Rethinking clinical decision-making to improve clinical reasoning

2022

Improving clinical reasoning techniques is the right way to facilitate decision-making from prognostic, diagnostic, and therapeutic points of view. However, the process to do that is to fill knowledge gaps by studying and growing experience and knowing some cognitive aspects to raise the awareness of thinking mechanisms to avoid cognitive errors through correct educational training. This article examines clinical approaches and educational gaps in training medical students and young doctors. The authors explore the core elements of clinical reasoning, including metacognition, reasoning errors and cognitive biases, reasoning strategies, and ways to improve decision-making. The article addres…

Fluvial activity of the late-glacial to Holocene “Bergstraßenneckar” in the Upper Rhine Graben near Heidelberg, Germany – first results

2022

Abstract. The term “Bergstraßenneckar” (BSN) refers to an abandoned course of the river Neckar. It flowed in a northern direction east of the river Rhine in the eastern part of the northern Upper Rhine Graben in southwestern Germany. The former meandering course merged with the Rhine ca. 50 km further north of the site of the present-day confluence near Mannheim. The palaeo-channels are still traceable by their depressional topography, in satellite images and by the curved boundaries of adjacent settlements and land parcels. In the plan view, satellite and aerial images reveal a succession of meander bends, with older bends being cut off from younger channels. Based on stratigraphic investi…

Passing the test of motherhood? Self‐esteem development and birth experience in the transition to motherhood : A longitudinal mixed methods study in …

2022

Aims To investigate women's childbirth experiences and their relation to self-esteem development in the postpartum year. Design A mixed methods study. Methods Women (N = 125) completed survey questionnaires regarding their self-esteem and childbirth experiences at three time points in 2020–2021: third trimester of pregnancy (T1), 4–8 weeks postpartum (T2) and 1 year postpartum (T3). The survey results were analysed using qualitative thematic and quantitative path analyses with latent change factors. The open-ended answers of the women who demonstrated a change in self-esteem between T2 and T3 were then compared. The STROBE checklist was used as the reporting guideline. Results The quantitat…

Endothelial angiopoietin-2 overexpression in explanted livers identifies subjects at higher risk of recurrence of hepatocellular carcinoma after live…

2022

BackgroundThough the precise criteria for accessing LT are consistently being applied, HCC recurrence (HCC-R_LT) still affects more than 15% of the patients. We analyzed the clinical, histopathological, and biological features of patients with HCC to identify the predictive factors associated with cancer recurrence and survival after LT.MethodsWe retrospectively analyzed 441 patients with HCC who underwent LT in our center. Overall, 70 (15.8%) of them developed HCC-R_LT. We matched them by age at transplant and etiology with 70 non-recurrent patients. A comparable cohort from the Liver Transplant Centre of Bologna served as validation. The clinical and biochemical characteristics and pre-LT…

Prediction and Surveillance Sampling Assessment in Plant Nurseries and Fields

2022

In this paper, we propose a structured additive regression (STAR) model for modeling the occurrence of a disease in fields or nurseries. The methodological approach involves a Gaussian field (GF) affected by a spatial process represented by an approximation to a Gaussian Markov random field (GMRF). This modeling allows the building of maps with prediction probabilities regarding the presence of a disease in plants using Bayesian kriging. The advantage of this modeling is its computational benefit when compared with known spatial hierarchical models and with the Bayesian inference based on Markov chain Monte Carlo (MCMC) methods. Inference through the use of the integrated nested Laplace app…

Congenital hypopituitarism and multiple midline defects in a newborn with non-familial Cat Eye syndrome

2022

Abstract Background Cat eye syndrome (CES) is a rare chromosomal disease, with estimated incidence of about 1 in 100,000 live newborns. The classic triad of iris coloboma, anorectal malformations, and auricular abnormalities is present in 40% of patients, and other congenital defects may also be observed. The typical associated cytogenetic anomaly relies on an extra chromosome, derived from an inverted duplication of short arm and proximal long arm of chromosome 22, resulting in partial trisomy or tetrasomy of such regions (inv dup 22pter-22q11.2). Case presentation We report on a full-term newborn, referred to us soon after birth. Physical examination showed facial dysmorphisms, including …

The effect of individual and classroom moral disengagement on antisocial behaviors in Colombian adolescents: A multilevel model

2022

The present study examined the predictive effect of moral disengagement (within and between classrooms) on antisocial behaviors in Colombian adolescents, as well as the interaction of moral disengagement with classroom composition by age, socioeconomic status (SES), and perceived teacher–student relationship quality. Multilevel modeling was used to identify individual, compositional, and contextual effects on antisocial behaviors. The predictive variables were: (a) classroom mean score (i.e., between-classroom analysis), and (b) student deviation from the classroom mean score (i.e., within-classroom analysis). The sample included 879 students nested in 24 seventh-grade classrooms in three C…

Biomarkers of Oxidative Stress in Acute and Chronic Diseases

2022

Molecular biomarkers consent to apply individual decisions in the complex management of both acute or chronic diseases, and their identification constitutes a fundamental phase for achieving the important object to develop personalized therapies [...]

Postural Assessment Systems in the Prevention of Haemophilic Arthropathy: A Narrative Review

2022

This narrative review aims to give an overview of some postural evaluation systems currently used in patients with haemophilia. Among them, first, we analyse the HJHS scale, recognized as a specific evaluation tool for haemophilic arthropathy. Second, we focus on other systems usually used in non-haemophilic patients that have also shown good applicability in this patient category, such as gait analysis, stabilometry, and baropodometric examination. This review underlines the use these tools could have in clinical practice to identify the early postural alterations in patients with haemophilia and set up personalised rehabilitation programs.

On List Coloring with Separation of the Complete Graph and Set System Intersections

2022

We consider the following list coloring with separation problem: Given a graph $G$ and integers $a,b$, find the largest integer $c$ such that for any list assignment $L$ of $G$ with $|L(v)|= a$ for any vertex $v$ and $|L(u)\cap L(v)|\le c$ for any edge $uv$ of $G$, there exists an assignment $\varphi$ of sets of integers to the vertices of $G$ such that $\varphi(u)\subset L(u)$ and $|\varphi(v)|=b$ for any vertex $u$ and $\varphi(u)\cap \varphi(v)=\emptyset$ for any edge $uv$. Such a value of $c$ is called the separation number of $(G,a,b)$. Using a special partition of a set of lists for which we obtain an improved version of Poincar\'e's crible, we determine the separation number of the c…

Tensorization of quasi-Hilbertian Sobolev spaces

2022

The tensorization problem for Sobolev spaces asks for a characterization of how the Sobolev space on a product metric measure space $X\times Y$ can be determined from its factors. We show that two natural descriptions of the Sobolev space from the literature coincide, $W^{1,2}(X\times Y)=J^{1,2}(X,Y)$, thus settling the tensorization problem for Sobolev spaces in the case $p=2$, when $X$ and $Y$ are infinitesimally quasi-Hilbertian, i.e. the Sobolev space $W^{1,2}$ admits an equivalent renorming by a Dirichlet form. This class includes in particular metric measure spaces $X,Y$ of finite Hausdorff dimension as well as infinitesimally Hilbertian spaces. More generally for $p\in (1,\infty)$ we…

Branding4Resilience: Explorative and Collaborative Approaches for Inner Territories

2022

This article analyzes inner and marginal territories in four Italian peripheral contexts by first discussing some of the results and future steps of the “B4R Branding4Resilience” research project, funded by the Italian Ministry of Research from 2020 to 2023. The overall research is based on three phases: (1) the exploration phase to analyze socio-economic data and territorial dynamics; (2) the co-design phase involving local actors to develop ideas for a selected pilot case; (3) the co-visioning phase where a future transformative perspective for the whole area was shared with the institutions. The article focuses on phase 1 and presents some first results achieved by the application of a m…

Plant-animal seed dispersal interactions as key drivers of ecological restoration in a changing world

2022

Many global and European commitments state the need to plant billions of trees and restore millions of hectares of degraded ecosystems to contrast biodiversity loss, desertification and climate change. Seed dispersal is a crucial process promoting vegetation dynamics, and in the Mediterranean, up to 65% of woody plant species need animals for seed dispersal. Therefore, such mutualistic ecological interaction represents a key nature-based solution to help us reaching our commitments. In this presentation first we will report the strong expansion rate and correlated finescale spatio-temporal patterns of woody natural regeneration over a pastureland, using a spatially-explicit framework deploy…

« Pequeña museografía sobre ilustraciones a la obra de Quevedo »

2022

Este trabajo pretende modestamente brindarle al lector enamorado de esa contemplación y quietud que albergan los museos, una pequeña museografía sobre ilustraciones (1966-1982) a la obra de Quevedo.
 Se ordenan dichas obras, principalmente estampas, según un criterio básicamente plástico: aguafuerte, litografía y xilografías. Un paseo, que se espera ameno, por el mundo del arte quevedesco.

The heterogeneity of the Mexican lithospheric mantle: Clues from noble gas and CO2 isotopes in fluid inclusions

2022

The abundance of mantle-derived rocks and lavas, in combination with its tectonic evolution, render Mexico a perfect laboratory to investigate the chemical and the isotopic heterogeneity of the lithospheric mantle. New data on the composition of noble gases and CO2in Mexican mantle xenoliths and lavas is reported. Our samples consist of six ultramafic nodules from the Durango Volcanic Field (DVF) and the San Quintin Volcanic Field (SQVF), monogenetic complexes belonging to the Mexican Basin and Range province; and four lavas from the Sierra Chichinautzin (SCN), a Quaternary monogenetic volcanic field located in the Mexican volcanic arc. Ne and Ar isotopes in fluid inclusions reveal mixing b…

Exploring the impact of COST Actions on scientific collaboration

2022

The goal of this study was to explore the effects of participating in a Cost Action on the level of scientific collaboration. The results show on average a remarkable increase of co-publications between an Action’s active members, including interdisciplinary publications, and an increased involvement of scientists from peripheral countries (i.e., inclusive target countries), early career researchers, and women. The impact of active participation in an Action is not limited to the period of the project, but it persists also after its conclusion. The increase in collaborative publications does not come at the expense of non-collaborative publications, which points out to a net positive …

Differential reproductive plasticity under thermal variability in a freshwater fish (Danio rerio)

2022

Human-driven increases in global mean temperatures are associated with concomitant increases in thermal variability. Yet, few studies have explored the impacts of thermal variability on fitness-related traits, limiting our ability to predict how organisms will respond to dynamic thermal changes. Among the myriad organismal responses to thermal variability, one of the most proximate to fitness—and, thus, a population's ability to persist—is reproduction. Here, we examine how a model freshwater fish ( Danio rerio ) responds to diel thermal fluctuations that span the species's viable developmental range of temperatures. We specifically investigate reproductive performance metrics including sp…

Factors leading to dissemination of cutaneous anthrax: an international ID-IRI study

2022

Background: Although anthrax is a rare zoonotic infection, it still causes significant mortality and morbidity. In this multicenter study, which is the largest anthrax case series ever reported, we aimed to describe the factors leading to dissemination of cutaneous anthrax.Methods: Adult patients with cutaneous anthrax from 16 referral centers were pooled. The study had a retrospective design, and included patients treated between January 1, 1990 and December 1, 2019. Probable, and confirmed cases based upon CDC anthrax 2018 case definition were included in the study. A descriptive statistical analysis was performed for all variables.Results: A total of 141 cutaneous anthrax patients were i…

Seven Shades of Grey: A Follow-Up Study on the Molecular Basis of Coat Colour in Indicine Grey Cattle Using Genome-Wide SNP Data

2022

Shades of grey and brown are a dominant component in mammal coat colours, representing a fundamental trait involved in a great number of processes including cryptism, sexual selection and signalling. The genetic mechanisms of the grey colouration in mammals are very complex and controlled by hundreds of genes whose effects and interactions are still largely unclear. In this study, we adopted a robust multi-cohort Fst outlier approach based on pairwise contrasts between seven grey indicine cattle breeds and both taurine and indicine non-grey cattle breeds in order to find genomic regions potentially related to the grey colouration. On the basis of three main drawn settings, built in order to…

The prevalence of onchocerciasis in Africa and Yemen, 2000-2018: a geospatial analysis.

2022

Abstract Background Onchocerciasis is a disease caused by infection with Onchocerca volvulus, which is transmitted to humans via the bite of several species of black fly, and is responsible for permanent blindness or vision loss, as well as severe skin disease. Predominantly endemic in parts of Africa and Yemen, preventive chemotherapy with mass drug administration of ivermectin is the primary intervention recommended for the elimination of its transmission. Methods A dataset of 18,116 geo-referenced prevalence survey datapoints was used to model annual 2000–2018 infection prevalence in Africa and Yemen. Using Bayesian model-based geostatistics, we generated spatially continuous estimates o…

In vivo molecular imaging of the neuroinflammatory response to peripheral acute bacterial infection in older patients with cognitive dysfunction: A c…

2022

IntroductionChronic neuroinflammatory events have been implicated in the pathophysiology of neurodegenerative conditions but no studies have directly examined the neuroinflammatory response to acute systemic infection in older people with dementia. The objective of this study was to determine the magnitude of the neuroinflammatory response triggered by acute systemic infection in older subjects with dementia and/or delirium compared to cognitively healthy controls.MethodsWe recruited 19 participants (4 with delirium, 4 with dementia, 4 with delirium superimposed on dementia, 7 cognitively healthy) hospitalized with acute systemic bacterial infection not involving the Central Nervous System.…

Influence of Cactus Pear Mucilage-Based Edible Coating on Marketability and Edibility Parameters of Minimally Processed Loquat Fruits

2022

Loquat fruit, popular all over the world for its mild, subacid, and sweet taste, has been classified as a non-climacteric fruit with a very short postharvest life. The fruit decays quickly after harvest, and losses in titratable acidity, taste, and juiciness, and internal browning occurs rapidly during shelf life. The aim of our study was to assess the effects of cactus pear mucilage-based coating on quality, nutraceutical value, microbiological growth, and sensorial parameters of minimally processed white-flesh Martorana and orange-red-flesh Gigante Rossa loquat fruits during cold storage. The effect of mucilage edible coating on the postharvest life, qualitative attributes, and nutraceuti…

Teacher Training and Linguistic Diversity: Methodological and Outcome Analysis of an Online Course

2022

This research aims to delve into sociolinguistic content in the context of teacher training itineraries at the Universitat Politècnica de València (Spain). Using both quantitative and qualitative methodologies, the presence of sociolinguistic content will be justified. Likewise, we will analyze the contents and methodology of the subject based on the access data to the materials and the evaluation of the students. The results obtained refer both in terms of the importance of dealing with linguistic attitudes in class and of assessing the tool itself and some of the students' work habits, which we can extrapolate to others similar training environments, in order to extract good practices.

Effects of Three Interventions Combining Impact or Walking at Intense Pace Training, with or without Calcium and Vitamin Supplements, to Manage Postm…

2022

The purpose was to assess the effects of three interventions on bone mineral density (BMD) to prevent the onset or progression of osteoporosis in postmenopausal women. Specifically, thirty-nine postmenopausal women, diagnosed with osteopenia or osteoporosis, implemented either high-impact training (G1), the same training + calcium and vitamin D intake (G2), or walked at an intense pace + calcium and vitamin D (G3). Baseline change (BC) in BMD was estimated using the femoral neck and lumbar spine T-scores. Participants were classified as having suffered fractures and/or falls before (24-month) and during the 2-year intervention. The participants—aged 61.8 years—were allocated int…

Manipulating Light with Tunable Nanoantennas and Metasurfaces

2022

The extensive progress in nanofabrication techniques enabled innovative methods for molding light at the nanoscale. Subwavelength structured optical elements and, in general, metasurfaces and metamaterials achieved promising results in several research areas, such as holography, microscopy, sensing and nonlinear optics. Still, a demanding challenge is represented by the development of innovative devices with reconfigurable optical properties. Here, we review recent achievements in the field of tunable metasurface. After a brief general introduction about metasurfaces, we will discuss two different mechanisms to implement tunable properties of optical elements at the nanoscale. In particular…

Bioactive Compounds and Antioxidant Properties with Involved Mechanisms of Eugenia involucrata DC Fruits

2022

In this study, the phytochemical profile and the antioxidative properties of Eugenia involucrata fruits were evaluated. Spectrophotometric assays indicated that these berries are a rich source of polyphenols with very high radical-scavenging and metal-reducing activities. High-performance liquid chromatography–Orbitrap analysis was able to carry out the annotation of 36 different compounds, mainly belonging to the flavonol, flavan-3-ol, and anthocyanin families. Antioxidant activity of the fruit extract was evaluated in a cell-based lipid peroxidation model. Obtained data showed that the extract, at very low concentration, was able to prevent oxidative damage in HepG2 cells exposed to oxida…

The Hajłasz Capacity Density Condition is Self-improving

2022

We prove a self-improvement property of a capacity density condition for a nonlocal Hajlasz gradient in complete geodesic spaces with a doubling measure. The proof relates the capacity density condition with boundary Poincare inequalities, adapts Keith-Zhong techniques for establishing local Hardy inequalities and applies Koskela-Zhong arguments for proving self-improvement properties of local Hardy inequalities. This leads to a characterization of the Hajlasz capacity density condition in terms of a strict upper bound on the upper Assouad codimension of the underlying set, which shows the self-improvement property of the Hajlasz capacity density condition. Open Access funding provided than…

ANALISI DEL COMPORTAMENTO MECCANICO DI SANDWICHES GREEN COSTITUITI DA PELLI IN BIOCOMPOSITO E CORE IN BALSA/SUGHERO

2022

Negli ultimi anni l’aumento della sensibilità nei confronti della salvaguardia ambientale, anche attraverso apposite norme in materia di lotta all’inquinamento e di riciclo dei materiali a fine vita, ha portato ad un notevole interesse dei ricercatori verso i cosiddetti compositi green, materiali costituiti in genere da rinforzi di origine naturale e matrici “bio-based” a basso impatto ambientale. Una categoria interessante di materiali innovativi, caratterizzati da una elevata resistenza a flessione unita ad un basso peso specifico, è rappresentata dai cosiddetti sandwiches, costituiti in genere da robuste pelli in composito fibro-rinforzato e da un core in materiale molto leggero e poco r…

Photon emissivity of the quark-gluon plasma: A lattice QCD analysis of the transverse channel

2022

We present results for the thermal photon emissivity of the quark-gluon plasma derived from spatially transverse vector correlators computed in lattice QCD at a temperature of 250 MeV. The analysis of the spectral functions, performed at fixed spatial momentum, is based on continuum-extrapolated correlators obtained with two flavours of dynamical Wilson fermions. We compare the next-to-leading order perturbative QCD correlators, as well as the ${\cal N}=4$ supersymmetric Yang-Mills correlators at infinite coupling, to the correlators from lattice QCD and find them to lie within $\sim10\%$ of each other. We then refine the comparison, performing it at the level of filtered spectral functions…

Una aproximación a la arquitectura doméstica en la ciudad romana de Lesera (Forcall, Castellón). La domus I

2022

In this article we study the remains of a first domus excavated in the Augustan municipium of Lesera (Forcall, Castellón). In the excavations, three construction phases could be distinguished that can be dated between the end of the 1st century BC and the Flavian period. Of these, the first and third are the best known and represent different moments in the process of cultural change of its inhabitants. The first house had an east-facing porch, it was divided into six rooms and was destroyed by fire around 30-40 AD. The third was built around 70-90 AD and presents properly Roman architectural and ornamental elements. It is a corridor house divided into four rooms: a kitchen equipped with a …

In Pursuit of Measuring Pre-reflective Music Listening Experiences

2022

While the diverse effects and uses of music and sound have been extensively documented within music psychology, relatively little attention has been paid to the process and experience of listening itself. Previous literature have, however, considered different ways of attending to sounds via the concept of listening modes, which highlights the different ways and strategies through which listeners intentionally orientate themselves to the activity of listening and creating the experiential meaning of the sound. In this paper, we continue on these lines by focusing on the very basic attentional dispositions for listening that often remain unconscious. As op posed to more deliberate and intent…

Magnetic coiffure: Engineering of human hair surfaces with polyelectrolyte-stabilised magnetite nanoparticles

2022

Here we report a spontaneous electrostatic coating of human hair with aqueous Fe3O4 colloids capable to tailor magnetic properties to hair, orienting and even moving them under the influence of the external magnetic field. Magnetite particles were modified by cationic and anionic polyelectrolytes and then successfully deposited in dense arrays, starting from cuticle gaps and spreading further over a major hair surface. These biocompatible and biodegradable magnetic nanoparticles may serve as carriers for drug loading and delivery for topical pharmaceutical treatments. The deposition process was imaged in real-time using dark-field microscopy. The hair specimens were further studied using a …

Når terskelen til velferdsstaten blir for høy Arbeidsledige polske migranters erfaringer

2022

Training Deep Neural Networks with Novel Metaheuristic Algorithms for Fatigue Crack Growth Prediction in Aluminum Aircraft Alloys

2022

Fatigue cracks are a major defect in metal alloys, and specifically, their study poses defect evaluation challenges in aluminum aircraft alloys. Existing inline inspection tools exhibit measurement uncertainties. The physical-based methods for crack growth prediction utilize stress analysis models and the crack growth model governed by Paris’ law. These models, when utilized for long-term crack growth prediction, yield sub-optimum solutions and pose several technical limitations to the prediction problems. The metaheuristic optimization algorithms in this study have been conducted in accordance with neural networks to accurately forecast the crack growth rates in aluminum alloys. Through ex…

Social stress under binge-like alcohol withdrawal in adolescence: evidence of cannabidiol effect on maladaptive plasticity in rats.

2022

Abstract Background Alcohol binge drinking may compromise the functioning of the nucleus accumbens (NAc), i.e. the neural hub for processing reward and aversive responses. Methods As socially stressful events pose particular challenges at developmental stages, this research applied the resident–intruder paradigm as a model of social stress, to highlight behavioural neuroendocrine and molecular maladaptive plasticity in rats at withdrawal from binge-like alcohol exposure in adolescence. In search of a rescue agent, cannabidiol (CBD) was selected due to its favourable effects on alcohol- and stress-related harms. Results Binge-like alcohol exposed intruder rats displayed a compromised defensi…

In Situ Synthesis of Polythiophene and Silver Nanoparticles within a PMMA Matrix: A Nanocomposite Approach to Thermoelectrics

2022

The processability of organic thermoelectric materials plays a crucial role due to their clear advantages of applicability in large-scale areas compared to traditional inorganic counterparts. A promising way to process thermoelectric materials based on conductive polymers is through in situ polymerization in an insulating polymer matrix. This work shows an interpenetrating polymeric network based on polythiophene, silver nanoparticles (Ag NPs), and poly(methyl methacrylate) (PMMA) produced by the oxidative polymerization of terthiophene by an oxidizing silver salt in a PMMA matrix. Ag NPs are in situ synthesized simultaneously as a byproduct. The reaction occurs very fast in the solid state…