Tourism and territorial growth determinants in insular regions: A comparison with mainland regions for some European countries (2008–2019)

2022

The article investigates the different growth patterns of islands and mainland regions by looking at their tourism and territorial characteristics differences. We considered per capita income and employment growth patterns in a panel data model focused on 74 regions in seven European coun- tries from 2008 to 2019. The results show how the impor- tance of some growth factors, especially those related to tourism and environmental sustainability, varies between islands and mainland regions. The article suggests specific policy implications for island regions in line with the European Union guidelines. Our findings support the need to pursue different approaches to sustain growth in islands and…

La transfiguración del sufrimiento ante la prueba del eterno retorno

2022

Este artículo explora el nuevo significado que adquiere el sufrimiento a partir de la doctrina cosmológica y ética del eterno retorno en la filosofía de Nietzsche. El papel del sufrimiento nos permite comprender por qué Nietzsche consideraba el eterno retorno «el gran pensamiento criador». El eterno retorno opera una transformación de la afectividad y selecciona nuevos valores y modos de experimentar el sufrimiento, aprobando la «disciplina del sufrimiento» y condenando la culpa, el castigo y el resentimiento. El sentido cultivador del eterno retorno reconcilia fuerzas y emociones opuestas, como la alegría y el sufrimiento, y sacaa la luz la visión trágica de la existencia.

New degrees of freedom for differential forms on cubical meshes

2022

We consider new degrees of freedom for higher order differential forms on cubical meshes. The approach is inspired by the idea of Rapetti and Bossavit to define higher order Whitney forms and their degrees of freedom using small simplices. We show that higher order differential forms on cubical meshes can be defined analogously using small cubes and prove that these small cubes yield unisolvent degrees of freedom. Significantly, this approach is compatible with discrete exterior calculus and expands the framework to cover higher order methods on cubical meshes, complementing the earlier strategy based on simplices.

Chromosome-scale assembly of the yellow mealworm genome

2022

Background: The yellow mealworm beetle, Tenebrio molitor, is a promising alternative protein source for animal and human nutrition and its farming involves relatively low environmental costs. For these reasons, its industrial scale production started this century. However, to optimize and breed sustainable new T. molitor lines, the access to its genome remains essential. Methods: By combining Oxford Nanopore and Illumina Hi-C data, we constructed a high-quality chromosome-scale assembly of T. molitor. Then, we combined RNA-seq data and available coleoptera proteomes for gene prediction with GMOVE. Results: We produced a high-quality genome with a N50 = 21.9Mb with a completeness of 99.5% an…

Geographical similarity and differences in the burden and genetic predisposition of NAFLD

2022

: NAFLD has become a major public health problem for more than 2 decades with a growing prevalence in parallel with the epidemic of obesity and type 2 diabetes (T2D). The disease burden of NAFLD differs across geographical regions and ethnicities. Variations in prevalence of metabolic diseases, extent of urban-rural divide, dietary habits, lifestyles, and the prevalence of NAFLD risk and protective alleles can contribute to such differences. The rise in NAFLD has led to a remarkable increase in the number of cases of cirrhosis, hepatocellular carcinoma, hepatic decompensation, and liver-related mortality related to NAFLD. Moreover, NAFLD is associated with multiple extrahepatic manifestatio…

Body mass index, basal insulin and glycemic control in children with type 1 diabetes treated with the advanced hybrid closed loop system remain stabl…

2022

BackgroundInformation on the influence of insulin treatment using advanced hybrid closed loop systems (AHCL) on body weight of young patients with type 1 diabetes (T1D) is scarce. The aim of this study was to observe whether there were any changes in body mass index (BMI) of children and adolescents with T1D treated using the Medtronic Minimed 780G AHCL after 1 year of follow up and to analyze potential associations between these changes and the insulin doses.Materials and methodsFor 50 children and adolescents (age 5.4-16.8 years, 24 (48%) boys, T1D for 3.9 ± 2.56 years) using an AHCL system anthropometric and AHCL data were collected prospectively. BMI Z-scores and two-week AHCL records o…

Clinical and genetic approach in the characterization of newborns with anorectal malformation

2022

Objective: This study aimed to investigate clinical, surgical, and genetic data of neonates with anorectal malformation (ARM). Study design: A retrospective observational study was conducted on neonates with ARM as an isolated type (group 1), with ≤2 (group 2), and with ≥3 associated malformations (group 3), born between 2009 and 2020. Distribution of ARM, associated abnormalities and genetic testing were analyzed, and risk factors for adverse outcomes were identified. Results: The 45 ARM cases (36% females) were divided as follows: 13 neonates belonging to group 1 (29%), 8 to group 2 (18%), and 24 to group 3 (53%). Cases were equally distributed over 11 years. Krickenbeck anatomy was: with…

Peaceful Foreign Policy and Remembrance of War Effort : The Conceptualisation of Willingness to Defend in Finland and Its Connections to Previous Arm…

2022

In Finland, a conceptualization of willingness to defend has been a traditional part of the defence-related debates and the state has vested interests to maintain the high level of willingness. This paper examines the connections to the Second World War in political discourse related to willingness to defend. Based on the analysis of political and societal debates, I will demonstrate that the Second World War serves as an historical experience for the understanding of the concept by offering an idea of individual sacrifice relevant to the survival of the state, as a prime example. peerReviewed

Prototyping Sentinel-2 green LAI and brown LAI products for cropland monitoring.

2022

Abstract For agricultural applications, identification of non-photosynthetic above-ground vegetation is of great interest as it contributes to assess harvest practices, detecting crop residues or drought events, as well as to better predict the carbon, water and nutrients uptake. While the mapping of green Leaf Area Index (LAI) is well established, current operational retrieval models are not calibrated for LAI estimation over senescent, brown vegetation. This not only leads to an underestimation of LAI when crops are ripening, but is also a missed monitoring opportunity. The high spatial and temporal resolution of Sentinel-2 (S2) satellites constellation offers the possibility to estimate …

Depth camera based dataset of hand gestures

2022

The dataset contains RGB and depth version video frames of various hand movements captured with the Intel RealSense Depth Camera D435. The camera has two channels for collecting both RGB and depth frames at the same time. A large dataset is created for accurate classification of hand gestures under complex backgrounds. The dataset is made up of 29718 frames from RGB and depth versions corresponding to various hand gestures from different people collected at different time instances with complex backgrounds. Hand movements corresponding to scroll-right, scroll-left, scroll-up, scroll-down, zoom-in, and zoom-out are included in the data. Each sequence has data of 40 frames, and there is a tot…

Luminescent inks based on Eu:PO4 nanoparticles and polyvinyl alcohol for anti-counterfeiting

2022

The role of self-esteem on fear of childbirth and birth experience

2022

Objective: Fear of childbirth (FOC), also referred to as tokophobia, can have detrimental consequences for a woman’s well-being during pregnancy and for their subjective birth experience. However, it is unknown what role self-esteem plays in the relationship between FOC and the experience of childbirth. This study investigates the relation between FOC and the birth experience, and the role of selfesteem in that relation. Methods: We studied 125 nulliparous and parous Finnish women from their third trimester of pregnancy to 4–8 weeks postpartum. Path analysis with MLR estimation was conducted using MPlus to predict the childbirth experience according to prior self-esteem and fear of childbir…

EVOO's Effects on Incretin Production: Is There a Rationale for a Combination in T2DM Therapy?

2022

Type 2 diabetes mellitus (T2DM) is a serious public health concern as it is one of the most common chronic diseases worldwide due to social and economic developments that have led to unhealthy lifestyles, with a considerable impact both in terms of morbidity and mortality. The management of T2DM, before starting specific therapies, includes cornerstones such as healthy eating, regular exercise and weight loss. Strict adherence to the Mediterranean diet (MedDiet) has been related to an inverse association with the risk of T2DM onset, as well as an improvement in glycaemic control; in particular, thanks to the consumption of extra virgin olive oil (EVOO). Agonists of gut-derived glucagon-like…

Performance of existing clinical scores and laboratory tests for the diagnosis of invasive candidiasis in critically ill, nonneutropenic, adult patie…

2022

Background The Fungal Infections Definitions in Intensive Care Unit (ICU) patients (FUNDICU) project aims to provide standard sets of definitions for invasive fungal diseases in critically ill, adult patients. Objectives To summarize the available evidence on the diagnostic performance of clinical scores and laboratory tests for invasive candidiasis (IC) in nonneutropenic, adult critically ill patients. Methods A systematic review was performed to evaluate studies assessing the diagnostic performance for IC of clinical scores and/or laboratory tests vs. a reference standard or a reference definition in critically ill, nonneutropenic, adult patients in ICU. Results Clinical scores, despite t…

Comprehensive Study on the Performance of Waste HDPE and LDPE Modified Asphalt Binders for Construction of Asphalt Pavements Application

2022

This research is aimed at investigating the mechanical behavior of the bitumen by the addition of high-density polyethylene (HDPE) and low-density polyethylene (LDPE) obtained from waste plastic bottles and bags. Polymers (HDPE and LDPE) with percentages of 0%, 2%, 4%, and 6% in shredded form by weight of bitumen were used to evaluate the spectroscopic, structural, morphological, and rheological properties of polymer-modified binders. The rheological properties for different factors; viscosity (ἠ) from Rotational Viscometer (RV), rutting factor G*/Sin (δ), fatigue characteristics G*. Sin (δ), for the modified binder from dynamic shear rheometer (DSR), Short and long-term a…

Non-Waste Technology for Utilization of Tree Branches

2022

The trees (e.g., fruit or decorative) growing on the homestead plots of private households provide opportunities for sustainable biomass obtained from pruned branches every year. Profitable production of fuel material requires high-performance equipment and methods by which wood chips can be produced at low cost. The practice of chopping tree branches shows that not all chopping machines are suitable for use on homestead plots. This research gives the five-year test results of a developed and patented tree branch chopping machine under special operating conditions. The machine was tested under the conditions of the homestead plot of a private household in the Poltava region, and the enginee…

ProHealth eCoach: user-centered design and development of an eCoach app to promote healthy lifestyle with personalized activity recommendations

2022

Abstract Background Regular physical activity (PA), healthy habits, and an appropriate diet are recommended guidelines to maintain a healthy lifestyle. A healthy lifestyle can help to avoid chronic diseases and long-term illnesses. A monitoring and automatic personalized lifestyle recommendation system (i.e., automatic electronic coach or eCoach) with considering clinical and ethical guidelines, individual health status, condition, and preferences may successfully help participants to follow recommendations to maintain a healthy lifestyle. As a prerequisite for the prototype design of such a helpful eCoach system, it is essential to involve the end-users and subject-matter experts throughou…

Neonatal Outcomes and Long-Term Follow-Up of Children Born from Frozen Embryo, a Narrative Review of Latest Research Findings

2022

In recent years, the growing use of ART (assisted reproductive techniques) has led to a progressive improvement of protocols; embryo freezing is certainly one of the most important innovations. This technique is selectively offered as a tailored approach to reduce the incidence of multiple pregnancies and, most importantly, to lower the risk of developing ovarian hyperstimulation syndrome when used in conjunction with an ovulation-triggering GnRH antagonist. The increase in transfer cycles with frozen embryos made it possible to study the effects of the technique in children thus conceived. Particularly noteworthy is the increase in macrosomal and LGA (large for gestational age) newborns, i…

Transformación educativa en el ande peruano. Doce respuestas desde Apurímac

2022

Aprender es cambio, pero educar es transformación. La sociedad está envuelta en constantes cambios de distinto calado e intensidad, pero siempre se pueden encontrar respuestas creativas y comprometidas con el proyecto humano llamado «educación». Educar es comprometerse con la transformación personal y social. no solo por el cambio que puede ser superficial o fútil. Y este libro, que busca sacar a la luz doce respuestas educativas elaboradas por los y las docentes de la región de Apurímac (Perú), va detrás de la transformación educativa a pesar de la pandemia y de las centenarias adversidades socioeducativas de esta región peruana. En cada una de estas doce propuestas, seleccionadas de casi …

Neuroprotective and Antioxidant Role of Oxotremorine-M, a Non-selective Muscarinic Acetylcholine Receptors Agonist, in a Cellular Model of Alzheimer …

2022

AbstractAlzheimer disease (AD) is a multifactorial and age-dependent neurodegenerative disorder, whose pathogenesis, classically associated with the formation of senile plaques and neurofibrillary tangles, is also dependent on oxidative stress and neuroinflammation chronicization. Currently, the standard symptomatic therapy, based on acetylcholinesterase inhibitors, showed a limited therapeutic potential, whereas disease-modifying treatment strategies are still under extensive research. Previous studies have demonstrated that Oxotremorine-M (Oxo), a non-selective muscarinic acetylcholine receptors agonist, exerts neurotrophic functions in primary neurons, and modulates oxidative stress and …

Are the playoffs different from the regular season? A comparison of in-game statistics in Icelandic elite handball

2022

There are many axioms in sport that are taken at face value. One of them is that the playoffs are somehow totally different from the regular season. The aim of this study was to test that axiom by comparing in-game statistics during the regular season and the playoffs in the semi-professional Icelandic elite men’s handball league. Data from 724 games (648 regular season games and 76 playoff games; 1448 data points) across five seasons were analysed using a two-level logistic regression analysis. The variables of interest were pace, fast breaks, legal stops, penalty throws given, 2-minute suspensions, and saves. The results indicated no meaningful differences in fast breaks, penalty throws g…

Brain dynamics of recommendation-based social influence on preference change: A magnetoencephalography study.

2022

People change their preferences when exposed to others’ opinions. We examine the neural basis of how peer feedback influences an individual’s recommendation behavior. In addition, we investigate if the personality trait of ‘agreeableness’ modulates behavioral change and neural responses. In our experiment, participants with low and high agreeableness indicated their degree of recommendation of commercial brands, while subjected to peer group feedback. The associated neural responses were recorded with concurrent magnetoencephalography. After a delay, the participants were asked to reevaluate the brands. Recommendations changed consistently with conflicting feedback only when peer recommenda…

Simulation-Based Analysis of "What-If" Scenarios with Connected and Automated Vehicles Navigating Roundabouts.

2022

Despite the potential of connected and automated vehicles (CAVs), there are still many open questions on how road capacity can be influenced and what methods can be used to assess its expected benefits in the progressive transition towards fully cooperative driving. This paper contributes to a better understanding of the benefits of CAV technologies by investigating mobility-related issues of automated vehicles operating with a cooperative adaptive cruise control system on roundabout efficiency using microscopic traffic simulation. The availability of the adjustment factors for CAVs provided by the 2022 Highway Capacity Manual allowed to adjust the entry capacity equations to reflect the pr…

The trilobite Serrodiscus Richter & Richter from Iberia, with systematic review of the genus and its international correlation through the Cambrian S…

2022

Serrodiscus is considered one of the first trilobite genera showing global distribution during the Cambrian and a key component for the international correlation of this period. However, this genus encompasses many poorly documented species, ambiguous diagnoses or characters that depend on taphonomy and deformation based on one single specimen. Thus, in the present work, we carry out a systematic overview of the genus, evaluating the taphonomic and deformational variability of a large number of specimens from the same locality and horizon. In addition, and due to the difficulty of making synonymy decisions, closely related species are grouped into three different groups taking into consider…

Area‐Selective Atomic Layer Deposition on Functionalized Graphene Prepared by Reversible Laser Oxidation

2022

Publisher Copyright: © 2022 The Authors. Advanced Materials Interfaces published by Wiley-VCH GmbH. Area-selective atomic layer deposition (ALD) is a promising “bottom-up” alternative to current nanopatterning techniques. While it has been successfully implemented in traditional microelectronic processes, selective nucleation of ALD on 2D materials has so far remained an unsolved challenge. In this article, a precise control of the selective deposition of ZnO on graphene at low temperatures (<250 °C) is demonstrated. Maskless femtosecond laser writing is used to locally activate predefined surface areas (down to 300 nm) by functionalizing graphene to achieve excellent ALD selectivity (up to…

Which regions produce the most innovation policy research?

2022

[EN] This article uses the data indexed in the Web of Science Core Collection and Scopus databases up to and including the year 2020 to map leading regions and trending topics in academic innovation policy research. The country analysis highlights four leading regions in this research field: Western Europe (led by the UK, the Netherlands, Germany, and Spain), North America (led by the USA), Scandinavia (led by Sweden and Denmark), and Asia-Pacific (led by China and Australia). The most common keywords are used to develop a conceptual framework. Applying the Tree of Science approach, we classify the most influential studies into three categories: foundational studies (the roots), structural …

PROTACs: The Future of Leukemia Therapeutics

2022

The fight to find effective, long-lasting treatments for cancer has led many researchers to consider protein degrading entities. Recent developments in PROteolysis TArgeting Chimeras (PROTACs) have signified their potential as possible cancer therapies. PROTACs are small molecule, protein degraders that function by hijacking the built-in Ubiquitin-Proteasome pathway. This review mainly focuses on the general design and functioning of PROTACs as well as current advancements in the development of PROTACs as anticancer therapies. Particular emphasis is given to PROTACs designed against various types of Leukemia/Blood malignancies.

Comparing the Impact of Electric Vehicles on Urban and Insular Networks

2022

Transport sector is moving towards clean and green transportation with the growing market of electric vehicles globally. Electric vehicles are independent fossil fuels consumption, but the massive adoption of electric vehicles soon can lead to a significant burden on the power distribution networks. In this paper, a study on the potential impact of electric vehicles on the power distribution networks of two different regions with totally different realities of population density, an average number of cars per inhabitant, and travel habits has been carried out. The first region is the island of Favignana having an insular power distribution network, while the other region, the city of Palerm…

Stability Analysis in a Vietnam Small Island for the Deployment of a Nearshore Wave Power Plant

2022

The requirement for a more sustainable energy mix is promoting the spreading of technologies supplied by renewable sources. However, the introduction of unprogrammable energy sources in small electrical grids could jeopardize the stability of the entire system. In this context, the paper analyses a small island in Vietnam, assessing the effects due to the installation of a new power plant supplied by sea wave energy. While the installation of this technology could represent a great opportunity to reduce the local energy dependence, on the other side the quality of the supply could be worsened. Solutions are assessed to allow a good network service.

Diversity and distribution of blackflies (Diptera: Simuliidae) of the Tormes river basin (western Spain)

2022

To enhance the partial knowledge on blackfly (Diptera: Simuliidae) fauna in Spain it is crucial to collect all the available data on this group to better understand their ecology and distribution over the years. This study presents data from samples collected along the Tormes river basin (western Spain) during the years 1988, 1989 and 1996 and then stored at the University of Salamanca. As a result of a research stay, a total of 19 species belonging to 3 genera (Prosimulium, Metacnephia and Simulium) and 5 Simulium subgenera (Boophthora, Eusimulium, Nevermannia, Simulium and Wilhelmia) were identified after examining 64% of the stored material, representing 35% of the species known from Sp…

Bioestratigrafía del Triásico de la zona Subbética (Cordillera Bética).

2022

Theree differents lithology can be differenciated basically in t he Triassic of the central sector of Betic: carbona­ tes (facies Muschelk alk), terrigenou s (facies Keuper) and evaporites (facies Keuper). The study of several ou t­ crops in this area allow to know better the paleoecologica ls aspects of Triassic, and to review the stratigraphic paleontology. In the carbonate section fosiil record is formed by molluscs and branchiopods. The occurrence of Costatoria goldfussi and Enantiostreon jlabellum permit us to date the studied series as middle-upper Ladinian in the wes­ tern sector of the Sephardic Province. In general, fossil record is very poor and preservat ion is very bad. The most…

Legislative drafting and gender: some linguistic insights into English and Italian

2022

Languages vary widely in terms of gender systems showing differences in the number of classes, underlying assignment rules and how and where gender is marked. The legislative drafting policy conventionally known as the ‘masculine rule’, whereby ‘he includes she’, raised opposition in the 1970s (under the pressure of feminist movements in the United States and Europe), and the adoption of plain English style forced legislative drafters to basically avoid sentences of undue length, superfluous definitions, repeated words and gender specificity with the aim of achieving clarity, minimising ambiguity, and enhance gender-neutrality. Given the prevalence of English as lingua franca, an increasing…

Energy Management System in Grid-Connected Small Scale AC/DC Microgrids Including Renewable Sources and Flexible Loads

2022

The growth of small scale microgrids with diverse distributed generations has drawn attention to their effective energy management. In this paper, for various energy scenarios, an energy management system is adopted to minimize the energy purchased by a hybrid AC/DC microgrid from the upstream grid due to high peak-hour energy prices and maximise generation from renewable sources, while adjusting the most optimal charge/discharge control strategies for flexible loads such as electric vehicles and storage systems, and the supply of non-controllable loads. In addition, peak shaving is simultaneously implemented in this proposed model without considering minimum power deviation as an objective…

Associations of Work-Family Conflict with Family-Specific, Work-Specific, and Well-Being-Related Variables in a Sample of Polish and Ukrainian Adults…

2022

The conflict between work and family demands increased during the COVID-19 pandemic due to changes in lifestyle related to the lockdown. This study examines the associations between work-family conflict (WFC) and family-work conflict (FWC) with work-specific, family-specific, and well-being-related variables during the second wave of the COVID-19 pandemic. The results may be used in practice to improve the well-being of employees by adjusting home-based work and family areas of life to dynamic changes during the pandemic. The sample of 736 adults from Poland (53.26%) and Ukraine (46.74%), aged between 19 and 72 (M = 39.40; SD = 10.80), participated in the study. The cross-sectional study wa…

Clinical Changes of Respiratory Parameters in Institutionalized Older Adults after a Physiotherapy Program Combining Respiratory and Musculoskeletal …

2022

Nowadays pulmonary diseases are an increasingly important cause of morbidity and mortality. Diaphragmatic breathing is a controlled-breathing technique that aims to optimize thoracoabdominal movements. The aim of this study was to apply a respiratory and musculoskeletal physiotherapy program in institutionalized older adults and to assess the effects on their pulmonary function tests and oxygen saturation. A randomized double-blind clinical trial was conducted with thirty institutionalized older adults, randomly assigned to a control group (CG), who conducted musculoskeletal exercises; or an experimental group (EG) who, in addition, carried out diaphragmatic breathing, administered for eigh…

Speaking of politics in parliament : experiences of writing a book on the digitized Bundestag debates, 1949–2017

2022

This article consists of ex post methodological reflections on the procedures and practices that I applied in my monograph Politik als parlamentarischer Begriff: Perspektiven aus den Plenardebatten des Deutschen Bundestags (Leverkusen, 2021). The book analyses through 18 parliamentary terms the conceptualization of politics in German Bundestag plenary debates from 1949 to 2017. The book was an illustration of my long-term aim of combining political theorizing with the empirical analysis of debate. In writing the book, my guiding idea was to apply Ludwig Wittgenstein’s point, that the meaning of a concept lies in its use, to an analysis of how parliamentary debates open a perspective on the …