showing 36 of ~574560 from 574555 documents
Validity and Reliability of the Leomo Motion-Tracking Device Based on Inertial Measurement Unit with an Optoelectronic Camera System for Cycling Peda…
2022
Background: The use of inertial measurement sensors (IMUs), in the search for a more ecological measure, is spreading among sports professionals with the aim of improving the sports performance of cyclists. The kinematic evaluation using the Leomo system (TYPE-R, Leomo, Boulder, CO, USA) has become popular. Purpose: The present study aimed to evaluate the reliability and validity of the Leomo system by measuring the angular kinematics of the lower extremities in the sagittal plane during pedaling at different intensities compared to a gold-standard motion capture camera system (OptiTrack, Natural Point, Inc., Corvallis, OR, USA). Methods: Twenty-four elite cyclists recruited from national a…
Stromal and Immune Cell Dynamics in Tumor Associated Tertiary Lymphoid Structures and Anti-Tumor Immune Responses
2022
Tertiary lymphoid structures (TLS) are ectopic lymphoid organs that have been observed in chronic inflammatory conditions including cancer, where they are thought to exert a positive effect on prognosis. Both immune and non-immune cells participate in the genesis of TLS by establishing complex cross-talks requiring both soluble factors and cell-to-cell contact. Several immune cell types, including T follicular helper cells (Tfh), regulatory T cells (Tregs), and myeloid cells, may accumulate in TLS, possibly promoting or inhibiting their development. In this manuscript, we propose to review the available evidence regarding specific aspects of the TLS formation in solid cancers, including 1) …
Developing human/AI interactions for chat-based customer services: lessons learned from the Norwegian government
2022
Advancements in human/AI interactions led to smartification of public services via the use of chatbots. Here, we present findings from a clinical inquiry research project in a key public service organisation in Norway. In this project, researchers and practitioners worked together to generate insights on the action possibilities offered to human service agents by chatbots and the potential for creating hybrid human/AI service teams. The project sensitised service agents to discover affordances based on their actual practices, rather than on the predefined use of chatbots. The different affordances identified can be useful for practitioners who design and deploy chatbot-based services. The a…
Modeling a Novel Variant of Glycogenosis IXa Using a Clonal Inducible Reprogramming System to Generate "Diseased" Hepatocytes for Accurate Diagnosis.
2022
The diagnosis of inherited metabolic disorders is a long and tedious process. The matching of clinical data with a genomic variant in a specific metabolic pathway is an essential step, but the link between a genome and the clinical data is normally difficult, primarily for new missense variants or alterations in intron sequences. Notwithstanding, elucidation of the pathogenicity of a specific variant might be critical for an accurate diagnosis. In this study, we described a novel intronic variant c.2597 + 5G > T in the donor splice sequence of the PHKA2 gene. To investigate PHKA2 mRNA splicing, as well as the functional consequences on glycogen metabolism, we generated hepatocyte-like ce…
Staff feeding practices, food neophobia, and educational level in early education and care settings: A cross-sectional study
2022
Feeding practices in early childhood education and care (ECEC) settings are important for the development of healthy eating habits early in life. However, there is limited research on feeding practices among ECEC staff working with infants and toddlers, and how these practices relate to staff education. This study assessed the feeding practices, level of food neophobia, and participation in shared meals among ECEC staff, and examined whether there were differences in feeding practices related to education and shared meals. Furthermore, we explored the association between food neophobia levels among ECEC staff and their respective feeding practices in ECEC. In total, 130 ECEC teachers and ot…
Un museo de ciencia accesible a la sociedad. Contribución e impacto
2022
El conocimiento es objeto de investigación y discusión; la ciudadanía lo utiliza de manera crítica transformándolo en herramientas que les permiten mejorar su vida a nivel individual y colectivo. Las diferencias sociales y jerárquicas que históricamente determinaban el acceso al capital formativo se han difuminado en el último siglo, y cada vez más se consume una gran variedad de formas de cultura, independientemente del nivel social, económico o cultural. Entre los centros culturales más visitados por los y las ciudadanas encontramos los museos. Estos núcleos de conocimiento trabajan para que su finalidad comunicativa esté en sintonía con los contenidos que ofrecen y tratan de dar respuest…
Global and Regional IUCN Red List Assessments: 13
2022
In this contribution, the conservation status assessment of two vascular plants according to IUCN categories and criteria are presented. It includes the global assessment of Isoëtes todaroana Troìa & Raimondo and Moluccella bucharica (B.Fedtsch.) Ryding.
Training of future STEAM teachers: Comparison between primary degree students and secondary master's degree students
2022
In recent years, the presence of the acronym STEAM has been growing in the educational field. All around the world we are faced with a growing demand for professional STEM skills, however, who has the responsibility to train future STEAM teachers? In this article, we explain the results of an investigation with university students pursuing a degree in primary education and Master’s degree students in secondary education, with technology speciality, participating in a seminar about STEAM projects design in two consecutive academic calendar years (18/19 and 19/20). We analyse the responses to a questionnaire which was specifically designed to discover their knowledge about STEAM and the pred…
Physical activity and health: Findings from Finnish monozygotic twin pairs discordant for physical activity.
2022
Genetic and early environmental differences including early health habits associate with future health. To provide insight on the causal nature of these associations, monozygotic (MZ) twin pairs discordant for health habits provide an interesting natural experiment. Twin pairs discordant for leisure-time physical activity (LTPA) in early adult life are thus a powerful study design to investigate the associations between long-term LTPA and indicators of health and wellbeing. We have identified 17 LTPA discordant twin pairs from two Finnish twin cohorts and summarize key findings of these studies in this paper. The carefully characterized rare long-term LTPA discordant MZ twin pairs have part…
Cushioning the Covid-19 Economic Consequences on Entrepreneurial Ecosystems: The Role of Stakeholders` Engagement, Collaboration, and Support
2022
The Covid-19 (corona virus) disruptions have necessitated a new way of thinking about how entrepreneurship and its environments (ecosystems) function in times of heightened uncertainty. Based on a sample of 237 entrepreneurial ecosystem (EE) stakeholders in Tanzania – an emerging economy, we examine the pandemic economic consequences steered by government countermeasures on the EE-perceived quality and performance. We further examined the role played by EE stakeholders` engagement, collaboration, and support during the crisis. Our structural equation model results suggest that strictness of government counter measures for containment of the current pandemic predicament has a bearing on EE- …
Keratin/alginate hybrid hydrogels filled with halloysite clay nanotubes for protective treatment of human hair
2022
Keratin/alginate hydrogels filled with halloysite nanotubes (HNTs) have been tested for the protective coating of human hair. Preliminary studies have been conducted on the aqueous colloidal systems and the corresponding hydrogels obtained by using Ca2+ ions as crosslinkers. Firstly, we have investigated the colloidal properties of keratin/alginate/HNTs dispersions to explore the specific interactions occurring between the biomacromolecules and the nanotubes. Then, the rheological properties of the hydrogels have been studied highlighting that the keratin/alginate interactions and the subsequent addition of HNTs facilitate the biopolymer crosslinking. Finally, human hair samples have been t…
Correspondence between theory and practice of a Beerkan infiltration experiment
2022
The Beerkan infiltration experiment is carried out by inserting the ring a short depth into the soil and establishing a positive head of water on the infiltration surface for at least a part of the run. Nevertheless, the data are analyzed by assuming a fully unconfined infiltration process (ring insertion depth, d = 0 cm) and a null ponded depth of water (H = 0 cm). The influence of ring insertion and ponded water on an infiltration process of 2 h sampled every minute was tested in this numerical investigation. Five soils varying from sand to silt loam, three ring radii (5–15 cm), and the Beerkan-specific range of values for both d and H (between 0 and 1 cm) were considered. The differences…
Analytical models for the pulse shape of a superconductor-ferromagnet tunnel junction thermoelectric microcalorimeter
2022
AbstractThe superconductor-ferromagnet thermoelectric detector (SFTED) is a novel ultrasensitive radiation detector based on the giant thermoelectric effect in superconductor-ferromagnet tunnel junctions. We demonstrate analytical models and solutions in the time domain for a SFTED operated as a microcalorimeter (pulse excitation), in the linear small-signal limit. Based on these solutions, the signal current and temperature pulse response were studied for two different electrical circuit models, providing design conditions for stable and non-oscillatory response.Kindly check and confirm whether the corresponding author is correctly identified.The corresponding author is correct.
Promising Strategies for Preserving Adult Endothelium Health and Reversing Its Dysfunction: From Liquid Biopsy to New Omics Technologies and Noninvas…
2022
The endothelium has multiple functions, ranging from maintaining vascular homeostasis and providing nutrition and oxygen to tissues to evocating inflammation under adverse conditions and determining endothelial barrier disruption, resulting in dysfunction. Endothelial dysfunction represents a common condition associated with the pathogenesis of all diseases of the cardiovascular system, as well as of diseases of all of the other systems of the human body, including sepsis, acute respiratory distress syndrome, and COVID-19 respiratory distress. Such evidence is leading to the identification of potential biomarkers and therapeutic targets for preserving, reverting, or restoring endothelium in…
Le champignon mycorhizien Funneliformis mosseae comme agent de biocontrôle de la septoriose du blé
2022
International audience; La septoriose, maladie causée par le champignon hémibiotrophe Zymoseptoria tritici, est l’une des maladies les plus dommageables pour la culture du blé. Dans un contexte de transition agroécologique, le développement des stratégies de lutte respectueuses de la santé humaine et de l’environnement est une priorité. La colonisation racinaire des plantes par les champignons mycorhiziens à arbuscules (CMA) est connue pour induire la MIR (Mycorrhiza Induced Resistance), correspondant à un état de résistance de la plante à divers bio-agresseurs. Nous avons ainsi testé l’efficacité du CMA Funneliformis mosseae à protéger le blé contre la septoriose dans le cadre du projet Bi…
Risk Factors for Anaplastic Thyroid Carcinoma: A Case Series From a Tertiary Referral Center for Thyroid Surgery and Literature Analysis
2022
Anaplastic thyroid carcinoma (ATC) is a very rare and extremely aggressive disease with a very poor prognosis. Several risk factors have been hypothesized, but there is no clear-cut literature data on it. We reviewed the literature concerning risk factors for ATC and analyzed the institutional database from 2005 to 2022. In total, 15 papers were suitable for review, while the retrospective data collection search, conducted on our institutional database, provided 13 results. In our experience, in agreement with literature data, ATC seems to be a neoplasm peculiar to old age (in our database, mean age is 72 years), with a higher prevalence in subjects with a low level of education and a long …
Risky Lives? Self-Directed Violence and Violence From Others Among Young People Not in Education, Employment, or Training (NEET)
2022
Self-directed violence and violence from others comprise a major public health concern in youth. However, we lack knowledge about the prevalence of violent experiences among young people that are not in education, employment, or training (NEET), whether violent occurrences are similar among girls and boys, and whether violence differs between NEET youths and young students. This cross-sectional study compared the occurrences of self-directed violence (suicide attempts and self-harm) and exposure to violence from others (violent threats, beaten without visible marks, or injured due to violent events) between 96 NEET youth and 384 age- and sex-matched upper secondary school students (16–21 ye…
Permanent deformation and fatigue damage interaction in asphalt concrete using energy approach
2022
The interaction of fatigue and permanent deformation is very complex phenomenon and little attempt is made on this topic. This paper presents an investigation on the interaction of the two damages using the energy approach. Laboratory tests were conducted for both fatigue and permanent deformation on two different asphalt concrete in a sequential test procedure. A new failure criterion is proposed based on the dissipated energy ratio (DER). The proposed criterion for permanent deformation gives more damage indicator (inflection points) than the conventional flow number/strain rate criterion. The sequential test procedure is also found economical that can be standardized. From the study, str…
Estimation of durability of new surface courses using accelerated load test and expert's opinions
2022
There is an increasing interest among road authorities in studying sustainability assessment of road infrastructure. The durability of the surface course is a critical factor in these calculations and must be carefully considered in the analysis. New types of asphalt mixes with the potential to improve the results in the sustainability assessment have no proven track record and are thus more likely not to be used until solid performance data is available. To bridge the gap and diminish the uncertainty about the durability of Green asphalt mixes for surface courses, a combination of laboratory tests and tests in a circular road simulator were performed. Eight mixes were tested in total, four…
Post-Quantum Secure Identity-Based Encryption Scheme using Random Integer Lattices for IoT-enabled AI Applications
2022
Identity-based encryption is an important cryptographic system that is employed to ensure confidentiality of a message in communication. This article presents a provably secure identity based encryption based on post quantum security assumption. The security of the proposed encryption is based on the hard problem, namely Learning with Errors on integer lattices. This construction is anonymous and produces pseudo random ciphers. Both public-key size and ciphertext-size have been reduced in the proposed encryption as compared to those for other relevant schemes without compromising the security. Next, we incorporate the constructed identity based encryption (IBE) for Internet of Things (IoT) …
A Cogging Torque Minimization Procedure for Interior Permanent Magnet Synchronous Motors Based on a Progressive Modification of the Rotor Lamination …
2022
This article describes a simple cogging torque minimization procedure for interior permanent magnet synchronous machines (IPMSMs), consisting of a progressive modification of the rotor lamination geometry. This procedure can be generalized for the main topologies of PMSM, independently of the number of stator slots or the location of the permanent magnets. For this purpose, a basic IPMSM structure is analyzed by means of the FEM (finite element method) approach, and then, several other IPMSM geometries, obtained by adequately modifying the rotor lamination geometry of the basic IPMSM model without changing its stator configuration, are proposed and discussed. The trends of the cogging torqu…
An Innovative Structural Dynamic Identification Procedure Combining Time Domain OMA Technique and GA
2022
In this paper an innovative and simple Operational Modal Analysis (OMA) method for structural dynamic identification is proposed. It combines the recently introduced Time Domain–Analytical Signal Method (TD–ASM) with the Genetic Algorithm (GA). Specifically, TD–ASM is firstly employed to estimate a subspace of candidate modal parameters, and then the GA is used to identify the structural parameters minimizing the fitness value returned by an appropriately introduced objective function. Notably, this method can be used to estimate structural parameters even for high damping ratios, and it also allows one to identify the Power Spectral Density (PSD) of the structural excitat…
Conducting a task while reconstructing its meaning
2022
This article investigates the way an institutional task of a meeting is oriented to by different meeting participants and developed in and through local interaction. Our data come from a city organization, where a large organizational change is planned and prepared through a series of face-to-face encounters and accompanying written texts. Using the notion of recontextualization and by connecting it to the conversation analytical method and to the notion of intersubjectivity, the study examines how the institutional task that is verbalized in written form prior to the meeting is conceptualized by meeting participants in their turns of talk. By doing so, the study will particularly shed ligh…
Leisure Adjustments of Older Finnish Adults during the Early Stages of the COVID-19 Pandemic
2022
The current approach to “aging well” emphasizes the importance of active leisure participation in late adulthood. This relates to the view that leisure activities enable older adults to stay physically, mentally, and socially active, and they thereby contribute to wellbeing. In spring 2020, leisure activity engagement was significantly hampered by the COVID-19 pandemic. This study explores leisure-related experiences and adaptation strategies among Finnish older adults during the period of strict physical distancing. The data comprises letters (N = 77) written by Finnish people (aged 70–93) that were analyzed using content analysis. The study suggests that the reorganization of leisure was …
Mocking fakeness
2022
Abstract Phonetic resources, like dialects and accents, are used in ethnic humour to build up a recognisable character that pokes fun at the stereotypes associated with a particular identity, sometimes with critical and political undertones. In this article, we examine the manipulation of one such resource, aspiration, used in performing and mocking one such clichéd character, called the fake Sámi. This character has a contested history in Finnish tourism and marketing practices, and is embedded in a long-standing debate about who can use emblems of Sámi identity for economic purposes. Adopting a sociophonetic language regard and folk linguistics approaches (Preston 2010; Niedzielski & …
Étude des températures simulées avec Méso-NH : sensibilité à l’artificialisation des sols à Grenoble et Lyon.
2022
International audience; La modélisation atmosphérique à très fine échelle permet d’analyser la dynamique de l’îlot dechaleur urbain en contexte de topographie complexe. Deux simulations (Urbaine et Non-Urbaine) mettenten évidence les effets associés à l'urbanisation. La taille des agglomérations, dans le cas de Lyon etGrenoble, n'influence pas la différence de température entre les deux simulations. Les conditions destabilité influencent fortement ces différences. L'ICU peut être intensifié par l'affaiblissement du vent oul’effet de piégeage et/ou le développement d’une couche d’inversion.
High-energy γ-ray detection of supernova remnants in the Large Magellanic Cloud
2022
We present the results of a cluster search in the gamma-ray sky images of the Large Magellanic Cloud (LMC) region by means of the Minimum Spanning Tree (MST) and DBSCAN algorithms, at energies higher than 6 and 10 GeV, using 12 years of Fermi-LAT data. Several significant clusters were found, the majority of which associated with previously known gamma-ray sources. We confirm our previous detection of the Supernova Remnants N 49B and N 63A and found new significant clusters associated with the SNRs N 49, N 186D and N 44. These sources are among the brightest X-ray remnants in the LMC and corresponds to core-collapse supernovae interacting with dense HII regions, indicating that an hadronic …
Manipulation as an ideological tool in the political genre of Parliamentary discourses
2022
AbstractThe present study analyzes the discursive strategies of manipulation in the political genre of a discourse in Parliament with an aim to convince the audience that the Prime Minister and his party are innocent of receiving illegal cash donations from a slush fund run in the party. For that purpose, we have usedVan Dijk’s (2006)scheme of strategies of manipulation at several levels of discourse (content, lexis, topics, syntax, rhetoric, and order of discourse). Findings of the study show that the Prime Minister’s speech presents characteristics of ideological discourse, since it follows a general strategy of positive in-group and negative out-group presentation, which has an overall l…
Current and emerging drugs for the treatment of atherosclerosis: the evidence to date
2022
Introduction: Atherosclerosis can be considered a chronic inflammatory process that stands out as a dominant cause of cardiovascular disease (CVD). Since blood lipids are the leading risk factor for atherosclerosis development, lowering low-density lipoprotein cholesterol (LDL-C) and other apolipoprotein B-containing lipoproteins reduces the risk of future cardiovascular events. However, there has been significant progress in developing lipid-lowering drugs for aggressive management of dyslipidemia, the rates of CVD events remain unacceptably high, so there is great need to identify novel therapeutic pathways targeting the atherosclerosis process.Areas covered: We discussed the current guid…
The Expression and Prognostic Significance of VEGF and CXCR4 in Gastric Cancer: Correlation with Angiogenesis, Lymphangiogenesis and Progression
2022
The cellular response to hypoxia includes the expression of hypoxia-inducible factor-1 (HIF-1) and its target genes: vascular endothelial growth factor (VEGF) and CXC chemokine receptor 4 (CXCR4). The aim of this study was to investigate the expression and prognostic significance of VEGF and CXCR4, which are responsible for angiogenesis and progression in gastric cancer. Twenty-eight gastric cancer patients were analyzed. The mRNA expression was examined in primary tumors and corresponding normal gastric mucosa by RT-PCR. The protein level was examined by immunohistochemistry staining. The high expression of VEGF and CXCR4 was found in 71.0 and 64.0% of tumors, respectively. The mean levels…
Mitogenomics of the Olive Seed Weevil, Anchonocranus oleae Marshall and Implications for Its Phylogenetic Position in Curculionidae
2022
Anchonocranus oleae Marshall (Coleoptera: Curculionidae) is a seed-feeding weevil native to southern Africa; its larvae are known to develop in the fruits of the African Wild Olive and, more rarely, cultivated olives. The species has been mainly found in the Western Cape province of South Africa, but it has remained in relative obscurity because it does not seem to represent a current threat to commercial olive production. As part of an ongoing effort to produce baseline genetic data for olive-associated entomofauna in South Africa, we generated reference DNA barcodes for A. oleae collected from wild and cultivated olives and sequenced its mitogenome for assessment of the phylogenetic posit…
Metabolic plasticity of mixotrophic algae is key for their persistence in browning environments
2022
Light availability is the main regulator of primary production, shaping photosynthetic communities and their production of ecologically important biomolecules. In freshwater ecosystems, increasing dissolved organic carbon concentrations, commonly known as browning, leads to lower light availability and the proliferation of mixotrophic phytoplankton. Here, a mixotrophic algal species (Cryptomonas sp.) was grown under five increasing dissolved organic carbon concentrations to uncover the plastic responses behind the success of mixotrophs in browning environments and their effect in the availability of nutritionally important biomolecules. In addition to the browning treatments, phototrophic, …
Some recent results on a singular p-laplacian equations
2022
Abstract A short account of some recent existence, multiplicity, and uniqueness results for singular p-Laplacian problems either in bounded domains or in the whole space is performed, with a special attention to the case of convective reactions. An extensive bibliography is also provided.
Karl Marx: Umanismo e Materialismo
2022
In the context of the contemporary age, Karl Marx represents a classical author. His theory of historical materialism is the basis of his general vision of reality with the principles of “self-consciousness” and “class consciousness”. To the optimism of idealism, centered on pure theory, Marx opposes a new cultural model in relation to praxis and political economy. His production must therefore be read in all its phases, from youth to maturity, with the aim of interpreting historical materialism as a peculiar form of humanism and naturalism. Humanism; Naturalism; Self-consciousness; Class Consciousness.
Radical Addition of Dihydroquinoxalin-2-ones to Trifluoromethyl Ketones under Visible-Light Photoredox Catalysis
2022
A visible-light photocatalytic radical addition reaction of dihydroquinoxalin-2-ones to trifluoromethyl ketones has been established using Ru(bpy)3Cl2 as photocatalyst, acetonitrile as solvent, and HP Single Blue LED as the source of light. The reaction provides a straightforward approach to the synthesis of dihydroquinoxalin-2-ones bearing a trifluoromethyl-substituted tertiary alcohol moiety in moderate to good yields under mild conditions.
Cytotoxic activity of several ent-kaurane derivatives of atractyligenin. Synthesis of unreported diterpenic skeleton by chemical rearrangement
2022
Atractyloside, carboxyatractyloside, their aglycon atractyligenin, and several synthetic derivatives were tested and found to be active against a panel of human tumor cell lines. Atractyligenin was subjected to oxidation, bromination, and elimination reactions, obtaining several compounds. A singular skeleton was synthesized by chemical rearrangement starting from 3 beta-bromo-2,15-diketoatractyligenin methyl ester. The synthesized compounds resulted active against all cell lines tested. In particular, 15-ketoatractyligenin methyl ester and 3 beta bromo-2,15-diketoatractyligenin methyl ester resulted the most active with IC50 values of 0.427 and 0.723 mu M against A375 melanoma cell line. E…