showing 36 of ~574560 from 574555 documents
Relation between autoradiographically measured blood flow and ATP concentrations obtained from imaging bioluminescence in tumors following hypertherm…
1993
The effects of moderate local hyperthermia (43.3 degrees C/30 min) on regional blood flow and regional ATP distribution in the amelanotic hamster melanoma A-Mel-3 were investigated by high-resolution techniques. Blood flow and ATP concentrations were measured simultaneously in treated and untreated tumors and in adjacent tissues by means of (14C)-Iodoantipyrine autoradiography and quantitative imaging bioluminescence in consecutive tissue sections at 3, 12 and 24 hr following treatment. Digital image processing and the use of a special algorithm allowed the regional interrelationship of the 2 parameters to be quantified. Measurements revealed a great heterogeneity of blood flow and ATP betw…
Monoclonal antibodies recognizing larval- and pupal-specific cuticular proteins of Tenebrio molitor (Insecta, Coleoptera)
1993
To study the sequential expression of insect epidermal cells during metamorphosis, a library of monoclonal antibodies (MABs) was prepared against the water-soluble proteins from preecdysial pupal cuticle of Tenebrio molitor. Six selected MABs recognizing only larval and pupal cuticular proteins (CPs) in immunoblot analysis were classified into three types. Type 1 recognized a 21.5 and a 22 kDa polypeptide, type 2, a 26 kDa polypeptide, and type 3, three polypeptides of 18.5, 19.5 and 21.5 kDa. They did not immunoreact with any protein of fat bodies or haemolymph from pharate pupae, suggesting that the antigens originate from the epidermis. The stage-specificity was confirmed by electron mic…
Viscosimetric investigation of the interaction between sodium dodecylsulfate micelles and a polymer drug carrier
1993
Abstract The viscosities of aqueous sodium dodecyl sulfate solutions with and without α,β-poly( N -hydroxyethyl)- dl -aspartamide (PHEA), at 15, 25 and 35°C are reported. The viscosities of SDS and of PHEA aqueous solutions are discussed in terms of the parameter D [D = ( η η 0 − 1)/φ] describing the non-ideal behavior of SDS micelles and of PHEA macromolecules. The viscosities of SDS plus PHEA aqueous solutions, discussed in terms of the parameter F [ F = η rel ( PHEA ) + η rel ( SDS ) − η rel ( SDS + PHEA )] M , demonstrate the occurrence of interactions between SDS micelles and the PHEA macromolecule. Both D and F are scarcely influenced by temperature variation.
A comparison of compatible, finite, and inductive graph properties
1993
Abstract In the theory of hyperedge-replacement grammars and languages, one encounters three types of graph properties that play an important role in proving decidability and structural results. The three types are called compatible, finite, and inductive graph properties. All three of them cover graph properties that are well-behaved with respect to certain operations on hypergraphs. In this paper, we show that the three notions are essentially equivalent. Consequently, three lines of investigation in the theory of hyperedge replacement - so far separated - merge into one.
Sensitive determination of probenecid in urine samples by reversed-phase liquid chromatography and UV-visible detection using solid-phase extraction …
1993
This study describes a rapid method for the determination of probenecid in human urine by liquid chromatography with UV detection at 254 nm, after clean-up through a C8 solid-phase extraction column. Liquid chromatography was carried out on a C18-bonded phase using an acetonitrile-acetate buffer (pH=4) gradient elution. Ethacrynic acid was used as internal standard. The system has been applied to the determination of probenecid in the 0.10–100.0 μg/ml concentration range; the limit of detection was 5 ng/mL.
A mode coupling analysis of the central peak at order disorder phase transitions
1993
The influence of local and translation invariant memory effects on the critical dynamics of a model undergoing a continous structural phase transition from a disordered (T>Tc) to an ordered distorted phase (T>Tc) is studied by mode coupling theory above the critical temperatureTc. It is shown that besides the existence of critical slowing-down modes there also exists a central peak as a consequence of correlations of the critical modes, increasing with the critical exponent γ when approachingTc. The dependence of the central peak on the wavevector\(\vec q\), temperatureT and on the spatial dimensiond is investigated. Ford=3 a scenario withlocal long time memory correlations is compared with…
In vivo effects of intravascularly applied Escherichia coli hemolysin: dissociation between induction of granulocytopenia and lethality in monkeys.
1993
The effects of intravascular application of endotoxin-depleted Escherichia coli hemolysin (HlyA) was studied in rabbits and monkeys. In rabbits, bolus application of HlyA calculated to effect final blood levels of approximately 2-3 HU/ml (200-300 ng/ml) caused an acute fall of polymorphonuclear blood leukocytes to less than 20% of starting levels within 5 min. Additionally, platelet counts dropped to approximately 30% of starting levels, whereas lymphocyte counts varied considerably and seldom fell to less than 50%. Nine out ten animals that received 2-4 HU/ml toxin died within 90 min post application. These animals presented with signs of acute respiratory failure and post mortem inspectio…
Non-markovian dynamics and spectrum of a moving atom strongly coupled to the field in a damped cavity
1993
Abstract We study the internal dynamics of an atom entering in its excited state in a damped cavity and strongly coupled to the field. We show that the time evolution of its dipole operator is described by a second order Langevin-like equation with time dependent coefficients. We use this equation to investigate the time dependence of the average population inversion and the spectrum of the emitted radiation. We discuss how Rabi oscillations are modified by the motion of the atom and how the spectrum changes from the vacuum Rabi doublet to a more complex structure having new lines, different frequency localizations and modified widths.
Histopathology of the Harderian gland of rodents exposed to ELF magnetic fields
1993
Abstract The Harderian gland is a possible magnetosensitive organ. The aim of this study was to look at the possible effects on the Harderian gland of mice after exposure to an artificial magnetic field. Sixty 0F1 three-month old female mice were selected for this study. The mice were exposed continuously to an artificial magnetic field of 1 G (10 −4 T) and 50 Hz during a three-month period. The effects were evaluated histologically. The results show, only in the experimental group, non-reversible histopathological lesions with anaplasic foci in 26% of Harderian glands. These lesions also include in situ development of adenocarcinomas. Confidence intervals applied to the statistical studies…
Retrograde Venenokklusion - Zur Therapie der verlogenen Impotenz
1993
Retrograde occlusion of penile drainage veins can produce improvement in patients with impotence due to venous leaks. We performed 50 transfemoral and three transjugular procedures; 46 (86%) were technically successful. Clinical improvement was found in 24 out of the 46 procedures (52%). In 20 patients spontaneous intercourse became possible, in four this occurred after intracavernous injection of vaso-active substances. In eleven patients there was deterioration after one to twenty months; in seven this was treated by repeated venous occlusion. In 13 patients improvement has been maintained over a period of one to thirty months (average 10.5 months). There were no complications.
On Meet-Complements in Cohn Geometries
1993
Within the frame of projective lattice geometry, the present paper investigates classes of meet-complements in Cohn geometries and especially in Ore and Bezout geometries. The algebraic background of these geometries is given by torsion free modules over domains — in particular Ore and Bezout domains. 1
Comparative studies on the detection of benzodiazepines in serum by means of immunoassays (FPIA).
1993
Serum was tested for benzodlazeplnes by fluorescence polarlzatlon Immunoassay (FPIA) on Abbott's ADx system uslng the benzodlazeplne serum reagents (Benzo S) and the benzodlazeplne urine reagents (Benzo U) after pretreatment of speclmens by means of acetone preclpltatlon. The followlng sera were included for comparing the two methods: negatlve sera spiked with varlous benzodlazeplnes; 80 sera randomly selected out of a total of 8654 serum specimens from Impalred drlvers; and blood speclmens from Indlvlduals who stated that they had taken benzodlazeplnes. The different benzodlazeplnes were added to serum st concentratlons of 25, 75, and 300 ng/mL. The low-dose benzodlazeplnes flunltrazepam a…
The effect of disorder on optical spectra of conjugated polymers
1993
Abstract Using the semi-empirical parametrization of the Pariser-Parr-Pople model we determine the excitonic states in conjugated polymers. The employed parameters correspond to a moderate strength of the long-range Coulomb interaction. In order to take the disorder into account, the nearest-neighbour transfer matrix elements are chosen according to a random distribution. Averaging the results over a large number of chains of 100 sites, which are known to be sufficiently long so that finite-size effects become negligible, we obtain the linear and third-order nonlinear optical susceptibilities. With increasing disorder the linear absorption, the two-photon absorption and the third-harmonic g…
Nuclear shell model applied to metallic clusters
1993
We apply the nuclear shell model to jellium clusters of up to twenty-one Na atoms. Binding energies, ionization potentials, and photoabsorption cross sections are calculated and compared with mean-field results.
Finite size effects at thermally-driven first order phase transitions: A phenomenological theory of the order parameter distribution
1993
We consider the rounding and shifting of a firstorder transition in a finited-dimensional hypercubicL d geometry,L being the linear dimension of the system, and surface effects are avoided by periodic boundary conditions. We assume that upon lowering the temperature the system discontinuously goes to one ofq ordered states, such as it e.g. happens for the Potts model ind=3 forq≧3, with the correlation length ξ of order parameter fluctuation staying finite at the transition. We then describe each of theseq ordered phases and the disordered phase forL≫ξ by a properly weighted Gaussian. From this phenomenological ansatz for the total distribution of the order parameter, all moments of interest…
Protein gene product (PGP) 9.5 immunoreactivity in nerve fibres and pinealocytes of guinea-pig pineal gland: interrelationship with tyrosine- hydroxy…
1993
This light-microscopic (LM) immunohistochemical study has evaluated the presence and distribution of the pan-neural and neuroendocrine marker protein gene product (PGP) 9.5 in pinealocytes and nerve fibres of guinea-pig pineal gland. The pattern of PGP 9.5-immunoreactive (ir) nerve fibres has been compared with that of fibres staining for tyrosine hydroxylase (TH) or neuropeptide Y (NPY). The vast majority of pinealocytes stained for PGP 9.5, although with variable intensity. PGP 9.5 immunoreactivity was localized in pinealocytic cell bodies and processes. Double-immunofluorescence revealed that PGP 9.5 immunoreactivity was absent from glial cells identified with a monoclonal antibody again…
Testing Prospect Theory in a Deterministic Multiple Criteria Decision-Making Environment
1993
Prospect theory by Kahneman and Tversky [7] is tested in a deterministic multiple criteria decision-making context. In two experiments conducted in classroom settings subjects made pairwise preference comparisons of condominiums for sale. The results of the experiments indicate that the traditional value model did not explain the subjects' revealed preferences as well as the prospect model. We conclude that prospect theory is a reasonable model of choice for many individuals in such a context.
Stochastic dynamics of nonlinear systems driven by non-normal delta-correlated processes
1993
In this paper, nonlinear systems subjected to external and parametric non-normal delta-correlated stochastic excitations are treated. A new interpretation of the stochastic differential calculus allows first a full explanation of the presence of the Wong-Zakai or Stratonovich correction terms in the Itoˆ’s differential rule. Then this rule is extended to take into account the non-normality of the input. The validity of this formulation is confirmed by experimental results obtained by Monte Carlo simulations.
A Basic Program for Calculating Scale Values Using Four Unidimensional Scaling Methods in Random Subsamples
1993
This MS BASIC program calculates and stores for further analysis scale values obtained from random subsamples using four unidimensional scaling methods: Dunn-Rankin's variance stable rank sums, Thurstone's case V (paired comparisons), Thurstone-Chave's IAI, and Green's successive categories.
The classical concept of mass: theoretical difficulties and students’ definitions
1993
An analysis of the concepts of mass in classical physics on the basis of their historical, philosophical and semantic connotations is given. A classification of the most current definitions of mass is proposed from its physical representation and topic area. The definitions of mass, and some related issues, given by several groups of secondary school students are analysed. The results seem to confirm a generalized qualitative‐teleological view of scientific concepts in contrast to the more orthodox formal‐quantitative formulation of physics.
La lingua di A. Kalvos
1993
Andreas Kalvos utilizza una lingua dotta che contiene elementi di greco antico, neologismi e financo idiomatismi settinsulari. Il presente studio costituisce una sorta di garmmatica delle "Odi"
Local porosity theory for electrical and hydrodynamical transport through porous media
1993
The current status of local porosity theory for transport in porous media is briefly reviewed. Local porosity theory provides a simple and general method for the geometric characterization of stochastic geometries with correlated disorder. Combining this geometric characterization with effective medium theory allows for the first time to understand a large variety of electrical and hydrodynamical flow experiments on porous rocks from a single unified theoretical framework. Rather than reproducing or rephrasing the original results the present review attempts instead to place local porosity theory within the context of other current developments in theory and experiment.
Effects of two selective dopaminergic antagonists on ethologically-assessed encounters in male mice
1993
Abstract 1. Although it is accepted that dopaminergic antagonists suppress aggressive behaviour, the drugs used have been relatively non-selective or specific to the D2 receptor. 2. The selective D1 antagonist, SCH 23390, makes it possible to evaluate the impact of this receptor on aggressive behaviour. 3. The effects of SCH 23390 and Spiperone (a D2 antagonist) on the aggressive behaviour of mice were assessed employing a “standard opponent” test. 4. Both drugs markedly decreased aggressive behaviour whilst increasing immobility. However, whilst SCH 23390 increased immobility to a small extent, Spiperone, produced a general decline in active behaviours. 5. It appears that the D1 receptor i…
Duopoly signal jamming
1993
This paper examines a repeated duopoly market with heterogeneous outputs. Firms have (common) prior beliefs over the values of an unknown parameter of each firm's demand curve. Firms cannot observe rivals' quantities, but can observe market prices, which are subject to random disturbances and hence provide noisy information that firms use to update their beliefs concerning the unknown parameters' values. Each firm can potentially signal jam, or strategically vary its output level in order to manipulate the distribution of likely market prices and hence the likely inferences drawn by the opponent. We find that the opportunity to signal-jam introduces two conflicting effects, arising out of t…
A new pericentric inv(8) in acute nonlymphocytic leukemia.
1993
Abstract Chromosome studies were carried out on unstimulated bone marrow cells from a patient with a diagnosis of acute nonlymphocytic leukemia (FAB M6 ANLL). Cytogenetic analysis revealed a mosaic chromosome pattern 46,XX46,XX,inv(8)(p21q24). This pericentric inversion has not been previously described in ANLL. Because, fragile sites, zinc finger gene loci, and the MYC protooncogene have been localized to band 8q24, a putative role for these sites and genes could be considered.
Calorimetric study of the solubilization of ethylenediamine, N,N-dimethylaminoethylamine and N,N,N?,N?-tetramethylethylenediamine by reversed AOT mic…
1993
Distribution constants and standard enthalpies of transfer of ethylenediamine (en), N,N-dimethylaminoethylamine (dmen) and N,N,N′,N′-tetramethylethylenediamine (tmen) partitioned between n-heptane and water containing reversed sodium bis(2-ethylhexyl) sulfosuccinate (AOT) micelles as a function of the molar concentration ratio R (R=[water]/[AOT]) were evaluated by a calorimetric method. The results show that en, dmen and tmen molecules, solubilized in the reversed micelles, are distributed between the micellar aqueous core and the micellar palisade layer. An analysis of the thermodynamic parameters of the partition process demonstrates the peculiar solvent properties of the water containing…
Surface order in body-centered cubic alloys
1993
Free (100)-surfaces of body-centered cubic binary alloys are studied in a parameter range where the bulk turns from the ordered B2-phase to the disordered A2-phase. A model is chosen that describes iron-aluminium alloys in a fairly realistic way. Mean field treatments and Monte Carlo investigations both show that under certain circumstances the surface remains ordered far above the bulk disordering temperatureT c, though the surface order parameter and the surface susceptibility exhibit a singularity atT c with critical exponents characteristic for the ordinary transition. One finds, that if the surface is nonstoechiometric and different layers are not equivalent with respect to perfect bul…
Parameters of microdischarges occuring at surfaces of repolarized ferroelectrical materials
1993
Parameters of the microdischarges occuring at the surfaces of the repolarized ferroelectric materials have been investigated. It has been found that in the case of BaTiO3ceramic the number of microdischarges increases linearly with increasing repolarizing voltage Upp, the photoelectric parameters of individual discharges being unchanged. The photoelectric and current parameters for system with TGS are very similar but the dependence of the amplitude of the current pulses on the repolarizing voltage differs distinctly from that for BaTiO3.
Free choline and choline metabolites in rat brain and body fluids: sensitive determination and implications for choline supply to the brain.
1993
In the central nervous system, choline is an essential precursor of choline-containing phospholipids in neurons and glial cells and of acetylcholine in cholinergic neurons. In order to study choline transport and metabolism in the brain, we developed a comprehensive methodical procedure for the analysis of choline and its major metabolites which involves a separation step, selective hydrolysis and subsequent determination of free choline by HPLC and electrochemical detection. In the present paper, we report the levels of choline, acetylcholine, phosphocholine, glycerophosphocholine and choline-containing phospholipids in brain tissue, cerebrospinal fluid and blood plasma of the untreated ra…
Spectroscopic study of molecular associations between riboflavin and some (dihydro) β-carboline derivatives
1993
Abstract The spectrophotometric and thermodynamic properties of molecular complexes of riboflavin (RFN) with some dihydro β-carboline derivatives have been investigated by using electronic absorption and fluorescence spectroscopic methods in aqueous solution. The molecular associations have been examined by means of eletronic absorption spectra, since in each, a new charge transfer-like band has been located, and also by observing the variation of the fluorescence emission of RFN on the solutions. The formation constants for the molecular complexes were determined from absorption data, using the Forster—Hammick—Wardley method. The quenching phenomenon observed in RFN fluorescence is related…
Cycloadditionen von Benzothiet und aromatischen Nitroso‐Verbindungen
1993
Cycloaddition Reactions of Benzothiete and Aromatic Nitroso Compounds The new heterocyclic ring systems 4H-3,1,2-benzoxathiazines 4 and 2,3-dihydro-1,2-benzothiazol 1-oxides 6 can be synthesized by cycloaddition of benzothiete (1) and aromatic nitroso compounds 3. The regioselectivity of the primary step and the secondary thermal or acid-catalyzed rearrangements are discussed.
Effects of sodium butyrate on DNA content, glutathione S-transferase activities, cell morphology and growth characteristics of rat liver nonparenchym…
1993
The effects of sodium butyrate, which has been shown to act as a differentiation promoting agent in several different tumor cell lines, were studied in a rat liver nonparenchymal epithelial cell line. Exposure of these cells to 3.75 mM butyrate resulted in an inhibition of cell proliferation and, at the same time, an increase in cell diameter (2- to 6-fold) and size of the nuclei (approximately 2-fold) after 3 days in culture. Binucleated cells arose, comprising approximately 12% of the cells investigated, and the number of cells with an abnormal set of chromosomes was increased. Intercellular communication, measured by dye transfer of Lucifer Yellow, was unchanged. From the various xenobio…
3D TOF MR Angiography of Cerebral Arteriovenous Malformations after Radiosurgery
1993
To investigate the potential of three-dimensional time-of-flight MR angiography (MRA) to complement SE imaging, 18 patients with intracerebral arteriovenous malformations were prospectively followed after undergoing radiosurgery. Vessel occlusion after stereotaxic single high dose radiotherapy develops slowly. The MRA detected signs of nidus obliteration earlier and with a higher sensitivity than did SE imaging. Six months after radiosurgery, MRA showed a reduction of the nidus flow signals in nine patients and after 1 year it showed reduction in 15 of the 18 patients. As shown by MRA, the loss of flow signals was related to a reduction of the nidus size in 4 patients after 6 months and in …
COLLECTIVE SPIN EXCITATIONS OF ALKALI-METAL CLUSTERS
1993
The response function of alkali-metal clusters, modeled as jellium spheres, to dipole (L=1) and quadrupole (L=2) spin-dependent fields is obtained within the time-dependent local-spin-density approximation of density-functional theory. We predict the existence of low-energy spin modes of surface type, which are identified from the strength function. Their collectivity and evolution with size are discussed.
Three-nucleon forces and the three-nucleon systems
1993
The basic principles and philosophy which have guided the area of few-nucleon physics are motivated and discussed. Recent advances have made it possible to solve accurately the Schrodinger (or Faddeev) equation for many of the configurations of the few-nucleon systems, A brief review is given of some of the results of these calculations, which also Indicate that one-pion exchange plays roughly the same role in binding these systems that it plays in electromagnetic meson-exchange currents. Finally, a qualitative discussion of chiral perturbation theory is presented, which highlights the role that chiral symmetry plays in the nuclear force. Three-body forces from different areas of physics ar…
The cauchy problem for non-linear Klein-Gordon equations
1993
We consider in ℝ n+1,n≧2, the non-linear Klein-Gordon equation. We prove for such an equation that there is a neighbourhood of zero in a Hilbert space of initial conditions for which the Cauchy problem has global solutions and on which there is asymptotic completeness. The inverse of the wave operator linearizes the non-linear equation. If, moreover, the equation is manifestly Poincare covariant then the non-linear representation of the Poincare Lie algebra, associated with the non-linear Klein-Gordon equation is integrated to a non-linear representation of the Poincare group on an invariant neighbourhood of zero in the Hilbert space. This representation is linearized by the inverse of the …