Comparison of Paroxetine and Maprotiline in Minor Depression

1994

Whilst the efficacy of paroxetine has been demonstrated in MDD, its clinical utility in minor depression has not been established. This study assesses the antidepressant efficacy of paroxetine in patients meeting RDC criteria for minor depression. All patients scored 13 points on the 17-item Hamilton Depression Rating Scale (HAMD) at baseline. After a 3 day washout period, patients were randomised to receive paroxetine 20–40mg/day or maprotiline 100-150mg/day, dose being titrated according to clinical response after 3 weeks treatment at the lower doses. Assessments conducted at baseline (day 0) and at weekly intervals for 6 weeks included the 17-item HAMD, the Montgomery-Asberg Depression R…

Purification of a cytochrome aa3 terminal oxidase from protoplast membrane vesicles of Micrococcus luteus

1994

Abstract A cytochrome aa 3 terminal oxidase was isolated from protoplast membrane vesicles of Micrococcus luteus grown under aerobic conditions. The purified complex showed similarities to cytochrome c oxidase (EC 1.9.3.1) of the electron transport chain of mitochondria and many prokaryotes. The enzyme was solubilized by subsequent treatment with the detergents CHAPS and n- dodecyl -β- d - maltoside and purified by ion-exchange chromatography using poly- l -lysine agarose and TMAE-fractogel-650 (S) columns, followed by hydroxyapatite chromatography. The purified complex is composed of two major subunits with apparent molecular masses of 54 and 32 kDa. After purification the isolated enzyme …

Significance of IgG and IgM HCV antibody secretion in vitro in patients with chronic hepatitis C: correlation with disease activity and response to i…

1994

Hepatitis C virus antibodies are found in the serum of most patients with chronic hepatitis C. However, the significance of the humoral response is still uncertain. In this study, in vitro IgG and IgM anti-hepatitis C virus secretion by peripheral blood mononuclear cells of patients with chronic hepatitis C was analyzed. Peripheral-blood mononuclear cells from 21 of 36 patients (58.3%) secreted IgG anti-hepatitis C virus in vitro, as demonstrated with anti-hepatitis C virus—specific enzyme immunoassays and recombinant immunoblot assays. Ten of the 36 patients (27.8%) showed both IgG and IgM anti-hepatitis C virus core in vitro. In 9 of these 10 patients, IgM anti-hepatitis C virus was also …

Secretion and Metabolism of Ecdysteroids by Oenocyte-Fat Body Complexes (OEFC) in Adult Males of Gryllus bimaculatus DEG (Insecta)

1994

Extracts of whole adult males of Gryllus bimaculatus show distinct maxima of free ecdysteroids on the 8th, 12th and 14th day after imaginal moult at a breeding temperature of 25 °C. Isolated OEFC of 11 days old males secrete in vitro free as well as conjugated ecdysteroids, although the latter predominate. The bulk of free ecdysteroids seem s to consist of E and 20 E according to their retention times in two HPLC systems. Apart from the polar ones, apolar m etabolites appear during incubation. By esterase the apolar metabolites are mostly split into polar ones, partly into 20 E and E. Further treatment of the polar metabolites with helicase leads again to E and 20 E. OEFC transform [3H]E pr…

Antimony-121 Mössbauer spectra of organoantimony derivatives containing Sb-Sb bonds

1994

121-Sb Mossbauer data are reported for a number of organoantimony rings and catena-stibanes. These compounds are representative of RSb(Sb)2 and R2SbSb type of coordination, and spectral parameters are compared and discussed in relation to RSbCl2 and R2SbCl systems. Although the trend in isomer shift is similar, the present compounds show slightly less negative isomer shift values together with a remarkable reduction of the quadrupolar coupling constant. A rationalization of the quadrupolar interaction in the above series of compounds appears feasible by using point charge model calculations whose results, in terms of bonding, indicate a large contribution of p-electron density along Sb-Sb b…

How to control stock markets

1994

This paper provides a different approach to the analysis of imperfect stock markets. The model we are concerned with is described by the interaction of three institutional classes of agents (the specialist trader, the professional trader and the non-professional trader), sharing different information. The dynamical discrete-time system obtained can be changed into a second-order linear difference equation forced by the fundamental value of the specialist trader. Using typical tools of control theory, we study the behaviour of the professional trader’s fundamental value influenced by the specialist’s one. © 1994 Taylor & Francis Group, LLC.

Ambulatory blood pressure monitoring in normotensive children

1994

OBJECTIVE To assess reference values of ambulatory blood pressure in normotensive children. SUBJECTS AND DESIGN Twenty-four-hour non-invasive ambulatory blood pressure monitoring (ABPM) was carried out in 241 healthy normotensive children aged from 6 to 16 years (126 boys, mean +/- SD age 11.2 +/- 2.7 years; 115 girls, mean +/- SD age 10.9 +/- 2.9 years). The subjects were subdivided into three age-sex groups: 6-9, 10-12 and 13-16 years. SETTING Primary care. MAIN OUTCOME MEASURES ABPM was performed using an oscillometric device (SpaceLabs model 90207) and appropriate cuff size during a regular school day. Blood pressure was measured every 20 min from 0600 to 2400 h, and thereafter every 30…

NEONATAL CAPSAICIN TREATMENT DOES NOT PREVENT SPLANCHNIC VASODILATATION IN PORTAL-HYPERTENSIVE RATS

1994

It has been suggested that the peripheral sensory neurons are involved in the splanchnic hemodynamic changes of portal hypertension. Therefore the influence of permanent ablation of sensory neurons by neonatal capsaicin pretreatment (50 mg/kg, subcutaneously) on the development of the hyperdynamic splanchnic circulation in portal-hypertensive rats was studied. In adulthood, portal hypertension was induced with partial portal vein ligation. In study 1, systemic and splanchnic hemodynamics were measured by means of a radiolabeled-microsphere technique in portal-hypertensive rats, under ketamine anesthesia, pretreated with capsaicin or vehicle. Mean arterial pressure, heart rate, cardiac index…

Low-Temperature Optical Spectroscopy of Native and Azide-Reacted Bovine Cu,Zn Superoxide Dismutase. A Structural Dynamics Study

1994

The optical absorption spectra of native and N(3-)-reacted Cu,Zn superoxide dismutase (SOD) has been studied in the temperature range 300-10 K. The broad d-d bands observed in the room temperature spectrum, centered at 14,700 cm-1 (native enzyme) and at 15,550 cm-1 (N(3-)-reacted enzyme), are clearly split at low temperature into two bands each, centered at 12,835 and 14,844 cm-1 and at 14,418 and 16,300 cm-1, respectively. The thermal behavior of the 23,720 cm-1 band present in the spectrum of the native enzyme indicates that this band belongs to the His61-->Cu(II) ligand to metal charge transfer transition. Analysis of the zeroth, first, and second moments of the various bands as a functi…

Kavapyrone enriched extract fromPiper methysticum as modulator of the GABA binding site in different regions of rat brain

1994

Regional differences in the modulation of [3H] muscimol binding to GABAA receptor complexes by kavapyrones, compounds of the rhizome of the plant Piper methysticum which possess sedative activity, were demonstrated using membrane fractions obtained from target brain centers of kavapyrone action: hippocampus (HIP), amygdala (AMY) and medulla oblongata (MED), and from brain centers outside the main kavapyrone effects as frontal cortex (FC) and cerebellum (CER). The kava extract enhanced the binding of [3H] muscimol in a concentration-dependent manner with maximal potentiation of 358% over control in HIP followed by AMY and MED (main target brain centers). Minimal stimulation was observed in C…

First spatial isotopic separation of relativistic uranium projectile fragments

1994

Abstract Spatial isotopic separation of relativistic uranium projectile fragments has been achieved for the first time. The fragments were produced in peripheral nuclear collisions and spatially separated in-flight with the fragment separator FRS at GSI. A two-fold magnetic-rigidity analysis was applied exploiting the atomic energy loss in specially shaped matter placed in the dispersive central focal plane. Systematic investigations with relativistic projectiles ranging from oxygen up to uranium demonstrate that the FRS is a universal and powerful facility for the production and in-flight separation of monoisotopic, exotic secondary beams of all elements up to Z = 92. This achievement has …

Equazioni monodimensionali di un gas viscoso barotropico con una perturbazione poco regolare

1994

Si considerino le equazioni di un gas viscoso barotropico in una dimensione spazialedν=(μ(ϱνe)e−pe)dt+dG,ϱt+ϱ2νe=0,p=ϱγ con una perturbazionedG sotto l’ipotesi cheG sia una funzione a variazione limitata inL2(Θ) o inH01 (Θ) (Θ=]0, α[) e si dimostrano l’esistenza e l’unicita della soluzione globale in una classe di soluzioni di «tipo forte» ed in una di «tipo debole». Questo risultato costituisce una generalizzazione del risultato di Kazhikhov [8] e di Shelukhin [10] e contiene osservazioni preliminari per le corrispondenti equazioni stocastiche.

Magnetic ordering in Fe-doped Gd2 BaCuO5

1994

The structural and magnetic properties of iron-doped Gd2BaCuO5 have been studied by X-ray diffractometry, Mossbauer spectroscopy and susceptibility measurements. Mossbauer data on Gd2BaCu0.8Fe0.2O5 show that at room temperature Fe is not magnetically ordered, displaying hyperfine parameters similar to those generally assigned to Fe at Cu(2) sites in the GdBa2(Cu1−x; Fe; x; )3O7 superconductor. Susceptibility measurements demonstrate that Gd2BaCu1−x; Fe; x; O5 behaves like a three-dimensional antiferromagnet withT; N=11.9±0.1 K, independent ofx. The effective magnetic moment calculated within a mean field approximation is consistent with an ordering of the Gd sublattice.

Tromboembolismo pulmonar y síndrome nefrótico: utilidad de la angiografía por resonancia magnética

1994

The Mössbauer effect and collective motions in glass-forming liquids and polymeric networks

1994

Glass-forming liquids, synthetic polymers and biopolymers share essential properties. Dynamic processes in these complex systems are characterized by cooperative motions with wide distributions of time scales, which manifest themselves in broad quasielastic lines in the Mossbauer spectrum. In this article, the application of the Mossbauer effect to the study of structural dynamics in complex systems is discussed.

Analysis of type-restricted and cross-reactive epitopes on virus-like particles of human papillomavirus type 33 and in infected tissues using monoclo…

1994

A panel of six monoclonal antibodies recognizing at least three different antigenic regions has been raised against the L1 major capsid protein of human papillo-mavirus type 33 (HPV-33), which is associated with cervical carcinoma. The antigenic sites defined by these antibodies have been mapped and classified as type-restricted or broadly cross-reactive using bacterially expressed L1 fusion proteins of a variety of HPV types. Conformational and linear epitopes have been distinguished using native and denatured virus-like particles. HPV infection of genital lesions has been analysed using both monoclonal antibodies and DNA amplification by PCR. The antibodies obtained should be useful to pr…

Pressure‐induced widths and shifts for the ν3 band of methane

1994

International audience; Widths and shifts of methane lines perturbed by nitrogen are calculated using a complex-valued implementation of Robert-Bonamy (RB) theory. The static intermolecular potential is described as a sum of electrostatic forces and Lennard-Jones (6-12) atom-atom terms, using literature values for all physical parameters. Vibrational dependence of the isotropic potential is obtained from the polarizability of methane assuming a dispersion interaction. The repulsive part of the Lennard-Jones accounts for the greatest part of widths, while dispersion interactions are largely responsible for shifts. Although the average error between calculated and observed linewidths (up to J…

MOLECULAR BASIS OF DRUG PHOTOTOXICITY: PHOTOSENSITIZED CELL DAMAGE BY THE MAJOR PHOTOPRODUCT OF TIAPROFENIC ACID

1994

Tiaprofenic acid is a photosensitizing nonsteroidal anti-inflammatory drug, whose major photoproduct (decarboxytiaprofenic acid) is also a potent photosensitizer. Because of the lack of the carboxylate moiety, this photoproduct is more lipophilic and might bind more efficiently to cell membranes, thereby causing phototoxic damage. To verify the feasibility of this hypothesis, we have prepared the 3H-labeled analogs of tiaprofenic acid and its photoproduct and examined the binding, persistence and phototoxicity of the photoproduct using poorly metabolizing (fibroblasts) and actively metabolizing cells (hepatocytes). The photoproduct of tiaprofenic acid accumulates in both cell types as it is…

An AM1 study on π-facial selectivity in Diels-Alder reactions of 2-aza-1, 3-dienes with azodienophiles

1994

Abstract A theoretical study of the π-facial selectivity in Diels-Alder reactions of chloro derivatives of 2-aza-1,3-dienes with azodienophiles has been carried out using the semiempirical AM1 method. Three transition structures for the model reaction of the diene 3 with the dienophile 4 were located. The Diels-Alder reaction of the non-substituted 2-aza-1,3-diene 6 with the trans -diimide was studied. All transition structures located show an important asynchronicity and the calculations reveal the presence of stereoelectronic effects. The predicted stereoselectivity is in agreement with the experimental evidence.

Medical and occupational preconditions for vibration-induced spinal disorders: occupational disease no. 2110 in Germany.

1994

The current state of scientific knowledge of the biodynamic behaviour of the vertebral column under the influence of whole-body vibration whilst sitting and results from epidemiological studies caused the medical board of experts on occupational health of the Federal Ministry of Labour in Germany to add a new occupational disease to the official list of occupational diseases. The occupational disease “diseases of the lumbar spine from disc degeneration caused by long-term (mainly vertical) whole-body vibration exposure” has been introduced. The medical preconditions with the symptoms and the diagnostic methods are presented. With regard to the occupational preconditions for the acknowledgem…

The kinetics of F-center aggregation under irradiation: many-particle effects in ionic solids

1994

The accumulation kinetics of primary Frenkel defects created in solids under permanent irradiation is calculated using the microscopic formalism of many-particle densities. It is based on the Kirkwood superposition approximation for three-particle densities as described in our previous paper p. N. Kuzovkov and E. A. Kotomin, Physica Scripta 47, 585 (1993)l. This formalism is generalized in this paper by incorporating the elastic attraction between similar defects (called in ionic solids F-centers) which causes their efficient aggregation. It is shown that the aggregation process starts only if the dose rate and elastic attraction energy exceed certain critical values; it also happpens in th…

Evaluation of multiple-scattering contribution in extended X-ray absorption fine structure for MO4 and MO6 clusters

1994

Abstract We present a theoretical ab initio evaluation of the multiple-scattering contribution in the extended X-ray absorption fine structure for MO4 and MO6 clusters with M = Mg, Ca, Mn, Zn, Se, Sr, Mo, Ag, Te, Ba, Nd, Tb, W, Au or Bi. The dependence of the multiple-scattering signal on the absorber type, the photoelectron angular momentum and the local distortion is discussed. It is shown that the multiple-scattering contribution is significant in the photoelectron wave-vector range up to 6–7 A−1 and strongly depends on both the path geometry and the atomic species involved in the scattering process.

Photoluminescence of chromium(III)-doped silicoaluminophosphate with AFI structure

1994

The distribution of stock returns: international evidence

1994

Although financial theory rests heavily on the normality assumption, daily stock returns display significant departures from normality. Different researchers have proposed alternative distributions. In this paper, the distribution of stock returns is examined in six stock markets. The empirical distributions present common features and are best represented by Student's t-distribution, while several alternative distributions are rejected.

A possible inflammatory reaction in a lateral neck cyst (branchial cyst) because of odontogenic infection

1994

Abstract We present the case of a woman who suffered from an acutely infected diffuse mass in the right neck. This mass had grown rapidly after difficult extraction of a tooth. Histologic analysis of the excised material revealed a lateral neck cyst with a lymph node that showed signs of an acute inflammation near the cyst. These findings support the theory that a preexisting lateral neck cyst may be “activated” by an intraoral inflammation. The different theories of the origin of lateral neck cysts are presented and discussed in the context of the case description.

p-Brauer characters ofq-defect 0

1994

For ap-solvable groupG the number of irreducible Brauer characters ofG with a given vertexP is equal to the number of irreducible Brauer characters of the normalizer ofP with vertexP. In this paper we prove in addition that for solvable groups one can control the number of those characters whose degrees are divisible by the largest possibleq-power dividing the order of |G|.

Centromeric heterochromatin and satellite DNA in the Chironomus plumosus species group

1994

Species of the Chironomus plumosus group display significant differences in their amount of centromeric heterochromatin. A tandem-repetitive satellite-like DNA has been isolated from C. plumosus. This DNA accounts for a major part of the centromeric heterochromatin. The DNA element has a Sau3AI restriction site ("Sau elements") and a monomer length of 165 or 166 bp. It is A-T rich (73%) and reveals a moderate DNA curvature, as shown by gel migration and computer analysis. The chromosomal localization and genomic organization of Sau elements were studied in 24 Chironomus species by in situ hybridization and (or) Southern analysis. The DNA is predominantly located in the centromeric regions …

Neck trouble in machine operating, dynamic physical work and sedentary work: a prospective study on occupational and individual risk factors.

1994

A prospective study on the effects of occupational and individual factors on neck trouble was carried out among 1832 men representing static work with whole-body vibration (machine operators), dynamic physical work (construction carpenters) and sedentary work (office workers). Neck trouble and occupational and individual factors were inquired about via postal questionnaires in 1984 and 1987. Machine operating was associated with an increased risk to contract severe neck trouble, and machine operating and dynamic physical work were associated with persistently severe neck trouble. Other predictors for contracting severe neck trouble were age and current smoking. Physical exercise decreased t…

A resorcinol derived calix[5]arene with C5-symmetry

1994

Abstract Condensation of 2,4-dihydroxy-3-hydroxymethyl benzophenone (4) in dioxane/H2SO4 gave the cyclic pentamer 5, a calix[5]arene with regular incorporation of the resorcinol units via their 2- and 6-positions. The structure follows from the 1H NMR and mass spectra and was further confirmed by single crystal X-ray analysis. Dynamic NMR in C2D2Cl4 gave a surprisingly high barrier of ΔG‡ = 17.3 kcal/mol for the cone-to-cone ring inversion.

Substituted methyl 5β-cholan-24-oates II.13C NMR spectral assignment

1994

The 13C NMR spectra were recorded and assigned for nine derivatives of methyl 5β-cholan-24-oates (esters of bile acids) including hydroxy, oxo and/or acetyloxy groups. Assignments were based on the empirical substituent-induced chemical shifts (SCS), spectral comparison with compounds of similar structure, distortionless enhancement by polarization transfer (DEPT) and proton coupled 13C NMR measurements.

Immunoglobulin-like domain is present in the extracellular part of the receptor tyrosine kinase from the marine sponge Geodia cydonium.

1994

We have isolated and characterized two cDNAs from the marine sponge Geodia cydonium coding for a new member of a receptor tyrosine kinase of class II. The deduced amino acid sequence shows two characteristic domains: (i) the tyrosine kinase domain; and (ii) and immunoglobulin-like domain. The latter part shows high homology to the vertebrate C2 type immunoglobulin domain. This result demonstrates that immunoglobulin domains are not recent achievements of higher animals but exist also in those animals which have diverged from other organisms about 800 million years ago.

57Fe and119Sn Mössbauer investigations on some substituted barium hexaferrites

1994

57Fe and119Sn Mossbauer measurements have been carried out on powder samples of three differently substituted M-type barium hexaferrites. By57Fe Mossbauer measurements in an external magnetic field applied parallel to the γ-ray direction, we found a canted spin structure for all samples. Furthermore, we detected a strong preference of the Sn4+ ions for the 4f2 sites. From57Fe Mossbauer measurements aboveT N, we conclude that the substitution does not influence the 2b sites. The analysis of the magnetically split119Sn Mossbauer spectra at room temperature in the case of the Co-Sn and Zn-Sn substituted samples shows a strong difference between the two. The spectra were interpreted due to the …

Mechanism of the cardiovascular activity of laudanosine: comparison with papaverine and other benzylisoquinolines.

1994

1. The activity of (+/-)-laudanosine, a benzyltetrahydroisoquinoline alkaloid, was investigated in pithed rats and rat isolated aorta. Its effects on [3H]-(+)-cis-diltiazem and [3H]-nitrendipine binding to rat cerebral cortical membranes, and on the different molecular forms of cyclic nucleotide phosphodiesterases (PDE) isolated from bovine aorta were investigated. 2. The dose-response curve to methoxamine (3-300 micrograms kg-1, i.v.) in normotensive pithed rats was shifted to the right by (+/-)-laudanosine, 3 and 6 mg kg-1. 3. (+/-)-Laudanosine inhibited in a concentration-dependent manner the contractile responses evoked by noradrenaline (NA 1 microM), depolarizing solution (KCl 80 mM) o…

High Levels Of Interferon-  In Boutonneuse Fever

1994

Sustained elimination of hepatitis B virus from serum induced in a patient with chronic hepatitis B and advanced human immunodeficiency virus infecti…

1994

A 48-year-old male patient was admitted with acquired immunodeficiency syndrome (stage III, Centers for Disease Control 1993) and viremic hepatitis B. Blood CD4 count was 15/microliters. Discontinuation of prednisolone, previously prescribed by the patient's family practitioner because of elevated liver enzymes, resulted in severe hepatitis (alanine aminotransferase > 300U/l). Administration of interferon-alpha (9 x 10(6) U s.c. 3 x weekly) was initiated. Serum markers of viral replication disappeared, and aminotransferase levels returned to normal within a few weeks. The patient's serum was found negative for HBsAg after 3 months. Immunohistochemical analysis of liver biopsies before and d…

Metastable electronic states induced by nuclear decay and light

1994

Radioactive atoms incorporated in insulating solid-state compounds create various kinds of chemical and physical “after-effects” upon nuclear disintegration. Mossbauer emission spectroscopy of57Co-labelled coordination compounds has undoubtedly become the most informative technique to detect such after-effects like aliovalent charge and spin states of the nucleogenic iron atom resulting from the57Co(EC)57Fe decay, low energy excitations of crystal field and Zeeman states, linkage isomerism, radical formation with subsequent redox reactions, and others. We have extensively studied57Co-labelled complexes with [CoIIN6] cores employing time-integral and time-resolved Mossbauer emission spectros…