showing 36 of ~574560 from 574555 documents
«Det finnes en sang for alt!» Ansattes begrunnelser for sang i barnehage og skole – en empirisk studie.
2022
This chapter is based on two studies which aim to provide knowledge about the position of singing in Norwegian kindergartens and schools: (a) a national quantitative cross-sectional survey with kindergarten teachers and primary school/lower secondary school teachers, and (b) case studies in selected kindergartens and schools, where the data collection consisted of participatory observation and interviews with leaders and teachers. The chapter presents an attempt to incorporate both studies into a triangulation design where different types of data material and different analysis methods (quantitative and qualitative) are combined to investigate the question “why sing?” – that is, how singing…
Immunological aspects of heat shock protein functions and their significance in the development of cancer vaccines
2022
The primary function of intracellular heat shock proteins (HSPs) is to protect the cell by suppressing the effects of various stress factors by either refolding misfolded proteins or blocking apoptosis. After neoplastic transformation, cells overexpress HSPs, which act as factors promoting the neoplastic process by stabilizing proteins responsible for carcinogenesis, however, HSPs can be released into the extracellular environment where they act as important modulators of the immune response. In a tumor microenvironment, extracellular HSPs are able to induce a pro- or anti-neoplastic response, using various mechanisms of affecting immune cells, The study of the role of extracellular HSPs in…
Subjugation, freedom, and recognition in Poulain de la Barre and Simone de Beauvoir
2022
In 1949, Simone de Beauvoir cited the fairly unknown author Poulain de la Barre in an epigraph for The Second Sex (1949). When reading The Second Sex, one soon realizes that there are profound similarities between the two authors’ discussions of women’s situation. Both Poulain and Beauvoir view the subjection of women as a process that includes choice as well as force. Liberation necessarily requires overcoming opinions rooted in custom and prejudice. The article develops a comparison between the arguments of Poulain and Beauvoir in order to illuminate interesting features in the works of both authors. The focus is on similarities as well as differences. The first section examines how preju…
Investigation on a MMACHC mutant from cblC disease: The c.394C>T variant
2022
The cblC disease is an inborn disorder of the vitamin B12 (cobalamin, Cbl) metabolism characterized by methylmalonic aciduria and homocystinuria. The clinical consequences of this disease are devastating and, even when early treated with current therapies, the affected children manifest symptoms involving vision, growth, and learning. The illness is caused by mutations in the gene codifying for MMACHC, a 282aa protein that transports and transforms the different Cbl forms. Here we present data on the structural properties of the truncated protein p.R132X resulting from the c.394C > T mutation that, along with c.271dupA and c.331C > T, is among the most common mutations in cblC. Althou…
The age and well-being “paradox”: a longitudinal and multidimensional reconsideration
2022
This paper explores qualifcations to the much-discussed paradox that although aging is associated with multiple physical and social losses, subjective well-being (SWB) is stable or increasing in later life. We explore age-related changes in cognitive, afective, and eudaimonic dimensions in three waves of data spanning up to 15 years from the Norwegian NorLAG study (N=4,944, age 40−95). We employ fxed-efect models to examine the nature and predictors of aging efects on SWB. Results indicate a general pattern of stability well into older age, but negative changes in advanced age across well-being measures. Declines in SWB are less pronounced and with a later onset for the cognitive compared w…
A methodology for developing evidence-based optimization models in humanitarian logistics
2022
AbstractThe growing need for humanitarian assistance has inspired an increasing amount of academic publications in the field of humanitarian logistics. Over the past two decades, the humanitarian logistics literature has developed a powerful toolbox of standardized problem formulations to address problems ranging from distribution to scheduling or locations planning. At the same time, the humanitarian field is quickly evolving, and problem formulations heavily rely on the context, leading to calls for more evidence-based research. While mixed methods research designs provide a promising avenue to embed research in the reality of the field, there is a lack of rigorous mixed methods research …
Atomic Layer Deposition of Intermetallic Fe4Zn9 Thin Films from Diethyl Zinc
2022
| openaire: EC/H2020/765378/EU//HYCOAT We present a new type of atomic layer deposition (ALD) process for intermetallic thin films, where diethyl zinc (DEZ) serves as a coreactant. In our proof-of-concept study, FeCl3 is used as the second precursor. The FeCl3 + DEZ process yields in situ crystalline Fe4Zn9 thin films, where the elemental purity and Fe/Zn ratio are confirmed by time-of-flight elastic recoil detection analysis (TOF-ERDA), Rutherford backscattering spectrometry (RBS), atomic absorption spectroscopy (AAS), and energy-dispersive X-ray spectroscopy (EDX) analyses. The film thickness is precisely controlled by the number of precursor supply cycles, as expected for an ALD process.…
Evaluating the Public's Reaction to Simulated Alerts on Mobile Phones in France: Scale Effects, and Challenges
2022
International audience; In case of sudden and extreme life-threatening situation, the most efficient system fulfils the requirement of mobile phone emergency alerting information services. But how much information and what type of content must be used in a textual message, and how adapt this alert to a large audience and diversified contexts? This paper proposes to address this challenge, 1) by presenting results obtained in France during simulated "alerting days", with sampling revealing the perception and understanding of SMS and CB by a non-specialized audience (161 respondents), and 2) by comparing findings obtained in different contexts (students and teaching staff in a university, cri…
Kolounioku | Clounioq
2022
La ciudad celtibérica se localiza en el cerro Alto del Cuerno (Coruña del Conde, Burgos), en las proximidades del lugar en el que posteriormente se asentó la ciudad de época imperial Clunia (Valdés 2017). Se menciona varias veces en las fuentes clásicas en relación con acontecimientos acaecidos en los años 75, 72 y 56 a.C. (TIR K-30, s.v. Clunia; Valdés 2017: 125-126). La producción monetaria de Kolounioq parece ser tardía, probablemente se acuñó durante el siglo I a.C. Se agrupa en dos fases, de la primera se conocen dos tipos de denarios que debieron acuñarse con poca distanca temporal, ya …
Organic Salts as Tectons for Self-assembly Processes in Solution
2022
The literature, covering the last decade, about the self-assembly processes of organic salts in conventional solvents was analyzed. In particular, data reported about imidazolium and ammonium salts have been considered. The analysis shows that these processes are highly determined by structural features of the salts. Indeed, besides the nature of the cationic head, features of the alkyl chain borne on the cation structure and its possible functionalization, as well as the nature of the anion play a pivotal role. These factors determine not only the nature of the solvent in which the process occurs but also the nature of the self-assembly mechanism. Consequently, the structure tunability of …
Use of Heating Configuration to Control Marangoni Circulation during Droplet Evaporation
2022
The present work presents a numerical study of the evaporation of a sessile liquid droplet deposited on a substrate and subjected to different heating configurations. The physical formulation accounts for evaporation, the Marangoni effect, conductive transfer in the support, radiative heating, and diffusion–convection in the droplet itself. The moving interface is solved using the Arbitrary Lagrangian–Eulerian (ALE) method. Simulations were performed using COMSOL Multiphysics. Different configurations were performed to investigate the effect of the heating conditions on the shape and intensity of the Marangoni circulations. A droplet can be heated by the substrate (different natures and thi…
Managing of Migraine in the Workplaces: Knowledge, Attitudes and Practices of Italian Occupational Physicians.
2022
Background and Objectives: Migraine is a debilitating disorder, whose incidence peak in the age group of 30–39 years overlaps with the peak of employment years, potentially representing a significant issue for occupational physicians (OP). The present study was performed in order to characterize their knowledge, attitudes and practices on migraine in the workplaces. Materials and Methods: A convenience sample of 242 Italian OP (mean age 47.8 ± 8.8 years, males 67.4%) participated in an internet-based survey by completing a structured questionnaire. Results: Adequate general knowledge of migraine was found in the majority of participants. Migraine was identified as a common and …
Reliģiski-filozofiski raksti, Speciālizlaidums I
2022
A special issue, “Remembering the Past and the Future - Korean Culture in a Changing World,” is devoted to understanding Korean culture. Regardless of the bulk of comprehensive information available today, accurate knowledge of the Asian culture in Europe or the European culture in Asia has not become considerably deeper. Sometimes even to the contrary – the old stereotypes continue to exist as part of the packaging for pseudo information adjusted to the short-term goals of the contemporary globalised society, supplemented by travel guides and announcements tailored to the needs of immediate politically economic conjuncture. And yet, this is only the top of the intercultural communication i…
Is the injection of tramadol effective at control of pain after impacted mandibular third molar extractions? A systematic review and meta-analysis.
2022
Third molar extraction is among the most common surgical procedures performed by oral-maxillofacial surgeons. Postoperative pain, swelling and trismus are common, especially in wisdom teeth, due to trauma to local tissues and the duration of the surgical procedure, among other factors. This systematic review was conducted in accordance with the ?Preferred Reporting Items for Systematic Reviews and Meta-Analyses? in order to answer the focused question: ?Is the local submucosal injection of tramadol effective at the control of postoperative pain in patients submitted to impacted mandibular third molar extractions??. We analyzed papers published until March 30, 2021 in the MEDLINE|PubMed, Web…
Low-Head Hydropower for Energy Recovery in Wastewater Systems
2022
Hydraulic turbines for energy recovery in wastewater treatment plants, with relatively large discharges values and small head jumps, are usually screw Archimedes or Kaplan types. In the specific case of a small head jump (about 3 m) underlying a rectangular weir in the major Palermo (Italy) water treatment plant, a traditional Kaplan solution is compared with two other new proposals: a Hydrostatic Pressure Machine (HPM) located at the upstream channel and a cross-flow turbine (CFT) located in a specific underground room downstream of the same channel. The fluid mechanical formulations of the flow through these turbines are analyzed and the characteristic parameters are stated. Numerical ana…
Adherence to oral hormonal anticancer agents in breast cancer.
2022
There is an increasing trend towards using oral antitumoral agents in oncological patients. Compared to parenteral therapy, oral treatment offers convenience for both the patient and the healthcare system, with similar efficacy. However, the benefit deriving from oral drugs will be obtained only if patients adhere strictly to the treatment. Medical oncologists must therefore seek to optimize patient adherence. Breast cancer patients, particularly, are often treated with oral hormonal anticancer agents. In this review, we summarized evidence about adherence of breast cancer patients to oral hormonal anticancer agents and the consequences of poor compliance, the barriers to oral treatment an…
Ag Nanoparticles for Biomedical Applications—Synthesis and Characterization—A Review
2022
Silver nanoparticles have been intensively studied over a long period of time because they exhibit antibacterial properties in infection treatments, wound healing, or drug delivery systems. The advantages that silver nanoparticles offer regarding the functionalization confer prolonged stability and make them suitable for biomedical applications. Apart from functionalization, silver nanoparticles exhibit various shapes and sizes depending on the conditions used through their fabrications and depending on their final purpose. This paper presents a review of silver nanoparticles with respect to synthesis procedures, including the polluting green synthesis. Currently, the most commonly used cha…
A New Simple Function for Combustion and Cyclic Variation Modeling in Supercharged Spark Ignition Engines
2022
Research in the field of Internal Combustion (IC) engines focuses on the drastic reduction of both pollutant and greenhouse gas emissions. A promising alternative to gasoline and diesel fuel is represented by the use of gaseous fuels, above all green hydrogen but also Natural Gas (NG). In previous works, the authors investigated the performance, efficiency, and emissions of a supercharged Spark Ignition (SI) engine fueled with mixtures of gasoline and natural gas; a detailed research involving the combustion process of this kind of fuel mixture has been previously performed and a lot of experimental data have been collected. Combustion modeling is a fundamental tool in the design and optimi…
“Let's organize”: The organizational basis for stable public governance
2022
This study carries two distinct contributions to extant litera-ture. Theoretically, it introduces an organizational approachto the study of public governance. Empirically, it demon-strates how the organizational architecture of governmentrepresents a stable and systemic capacity for public gover-nance across time. The study establishes how stabilityserves as an enduring feature of public governance andhow this is anchored in theorganizational architectureofgovernment systems. Moreover, structured flexibility isillustrated by how the civil service adapts to both interna-tional organizations and societal stakeholders. Theorizingthe organizational dimension of public governance, thisstudy also…
Co-citation Percentile Rank and JYUcite : a new network-standardized output-level citation influence metric and its implementation using Dimensions A…
2022
AbstractJudging value of scholarly outputs quantitatively remains a difficult but unavoidable challenge. Most of the proposed solutions suffer from three fundamental shortcomings: they involve (i) the concept of journal, in one way or another, (ii) calculating arithmetic averages from extremely skewed distributions, and (iii) binning data by calendar year. Here, we introduce a new metric Co-citation Percentile Rank (CPR), that relates the current citation rate of the target output taken at resolution of days since first citable, to the distribution of current citation rates of outputs in its co-citation set, as its percentile rank in that set. We explore some of its properties with an examp…
Examining Anxiety, Sleep Quality, and Physical Activity as Predictors of Depression among University Students from Saudi Arabia during the Second Wav…
2022
Conducted during the second wave of the pandemic, this cross-sectional study examined the link between sleep quality, physical activity, exposure, and the impact of COVID-19 as predictors of mental health in Saudi undergraduate students. A convenience sample of 207 participants were recruited, 89% of whom were females and 94% were single. The measures included questionnaires on the level of exposure and the perceived impact of COVID-19, a physical activity measure, GAD-7, PHQ-9, and PSQI. The results indicated that approximately 43% of participants exhibited moderate anxiety, and 50% were at risk of depression. Overall, 63.93% of students exposed to strict quarantine for at least 14 days (n…
Making regional cultural policy: regional government bodies’ cultural policy activities in Finland
2022
In Finnish cultural policy, power and responsibilities have been distributed to various regional government bodies and a distinct regional authority is lacking. This presents a notable difference to Sweden where the self-governing and politically elected assemblies at the regional level function as key regional cultural policy authorities. This article examines how the regional government bodies in Finland are participating in cultural policymaking in contrast to Sweden by recognising different activities that are carried out by the regional level. The analysis is conducted in two case regions (Central Finland and Värmland) based on interview data, legislation and policy documents. The resu…
ULTRASOUND (US) GUIDED DIAGNOSTIC PROCEDURES AND MALIGNANT PLEURAL EFFUSIONS
2022
Introduction: Malignant pleural effusion (PE) is a rather frequent complication of several intrathoracic and extrathoracic tumors and has an incidence of about 660 patients per million inhabitants per year. Materials and methods: We retrospectively studied (2000 to 2018) the utility of US guided percutaneous puncture (PP) of PE, in the diagnosis/therapy of 121 patients (67 women and 54 men) with PE and suspected malignant neoplasm, mean age 52 years (39-78 years), Results: The diagnostic accuracy of the US guided PP fluid examination, (diagnoses of malignant PE), was 91.7% (111/121), with sensitivity of 89.5% (86/96) and specificity of 100%. (25/25). 10 patients did not have confirmation of…
The burden of injury in Central, Eastern, and Western European sub-region: a systematic analysis from the Global Burden of Disease 2019 Study
2022
Abstract Background Injury remains a major concern to public health in the European region. Previous iterations of the Global Burden of Disease (GBD) study showed wide variation in injury death and disability adjusted life year (DALY) rates across Europe, indicating injury inequality gaps between sub-regions and countries. The objectives of this study were to: 1) compare GBD 2019 estimates on injury mortality and DALYs across European sub-regions and countries by cause-of-injury category and sex; 2) examine changes in injury DALY rates over a 20 year-period by cause-of-injury category, sub-region and country; and 3) assess inequalities in injury mortality and DALY rates across the countries…
Orthodontic bracket bonding techniques and adhesion failures: A systematic review and meta-analysis.
2022
This systematic review compared the bonding failures of orthodontic brackets bonded by indirect or direct techniques. Data sources: The searched databases were Cochrane Library, LILACS, BBO, PubMed, Scopus, Web of Science.A search for randomized clinical trials comparing the two techniques was carried out to answer the research question: When considering orthodontic bracket bonding on permanent teeth, does the indirect technique reduce the number of bonding failures compared to the direct one over time? The quality of the included papers was assessed with Cochrane risk of bias tool and the quality of evidence with GRADE.From 3096 articles identified, seven were included in the systematic re…
Geoconservation in Sicily (Italy): the Example of the Isola delle Femmine (Palermo)
2022
Abstract The Regional Administration of Sicily recently erected Isola delle Femmine—a small island of the Tyrrhenian Sea, close to Palermo—as a geosite. A detailed geological survey has been carried out in order to define the most important geological features of the island together with the development of a new geological map based on topographic data and a digital model at 1:2.000 scale specially processed. Finally, a geological pathway through the island has been traced and illustrated. The geological substrate of Isola delle Femmine consists of a Mesozoic carbonate succession belonging to the Panormide Carbonate Platform. Two lithostratigraphic units have been differentiated. The lowest…
Education for optimized Life Cycle Management : The Project e-CIRP and its insights into embedding circular economy aspects to product design via tea…
2022
Publisher Copyright: © The Authors, published by EDP Sciences. The integration of circular economy-based life cycle management (LCM) into product design and optimisation is essential for the transformation towards a circular economy (CE). However, companies often lack the expertise to adapt life-cycle design (LCD) thinking in their business operations and are in need of respective capacity building. To close this apparent gap is the aim of the project e-CirP (Embedding Circular Economy into Product Design and Optimization) where LUT University, Fraunhofer, Technical University of Denmark, University of Padova, Delft University of Technology, University of Helsinki and Metso Outotec have wor…
Anterior cervical discectomy and fusion is more effective than cervical arthroplasty in relieving atypical symptoms in patients with cervical spondyl…
2022
Background and purpose Patients with cervical spondylosis often present with concurrent 'atypical symptoms' of unknown etiology that have been associated with cervical spondylotic disease, including dizziness, headache, nausea, tinnitus, blurred vision, palpitations, and memory and gastrointestinal disturbances. Few studies have addressed whether surgical intervention to treat classic symptoms of cervical spondylosis can also effectively alleviate atypical symptoms. Accordingly, the purpose of this study is to compare the ability of cervical arthroplasty (CA) and anterior cervical discectomy and fusion (ACDF) to alleviate atypical symptoms associated with cervical spondylosis. Materials and…
Electronic Sensor Technologies in Monitoring Quality of Tea: A Review.
2022
Tea, after water, is the most frequently consumed beverage in the world. The fermentation of tea leaves has a pivotal role in its quality and is usually monitored using the laboratory analytical instruments and olfactory perception of tea tasters. Developing electronic sensing platforms (ESPs), in terms of an electronic nose (e-nose), electronic tongue (e-tongue), and electronic eye (e-eye) equipped with progressive data processing algorithms, not only can accurately accelerate the consumer-based sensory quality assessment of tea, but also can define new standards for this bioactive product, to meet worldwide market demand. Using the complex data sets from electronic signals integrated with…
Regional Ambassadors or State Agents? Assessing the Role of Catalan Cabinet Ministers in Spain
2022
Identificador de proyecto: UPO-FEDER (grant number UPO-1380883)
Information Dynamics of Electric Field Intensity before and during the COVID-19 Pandemic.
2022
This work investigates the temporal statistical structure of time series of electric field (EF) intensity recorded with the aim of exploring the dynamical patterns associated with periods with different human activity in urban areas. The analyzed time series were obtained from a sensor of the EMF RATEL monitoring system installed in the campus area of the University of Novi Sad, Serbia. The sensor performs wideband cumulative EF intensity monitoring of all active commercial EF sources, thus including those linked to human utilization of wireless communication systems. Monitoring was performed continuously during the years 2019 and 2020, allowing us to investigate the effects on the patterns…
Impact of Chemical Endocrine Disruptors and Hormone Modulators on the Endocrine System
2022
There is growing concern regarding the health and safety issues of endocrine-disrupting chemicals (EDCs). Long-term exposure to EDCs has alarming adverse health effects through both hormone-direct and hormone-indirect pathways. Non-chemical agents, including physical agents such as artificial light, radiation, temperature, and stress exposure, are currently poorly investigated, even though they can seriously affect the endocrine system, by modulation of hormonal action. Several mechanisms have been suggested to explain the interference of EDCs with hormonal activity. However, difficulty in quantifying the exposure, low standardization of studies, and the presence of confounding factors do n…
PERCUTANEOUS US (ULTRA SOUND) GUIDED FINE NEEDLE ASPIRATION (FNA) OF ENDOTHORACIC NEOPLASM
2022
Introduction: Ultrasound (US)-guided fine needle aspiration (FNA) of percutaneous, transparietal endothoracic lesions, is a useful method in the diagnostic process for anatomopathological characterization. This sampling is a minimally invasive procedure, with a low complication rate and can be performed under loco-regional anesthesia Material and methods: We retrospectively studied (2009 to 2019) the utility of US guided transthoracic FNA in the diagnosis of suspected endothoracic lesions on 54 patients (34 men and 20 women), aged between 44 and 79 years, with pleural, pulmonary or mediastinal neoplasm viewable with an US examination. Results: The definitive diagnosis of malignant or benign…
Activation of indistinguishability-based quantum coherence for enhanced metrological applications with particle statistics imprint
2022
Quantum coherence, an essential feature of quantum mechanics allowing quantum superposition of states, is a resource for quantum information processing. Coherence emerges in a fundamentally different way for nonidentical and identical particles. For the latter, a unique contribution exists linked to indistinguishability that cannot occur for nonidentical particles. Here, we experimentally demonstrate this additional contribution to quantum coherence with an optical setup, showing that its amount directly depends on the degree of indistinguishability, and exploiting it in a quantum phase discrimination protocol. Furthermore, the designed setup allows for simulating fermionic particles with p…
No evidence of DUI in the Mediterranean alien species Brachidontes pharaonis (P. Fisher, 1870) despite mitochondrial heteroplasmy
2022
AbstractTwo genetically different mitochondrial haplogroups of Brachidontes pharaonis (p-distance 6.8%) have been identified in the Mediterranean Sea. This hinted at a possible presence of doubly uniparental inheritance in this species. To ascertain this possibility, we sequenced two complete mitogenomes of Brachidontes pharaonis mussels and performed a qPCR analysis to measure the relative mitogenome copy numbers of both mtDNAs. Despite the presence of two very similar regions composed entirely of repetitive sequences in the two haplogroups, no recombination between mitogenomes was detected. In heteroplasmic individuals, both mitogenomes were present in the generative tissues of both sexes…
Application of ultrasound as clean technology for extraction of specialized metabolites from stinging nettle (Urtica dioica L.)
2022
Nettle is a highly valued medicinal plant that is still largely neglected, both in terms of nutrition and use for pharmacological purposes. Tinctures, i.e., alcoholic extracts, are becoming increasingly popular nettle products, mainly because they allow better availability of phytochemicals and their stability over a longer period of time. The production of alcoholic extracts is a chemically demanding process that is still usually carried out using conventional techniques, which have numerous drawbacks. The use of green technologies such as ultrasound-assisted extraction (UAE), which is characterized by high efficiency of phytochemical extraction, shorter treatment time, and a much lower en…