showing 36 of ~574560 from 574555 documents
Prevalence and correlates of depression during the COVID-19 pandemic and the major role of stigmatization in low- and middle-income countries: A mult…
2021
Highlights • There are significant differences on the prevalence of depression between the four LMICs. • Stigmatization related to COVID-19, but not exposure to COVID-19 was the strongest predictor of depression. • Resilience was a protective factor for DR Congo and Togo. • Younger age, gender (female), and exposure and stigmatization related to Covid-19, and resilience were associated with depression in the pooled data.
Investigation on four centuripe vases (late 3rd-2nd cent. B.C.) by portable X-ray fluorescence and total reflectance-FTIR
2021
Abstract Four Centuripe vases dated back to the late 3rd-2nd centuries B.C. were analysed using imaging under visible and ultra-violet illumination as well as complementary non-invasive and non-destructive portable X-Ray Fluorescence (XRF) and Total Reflectance – Fourier Transform InfraRed (TR-FTIR) spectroscopies. The vases are of great importance since they represent a rare expression of the Hellenistic vase painting. Four specimens, a “pyxis”, a “lebes gamikos” and two “lekanides” decorated with figures of different type, are exhibited in the Antonino Salinas Archaeological Museum in Palermo-Italy. The investigation was aimed to identify the used pigments and the painting technique, to r…
Documento de consenso sobre asma y tabaquismo del Foro Autonómico de Asma de la SEPAR
2021
La prevalencia de tabaquismo activo en adultos con asma es similar a la de la población general. El tabaquismo se asocia con un peor control clínico de la enfermedad, una disminución acelerada de la función pulmonar y una respuesta irregular a la terapia con glucocorticoides. El consumo de tabaco impacta negativamente en la calidad de vida de los pacientes asmáticos y provoca un incremento en el número de visitas y de hospitalizaciones por exacerbaciones. Además, el tabaquismo aumenta el riesgo de cáncer de pulmón, comorbilidades cardiovasculares y muerte en pacientes asmáticos. A pesar de todo ello, las guías actuales del manejo del asma no incluyen recomendaciones específicas para el mane…
Hydrogeochemical changes during managed aquifer recharge (MAR) in a salinised coastal aquifer
2021
15 p. - Supplementary data to this article can be found online at https://doi.org/10.1016/j.apgeochem.2020.104866. - The data used to support the findings of this study are available from http://repositori.uji.es/xmlui/handle/10803/620641.
Measuring diversity. A review and an empirical analysis
2021
Abstract Maximum diversity problems arise in many practical settings from facility location to social networks, and constitute an important class of NP-hard problems in combinatorial optimization. There has been a growing interest in these problems in recent years, and different mathematical programming models have been proposed to capture the notion of diversity. They basically consist of selecting a subset of elements of a given set in such a way that a measure based on their pairwise distances is maximized to achieve dispersion or representativeness. In this paper, we perform an exhaustive comparison of four mathematical models to achieve diversity over the public domain library MDPLIB, …
Type 2 Diabetes Mellitus and COVID-19: A Narrative Review
2021
The pandemic of coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has involved more than one hundred million individuals, including more than two million deaths. Diabetes represents one of the most prevalent chronic conditions worldwide and significantly increases the risk of hospitalization and death in COVID-19 patients. In this review, we discuss the prevalence, the pathophysiological mechanisms, and the outcomes of COVID-19 infection in people with diabetes. We propose a rationale for using drugs prescribed in patients with diabetes and some pragmatic clinical recommendations to deal with COVID-19 in this kind of patient.
Financial Behaviour Under Economic Strain in Different Age Groups: Predictors and Change Across 20 Years
2021
AbstractThe present study examined the multiple micro- and macro-level factors that affect individuals’ financial behaviour under economic strain. The following sociodemographic and economic factors that predict financial behaviour were analysed: age group, year of data gathering, and attitudes towards consumption (economical, deprived, and hedonistic). Subjective financial situations and demographic characteristics were controlled for. Finnish time series data that consisted of five cross-sectional nationally representative surveys were used (n = 10 043). The analyses revealed four types of financial behaviour: cutting expenses, borrowing, increasing income, and gambling. Young adults aged…
Von der KI-Ethik zur Bewusstseinsethik: Ethische Aspekte der Computational Psychiatry
2021
Zusammenfassung Ziel Ermittlung ethischer Probleme, die sich aus KI-Forschung und Computational Psychiatry für die psychiatrische Forschung und Praxis ergeben. Methode Begriffliche Analyse und Diskussion ethisch relevanter Projekte innerhalb der Computational Psychiatry. Ergebnisse Die Computational Psychiatry verspricht v. a. einen Beitrag zur Verbesserung von Diagnostik und Therapie(-prognosen). Ethische Probleme betreffen u. a. den Umgang mit Datenschutz, Folgen für unser Selbstverständnis sowie das Risiko der Biologisierung und der Vernachlässigung des bewussten Erlebens. Schlussfolgerung Es ist erforderlich, sich jetzt mit möglichen Anwendungen der KI und Computational Psychiatry zu be…
Improved centrifugal and hyperfine analysis of ND2H and NH2D and its application to the spectral line survey of L1544
2021
Abstract Quantifying molecular abundances of astrochemical species is a key step towards the understanding of the chemistry occurring in the interstellar medium. This process requires a profound knowledge of the molecular energy levels, including their structure resulting from weak interactions between nuclear spins and the molecular rotation. With the aim of increasing the quality of spectral line catalogs for the singly- and doubly-deuterated ammonia (NH2D and ND2H), we have revised their rotational spectra by observing many hyperfine-resolved lines and more accurate high-frequency transitions. The measurements have been performed in the submillimeter-wave region (265–1565 GHz) using a fr…
Synthesis, X-Ray Structure, Tautomerism Aspect, and Chemical Insight of The 3-(1H-Indol-2-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-ol
2021
The 3-(1H-indol-2-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-ol 2 was obtained exclusively in the enol configuration starting from triazolyl-indole derivative 1 and alkyl halo-esters in the presence of K2CO3. Chemical structure elucidations with the aid of physicochemical characterizations were used to predict its molecular structure while single crystal X-ray diffraction technique was used to shed the light on the supramolecular structure of 2. DFT calculations agreed very well with the reported X-ray structure where the most stable form thermodynamically is the enol form. Its optimized geometry agreed very well with the experimental structure where the correlation coefficients betwe…
Evaluación de los trabajadores por los clientes: Reputación digital y Reglamento General de Protección de Datos de la UE
2021
La evaluacion de los trabajadores por parte de los clientes y empleadores y su publicacion en internet plantean retos en el ordenamiento juridico actual de la Union Europea (UE). Los trabajadores sometidos a tales evaluaciones estan expuestos a un grado de vigilancia de su trabajo mucho mas intenso que los trabajadores tradicionales. El fenomeno surge a partir de la adopcion de una perspectiva del cliente, que trata de hacer el trabajo observable en todo momento sin costo para la empresa. El autor analiza a este respecto el Reglamento General de Proteccion de Datos de la Union Europea, que establece restricciones muy especificas en cuanto a la recopilacion y publicacion de informacion sobre…
Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study
2021
Background: To date, 750 000 patients with COVID-19 worldwide have required mechanical ventilation and thus are at high risk of acute brain dysfunction (coma and delirium). We aimed to investigate the prevalence of delirium and coma, and risk factors for delirium in critically ill patients with COVID-19, to aid the development of strategies to mitigate delirium and associated sequelae. Methods: This multicentre cohort study included 69 adult intensive care units (ICUs), across 14 countries. We included all patients (aged ≥18 years) admitted to participating ICUs with severe acute respiratory syndrome coronavirus 2 infection before April 28, 2020. Patients who were moribund or had life-suppo…
Forward dijets in proton-nucleus collisions at next-to-leading order: the real corrections
2021
Using the CGC effective theory together with the hybrid factorisation, we study forward dijet production in proton-nucleus collisions beyond leading order. In this paper, we compute the "real" next-to-leading order (NLO) corrections, i.e. the radiative corrections associated with a three-parton final state, out of which only two are being measured. To that aim, we start by revisiting our previous results for the three-parton cross-section presented in our previous paper. After some reshuffling of terms, we deduce new expressions for these results, which not only look considerably simpler, but are also physically more transparent. We also correct several errors in this process. The real NLO …
Vegetation Diversity of Screes and Taluses of The Pamir and South-Western Tian Shan in Middle Asia
2021
AbstractThis paper presents the results of phytosociological research on scree vegetation of the Pamir and south-western Tian Shan. We collected 222 phytosociological relevés during field studies conducted in 2015–2019, applying the Braun-Blanquet approach. We identified 21 plant communities on mobile and stabilized screes of colluvial cones, aprons and fans, inhabiting mainly the montane and alpine belts in several ranges (e.g. Peter the First, Alichur, Shugnan, Shachdarian, Darvaz, Rushan, Vanch, Fergana, Kyrgyz and Terskey ranges). As a result we provide the first comprehensive hierarchical syntaxonomic synopsis of scree communities at montane and alpine elevations in the eastern Middle …
The Safety of Slaughterhouse Workers during the Pandemic Crisis
2021
The working conditions in a slaughterhouse are difficult because of the low temperatures, high humidity, and little natural light. Therefore, in these facilities, there is a high demand in the maintenance of strict hygiene rules. Lately, the new SARS-CoV-2 pandemic situation has brought new challenges in the meat industry, as this sector has to maintain its operability to supply the meat and meat products demanded by the consumers. In this challenging period, the safety of the workers is as important as keeping the high demands for the safety of the meat and meat products along with consumer confidence. This paper aims to give an overview of the risks associated with the SARS-CoV-2 virus tr…
Implications of the EFSA Scientific Opinion on Site Directed Nucleases 1 and 2 for Risk Assessment of Genome-Edited Plants in the EU
2021
Genome editing is a set of techniques for introducing targeted changes in genomes. It may be achieved by enzymes collectively called site-directed nucleases (SDN). Site-specificity of SDNs is provided either by the DNA binding domain of the protein molecule itself or by RNA molecule(s) that direct SDN to a specific site in the genome. In contrast to transgenesis resulting in the insertion of exogenous DNA, genome editing only affects specific endogenous sequences. Therefore, multiple jurisdictions around the world have exempted certain types of genome-edited organisms from national biosafety regulations completely, or on a case-by-case basis. In the EU, however, the ruling of the Court of J…
Oh, wait, O8 de Sitter may be unstable!
2021
We analyze the stability of four-dimensional de Sitter vacua constructed by compactifying massive Type IIA supergravity in the presence of two O8 sources [1]. When embedded in String Theory the first source has a clear interpretation as an O8$_-$ plane, but the second one could correspond to either an O8$_+$ plane or to an O8$_-$ plane with 16 D8-branes on top. We find that this latter solution has a tachyonic instability, corresponding to the D8-branes moving away from the O8$_-$ plane. We comment on the possible ways of distinguishing between these sources.
A deeper look into natural sciences with physics-based and data-driven measures
2021
Summary With the development of machine learning in recent years, it is possible to glean much more information from an experimental data set to study matter. In this perspective, we discuss some state-of-the-art data-driven tools to analyze latent effects in data and explain their applicability in natural science, focusing on two recently introduced, physics-motivated computationally cheap tools—latent entropy and latent dimension. We exemplify their capabilities by applying them on several examples in the natural sciences and show that they reveal so far unobserved features such as, for example, a gradient in a magnetic measurement and a latent network of glymphatic channels from the mous…
Factors Differentiating Rural and Urban Population in Determining Anxiety and Depression in Patients with Chronic Cardiovascular Disease: A Pilot Stu…
2021
The aim of this cross-sectional study was to analyze selected variables differentiating rural from urban populations, as well as identify potentially increased levels of depression and anxiety in patients with chronic cardiovascular disease. The study was carried out in 193 patients. The study used the Camberwell Assessment of Need Short Appraisal Schedule (CANSAS), the Health Behavior Inventory Questionnaire (HBI), the WHOQOL-BREF Quality of Life Questionnaire, and the Hospital Anxiety and Depression Scale–Modified Version (HADS-M). Spearman’s rank correlation coefficient test and logistic regression were used for analyses. In rural patients, we observed a relationship between anxiety and …
Replicating consumer value scales: A comparative study of EVS and PERVAL at a cultural heritage site
2021
Abstract PERVAL (PERceived VALue) scale has been frequently replicated and adapted in tourism to measure consumer value; however, EVS (Experiential Value Scale) better reflects the experiential nature of tourism consumption. Focusing on a famous cultural heritage site in France (Chambord castle), this research compares PERVAL and EVS by replicating them as concisely as possible. The results of a quantitative survey of 402 visitors show the similarities and dissimilarities between these two scales regarding their psychometric properties, predictive ability, practicality, and actionability. In contrast to a literature review (favoring PERVAL scale for tourism), this research underlines the co…
Prevalence of pathogenic copy number variants among children conceived by donor oocyte.
2021
AbstractDevelopment of assisted reproductive technologies to address infertility has favored the birth of many children in the last years. The majority of children born with these treatments are healthy, but some concerns remain on the safety of these medical procedures. We have retrospectively analyzed both the fertilization method and the microarray results in all those children born between 2010 and 2019 with multiple congenital anomalies, developmental delay and/or autistic spectrum disorder (n = 486) referred for array study in our center. This analysis showed a significant excess of pathogenic copy number variants among those patients conceived after in vitro fertilization with donor …
Epidemiology, Clinical Features and Prognostic Factors of Pediatric SARS-CoV-2 Infection: Results From an Italian Multicenter Study
2021
Background: Many aspects of SARS-CoV-2 infection in children and adolescents remain unclear and optimal treatment is debated. The objective of our study was to investigate epidemiological, clinical and therapeutic characteristics of pediatric SARS-CoV-2 infection, focusing on risk factors for complicated and critical disease.Methods: The present multicenter Italian study was promoted by the Italian Society of Pediatric Infectious Diseases, involving both pediatric hospitals and general pediatricians/family doctors. All subjects under 18 years of age with documented SARS-CoV-2 infection and referred to the coordinating center were enrolled from March 2020.Results: As of 15 September 2020, 75…
A systematic literature review of the transition to the circular economy in business organizations: Obstacles, catalysts and ambivalences
2021
There is a need for a transition from unsustainable linear business models to a more sustainable circular approach, called the circular economy. To promote this need, a deeper understanding of which issues hinder organizations’ transition to the circular economy and which ones catalyse it is needed. A systematic literature review was performed on the business implementation of the circular economy and 69 articles covering the topic were found. The review identifies different types of catalyst, obstacles and ambivalent factors influencing circular economy implementation in business. This study contributes to research on circular economy implementation at business organizations by providing u…
Effects of a Teaching Personal and Social Responsibility Model Intervention in Competitive Youth Sport
2021
The aim of this study was to implement the teaching personal and social responsibility (TPSR) model in a competitive context analyzing the differences between the intervention and the control group on personal and social responsibility, prosocial behaviors, and self-efficacy in youth soccer players. Participants were 34 youth soccer players between the ages of 14 and 16 years old (15.18 ± 0.72) divided into two different soccer teams of 17 members, corresponding to the control and intervention groups. The implementation of the TPSR model took place during 9 months, including initial and ongoing coach training (3 months), program implementation (three sessions per week lasting 90 min during …
Quantity and Quality of Aquaculture Enrichments Influence Disease Epidemics and Provide Ecological Alternatives to Antibiotics
2021
Environmental heterogeneity is a central component influencing the virulence and epidemiology of infectious diseases. The number and distribution of susceptible hosts determines disease transmission opportunities, shifting the epidemiological threshold between the spread and fadeout of a disease. Similarly, the presence and diversity of other hosts, pathogens and environmental microbes, may inhibit or accelerate an epidemic. This has important applied implications in farming environments, where high numbers of susceptible hosts are maintained in conditions of minimal environmental heterogeneity. We investigated how the quantity and quality of aquaculture enrichments (few vs. many stones
The 40-Year Mystery of Insect Odorant-Binding Proteins
2021
International audience; The survival of insects depends on their ability to detect molecules present in their environment. Odorant-binding proteins (OBPs) form a family of proteins involved in chemoreception. While OBPs were initially found in olfactory appendages, recently these proteins were discovered in other chemosensory and non-chemosensory organs. OBPs can bind, solubilize and transport hydrophobic stimuli to chemoreceptors across the aqueous sensilla lymph. In addition to this broadly accepted “transporter role”, OBPs can also buffer sudden changes in odorant levels and are involved in hygro-reception. The physiological roles of OBPs expressed in other body tissues, such as mouthpar…
Evidences on alterations in skeleton composition and mineralization in a site-attached fish under naturally acidified conditions in a shallow CO2 vent
2021
Abstract Background Ocean acidification may affect fish mineralized structures (i.e. otoliths and skeleton). Methods Here, we compared the elemental composition of muscle and skeleton and the mineral features of skeleton in the site-attached fish Gobius bucchichi naturally exposed to high pCO2/low pH conditions in a shallow CO2 vent with fish of the same species exposed to normal pH. Results Overall, no skeleton malformations were found in both pH conditions, but among-site differences were found in the elemental composition. Interestingly, higher Ca/P values, inducing a moderate skeleton maturation, were found in fish exposed to acidified conditions than in controls. Conclusion Our finding…
A genealogy of technocritics
2021
International audience
Tight Junctions as a Key for Pathogens Invasion in Intestinal Epithelial Cells
2021
Tight junctions play a major role in maintaining the integrity and impermeability of the intestinal barrier. As such, they act as an ideal target for pathogens to promote their translocation through the intestinal mucosa and invade their host. Different strategies are used by pathogens, aimed at directly destabilizing the junctional network or modulating the different signaling pathways involved in the modulation of these junctions. After a brief presentation of the organization and modulation of tight junctions, we provide the state of the art of the molecular mechanisms leading to permeability breakdown of the gut barrier as a consequence of tight junctions’ attack by pathogens, including…
Project-based learning in a computer modelling course
2021
AbstractThe paper reports authors’ experience of implementing educational projects in a computer modelling course offered to the students majoring in “Secondary Education (Computer Science)” at Ternopil Volodymyr Hnatiuk National Pedagogical University. We analyze approaches to teaching mathematical and computer modelling such as: integration of modelling tasks, naturalistic case study, using of role-playing games, possibilities of STEM-education, motivation and positive attitude to modelling training, etc. Then we illustrate the implementation of the project to study the population dynamics of the grape snail Helix pomatia. The implementation of the project splits into several stages: form…
Within the symbolic world of the prehistoric hunters: A GIS-based and 3D model analysis of sites with complexes of linear incisions in western Sicily
2021
Abstract The prehistoric peopling of Sicily has left scattered traces of symbolic activities through well-known rock art expressions in caves and rock shelters located all around the island (among the most significant, the sites of Addaura, Racchio and Genovese). A peculiar phenomenon is the incision of linear signs, often grouped on the same rocky walls, hidden in fissures or placed at the entrance of the underground chambers of caves. In this report, we investigate a sample of these graphic expressions from a spatial and technical point of view. A GIS-based approach presents the territorial pattern providing insight, on a macroscale, into the intentional positioning of the sign complexes.…
The Sources of Global Administrative Law
2021
International audience; The "Global administrative law" emerged in the United States in the mid-2000s as a research project aimed at observing and promoting the development of administrative-type norms beyond the state: transparency of international decision-making processes, motivation of decisions, emergence of appeals, etc. GAL's doctrine starts from the questionable assumption that classical international law, too stato-centric, would not allow the analysis of these phenomena. In particular, it rejects the notion of the source of law, but retains certain reflexes marked by classicism by excluding multinational companies from the reflection. An analysis of the limits of the GAL has there…
Preparation of monolithic polymer-magnetite nanoparticle composites into poly(ethylene-co-tetrafluoroethylene) tubes for uses in micro-bore HPLC sepa…
2021
[EN] This paper describes the fabrication of a novel microbore monolithic column modified with magnetite nanoparticles (MNPs) prepared in a poly(ethylene-co-tetrafluoroethylene) (EFTE) tubing, and its application as stationary phase for the chromatographic separation of phosphorylated compounds. In order to obtain the composite column, a two-step procedure was performed. The formation of a glycidyl methacrylate-based monolith inside the activated ETFE tube was firstly carried out. Then, two incorporation approaches of MNPs in monoliths were investigated. The generic polymer was modified with 3-aminopropyltrimethoxysilane (APTMS) to be subsequently attached to MNP surfaces. Alternatively, AP…
Materiali argillosi ibridi con potenziale attività biologica
2021
The Role of Vitamin D as a Biomarker in Alzheimer’s Disease
2021
Vitamin D and cognition is a popular association, which led to a remarkable body of literature data in the past 50 years. The brain can synthesize, catabolize, and receive Vitamin D, which has been proved to regulate many cellular processes in neurons and microglia. Vitamin D helps synaptic plasticity and neurotransmission in dopaminergic neural circuits and exerts anti-inflammatory and neuroprotective activities within the brain by reducing the synthesis of pro-inflammatory cytokines and the oxidative stress load. Further, Vitamin D action in the brain has been related to the clearance of amyloid plaques, which represent a feature of Alzheimer Disease (AD), by the immune cell. Based on the…
Habilidades matemáticas tempranas en niños chilenos con Trastorno del Desarrollo del Lenguaje: Un estudio comparativo
2021
En las últimas décadas se ha incrementado el interés de las investigaciones respecto a las dificultades académicas que presentan los niños con Trastorno del Desarrollo del Lenguaje (TDL). No obstante, su relación con las habilidades matemáticas es una de las menos estudiadas. El objetivo de este estudio consistió en determinar si existen diferencias relevantes entre las habilidades matemáticas tempranas de niños con TDL y con desarrollo típico (DT). Participaron 78 niños de 4 a 7 años 11 meses de edad, pertenecientes a colegios con programas de integración escolar de Santiago de Chile. Se conformó un grupo de 44 niños con TDL y un grupo de 34 con DT. Se establecieron comparaciones del rendi…