Analysis of antigens recognized on human melanoma cells by A2-restricted cytolytic t lymphocytes (CTL)

1993

We have pursued our analysis of potential tumor-rejection antigens recognized on human melanoma by autologous cytolytic T lymphocytes (CTL). We reported previously that 3 distinct antigens (A,B,C) were recognized on melanoma cell line SK29-MEL in association with HLA-A2. Selection for melanoma-cell variants resistant to anti-A CTL revealed that antigen A consists of at least 2 determinants (Aa, Ab) which can be lost separately. Genetic linkage between Aa and Ab was suggested by concomitant loss of Aa and Ab in an immunoselected tumor-cell variant. This variant was also resistant to an autologous CTL clone restricted by HLA-B45, indicating that this CTL may also recognize a determinant of an…

Metalloproteinase and TIMP expression by the human breast carcinoma cell line 8701-BC.

1993

It is widely accepted that collagenolytic enzymes are required to facilitate the invasion and spread of tumour cells into host tissues. Immunohistochemical, zymographic and PCR analyses have produced evidence that the recently established human mammary carcinoma cell line, 8701-BC, expresses several metalloproteinases (MMP-1, -2, -9 and -10) and their tissue inhibitors (TIMP-1 and -2). Application of these different techniques has led to several observations, both complementary and dissimilar. Whereas PCR analysis showed that mRNA was detected for each of the proteins, the immunolocalization study demonstrated that MMP-1, MMP-2, MMP-9 and TIMP-1 production was restricted to only a proportio…

Cytogenetic analysis of epithelial renal-cell tumors: Relationship with a new histopathological classification

1993

Renal-cell carcinomas (RCC) are clinically, histologically and cytogenetically very heterogeneous. The present histological WHO classification shows no clear correlation between histologic subtypes and specific chromosomal abnormalities. In 1986, a new classification was proposed by Thoenes and Storkel based on the cell type from which the tumor arises. They distinguish S cell types: clear-cell, chromophilic, chromophobic, ductus Bellini and oncocytic. Results of 105 primary tumors show that, in this new classification, there is a correlation between different subtypes of renal-cell tumor and specific chromosomal abnormalities at a microscopic and/or molecular level. The clear-cell compact …

Onset of nuclear vaporization inAu197+197Au collisions

1993

Multifragmentation has been measured for [sup 197]Au+[sup 197]Au collisions at [ital E]/[ital A]=100, 250, and 400 MeV. The mean fragment multiplicity increases monotonically with the charged particle multiplicity at [ital E]/[ital A]=100 MeV, but decreases for central collisions with incident energy, consistent with the onset of nuclear vaporization. Molecular dynamics calculations follow some trends but underpredict the observed fragment multiplicities. Including the statistical decay of excited residues improves the agreement for peripheral collisions but worsens it for central collisions.

Cooperative formation of inorganic-organic interfaces in the synthesis of silicate mesostructures.

1993

A model is presented to explain the formation and morphologies of surfactant-silicate mesostructures. Three processes are identified: multidentate binding of silicate oligomers to the cationic surfactant, preferential silicate polymerization in the interface region, and charge density matching between the surfactant and the silicate. The model explains present experimental data, including the transformation between lamellar and hexagonal mesophases, and provides a guide for predicting conditions that favor the formation of lamellar, hexagonal, or cubic mesostructures. Model Q(230) proposed by Mariani and his co-workers satisfactorily fits the x-ray data collected on the cubic mesostructure …

Etude des composés volatils de la racine d'Angelique (Angelica archangelica) par couplages CPG-SM et GPG-IRTF

1993

numéro spécial; National audience

An experimental study of γγ → hadrons at LEP

1993

An analysis of γγ interactions has been performed using untagged hadronic data obtained by the ALEPH detector at LEP. The data show at low transverse momentum (pt) are well reproduced by a model based on the vector meson dominance mechinism (VDM). At high pt thrust the presence of hard scattering processes is demonstrated. This component is well described in shape and normalization by a QCD calculation.

Elucidation of reaction process between solid tricalcium silicate and a lanthanum salt solution in connection with the precipitation pH. Extension to…

1993

Abstract Dissolution of tricalcium silicate is strongly accelerated in a La salt solution and releases the amounts of OH, Ca and silicate ions just required to precipitate all of lanthanum at pH 8. It remained to be proved that (1) La silicate hydrate could form at pH 8, and (2) Ca silicate hydrate could not precipitate simultaneously. The plot of silicate hydrate and hydroxide precipitation pH of La, Ca and other elements (Th, Zr) against the dropped volume of K2SiO3 and KOH solution and some physico-chemical characterization methods bring affirmative answers to these questions and allow the immobilization process of La and other elements in the presence of tricalcium silicate to be better…

Bilaterally recorded multiple-unit activity of the cingulate cortex during head turning conditioning with unilateral medial forebrain bundle stimulat…

1993

Cats were conditioned to turn their heads using a tone conditioned stimulus (CS) and medial forebrain bundle stimulation (MFB) unconditioned stimulus (US). The CS+ was delivered to one ear at a time, in random order, followed by the US. A tone of a different frequency was used as a CS-. The cats learned to respond differentially to the CSs showing head movements of greater acceleration to the CS+ than CS- over sessions. Bilateral recordings of cingulate cortex multiple-unit activity showed increased response amplitudes over sessions and larger responses in the hemisphere ipsilateral to the US. Since ipsilateral multiple-unit responses did not differ for the CSs, the asymmetry was probably d…

Chloroplastic glutamine synthetase from Brassica napus.

1993

ABNORMALLY HIGH THROMBOXANE BIOSYNTHESIS IN HOMOZYGOUS HOMOCYSTINURIA. EVIDENCE FOR PLATELET INVOLVEMENT AND PROBUCOL-SENSITIVE MECHANISM.

1993

Homocystinuria due to homozygous cystathionine beta-synthase deficiency is an inborn error of metabolism characterized by a high incidence of thrombosis and premature atherosclerosis. We evaluated TXA2 biosynthesis in vivo and several in vitro tests of platelet function in 11 homocystinuric patients and 12 healthy controls. In vitro, patients' platelet aggregation was within control values as were TXB2 formation, fibrinogen binding, and ATP secretion in response to thrombin. In contrast, the urinary excretion of 11-dehydro-TXB2, a major enzymatic derivative of TXA2, was > 2 SD of controls in all patients (1,724 +/- 828 pg/mg creatinine, mean +/- SD, in patients vs. 345 +/- 136 in controls, …

Critical behavior of short range Potts glasses

1993

We study by means of Monte Carlo simulations and the numerical transfer matrix technique the critical behavior of the short rangep=3 state Potts glass model in dimensionsd=2,3,4 with both Gaussian and bimodal (±J) nearest neighbor interactions on hypercubic lattices employing finite size scaling ideas. Ind=2 in addition the degeneracy of the glass ground state is computed as a function of the number of Potts states forp=3, 4, 5 and compared to that of the antiferromagnetic ground state. Our data indicate a transition into a glass phase atT=0 ind=2 with an algebraic singularity, aT=0 transition ind=3 with an essential singularity of the form χ∼exp(const.T−2), and an algebraic singularity atT…

Real-time ultrasonography in the otolaryngology office setting

1993

Over the past two decades, diagnostic ultrasonography has evolved into an extensively used noninvasive imaging modality. It plays a vital role in the disciplines of vascular surgery, cardiology, neonatology, pediatrics, ophthalmology, gynecology, and urology, to name a few, but it is in the field of obstetrics that this technology has been maximally used as an office procedure to evaluate the status of the fetus. In the evaluation of head and neck disorders, ultrasonography has been the subject of sporadic reports for the past 15 years.le3 However, except for the evaluation of thyroid masses,4 it has never been widely accepted in the United States as a diagnostic modality, and has taken a b…

„Stent-in-Stent”

1993

Ag/(Bi, Pb)-Sr-Ca-Cu-O superconducting tape processing: Solid state chemistry aspects

1993

Abstract Different preparation methods have been used to obtain starting powders used in the fabrication of composite tapes by the powder-in-tube method. The effect of these distinct starting powders on the superconducting properties of Ag/Bi-Sr-Ca-Cu-O monofilament tapes has been investigated. The changes in the physical properties, including the critical current density at 77 K and ac magnetic susceptibility, and microstructure, using optical and electronic microscopy, have been analyzed in relation to the solid state reactions involved in the Bi 2 Sr 2 CaCu 2 O 8+δ and Bi 2 Sr 2 Ca 2 Cu 3 O 10+δ phase transformations.

Metal complexes of sulfanilamide derivatives. Spectroscopic characterization of the dichloro disulfathiazole methanol copper(II) complex

1993

The synthesis and spectral characterization of the [Cu(Hstz)2(MeOH)Cl2] complex are described. Both polycrystalline powder EPR and single crystal EPR spectra recorded at room temperature show rhombic distortion with values of g1=2.25, g2=2.09 and g3=2.03 in agreement with a copper polyhedron, intermediate between trigonal bipyramid and square pyramidal.

Existence and gap-bifurcation of multiple solutions to certain nonlinear eigenvalue problems

1993

IN THIS PAPER we study: (i) a class of operator equations in an abstract Hilbert space; and (ii) the L2-theory of certain nonlinear Schrodinger equations which can be viewed as special cases of (i). In order to describe the type of abstract nonlinear eigenvalue problems to be discussed, consider a real Hilbert space H with scalar product (* , *) and norm II.11 and let S be a (not necessarily bounded) positive self-adjoint linear operator in li. We write S in the form

Modelling Dislocation Patterns by Molecular Dynamics

1993

Non-Bloch decay of transient nutations in S=1/2 systems: An experimental investigation.

1993

The decay of transient nutations has been experimentally investigated in S=1/2 spin systems at microwave frequency: E' centers in silica and [${\mathrm{AlO}}_{4}$${]}^{0}$ centers in quartz have been studied. We have found that the damping is well described by a single exponential decay function, as expected from a ${\mathit{T}}_{1}$-${\mathit{T}}_{2}$ model (Bloch model). However, the agreement is only qualitative. In fact the measured decay rate \ensuremath{\Gamma} is faster than expected and depends on the driving-field amplitude: it tends to the Bloch value ${\mathrm{\ensuremath{\Gamma}}}_{\mathit{B}}$=1/2${\mathit{T}}_{2}$ in the low-power limit and becomes faster and faster on increas…

Flow-injection spectrophotometric determination of amino acids based on an immobilised copper(II) -zincon system

1993

Abstract The flow-injection spectrophotometric determination of different amino acids was carried out by reaction with copper(II) ions entrapped in a polymeric material and filling a packed-bed reactor; the released copper(II), complexed with the amino acid, reacted with zincon in a basic medium producing a blue colour that was monitored at 600 nm. The method was applied to determine the contents of different amino acids in pharmaceutical formulations. The calibration graph for glycine was linear over the range 0.5–20 μg ml −1 with a relative standard deviation of 0.8% ( n = 6) at 10 μg ml −1 and a sample throughput of 108 h −1 .

Relationship between microscopic and macroscopic structures of organic thin films for SHG

1993

The experiments described in this paper were undertaken in order to obtain information about the relationship between the structure and non-linear optical properties (second-harmonic generation) of organic thin films. For this purpose, two closely related dyes, diones and tetrones, were compared, both of which are shown to have large hyperpolarisabilities. Their microscopic properties are investigated by conformational analysis and electron diffraction. It could be shown that detailed knowledge about the structure and the adjacent neighbour packing can be obtained from conformational analysis and electron diffraction in order to understand the non-linear optical properties of the two dyes.

Effects of Gibberellic Acid on Morphogenesis and Cardenolide Accumulation in Juvenile and Adult Digitalis obscura Cultures

1993

Summary Effects of gibberellic acid on morphogenesis and cardenolide accumulation in in vitro cultures of Digitalis obscura are reported. Cultures were established from hypocotyls or leaves of axenic seedlings and shoot tips of mature plants. Irrespective of the kind of explant, gibberellic acid by itself did not induce morphogenesis but modified those morphogenic responses promoted by auxins and/or cytokinins, always inhibited organogenesis and favoured both embryo formation and conversion into plants. Gibberellic acid did not significantly affect cardenolide content of plants regenerated from juvenile or mature D. obscura explants.

The biproportional factorial analysis

1993

Beyond the Factorial Analysis of Correspondences, the paper presents a newmethod of data analysis: the Biproportional Factorial Analysis. In the Factorial Analysis of Correspondences, the matrix to be diagonalised is the product o f the two matrices o f profiles, row and columns: this matrix is not symmetrical. In the Biproportional Factorial Analysis, the matrix to be diagonalised is the symmetrical product o f an intermediate matrix over itself; this intermediate matrix is calculated as the biproportion o f the data matrix over normalisedmargins. This provides a full symmetry between rows and columns. After recalling the Factorial Analysis of Correspondences, the paper recall what it is b…

The genetic epidemiology of unipolar depression and panic disorder.

1993

A Log-Rank Test for Equivalence of Two Survivor Functions

1993

We consider a hypothesis testing problem in which the alternative states that the vertical distance between the underlying survivor functions nowhere exceeds some prespecified bound delta0. Under the assumption of proportional hazards, this hypothesis is shown to be (logically) equivalent to the statement [beta[log(1 + epsilon), where beta denotes the regression coefficient associated with the treatment group indicator, and epsilon is a simple strictly increasing function of delta. The testing procedure proposed consists of carrying out in terms of beta (i.e., the standard Cox likelihood estimator of beta) the uniformly most powerful level alpha test for a suitable interval hypothesis about…

Metastatic spinal cord compression--options for surgical treatment.

1993

Fourty-three cases with metastatic spinal cord compression were reviewed post-operatively to clarify the usefulness of the procedures concerning restoration of neurological function, and pain relief. Only patients with pathological spinal instability and neurological sequelae were included. Posterior decompression and stabilization was performed in all but six patients. All but four patients (91%) reported decrease of pain symptoms. Amelioration of neurological function was achieved in 58%. Re-establishment of walking ability was obtained in 57%. Post-surgery life expectancy averaged 11 months. In patients with widespread metastatic disease and/or multi-level instability of the spine restri…

The relationship between Gray's and Eysenck's personality spaces

1993

In a sample of 171 healthy volunteers, the present study examined the relationships between questionnaire measures of trait anxiety, punishment sensitivity, and impulsivity with the measures from the Eysenck Personality Questionnaire (EPQ). This was undertaken in order to explore the relative location of the personality dimensions central to the ideas of Gray and Eysenck. Results confirmed that the behavioural inhibition personality dimension (anxiety) lies at a non-negligible angle relative to neuroticism (N) especially when measured via special purpose questionnaires. This dimension also appeared largely independent of psychoticism (P) which suggests limits on the importance of a hypoacti…

C4BQO in familial clustering of liver cirrhosis

1993

Gene arrangement phylogeny of the E element in Drosophila species of the Obscura group

1993

Heavy quark symmetry at large recoil: the case of baryons

1993

We analyze the large recoil behaviour of heavy baryon transition form factors in semileptonic decays. We use a generalized Brodsky-Lepage hard scattering formalism where diquarks are considered as quasi-elementary constituents of baryons. In the limit of infinitely heavy quark masses the large recoil form factors exhibit a new model-independent heavy quark symmetry which is reminiscent but not identical to the Isgur-Wise symmetry at low recoil.

P. R. Krugman: Geografía y Comercio, Antoni Bosch, ed. 1993. Indice temático y bibliografía.

1993

Fast synthesis of single-phased 110 K bismuth superconductor by freeze-drying of acetic precursors. Kinetic role of calcium and copper oxides

1993

Abstract Although the usefulness of solution procedures to improve the synthesis of bismuth HTSC has been argued, an adequate control of the procedural variables has allowed us to isolate the 110 K phase as the only superconducting phase after such a short sintering time as 22 h. The precursors used have been freeze-dried powders resulting from acetic solutions containing excess Ca and Cu. TGA-DTA and XRD experiments have been performed to follow the subsequent solid-state reaction processes. The initial formation of a mixed bismuth-lead oxoacetate, as intermediate to (Bi 1− y Pb y ) 2 CuO 4 , and the presence of an excess of Ca 2 CuO 3 in the last reaction step are two of the main factors …

Architecture in cortical bone and ultrasound transmission velocity

1993

The square of ultrasound transmission velocity in a material is correlated to the modulus of elasticity, which is an indicator of its mechanical properties. This might make the measurement of ultrasound transmission velocity useful in the noninvasive diagnosis of bone diseases. Bone, however, is not an isotropic material but is architecturally structured. The aim of our study was to investigate and especially to quantify the influence of architecture in cortical bone on ultrasound transmission velocity. Twenty-two rectangular, flat specimens of cortical bone were prepared from diaphysis of fresh pig radius. Ultrasound transmission velocity was measured parallel and perpendicular to directio…

Chemistry and properties of solids with the [NZP] skeleton

1993

Abstract Solids with an [NZP] skeleton in their structure from a very broad family presenting very different properties with varying chemical composition. These properties range from radioactive nuclide immobilization and insulation to ionic and/or electronic conduction, extending to the field of very low thermal expansion among others. The open [NZP] skeleton provides the stability and flexibility necessary to form continuous ranges of solid solution, allowing the tailoring of the best composition-property-structure material. Chemical activity may become particularly high at the surface and absorption reactions and catalytic properties have the highest interest at present. In this paper, c…

First images obtained in the near infrared spectrum with the photon scanning tunneling microscope

1993

Abstract First images obtained in the near infrared spectrum with a photon scanning tunneling microscope are presented. The intensity of the light collected by the fibertip, at λ = 1.3 λm , which is a function of the separation between the tip and the sample surface is in agreement with that predicted by the theory. Images of quartz and silicon oxide are presented and the latter is compared with that obtained by an atomic force microscope.

Actions and Invariant Character Degrees

1993

point subgroup. In general, we use the same notation as in 6 and 7 .wx wxPart of the proof of Theorem A depends on the basic properties of theGajendragadkar p-special characters 1 and we assume the reader iswxfamiliar with those. However, we will repeatedly use a deeper fact: anirreducible character a of a Hall p-subgroup