevalence of the oral lesions associated to COVID-19 disease; and evaluate their clinical presentation and the hypothesized etiology. Material and methods An electronic literature search was performed in PubMed, Scopus and Indice Medico Espanol databases. The following combination of keywords and Boolean operators were used: "COVID-19 AND oral manifestations"; "COVID-19 AND o…
Carbon sequestration in French agricultural soils: A spatial economic evaluation
2021
International audience; Soil organic carbon sequestration measures entail costs to farmers with different individual characteristics and located in different areas. A cost‐effective analysis taking into account these heterogeneities is crucial for developing effective public policy aimed at increasing carbon sequestration. We undertake such an analysis focusing on three soil organic carbon sequestration measures: no‐till, extension of temporary grasslands, and hedgerows. Through an optimization model applied to France, our results show that only extension of temporary grasslands can store carbon at low cost, though their potential for carbon sequestration is also low. For an ambitious carbo…
Adversarial reverse mapping of condensed-phase molecular structures: Chemical transferability
2021
Switching between different levels of resolution is essential for multiscale modeling, but restoring details at higher resolution remains challenging. In our previous study we have introduced deepBackmap: a deep neural-network-based approach to reverse-map equilibrated molecular structures for condensed-phase systems. Our method combines data-driven and physics-based aspects, leading to high-quality reconstructed structures. In this work, we expand the scope of our model and examine its chemical transferability. To this end, we train deepBackmap solely on homogeneous molecular liquids of small molecules, and apply it to a more challenging polymer melt. We augment the generator's objective w…