showing 36 of ~574560 from 574555 documents
Giant deep lobe parotid tumor removal via total parotidectomy without mandibulotomy. A simple and safe technique
2021
The transmandibular route is often combined with the transparotid-transcervical approach when extensive surgical field exposure is required, as in the case of deep parotid lobe tumors measuring over 4 cm in size. This procedure implies great morbidity and prolongs surgery time. Furthermore, in cases where additional lip division is performed, the aesthetic outcomes may be poorer. A description is made of the technique used for the removal of giant pleomorphic adenomas of the parapharyngeal space, without mandibulotomy. Key words:Parapharyngeal space tumor, pleomorphic adenoma, transcervical-transparotid approach, transmandibular approach.
Preparation of monolithic polymer-magnetite nanoparticle composites into poly(ethylene-co-tetrafluoroethylene) tubes for uses in micro-bore HPLC sepa…
2021
[EN] This paper describes the fabrication of a novel microbore monolithic column modified with magnetite nanoparticles (MNPs) prepared in a poly(ethylene-co-tetrafluoroethylene) (EFTE) tubing, and its application as stationary phase for the chromatographic separation of phosphorylated compounds. In order to obtain the composite column, a two-step procedure was performed. The formation of a glycidyl methacrylate-based monolith inside the activated ETFE tube was firstly carried out. Then, two incorporation approaches of MNPs in monoliths were investigated. The generic polymer was modified with 3-aminopropyltrimethoxysilane (APTMS) to be subsequently attached to MNP surfaces. Alternatively, AP…
Implementación de un panel de genes para el diagnóstico genético de la discinesia ciliar primaria
2021
Resumen Introduccion La discinesia ciliar primaria (DCP) es una enfermedad caracterizada por una alteracion en la estructura ciliar que impide el correcto aclaramiento de las secreciones respiratorias. Su diagnostico es complejo y se basa en una combinacion de tecnicas. El objetivo de este estudio fue disenar un panel de genes incluyendo todos los genes causantes conocidos y comprobar su utilidad diagnostica en una cohorte de pacientes espanoles. Metodos Estudio transversal multicentrico de pacientes con sospecha elevada de DCP, aplicando los criterios de la European Respiratory Society. Diseno de un panel de genes para secuenciacion masiva con la tecnologia de captura SeqCap EZ technology,…
Relationship between Thyroid Status during the First Trimester of Pregnancy and Neonatal Well-Being
2021
Iodine is an essential micronutrient for the synthesis of thyroid hormones. The proper functioning of the thyroid axis is essential for the normal development of the nervous system, especially in the first trimester of gestation. The aim of the present study was to analyze the perinatal outcomes, anthropometry, and APGAR test scores of newborns and to relate them to maternal thyroid status. A total of 190 newborns participated in the study. No correlation was found between thyroid stimulating hormone (TSH) and maternal ioduria values in the first trimester of gestation with the weight or length of the newborn, or the APGAR score at one minute after birth. However, we found significant diffe…
Ongoing Evolution in the Genus Crocus: Diversity of Flowering Strategies on the Way to Hysteranthy
2021
[EN] Species of the genus Crocus are found over a wide range of climatic areas. In natural habitats, these geophytes diverge in the flowering strategies. This variability was assessed by analyzing the flowering traits of the Spanish collection of wild crocuses, preserved in the Bank of Plant Germplasm of Cuenca. Plants of the seven Spanish species were analyzed both in their natural environments (58 native populations) and in common garden experiments (112 accessions). Differences among species observed in the native habitats were maintained under uniform environmental conditions, suggesting a genetic basis for flowering mechanisms. Two eco-morphological types, autumn- and spring-flowering …
Intranasal Insulin Administration to Prevent Delayed Neurocognitive Recovery and Postoperative Neurocognitive Disorder: A Narrative Review
2021
Delayed neurocognitive recovery and postoperative neurocognitive disorders are major complications of surgery, hospitalization, and anesthesia that are receiving increasing attention. Their incidence is reported to be 10–80% after cardiac surgery and 10–26% after non-cardiac surgery. Some of the risk factors include advanced age, level of education, history of diabetes mellitus, malnutrition, perioperative hyperglycemia, depth of anesthesia, blood pressure fluctuation during surgery, chronic respiratory diseases, etc. Scientific evidence suggests a causal association between anesthesia and delayed neurocognitive recovery or postoperative neurocognitive disorders, and various pathophysiologi…
Investigating the effect of residual stress on hydrogen cracking in multi-pass robotic welding through process compatible non-destructive testing
2021
Abstract In this paper, the effect of Welding Residual Stress (WRS) on the size and morphology of hydrogen-induced cracks (HIC) is studied. Four samples were manufactured using a 6-axis welding robot and in two separate batches. The difference between the two batches was the clamping system used, which resulted in different amounts of welding deformation and WRS. The hydrogen cracks were intentionally manufactured in the samples using a localised water-quenching method, where water was sprayed over a specific weld pass in a predetermined position. The Phased-Array Ultrasonic Testing (PAUT) system was implemented during the welding process (high-temperature in-process method), to detect the …
Intervención cognitivo conductual para mujeres con trastorno depresivo persistente: sintomatología ansiosa, depresiva y satisfacción vital
2021
Antecedentes. El trastorno depresivo persistente (TDP) es una afectación del estado de ánimo frecuente en mujeres. Se ha empleado la terapia cognitivo conductual (TCC), la terapia cognitiva basada en mindfulness y la terapia centrada en la compasión de forma aislada. Objetivos. Evaluar la eficacia de un programa de intervención grupal multicomponente. Método. Tras la firma del consentimiento informado, las participantes (n = 6) respondieron (pre, post intervención y seguimiento) cuestionarios sobre: ansiedad, depresión, satisfacción con la vida y satisfacción con la intervención. Resultados. Nuestros resultados previos al tratamiento muestran niveles elevados de sintomatología ansiosa y dep…
The Z(3985) as a threshold effect from the D¯s⁎D+D¯sD⁎ interaction
2021
Abstract We study the e + e − → K + ( D s ⁎ − D 0 + D s − D ⁎ 0 ) reaction recently measured at BESIII, from where a new Z c s state has been reported. We study the interaction of D ¯ s D ⁎ with the coupled channels J / ψ K − , K ⁎ − η c , D s − D ⁎ 0 , D s ⁎ − D 0 by means of an extension to the charm sector of the local hidden gauge approach. We find that the D s − D ⁎ 0 + D s ⁎ − D 0 combination couples to J / ψ K − and K ⁎ − η c , but the D s − D ⁎ 0 − D s ⁎ − D 0 combination does not. The coupled channels help to build up strength in the D s − D ⁎ 0 + D s ⁎ − D 0 diagonal scattering matrix close to threshold and, although the interaction is not strong enough to produce a bound state or…
Contribution à l’étude clinique des institutions de soins. Le fantasme de l’institution malfaisante
2021
Resume Cet article veut eclairer, a partir d’une recherche-action cooperative dans un CHU francais, une construction mentale inconsciente a la racine du phenomene de « paranoia institutionnelle » : le fantasme de l’« institution malfaisante ». Grâce a l’analyse thematique de plus de 80 entretiens au cours d’une enquete de terrain d’un an, nous montrons que le fantasme de l’institution malfaisante procede d’une triade d’elements constitutifs : 1) un flou concernant l’etablissement et l’incarnation de sa direction ; 2) la reconnaissance de la puissance symbolique de cet etablissement, notamment de son pouvoir de contrainte ; et 3) l’attribution par projections agressives d’intentions negative…
CT-Determined Maximum Pulmonary Artery to Ascending Aorta Diameter Ratio in Nonsevere COVID-19 Patients
2021
IGF2BP3 Associates with Proliferative Phenotype and Prognostic Features in B-Cell Acute Lymphoblastic Leukemia
2021
Simple Summary Although the prognosis of acute lymphoblastic leukemia (ALL) has improved significantly during the past decades, ALL remains a major cause of pediatric cancer mortality, and more accurate risk-stratification is required. We investigated IGF2BP3, which has previously been associated with aggressive cancers, and found high and subtype-specific expression of IGF2BP3 in B-cell ALL, that was associated with good outcome in high-risk patients. Results suggest that IGF2BP3 could be useful to improve stratification and prognosis of B-ALL. Abstract The oncofetal protein insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) belongs to a family of RNA-binding proteins involved i…
Hidden Strange Nonchaotic Attractors
2021
In this paper, it is found numerically that the previously found hidden chaotic attractors of the Rabinovich–Fabrikant system actually present the characteristics of strange nonchaotic attractors. For a range of the bifurcation parameter, the hidden attractor is manifestly fractal with aperiodic dynamics, and even the finite-time largest Lyapunov exponent, a measure of trajectory separation with nearby initial conditions, is negative. To verify these characteristics numerically, the finite-time Lyapunov exponents, ‘0-1’ test, power spectra density, and recurrence plot are used. Beside the considered hidden strange nonchaotic attractor, a self-excited chaotic attractor and a quasiperiodic at…
Entre l’université et l’école : la temporalité dans l’alternance en formation professionnelle en enseignement d’éducation physique
2021
International audience; Avec la professionnalisation de l’enseignement, l’alternance entre l’université et le milieu scolaire est devenue un impératif dans la formation initiale à l’enseignement en éducation physique. Dès lors, les stages ont vu leur durée s’allonger, tout en devenant incontournables pour le développement des compétences professionnelles. Grâce à des allers-retours entre le milieu scolaire et l’université, il s’agit de rapprocher deux espaces de formation ancrés dans des cultures et des organisations distinctes. Cet écart que l’on cherche à combler par l’alternance est à l’origine de plusieurs programmes de formation continue, qui cherchent à articuler les expériences et le…
Attosecond state-resolved carrier motion in quantum materials probed by soft x-ray XANES
2021
Recent developments in attosecond technology led to tabletop X-ray spectroscopy in the soft X-ray range, thus uniting the element- and state-specificity of core-level x-ray absorption spectroscopy with the time resolution to follow electronic dynamics in real time. We describe recent work in attosecond technology and investigations into materials such as Si, SiO2, GaN, Al2O3, Ti, TiO2, enabled by the convergence of these two capabilities. We showcase the state-of-the-art on isolated attosecond soft x-ray pulses for x-ray absorption near edge spectroscopy (XANES) to observe the 3d-state dynamics of the semi-metal TiS2 with attosecond resolution at the Ti L-edge (460 eV). We describe how the …
Periodic Table of the Elements, History, Education and Evaluation
2021
The periodic tables of transition metal thiophosphates MPS3, transition metal dichalcogenides MX2 and other materials, the origin of chemical elements and toxic trace elements in dried mushrooms are provided. The effective nucleus-electron attraction is proportional to the effective nuclear charge (Zeff) and inversely proportional to the effective principal quantum number (n*). The periodic arch is one of many modern visual displays that have been developed to augment the traditional periodic table of the chemical elements. The table is related to the multiparameter optimisation of N atom, nuclear magnetic resonance and everyday life. Educational activities were developed and evaluated. Se …
Exploring use of activity monitors for patients with obesity during weight-loss treatment - a qualitative study
2021
Background Obesity is a major health concern in western countries. In Norway, patients with obesity can attend weight-loss programmes, which focus on changes in dietary and physical activity habits. Use of self-monitoring is advocated when changing dietary and physical activity habits for adults with obesity. This study aimed to explore the experiences of patients with obesity who used activity monitors while attending a weight-loss programme. Methods Patients with body mass index (BMI) > 35 kg/m2 with weight related comorbidities or a BMI > 40 kg/m2 referred to an intermittent weight-loss programme were recruited into this study. They were introduced to one of three different activity moni…
Ehdotus ihmistä suhteellistavaksi sanastoksi
2021
”Ehdotus ihmistä suhteellistavaksi sanastoksi” käsittelee ja esittelee teoriasuuntausta, joka tunnetaan ”posthumanistisena”, keskittyen erityisesti sen käsitteisiin ja termeihin. Posthumanistinen ajattelu pyrkii käsitteelliseen uudistamiseen, jotta tunnistaisimme paremmin ne suhteellisuudet, joiden varassa ja lomassa ihmisten elämä ja merkitykset muotoutuvat – ja ne historiat, joissa ihminen on muotoutunut erilliseksi. Ehdotamme sanastoa, joka suhteellistaa juuri tätä käsitteellistä, kartesiolaisen humanismin ihmistä. Yhtäältä seuraamme käsitteellisen ajattelun muotoutumista erilaisten kontekstien paineissa, toisaalta pysähdymme tarkastelemaan tiettyjä, työskentelyssämme tärkeitä käsitteitä…
Implications of the EFSA Scientific Opinion on Site Directed Nucleases 1 and 2 for Risk Assessment of Genome-Edited Plants in the EU
2021
Genome editing is a set of techniques for introducing targeted changes in genomes. It may be achieved by enzymes collectively called site-directed nucleases (SDN). Site-specificity of SDNs is provided either by the DNA binding domain of the protein molecule itself or by RNA molecule(s) that direct SDN to a specific site in the genome. In contrast to transgenesis resulting in the insertion of exogenous DNA, genome editing only affects specific endogenous sequences. Therefore, multiple jurisdictions around the world have exempted certain types of genome-edited organisms from national biosafety regulations completely, or on a case-by-case basis. In the EU, however, the ruling of the Court of J…
Evaluation of training in guideline-oriented biopsychosocial management of low back pain in occupational health services:Protocol of a cluster random…
2021
Background To prevent low back pain (LBP) from developing into a prolonged disabling condition, clinical guidelines advocate early stage assessment, risk‐screening, and tailored interventions. Occupational health services recommend guideline‐oriented biopsychosocial screening and individualized assessment and management. However, it is not known whether training a limited number of health care professionals improves the management process. The primary objective of this study is to investigate whether training in the biopsychosocial practice model is effective in reducing disability. Furthermore, we aim to evaluate health‐economic impacts of the training intervention in comparison to usual m…
Dlk1 dosage regulates hippocampal neurogenesis and cognition
2021
Significance Generation of new neurons occurs normally in the adult brain in two locations: the subventricular zone (SVZ) in the walls of the lateral ventricles and the subgranular zone (SGZ) in the dentate gyrus (DG) of the hippocampus. Neurogenesis in the adult hippocampus has been implicated in cognitive functions such as learning, memory, and recovery of stress response. Imprinted genes are highly prevalent in the brain and have adult and developmental important functions. Genetic deletion of the imprinted gene Dlk1 from either parental allele shows that DLK1 is a key mediator of quiescence in adult hippocampal NSCs. Additionally, Dlk1 is exquisitely dosage sensitive in the brain with p…
Metal-Organic Frameworks as Versatile Heterogeneous Solid Catalysts for Henry Reactions
2021
Metal–organic frameworks (MOFs) have become one of the versatile solid materials used for a wide range of applications, such as gas storage, gas separation, proton conductivity, sensors and catalysis. Among these fields, one of the more well-studied areas is the use of MOFs as heterogeneous catalysts for a broad range of organic reactions. In the present review, the employment of MOFs as solid catalysts for the Henry reaction is discussed, and the available literature data from the last decade are grouped. The review is organized with a brief introduction of the importance of Henry reactions and structural properties of MOFs that are suitable for catalysis. The second part of the review dis…
Exploring the Effectiveness of Dialectical Behavior Therapy Versus Systems Training for Emotional Predictability and Problem Solving in a Sample of P…
2021
Dialectical behavior therapy (DBT) and systems training for emotional predictability and problem solving (STEPPS) are two treatment protocols for people with borderline personality disorder (BPD) that have received important empirical support. However, their possible differential effectiveness has not yet been studied. The objective of this study is to explore the effectiveness of these two treatment programs. A nonrandomized clinical trial was carried out in which both treatments were applied for six months. The sample consisted of 72 patients diagnosed with BPD. The results indicate that both groups experienced a statistically significant reduction in BPD symptom, emotional regulation, i…
Effect of Chronic Exercise Training on Blood Lactate Metabolism Among Patients With Type 2 Diabetes Mellitus : A Systematic Review and Meta-Analysis
2021
Purpose: To assess the effect of chronic exercise training on blood lactate metabolism at rest (i.e., basal lactate concentrations) and during exercise (i.e., blood lactate concentration at a fixed load, load at a fixed blood lactate concentration, and load at the individual blood lactate threshold) among patients with type 2 diabetes mellitus (T2DM).Methods: PubMed (MedLine), Embase, Web of Science, and Scopus were searched. Randomized controlled trials, non-randomized controlled trials, and case-control studies using chronic exercise training (i.e., 4 weeks) and that assessed blood lactate concentrations at rest and during exercise in T2DM patients were included.Results: Thirteen studies …
Computing temporal sequences associated with dynamic patterns on the C. elegans connectome
2021
AbstractUnderstanding how the structural connectivity of a network constrains the dynamics it is able to support is a very active and open area of research. We simulated the plausible dynamics resulting from the known C. elegans connectome using a recent model and theoretical analysis that computes the dynamics of neurobiological networks by focusing on how local interactions among connected neurons give rise to the global dynamics in an emergent way, independent of the biophysical or molecular details of the cells themselves. We studied the dynamics which resulted from stimulating a chemosensory neuron (ASEL) in a known feeding circuit, both in isolation and embedded in the full connectome…
Optimizing geometry of low-Q all-metal Fabry-Pérot microcavity for fluorescence spectroscopy
2021
Abstract Fluorescence spectroscopy is commonly employed to study the excited-state photophysics of organic molecules. Planar Fabry-Pérot microcavities play an essential role in such studies and a strategic cavity design is necessary to attain an enhanced light-matter interaction. In this work, we computationally study different geometries for a planar metallic Fabry-Pérot microcavity tuned for the absorption of Sulforhodamine 101, a typical dye for fluorescence spectroscopy. The cavity consists of a polymer layer enclosed between two silver mirrors, where the thicknesses of all the three layers are varied to optimize the cavity. Our transfer-matrix and finite-difference time-domain simulati…
A comment on “The growth of cognition: Free energy minimization and the embryogenesis of cortical computation”
2021
Thermo‐Hydro‐Mechanical Model and Caprock Deformation Explain the Onset of an Ongoing Seismo‐Volcanic Unrest
2021
Acknowledgments The authors are grateful to the Editor, Prof. Ben‐Zion Yehuda, and the reviewers: Prof. Micol Todesco and an anonymous reviewer, whose comments and recommendations have significantly improved the quality of this work. The authors acknowledge the financial support of the Petroleum Technology Development Fund (PTDF) Nigeria for this research. The comparison of our models with monitoring data was made possible by the outstanding efforts of the staff at the INGV‐Osservatorio Vesuviano, who provide weekly information about geophysical parameters at the Campanian volcanoes (http://www.ov.ingv.it/ov/en/bollettini/272-campi-flegrei-bollettini-settimanali.html). The authors are parti…
The Sources of Global Administrative Law
2021
International audience; The "Global administrative law" emerged in the United States in the mid-2000s as a research project aimed at observing and promoting the development of administrative-type norms beyond the state: transparency of international decision-making processes, motivation of decisions, emergence of appeals, etc. GAL's doctrine starts from the questionable assumption that classical international law, too stato-centric, would not allow the analysis of these phenomena. In particular, it rejects the notion of the source of law, but retains certain reflexes marked by classicism by excluding multinational companies from the reflection. An analysis of the limits of the GAL has there…
Implications of SARS-COV-2 infection in the diagnosis and management of the pediatric gastrointestinal disease
2021
AbstractGastrointestinal diseases such as celiac disease, functional gastrointestinal disorders (FGIDs), inflammatory bowel disease (IBDs) and acute or chronic diarrhea are quite frequent in the pediatric population. The approach, the diagnosis and management can be changed in the 2019 coronavirus disease (COVID-19) pandemic era. This review has focused on: i) the current understanding of digestive involvement in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected children and adolescents and the clinical implications of COVID-19 for pediatric gastroenterologists, ii) the impact of COVID-19 on the clinical approach to patients with pre-existing or onset diseases, including…
Phase error analysis of clipped waveforms in surface topography measurement using projected fringes
2021
Abstract When working with the method of projected fringes outside the optical laboratory one often encounters the problem of uncontrollable ambient light. This might cause saturation of the camera which in turn results in clipping of the fringes. Since standard theories describing phase-shifting techniques assume the projected fringes to be purely sinusoidal, such clipping will result in measurement error. In this paper a detailed analysis of this problem is given, and relations between phase errors, the amount of fringe clipping and the number of phase steps are found. Moreover, the phase difference between the clipped and the unclipped fringes is described. This investigation is based on…
Diversity of Omega Glutathione Transferases in mushroom-forming fungi revealed by phylogenetic, transcriptomic, biochemical and structural approaches
2021
International audience; The Omega class of glutathione transferases (GSTs) forms a distinct class within the cytosolic GST superfamily because most of them possess a catalytic cysteine residue. The human GST Omega 1 isoform was first characterized twenty years ago, but it took years of work to clarify the roles of the human isoforms. Concerning the kingdom of fungi, little is known about the cellular functions of Omega glutathione transferases (GSTOs), although they are widely represented in some of these organisms. In this study, we re-assess the phylogeny and the classification of GSTOs based on 240 genomes of mushroom-forming fungi (Agaricomycetes). We observe that the number of GSTOs is…
Case report : partial uniparental disomy unmasks a novel recessive mutation in the LYST gene in a patient with a severe phenotype of Chediak-Higashi …
2021
Síndrome de Chédiak-Higashi; LYST; Disomia uniparental Síndrome de Chédiak-Higashi; LYST; Disomía uniparental Chédiak-Higashi syndrome; LYST; Uniparental disomy Chédiak-Higashi syndrome (CHS) is a rare autosomal recessive (AR) immune disorder that has usually been associated to missense, nonsense or indels mutations in the LYST gene. In this study, we describe for the first time the case of a CHS patient carrying a homozygous mutation in the LYST gene inherited as a result of a partial uniparental isodisomy (UPiD) of maternal origin. Sanger sequencing of the LYST cDNA and single nucleotide polymorphism (SNP)-arrays were performed to identify the causative mutation and to explain the molecul…
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2021
This article explores Finnish different-sex couples’ (n = 12) negotiations on their parental division of labour. Theoretically, the article is based on the literature on gendered parenting practices and relational negotiations. Our discourse analysis reveals how the couples produced ‘togetherness’ and ‘our family’ by representing their care practices as agreements, irrespective of whether the care was described as equally shared or distinctly gendered. Disagreements reflecting more individualistic tones, and mainly resulting from the mothers’ sense of unfairness, were especially foregrounded when the distribution of household duties was discussed. The analysis also revealed how men cited in…
Editorial – Preface to the Special Issue on Numerical Techniques Meet with OR
2021
Abstract This special issue of the Foundations of Computing and Decision Sciences, titled ”Numerical Techniques Meet with OR”, is devoted to the numerical techniques and their applications in real-world phenomena. The special issue and its editorial present numerical algorithms as they meet with different research topics such as, e.g., from operational research, supply chain management, geometrical structures and Covid-19 effects on financial applications. Besides, the special issue covers instructional information about numerical techniques which are useful for OR research problems and real-world applications on such issues.
Measuring diversity. A review and an empirical analysis
2021
Abstract Maximum diversity problems arise in many practical settings from facility location to social networks, and constitute an important class of NP-hard problems in combinatorial optimization. There has been a growing interest in these problems in recent years, and different mathematical programming models have been proposed to capture the notion of diversity. They basically consist of selecting a subset of elements of a given set in such a way that a measure based on their pairwise distances is maximized to achieve dispersion or representativeness. In this paper, we perform an exhaustive comparison of four mathematical models to achieve diversity over the public domain library MDPLIB, …