showing 36 of ~574560 from 574555 documents
Exploring the mediator role of self-critical rumination between emotion regulation and psychopathology: A validation study of the Self-Critical Rumin…
2021
Abstract Self-critical rumination is a negative and repetitive self-thinking process related to different disorders and negative psychological outcomes such as emotion dysregulation. The objectives of this study are twofold: (a) to examine the factor structure of the Spanish version of the Self-Critical Rumination Scale (SCRS), providing further evidence on its construct validity, and (b), to explore the mediator role of self-critical rumination between emotion dysregulation and psychopathology. A sample of 431 Spanish participants were recruited and completed online questionnaires. Confirmatory factor analysis, mediation analysis, and Pearson's correlations were conducted. A single factor …
Testing a theoretically-based overland flow resistance law by Emmett’s database
2021
Abstract The main aim of this paper was to test a recently theoretically deduced flow resistance equation, based on a power-velocity profile, using a wide database of available measurements carried out in laboratory and field experimental runs with overland flow under simulated rainfall. In comparison with previous calibrations and validations of this theoretically deduced flow resistance equation, the used database by Emmett is characterized by a wide range of rainfall intensities (from 79.2 to 303.5 mm h−1 for laboratory runs and from 178.3 to 215.9 mm h−1 for field investigations) and bed slopes (from 0.33 to 17% for laboratory runs and from 2.9 to 33.2% for field investigations). For th…
Effect of Coronary Disease Characteristics on Prognostic Relevance of Residual Ischemia After Stent Implantation
2021
Objectives: We investigated the influence of coronary disease characteristics on prognostic implications of residual ischemia after coronary stent implantation.Methods: This study included 1,476 patients with drug-eluting stent implantation and available pre- and post-percutaneous coronary intervention (PCI) fractional flow reserve (FFR) measurements. Residual ischemia was defined as post-PCI FFR ≤ 0.80. Coronary disease characteristics with significant interaction hazard ratios (HRs) for clinical outcomes with residual ischemia were defined as interaction characteristics with residual ischemia (ICwRI). The primary outcome was target vessel failure (TVF)—a composite of cardiac death, target…
Recensione a: Aree naturali protette e valorizzazione di territori marginali. Il Parco Regionale delle Serre nel cuore della Calabria, di Caterina Ba…
2021
Recensione del volume "Aree naturali protette e valorizzazione di territori marginali. Il Parco Regionale delle Serre nel cuore della Calabria" di Caterina Barilaro Review of the book "Protected natural areas and enhancement of marginal territories. The Serre Regional Park in the heart of Calabria" by Caterina Barilaro
Homogeneous and inhomogeneous broadening in single perovskite nanocrystals investigated by micro-photoluminescence
2021
Abstract Metal halides with perovskite crystalline structure have given rise to efficient optoelectronic and photonic devices. In the present work, we have studied the light emission properties of single CsPbBr3 and CsPbI3 semiconductor perovskite nanocrystals (PNCs), as the basis for a statistical analysis of micro-photoluminescence (micro-PL) spectra measured on tens of them. At room temperature, the linewidth extracted from PL spectra acquired in dense films of these nanocrystals is not very different from that of micro-PL measured in single nanocrystals. This means that the homogeneous linewidth due to exciton-phonon interaction is comparable or larger than the inhomogeneous effect asso…
Ideal cardiovascular health at age 5–6 years and cardiometabolic outcomes in preadolescence
2021
AbstractBackgroundThe American Heart Association (AHA) developed a definition of ideal cardiovascular health (ICH) based on the presence of both ideal health behaviours (diet, physical activity, weight status and smoking) and ideal health factors (glucose, total cholesterol and blood pressure levels). However, research of ICH in the paediatric population is scarce. We aimed to study ICH at age 5–6 years by extending the original ICH score with the health behaviours: sleep duration, screen time and prenatal smoke exposure, and to evaluate its association with cardiometabolic outcomes at age 11–12.MethodsA total of 1666 children aged 5–6 years were selected from the database of the ABCD-study…
Biodiversity Patterns and Ecological Preferences of the Photobionts Associated With the Lichen-Forming Genus Parmelia
2021
The worldwide, ecologically relevant lichen-forming genusParmeliacurrently includes 41 accepted species, of which theParmelia sulcatagroup (PSULgp) and theParmelia saxatilisgroup (PSAXgp) have received considerable attention over recent decades; however, phycobiont diversity is poorly known inParmelias. lat. Here, we studied the diversity ofTrebouxiamicroalgae associated with 159 thalli collected from 30 locations, including nineParmeliaspp.:P. barrenoae, P. encryptata, P. ernstiae, P. mayi, P. omphalodes, P. saxatilis, P. serrana, P. submontana, andP. sulcata. The mycobionts were studied by carrying out phylogenetic analyses of the nrITS. Microalgae genetic diversity was examined by using …
Biological activity and toxicity of plant nutraceuticals: an overview
2021
Plant nutraceuticals have currently been receiving international attention due to their potentially health-promoting effects when consumed as part of a varied diet, including antioxidant, anti-inflammatory, and anti-proliferative properties. These beneficial effects have been attributed to the presence of bioactive compounds naturally occurring in food or produced de novo through metabolic pathways. However, taken into account that nutraceuticals could be concentrated forms of the food or plants, it is probable to find undesirable substances utilized in crop protection, such as pesticides, and other contaminants (e.g. mycotoxins), which could be concentrated during the extraction process. H…
Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ
2021
Cancer is characterized by pervasive epigenetic alterations with enhancer dysfunction orchestrating the aberrant cancer transcriptional programs and transcriptional dependencies. Here, we epigenetically characterize human colorectal cancer (CRC) using de novo chromatin state discovery on a library of different patient-derived organoids. By exploring this resource, we unveil a tumor-specific deregulated enhancerome that is cancer cell-intrinsic and independent of interpatient heterogeneity. We show that the transcriptional coactivators YAP/TAZ act as key regulators of the conserved CRC gained enhancers. The same YAP/TAZ-bound enhancers display active chromatin profiles across diverse human t…
Copolymerization of Ethylene with Selected Vinyl Monomers Catalyzed by Group 4 Metal and Vanadium Complexes with Multidentate Ligands: A Short Review
2021
This paper gives a short overview of homogeneous post-metallocene catalysts based on group 4 metal and vanadium complexes bearing multidentate ligands. It summarizes the catalytic behavior of those catalysts in copolymerization of ethylene with 1-olefins, with styrenic monomers and with α,ω-alkenols. The review is focused on finding correlations between the structure of a complex, its catalyst activity and comonomer incorporation ability, as well as the microstructure of the copolymer chains.
Fasting does not guarantee empty stomach in the intensive care unit: A prospective ultrasonographic evaluation (The NUTRIGUS study).
2021
BACKGROUND In the intensive care unit (ICU), a fasting period is usually respected to avoid gastric aspiration during airway management procedures. Since there are no recognised guidelines, intensive care physicians balance the aspiration risk with the negative consequences of underfeeding. Our objective was to determine the impact of fasting on gastric emptying in critically ill patients by using gastric ultrasound. MATERIAL AND METHODS Among the 112 patients that met the inclusion criteria, 100 patients were analysed. Gastric ultrasonography was performed immediately before extubation. Patients with either 1/ an absence of visualised gastric content (qualitative evaluation) or 2/ a gastri…
Economic cycles and inequalities in alcohol‐related mortality in the Baltic countries and Finland in 2000–2015: a register‐based study
2021
Publisher Copyright: © 2021 The Authors. Addiction published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction. Aim: To estimate whether large macroeconomic fluctuations in the 2000s affected inequalities in alcohol-related mortality in the Baltic countries and Finland. Design: Longitudinal register-based follow-up study. Setting: Estonia, Latvia, Lithuania and Finland. Participants: General population in the 35–74 age group. Measurements: Socioeconomic status was measured by the highest achieved educational level and was categorised using the International Standard Classification of Education 2011 as low (included categories 0–2), middle (3–4), and high (5–8). Educat…
Atención a la salud mental en adolescentes en conflicto con la ley: Una revisión comparativa de Brasil y España
2021
Se realizó un estudio comparativo descriptivo de las políticas de atención de salud mental dirigidas a adolescentes en conflicto con la ley en Brasil y España. Se realizaron búsquedas en las bases de datos Google Académico, Medline y Scopus utilizando dos estrategias de búsqueda integral para identificar y sintetizar la literatura. Se identificaron tres categorías principales que permiten definir y analizar las políticas de atención a la salud mental dirigidas a adolescentes en conflicto con la ley en Brasil y España: 1) modelos de atención a la salud y salud mental, 2) redes de atención a la salud mental infanto-juvenil, y 3) atención de salud mental a adolescentes en conflicto con la ley.…
Sentinel lymph node BIOPSY after neoadjuvant therapy in breast cancer patients with lymph node involvement at diagnosis. Could wire localization of c…
2021
Abstract Introduction Sentinel lymph node biopsy (SLNB) after neoadjuvant therapy (NAT) in node-positive (N+) breast cancer patients at diagnosis remains a controversial issue, with no consensus on implementation or safety. Objectives We sought to assess the accuracy of SLNB after NAT in biopsy-proven N+ cases at diagnosis and the efficacy and accuracy of wire localization of the clipped node to improve results. Material and methods A cross-sectional diagnostic technique validation study in N+ patients following NAT was performed. The biopsy-proven affected lymph node was clipped at diagnosis. SLNB and axillary lymph node dissection (ALND) were performed in cases of clinical-radiological ly…
A Scoping Review of the Empirical Literature on Peer Support for People Living with HIV
2021
People living with HIV receiving antiretroviral therapy need support related to linkage to care and self-management in everyday life. Peer support has been found to provide varied support according to the unique needs of the group. This scoping review aims to provide an overview of research on peer support provided to people living with HIV. A search was conducted in eight databases until May 2021, and two reviewers independently screened all identified studies. We sorted the included studies into categories and conducted descriptive analyses. For this communication, we included 34 studies representing three study categories: the experiences of peer support (n = 23), program descriptions (…
Digital Pathology Enables Automated and Quantitative Assessment of Inflammatory Activity in Patients with Chronic Liver Disease
2021
Traditional histological evaluation for grading liver disease severity is based on subjective and semi-quantitative scores. We examined the relationship between digital pathology analysis and corresponding scoring systems for the assessment of hepatic necroinflammatory activity. A prospective, multicenter study including 156 patients with chronic liver disease (74% nonalcoholic fatty liver disease-NAFLD, 26% chronic hepatitis-CH etiologies) was performed. Inflammation was graded according to the Nonalcoholic Steatohepatitis (NASH) Clinical Research Network system and METAVIR score. Whole-slide digital image analysis based on quantitative (I-score: inflammation ratio) and morphometric (C-sco…
Una pioggia vitale
2021
Pioggia di Libri è una manifestazione promossa da Andrea Sciascia, nell’ambito delle attività didattiche e scientifiche del Dipartimento di Architettura che ha lo scopo di divulgare ed incentivare il rapporto tra gli studenti ed il mondo accademico. Con il presente contributo, l’autore (da delegato alla Didattica per il Dipartimento di Architettura) evidenzia alcune importanti ricadute dirette di questa iniziativa sul piano formativo per gli studenti. Rain of Books is an event promoted by Andrea Sciascia, as part of the educational and scientific activities of the Department of Architecture which aims to disseminate and encourage the relationship between students and the academic world. Wit…
Estimating the thermal photon production rate using lattice QCD
2021
We present results for the photon emission rate determined from the transverse channel vector correlator at fixed spatial momentum using two flavors of dynamical Wilson fermions at $T\sim$250 MeV. We estimate the transverse channel spectral function using the continuum extrapolated correlator by applying various fit ans\"atze with a smooth matching to the NLO perturbative result. We confront our estimate based on this channel with the latest results of our collaboration based on the difference of the transverse and longitudinal channels.
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2021
Abstract We propose a signal deconvolution procedure for imaging spectrometer data, where a measured point spread function (PSF) is deconvolved itself before being used for deconvolution of the signal. We evaluate the effectiveness of our procedure for improvement of the spatio-spectral signal, as well as our target application, i.e. estimation of sun-induced fluorescence (SIF). Imaging spectrometers are well established instruments for remote sensing. When used for scientific purposes these instruments are usually calibrated on a regular basis. In our case the point spread function of the optics is measured in an elaborate procedure with a tunable monochromator point light source. PSFs are…
Impact of rapid maxillary expansion on mouth-breathing children and adolescents : a systematic review
2021
Background Rapid maxillary expansion (RME) is an orthodontic procedure used to correct transverse maxillary deficiency. Due to the anatomical relationship between the palate and the nasal cavity, RME promotes an increase in nasal dimensions, which should hypothetically improve nasal respiratory function. Objective: This review aimed to systematically verify studies that assessed the effects of RME on nasal patency in mouth-breathing children and adolescents. Material and Methods An electronic search was performed in the MEDLINE databases via OVID, Scopus and EMBASE. The terms were: “children and adolescents”, “rapid maxillary expansion” and “mouth breathing”. The search was conducted in Oct…
Development of extracellular vesicle-based medicinal products: A position paper of the group “Extracellular Vesicle translatiOn to clinicaL perspecti…
2021
International audience; Extracellular vesicles (EV) are emergent therapeutic effectors that have reached clinical trial investigation. To translate EV-based therapeutic to clinic, the challenge is to demonstrate quality, safety, and efficacy, as required for any medicinal product. EV research translation into medicinal products is an exciting and challenging perspective. Recent papers, provide important guidance on regulatory aspects of pharmaceutical development, defining EVs for therapeutic applications and critical considerations for the development of potency tests. In addition, the ISEV Task Force on Regulatory Affairs and Clinical Use of EV-based Therapeutics as well as the Exosomes C…
Livedo: une présentation clinique rare de mycosis fongoïde avec vascularite
2021
Introduction Le mycosis fongoide (MF), lymphome cutane T primitif le plus frequent, peut prendre des formes cliniques tres variees. Nous rapportons 3 cas d’une forme rare associant des plaques de MF a des lesions livedoides necrotiques correspondant a une vasculite cutanee (VC) associee. Materiel et methodes Cas 1: Un patient de 82 ans aux antecedents de leucemie lymphoide chronique B et de MF traite par dermocorticoides presentait un livedo racemosa du tronc, complique de necroses et ulcerations cutanees douloureuses. L’aspect histologique etait celui d’un infiltrat lymphoide dermique atypique, de phenotype T CD3(+), CD4(+), CD8(-) avec pilotropisme et epidermotropisme, associe en profonde…
Contributions for a vascular flora of Tuscany. XIII (813-873)
2021
New localities and/or confirmations concerning 61 specific and subspecific plant taxa of Tuscan vascular flora, belonging to 56 genera and 25 families are presented: Delosperma (Aizoaceae), Ridolfia (Apiaceae), Dracunculus (Araceae), Gamochaeta, Hieracium, Matricaria, Rhagadiolus, Senecio, Tolpis (Asteraceae), Atriplex (Amaranthaceae), Iberis, Thlaspi (Brassicaceae), Legousia (Campanulaceae), Canna (Cannaceae), Lonicera, Symphoricarpos, Valerianella (Caprifoliaceae), Sabulina, Scleranthus, Silene (Caryophyllaceae), Sedum (Crassulaceae), Carex, Cyperus, Eleocharis (Cyperaceae), Orthilia (Ericaceae), Acacia, Albizia, Astragalus, Lathyrus, Medicago, Trifolium, Trigonella (Fabaceae), Streptopus…
A 3D Network Based Shape Prior for Automatic Myocardial Disease Segmentation in Delayed-Enhancement MRI
2021
Abstract Objectives: In this work, a new deep learning model for relevant myocardial infarction segmentation from Late Gadolinium Enhancement (LGE)-MRI is proposed. Moreover, our novel segmentation method aims to detect microvascular-obstructed regions accurately. Material and methods: We first segment the anatomical structures, i.e., the left ventricular cavity and the myocardium, to achieve a preliminary segmentation. Then, a shape prior based framework that fuses the 3D U-Net architecture with 3D Autoencoder segmentation framework to constrain the segmentation process of pathological tissues is applied. Results: The proposed network reached outstanding myocardial segmentation compared wi…
La Sicilia dei centri minori: Above the clouds nella Valle di Bolognetta : architettura, arti performative e nuovi immaginari
2021
Il lavoro elaborato dal Gruppo di ricerca LabCity Architecture sulla rigenerazione dei piccoli centri rurali del territorio siciliano, vittime della crisi economica e demografica di quest’ultimo decennio, evidenzia l’urgenza di un ripensamento delle strategie di intervento in questi luoghi con forti potenzialità territoriali, patrimoniali e culturali, proponendo progetti di ricerca-azione in sinergia con le comunità locali coinvolte. La recente emergenza sanitaria causata dalla pandemia da Covid-19 ha evidenziato l’esigenza di una ricerca mirata ad individuare i caratteri e le esigenze specifiche soprattutto dei centri minori, destinatari di politiche e di interventi spesso inadeguati. In q…
Nonlinear refraction and absorption of spectrally tuneable picosecond pulses in carbon disulfide
2021
Abstract We analyze the spectral dependence of the nonlinear refractive index and nonlinear absorption coefficient of carbon disulfide (CS2) in the spectral range of 400–1100 nm using picosecond laser pulses. An increase of the nonlinear refractive index of CS2 at the shorter wavelength region compared with the near infrared region (9 × 10−14 cm2 W−1 (λ = 700 nm) and 4 × 10−14 cm2 W−1 (λ = 1000 nm), respectively) follows by a decrease of this parameter at the wavelengths below 600 nm. We compare the spectral dependences of the lower- and higher-order nonlinear absorption coefficients in carbon disulfide. The three-photon absorption coefficient was found to be maximal at λ = 1000 nm (β3PA = …
Street Names through Sociological Lenses. Part II: Constructionism and Utilitarianism
2021
Abstract As toponymic means of inscribing urban space, street names have been addressed mainly by human geographers, who have articulated the field of critical place-name studies. In this paper, I continue the endeavor started in the previous issue published in Social Change Review of reading street names through sociological lenses. Whereas in the first part of this two-part contribution the analysis was made from functionalist and conflictualist perspectives, this second and final part employs social constructionism and the utilitarian theoretical tradition in making sociological sense of street nomenclatures. First, conceiving of street names as forming discursively constructed linguisti…
IPR-aineistojen mahdollisuuksia, replikointitarpeita ja teknisiä haasteita
2021
Tässä artikkelissa tehdään katsaus aineettomien oikeuksien eli IPR- (intellectual property rights) aineistoihin erityisesti suomalaisesta ja eurooppalaisesta näkökulmasta. Keskityn patentti-, hyödyllisyysmalli-, tavaramerkki- ja mallioikeusaineistoihin eli teollisoikeuksiin jättäen tekijänoikeudet tarkastelun ulkopuolelle. Digitalisaation myötä rekisteriaineistojen laatu ja saatavuus ovat jatkuvasti lisääntyneet ja IPR-järjestelmien toiminnan tutkimus sekä hypoteesien empiirinen testaus ovat tulleet mahdolliseksi ennennäkemättömällä tavalla. Eräitä mielenkiintoisia aiheita, joiden tutkimuksen yhä laadukkaammat IPR-aineistot mahdollistavat ovat 1) kokonaisvaltaisempi IPR-analyysi, joka paten…
Transcriptomic autophagy-related gene signature investigation for type 2 diabetes in Mediterranean subjects
2021
Abstract Background Autophagy (involving degradation and clearance of damaged organelles and compounds) plays a role in type 2 diabetes (T2D). There are three main types of autophagy and several genes involved. These genes have been well studied in animal models, but there are few transcriptomic studies in humans. Our aim is to analyze the differential gene expression, and the functional enrichment of the main autophagy-related genes (ARG) in T2D subjects from a Mediterranean population Methods We analyzed 120 White-European subjects (mean age 61,4 years; 50% women; 24 T2D) from Valencia, Spain. Clinical and lifestyle data were obtained. ARN was isolated from blood. Transcriptome-wide gene …
Acceptance towards digital health interventions – Model validation and further development of the Unified Theory of Acceptance and Use of Technology
2021
Internet- and mobile-based interventions (IMI) offer an effective way to complement health care. Acceptance of IMI, a key facilitator of their implementation in routine care, is often low. Based on the Unified Theory of Acceptance and Use of Technology (UTAUT), this study validates and adapts the UTAUT to digital health care. Following a systematic literature search, 10 UTAUT-grounded original studies (N = 1588) assessing patients' and health professionals' acceptance of IMI for different somatic and mental health conditions were included. All included studies assessed Performance Expectancy, Effort Expectancy, Social Influence, Facilitating Conditions and acceptance as well as age, gender,…
Bigorexia and orthorexia: an indissoluble relationship?
2021
BACKGROUND: Bigorexia or muscle dysmorphia (MD) is a subtype of body dysmorphic disorder, and it is characterized by an excessive dissatisfaction with body size and muscularity. Orthorexia nervosa (ON) is an obsessive focus on healthy eating and emotional distress related to food choices that are perceived as unhealthy. MD and ON are considered two emerging psychiatric disorders. METHODS: The aim of this study was to evaluate the prevalence of traits of ON and MD between amateurs and professional athletes who practice bodybuilding. The secondary endpoint of the study is to identify the anabolic steroid abuse among the athletes. To this end we have administered a dichotomic questionnaire to …
L'analisi economico aziendale dei risultati di bilancio delle aziende vitivinicole siciliane imbottigliatrici "grandi" nell'esercizio 2020
2021
Abstract The subject of the previous contribution is the analysis of the financial statements of Sicilian large" wineries bottlers, with particular reference to 2020. The conditions of resistance to the pandemic phenomenon still underway were examined, the strategies implemented to counteract the reduction in turnover and the economic results from the twenty-three companies examined. In general, the companies have shown good sealing ability, despite a generalized loss in turnover of around 20%, in a positive recovery currently underway in 2021.
Woodstock: les musiques populaires à l'heure de la contre culture
2021
Opus 11, revue Musicologies Nouvelles, Agrégation 2022; International audience
Neurogranin as a Reliable Biomarker for Synaptic Dysfunction in Alzheimer’s Disease
2021
(1) Background: Neurogranin is a post-synaptic protein expressed in the neurons of the hippocampus and cerebral cortex. It has been recently proposed as a promising biomarker of synaptic dysfunction, especially in Alzheimer’s disease (AD). However, more efforts are needed before introducing it in clinical practice, including the definition of its reference interval (RI). The aim of the study was to establish the RI of cerebrospinal fluid (CSF) neurogranin levels in controls and individuals with non-neurodegenerative neurological diseases; (2) We included a total of 136 individuals that were sub-grouped as follows: AD patients (n = 33), patients with non-neurodegenerative neurological …
Seed germination reports for Sicilian endemic taxa of the genus Helichrysum (Asteraceae)
2021
In the present study, successful germination protocols for 11 different taxa of the genus Helichrysum native to Sicily are discussed. Eight of them are representative of strict endemic Sicilian taxa, 2 are Italian sub endemic and one, namely H. stoechas, is a widespread W Mediterranean species. Given the controversial taxonomic status and relationships of the Mediterranean Helichrysum, the taxonomic approach enhancing the existing diversity of Sicilian populations was herein adopted from current literature. First germination records are given for some of the investigated taxa.
Redox Systems, Oxidative Stress, and Antioxidant Defences in Health and Disease
2021
Reactive oxygen and nitrogen species (RONS) play a key role in the regulation of cell survival. While adequate levels of RONS are essential to sustain cell proliferation and survival, disruption of the endocellular redox state induces cell dysfunction and death. Indeed, under physiological conditions, a balance between the generation and elimination of RONS ensures the proper function of redox-sensitive signalling proteins. Conversely, alterations to the redox homeostasis may disrupt the function of key transcription factors, signaltransduction pathways and cell-death regulators. Along these lines, understanding the mechanisms underlying cellular redox homeostasis may help to develop nutrac…