showing 36 of ~574560 from 574555 documents
Onset of effect and impact on health-related quality of life, exacerbation rate, lung function, and nasal polyposis symptoms for patients with severe…
2021
Background: ANDHI was done to assess the efficacy of benralizumab, including onset of effect and impact on health-related quality of life (HRQOL), exacerbation rate, lung function, and nasal polyposis symptoms. Methods: This phase 3b, randomised, double-blind, parallel-group, placebo-controlled ANDHI study was completed in adults (aged 18–75 years) with severe eosinophilic asthma with at least 2 exacerbations in the previous year, despite high-dose inhaled corticosteroid plus additional controllers, screening blood eosinophil counts of at least 150 cells per μL, and an Asthma Control Questionnaire 6 (ACQ-6) score of 1·5 or more. Patients who met eligibility criteria were randomly assigned (…
Two-Step Digital Follow-up of Patients at High Risk for Melanoma: a Retrospective Analysis of 152 Patients
2021
Antecedentes: La dermatoscopia digitalizada (DD) ha demostrado mejorar la precisión en el diagnóstico del melanoma (MM) en pacientes de alto riesgo. La combinación de DD y fotografía corporal total (FCT) puede facilitar la detección de nuevas lesiones o la aparición de cambios macroscópicos precoces en lesiones previamente registradas. Objetivos: El objetivo del presente estudio fue determinar el número de biopsias necesarias para diagnosticar un MM y, las características clínicas y dermatoscópicas asociadas al diagnóstico de melanoma en pacientes en seguimiento, mediante DD y FCT, de lesiones pigmentadas. Pacientes y métodos: Se realizó un estudio retrospectivo de 152 pacientes con elevado…
Influence of oscillating main flow on separation efficiency in asymmetrical flow field-flow fractionation.
2021
The steadily rising interest in the investigation of interactions between nanomaterials and biological media has also led to an increasing interest in asymmetrical flow field-flow fractionation (AF-FFF). The biggest strength of AF-FFF is the possibility to alter the flow profiles to suit a specific separation problem. In this paper, the influence of an oscillating main flow on the separation efficiency of AF-FFF is investigated. Such oscillations can e.g. be caused by the main pump To investigate the influence of such flow conditions on the separation efficiency in AF-FFF systematically, different oscillation profiles were applied and their influence on the elution profile and the retention…
The Relevance of Dual Tasking for Improving Trunk Muscle Endurance After Back Surgery
2021
Abstract Objective To determine the effect of dual tasking on trunk muscle endurance in patients after lumbar diskectomy. Design Cross-sectional study. Setting Rehabilitation hospital setting. Participants Individuals (N=14) undergoing primary lumbar diskectomy. Intervention Using a randomized design on 2 separate days, muscle endurance was evaluated during prone bridging and Biering-Sorensen tests. Each test was randomly performed under 2 cognitive conditions: single task without cognitive condition and self-regulated dual task (ie, mathematical task). Main Outcome Measures The primary outcomes were time to failure and pain assessed by the visual analog scale from 0 to 100 mm. The secondar…
MUC4 is overexpressed in idiopathic pulmonary fibrosis and collaborates with transforming growth factor β inducing fibrotic responses.
2021
Several mucins are implicated in idiopathic pulmonary fibrosis (IPF); however, there is no evidence regarding the role of MUC4 in the development of IPF. Here we demonstrated that MUC4 was overexpressed in IPF patients (n = 22) compared with healthy subjects (n = 21) and located in pulmonary arteries, bronchial epithelial cells, fibroblasts, and hyperplastic alveolar type II cells. Decreased expression of MUC4 using siRNA–MUC4 inhibited the mesenchymal/myofibroblast transformations of alveolar type II A549 cells and lung fibroblasts, as well as cell senescence and fibroblast proliferation induced by TGF-β1. The induction of the overexpression of MUC4 increased the effects of TGF-β1 on mesen…
Scaffolding patterns of dialogic exchange in toddler classrooms
2021
The present study investigates how often episodes of dialogic exchange can be identified in educator–toddler interactions during play and emerging academic activities, what kind of scaffolding strategies educators use during the episodes of dialogic exchange and, ultimately, what kind of scaffolding patterns of dialogic exchange can be identified based on educators' use of scaffolding strategies. Educator–child interactions were video-recorded in seven European countries, in two toddler classrooms in each country. The video recordings of emerging academic and play activities were transcribed and analysed, combining the principles of theory and a data-driven content analysis. First, 69 episo…
A nonlinear mixed model approach to predict energy expenditure from heart rate.
2021
Abstract Objective. Heart rate (HR) monitoring provides a convenient and inexpensive way to predict energy expenditure (EE) during physical activity. However, there is a lot of variation among individuals in the EE-HR relationship, which should be taken into account in predictions. The objective is to develop a model that allows the prediction of EE based on HR as accurately as possible and allows an improvement of the prediction using calibration measurements from the target individual. Approach. We propose a nonlinear (logistic) mixed model for EE and HR measurements and an approach to calibrate the model for a new person who does not belong to the dataset used to estimate the model. The …
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2021
Abstract Applying social investment theory (SIT), we examined whether employment trajectories until midlife, with differential investments in education and employment, are associated with social investments during early life and with work-related well-being in midlife, with a special reference to potential differences between self-employment and paid work. In the Northern Finland Birth Cohort 1966 (n = 6496; 2963 men, 3533 women), life-history calendars from age 16–45 were used to determine the respondents’ yearly employment statuses (student, full-time employee, part-time employee, self-employed, unemployed, on parental leave, on sabbatical leave or otherwise not working). Latent class ana…
The Use of Online Training Tools in Competition Cyclists During COVID-19 Confinement in Spain
2021
COVID-19 confinement has supposed a challenge to the whole wide world, especially in athletes that have frustrated their expectations about training programs and competitions. Specifically, competition cyclists during confinement had lot of difficulties to train due to the need to train outside their homes. However, the increase of online training sessions, or virtual training tools could help to overcome training difficulties due to confinement although there are not studies that analyse the effects of using these types of tools in cyclists. This study aims to test how the use of online training tools in competition cyclists during confinement is related to training frequency and duration,…
Implicaciones de la COVID-19 sobre el marketing de servicios educativos: un estudio desde las motivaciones y estados de ánimo de universitarios en Co…
2021
Este estudio analizó las implicaciones que tiene la pandemia en la aplicación del marketing de servicios educativos en instituciones de educación superior en Colombia; en particular, se revisaron las implicaciones asociadas con las motivaciones por estudiar y los estados de ánimo presentes en los estudiantes. Para ello, se realizó un estudio empírico en cinco universidades, que recogió las opiniones de 695 estudiantes. Primero, se realizó un análisis factorial exploratorio y luego un análisis clúster. Los resultados evidenciaron las diferentes dificultades que se presentaron en la aplicación del marketing, desde la perspectiva estudiantil. Como resultado, el estudio sugiere algunas recomend…
P40.04 Knowledge, Attitudes and Perception of Lung Cancer Screening Among Smoking Soft-Ware Professionals in India
2021
The Sources of Global Administrative Law
2021
International audience; The "Global administrative law" emerged in the United States in the mid-2000s as a research project aimed at observing and promoting the development of administrative-type norms beyond the state: transparency of international decision-making processes, motivation of decisions, emergence of appeals, etc. GAL's doctrine starts from the questionable assumption that classical international law, too stato-centric, would not allow the analysis of these phenomena. In particular, it rejects the notion of the source of law, but retains certain reflexes marked by classicism by excluding multinational companies from the reflection. An analysis of the limits of the GAL has there…
Using System Dynamics modelling to frame environmental voluntary commitment programs: the French experience
2021
This study stems from a research project aimed at investigating the factors facilitating and hampering the success of the EVE (Engagements Volontaires pour l’Environnement) program recently launched in France. Similarly to other countries, in which successfully environmental voluntary commitment programs are currently in place (SmartWay in the USA), EVE program aspires to improve transport operators efficiency and to reduce CO2 emissions in the environment. However, the multiple relationships between public and private actors involved in the program (ranging from the program coordinator to transport organisations), the complexity of transport and logistics sector (including the differences …
Salt and Aroma Compound Distributions Influence Flavour Release and Temporal Perception While Eating Hot-Served Flans.
2021
International audience; To counteract the negative effect of salt overconsumption on health, strategies have been developed to reduce the salt content in food products. Among them, two promising strategies based on odour-induced saltiness enhancement and the heterogeneous distribution of flavour compounds were combined and assessed in four-layer cream-based snacks. To investigate the relationship between saltiness enhancement, temporal release and perception of flavour compounds in hot snacks with heterogeneous distribution of salt and aroma compounds, complementary techniques were used: nose space PTR-Tof-MS (Proton Transfer Reaction-Time of Flight–Mass Spectrometry) to assess the release …
Thermal response test analysis for U-pipe vertical borehole heat exchangers under groundwater flow conditions
2021
[EN] Conventional models used in the analysis of thermal response test data only consider conduction as heat transfer mechanism. In cases where presence of groundwater is detected, convection heat transmission plays an important role, so its influence must be determined in the calculation of the effective thermal conductivity, usually overestimated in these situations, increasing its value the higher the power injected and the time elapsed. In this work, based on the data collected in a borehole located at UPV (Valencia) in which have been carried out three thermal response tests with different characteristics, has been implemented a variation of the finite line source model introducing an …
Single-Element Reflective Digital Holographic Microscopy
2021
Digital holographic microscopy (DHM) is a well-known microscopy technique using an interferometric architecture for quantitative phase imaging (QPI) and it has been already implemented utilizing a large number of interferometers. Among them, single-element interferometers are of particular interest due to its simplicity, stability, and low cost. Here, we present an extremely simple common-path interferometric layout based on the use of a single one-dimensional diffraction grating for both illuminating the sample in reflection and generating the digital holograms. The technique, named single-element reflective digital holographic microscopy (SER-DHM), enables QPI and topography analysis of r…
The emissions reduction potential of substituting short-haul flights with non-high-speed rail (NHSR): The case of Finland
2021
Abstract Replacing short-haul flights with high-speed rail (HSR) has been widely discussed as one solution to mitigate the climate change impacts of aviation. However, although HSR can provide travel times similar to those provided by short-haul flights, and at lower emission levels, it also requires considerable investments in time and infrastructure to build. Instead, this study considers the feasibility of replacing short-haul flights with existing non-high-speed rail (NHSR). Our study is based in Finland, a country that has an extensive route network of short-haul flights but does not possess any HSR. We compared all 16 city pairs for which short-haul flights are offered with existing N…
Phase error analysis of clipped waveforms in surface topography measurement using projected fringes
2021
Abstract When working with the method of projected fringes outside the optical laboratory one often encounters the problem of uncontrollable ambient light. This might cause saturation of the camera which in turn results in clipping of the fringes. Since standard theories describing phase-shifting techniques assume the projected fringes to be purely sinusoidal, such clipping will result in measurement error. In this paper a detailed analysis of this problem is given, and relations between phase errors, the amount of fringe clipping and the number of phase steps are found. Moreover, the phase difference between the clipped and the unclipped fringes is described. This investigation is based on…
Une aventure conjointe
2021
International audience
Perimenopausal women show modulation of excitatory and inhibitory neuromuscular mechanisms.
2021
Background Menopausal transition exposes women to an early decline in muscle force and motor function. Changes in muscle quality and function, especially in lower limbs, are crucial, as they expose individuals to increased risk of falls. To elucidate some of the related neuromuscular mechanisms, we investigated cortical inhibition and peripheral muscle twitch force potentiation in women during the early and late stages of perimenopause. Methods Participants were 63 women aged 48–55 years categorized as early (EP, n = 25) or late (LP, n = 38) perimenopausal according to serum follicle-stimulating hormone (FSH) levels and menstrual diaries. EP women had an irregular menstrual cycle and FSH 2…
Sensory reweighting in frail aged adults: Are the balance deficiencies mainly compensated by visual or podal dependences?
2021
Abstract Background Postural control is based on the integration of different sensory inputs. The process of scaling the relative importance of these sensory cues (visual, vestibular and proprioceptive) depends on individuals and creates sensory preferences, leading to sensory dependences when one particular source is preponderant. In this context, the literature showed a frequent visual dependence (visual inputs weighting) in aged adults. However, the somaesthetic inputs can also be prioritised in a podal-dependent profile. In the frail aged adults, none study has shown the distribution of these two dependences. Research question Which sensory orientation profile is preferentially adopted …
Successful Foley catheter tamponade of an epigastric vessel trocar injury in a toddler – A case report
2021
Highlights • Epigastric vessel injury is a well recognized complication during laparoscopic trocar placement. • Precautionary measures to prevent trocar induced injuries should be implemented to lower the incidence of this complication. • If this complication is encountered, tamponade by Foley catheter placement is an effective measure to provide hemostasis. • Hemorrhage control using a Foley catheter is feasible even in small children and toddlers.
Oral tissues regeneration using intraoral mesenchymal stem cells
2021
Background Oral pathologies or some treatments can cause facial and functional alterations, being fundament to retrieve those functions restoring the original anatomy of the lost tissues. On this purpose, various techniques have been studied, one of these was the tissue engineering. Mesenchymal stem cells (MSC) are multipotent adult stem cells. The MSC in the oral cavity have been striking for regenerative therapies by its high plasticity, good interaction with scaffolds and growth factors, good proliferation and differentiation, they are also easy to obtain. Objective: The objective of this study was to describe the current uses of the intraoral MSC for the regeneration of the tissues of t…
Correction to: The dysregulated innate immune response in severe COVID-19 pneumonia that could drive poorer outcome
2021
Although immune modulation is a promising therapeutic avenue in coronavirus disease 2019 (COVID-19), the most relevant targets remain to be found. COVID-19 has peculiar characteristics and outcomes, suggesting a unique immunopathogenesis.Thirty-six immunocompetent non-COVID-19 and 27 COVID-19 patients with severe pneumonia were prospectively enrolled in a single center, most requiring intensive care. Clinical and biological characteristics (including T cell phenotype and function and plasma concentrations of 30 cytokines) and outcomes were compared.At similar baseline respiratory severity, COVID-19 patients required mechanical ventilation for significantly longer than non-COVID-19 patients …
Exploring Relationships Between Anthropometry, Body Composition, Maturation, and Selection for Competition: A Study in Youth Soccer Players
2021
PurposeThe purpose of this study was to analyze variations of selection for competition between late and early mature players and test the relationships between anthropometry, body composition, maturation, and selection for competition.MethodsSeventy-nine youth soccer players from under-11 to under-14 participated in this study, over 6 months. Body composition and maturity offset were estimated based on anthropometric data collected. Participants were also monitored for their number of matches as starters and time of play accrued in minutes.ResultsMinutes played had large correlation coefficients with maturity offset (r = 0.58), and leg length and sitting height interaction (r = 0.56). Mult…
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2021
Abstract Research-based discussions about 21st-century skills are currently needed; 21st-century skills refer to skills that today's students are expected to possess for successful future careers. The ways students perceive these skills or what kind of dispositions they have in this regard are significant. This paper provides an overview of the development of pre-service teachers' perceived 21st-century skills and dispositions. The quantitative data was collected in three phases during 2014, 2015, and 2016 at three Finnish universities. The number of respondents at each measurement point varied from 209 to 267. Data were analysed using latent growth curve modeling. The study focuses on stud…
Clinical Development of Mepolizumab for the Treatment of Severe Eosinophilic Asthma: On the Path to Personalized Medicine.
2021
The development of mepolizumab, an anti-IL-5 monoclonal antibody for the treatment of severe eosinophilic asthma, is an example of a clinical development program that evolved over time based on sound, basic scientific principles. Initial clinical data on the effects of mepolizumab on lung function in a general asthmatic population were disappointing. However, it became clear that mepolizumab may be more effective against other clinical endpoints, particularly asthma exacerbations, in patients with more severe disease. Furthermore, a developing understanding of asthma disease pathobiology led to the identification of an appropriate target population and predictive biomarker for mepolizumab t…
Powered by assemblage : language for multiplicity
2021
Abstract Assemblage is one way to examine complexities in today’s world. In Deleuzian thinking, assemblage refers to both the act of assembling diverse elements and the arrangements of these elements for a specific purpose. Importantly, it is the interaction between elements that allows the assemblage to become more than the sum of its parts. Applying this concept to long-term research on Cold Rush – the transformation of the Arctic commons into commodities – I argue that examining the boom, bust, and buzz around the commons can be fruitfully conceptualised and studied with assemblage. This approach brings with it an ontological shift from binaries into multiplicities and multiple temporali…
Evaluating the effects of forest tree species on rill detachment capacity in a semi-arid environment
2021
Abstract The beneficial effects of plant roots in decreasing soil detachment in forest ecosystems exposed to rill erosion are well known. However, these effects vary largely between different plant species. There has been lots of research into the relationship between root-soil systems and rill erodibility with a particular focus on grass species. Conversely, fewer studies are available for tree species, especially in forests of semi-arid or arid environments. Greater knowledge is therefore needed to identify the most effective tree species against rill erosion in these ecosystems, where water availability is the limiting factor for vegetation growth and afforestation is often the only solu…
Multilingualism and Ethnic Prejudice
2021
Abstract. This study explored the relationship between the ability to talk to others in more than one language and ethnic prejudice, considering the quality and quantity of intergroup contact. A structural equation model analysis was carried out on a sample of 631 Italian citizens. The results showed that multilingualism led to an increase of acceptance of intergroup differences and positive attitudes toward Moroccans and that the quality (but not quantity) of intergroup contact-mediated those relationships. The mediating role of the quality of intergroup contact extends previous results on the relationship between multilingualism and positive attitudes toward ethnic out-groups. These find…
Worry about COVID-19 contagion and general anxiety: Moderation and mediation effects of cognitive emotion regulation
2021
The global pandemic caused by coronavirus disease 2019 (COVID-19) occasioned that most of the population in Spain was confined to home to reduce the risk of contagion. This affected mental health, increasing anxiety and worry about COVID-19 contagion. The aim of this study was assessing the moderation and mediation effect of cognitive emotion regulation strategies (CERS) on general anxiety and whether the mediation effect was moderated by gender and/or age. A total of 1753 Spanish adults (78,6% female; M = 40.4 years, SD = 12.9) participated in an online survey that was available from March 26 to April 25 (2020) during the time period in which the population in Spain was confined. Participa…
Perioperative diaphragm point-of-care ultrasound as a prediction tool of postoperative respiratory failure in high-risk patients: A feasibility study…
2021
Abstract Introduction Respiratory muscle function in the postoperative period is a key to whether a patient develops Postoperative Respiratory Failure (PRF) or not. PRF occurs when the gas exchange does not meet metabolic needs. Ipsilateral paralysis of the hemidiaphragm after interscalenic brachial plexus block (ISB) causes an acute reduction of respiratory muscle function. This reduction does not cause PRF when the contralateral hemidiaphragm generates enough gas exchange to meet metabolic demands. Objectives To study the evolution of hemidiaphragmatic muscle function during the perioperative period with diaphragmatic ultrasound (D-POCUS), and use it as an innovative tool to predict PRF, …
Facilitators and inhibitors of organic food buying behavior
2021
Abstract Consumption patterns across the globe indicate consumers’ rising interest in purchasing organic food due to increasing personal-health consciousness. However, research on organic food shows a low translation of this interest into stated preferences for purchasing organic food. Limited academic research has explored this puzzling buying behavior of consumers, particularly in developed economies such as Japan. Our study addresses this gap by examining the factors that facilitate or inhibit Japanese consumers’ buying behavior toward organic food. We use the Stimulus-Organism-Response framework, Innovation Resistance Theory, and Dual-Factor Theory to examine these factors by analyzing …
Global epidemiology of coronavirus disease 2019 and lessons for effective control of this and future pandemics
2021
Barely 1 year after severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was first reported in China, the virus has infected approximately 120 million people, caused around 3 million deaths, and adversely affected the global economy Despite stringent measures to flatten the epidemiologic curve of the pandemic, there have been spikes and waves of the infection in many countries, particularly in the American, European, and Asian continents This review critically evaluated the global epidemiology of the novel coronavirus disease 2019 (COVID-19) to provide advice on other possible ways of managing the disease as various COVID-19 vaccines are being rolled out To effectively control this …
Rasch Analysis of Authentic Evaluation of Young Children's Functioning in Classroom Routines.
2021
This study evaluated the functioning of children in early childhood education classroom routines, using the 3M Functioning in Preschool Routines Scale. A total of 366 children aged 36 to 70 months and 22 teachers from six early childhood education centers in Spain participated in the study. The authors used the Rasch model to determine the item fit and the difficulty of the items in relation to children's ability levels in this age range. The Rasch Differential Item Functioning (DIF) analysis by child age groups showed that the item difficulty differed according to the children's age and according to their levels of competence. The results of this study supported the reliability and validit…
Gaze Parameters in the Analysis of Ambiguous Geometric Shapes.
2021
This study explores perceptual organisation and shape perception when viewing a tetragon and an additional element (a dot) that is located at varying positions and distances next to the tetragon. The aim of the study is to determine the factors that can alter the interpretation of object configuration and impact whether the presented tetragon is perceived as a diamond or a square. Methods used in this study are a forced-choice task as a subjective measurement and eye tracking as an objective measurement of perceptual processes. Overall, 31 stimuli were presented to the participants: a tetragon in two different sizes with an additional element (a dot) located inside or outside the object at…