Rats bred for low intrinsic aerobic exercise capacity link obesity with brain inflammation and reduced structural plasticity of the hippocampus.

2021

Abstract BACKGROUND Increasing evidence shows obesity and poor metabolic health are associated with cognitive deficits, but the mechanistic connections have yet to be resolved. We studied rats selectively bred for low and high intrinsic aerobic capacity in order to test the association between low physical fitness, a genetic predisposition for obesity, and brain health. We hypothesized that low-capacity runner (LCR) rats with concurrently greater levels of adiposity would have increased hippocampal inflammation and reduced plasticity compared to the more physically fit high-capacity runner (HCR) rats. METHODS We examined markers for inflammation and brain plasticity in the hippocampi of LCR…

Low-level environmental metal pollution is associated with altered gut microbiota of a wild rodent, the bank vole (Myodes glareolus)

2021

Mining and related industries are a major source of metal pollution. In contrast to the well-studied effects of exposure to metals on animal physiology and health, the impacts of environmental metal pollution on the gut microbiota of wild animals are virtually unknown. As the gut microbiota is a key component of host health, it is important to understand whether metal pollution can alter wild animal gut microbiota composition. Using a combination of 16S rRNA amplicon sequencing and quantification of metal levels in kidneys, we assessed whether multi-metal exposure (the sum of normalized levels of fifteen metals) was associated with changes in gut microbiota of wild bank voles (Myodes glareo…

CLAYS IN COSMETICS AND PERSONAL-CARE PRODUCTS

2021

Clays are used in various cosmetic formulations, such as sunscreens, toothpastes, deodorants, creams, hair cosmetics, makeups, nail polish, facial masks, and shampoos, among others, to improve the organoleptic and physicochemical characteristics, to increase the stability, or to facilitate elaboration. Together with their technological functionalities, clays are cosmetologically active ingredients with cleaning, anti-aging, anti-wrinkling, and sun-care functionalities. Talc, kaolinite, mica, and some smectites are the clay minerals used most frequently in cosmetic products, but several other phyllosilicates as well as modified and synthetic clays are also used. Sometimes, clays are useful i…

Theoretical Studies on the Mechanism of the Formation of Cyclopentadienes and Dihydropyridazines

2021

In vivo analysis of noise dependent activation of white blood cells and microvascular dysfunction in mice

2021

This article contains supporting information on data collection for the research article entitled “Aircraft noise exposure drives the activation of white blood cells and induces microvascular dysfunction in mice” by Eckrich et al. We found that noise-induced stress triggered microvascular dysfunction via involvement of innate immune-derived reactive oxygen species. In this article, we present the instrumentation of mice with dorsal skinfold chambers for in vivo microscopic imaging of blood flow, interaction of leukocytes with the vascular wall (also by fluorescent labelling of blood cells) and vessel diameter. In addition, we explain the preparation of cerebral arterioles for measurement of…

Impact of the COVID-19 pandemic on music: a method for clustering sentiments

2021

The outbreak of coronavirus disease 2019 (COVID-19) was highly stressful for people. In general, fear and anxiety about a disease can be overwhelming and cause strong emotions in adults and children. One way to cope with this stress consists in listening to music. Aim of this work is to understand if the music heard during the lock-down reflects the emotions generated by the pandemic on each of us. So, the primary goal of this work is to build two indices for measuring the anger and joy levels of the top streamed songs by Italian Spotify users (during the SARS-CoV-2 pandemic), and study their evolution over time. A Hierarchical Cluster Analysis has been applied in order to identify groups o…

Experimental and CFD evaluation of ozone efficacy against coronavirus and enteric virus contamination on public transport surfaces

2021

The limited information about the routes of the transmission of SARS-CoV-2 within the ongoing pandemic scenario mobilized the administration, industry and academy to develop sanitation and disinfection systems for public and private spaces. Ozone has been proposed as an effective disinfection method against enveloped and non-enveloped viruses, including viruses with similar morphology to SARS-CoV-2. Due to this efficacy, numerous gaseous and aqueous phase ozone applications have emerged potentially to inhibit virus persistence in aerosols, surfaces, and water. In this work, a numerical model, a RANS CFD model for ozone dispersion inside tram and underground coach has been developed includin…

Future-oriented coping: Dispositional influence and relevance for adolescent subjective wellbeing, depression, and anxiety

2021

Abstract Extensive literature has explored the predictive role of personality in the use of coping strategies. However, proactive and preventive coping that aim to take action before stressful events occur currently remain largely unexplored. This study examined the associations between proactive and preventive coping and personality (domains and facets) and subjective wellbeing, depression, and anxiety. The results obtained in 934 Spanish adolescents showed that all personality domains were predictors of both types of coping, except for Extraversion, which did not predict preventive coping. Attention to the facets allowed increases in the predicted percentage of variance and a greater unde…

Pharmaceuticals and other urban contaminants threaten Amazonian freshwater ecosystems

2021

Abstract Urban areas in the Brazilian Amazon have grown at an unprecedented rate during the last years. About 90% of the wastewater produced by these urban areas are discharged untreated into Amazonian freshwater ecosystems, constituting a potential environmental pathway for pharmaceuticals and other chemicals consumed by modern societies (e.g. psychostimulants, personal-care products, hormones). The distribution of these chemicals into the Amazon River and their potential risks for freshwater biodiversity have not been evaluated so far. Here, we show the results of the largest chemical monitoring campaign conducted in the Amazon region. We assessed exposure patterns for 43 pharmaceuticals …

Thiourea Organocatalysts as Emerging Chiral Pollutants: En Route to Porphyrin-Based (Chir)Optical Sensing

2021

Environmental pollution with chiral organic compounds is an emerging problem requiring innovative sensing methods. Amino-functionalized thioureas, such as 2-(dimethylamino)cyclohexyl-(3,5-bis(trifluoromethyl)phenyl)thiourea (Takemoto’s catalyst), are widely used organocatalysts with virtually unknown environmental safety data. Ecotoxicity studies based on the Vibrio fischeri luminescence inhibition test reveal significant toxicity of Takemoto’s catalyst (EC50 = 7.9 mg/L) and its NH2-substituted analog (EC50 = 7.2–7.4 mg/L). The observed toxic effect was pronounced by the influence of the trifluoromethyl moiety. En route to the porphyrin-based chemosensing of Takemoto-type thioureas, their s…

Human Drug Pollution in the Aquatic System: The Biochemical Responses of Danio rerio Adults

2021

Simple Summary The release of medicinal products for human use in the aquatic environment is now a serious problem, and can be fatal for the organisms that live there. Danio rerio is a freshwater fish that provides the possibility to study the effects of these pollutants on the health of aquatic organisms. The results of the various existing scientific studies are scarce and conflicting. Here, we review the scientific studies that have analyzed these effects, highlighting that the impacts of drugs are evident in the biochemical responses of these animals. Abstract To date, drug pollution in aquatic systems is an urgent issue, and Danio rerio is a model organism to study the toxicological ef…

The emission reduction potential of electric transport modes in Finland

2021

The transportation sector has become the fastest growing source of greenhouse gas (GHG) emissions. One solution to mitigate the impacts is a shift towards electric modes. Where previous studies have only focused on the replacement of individual modes, our study presents a more holistic approach by comparing land-based, water-based and airborne transportation modes. We study the GHG emission reduction potentials of electric cars, buses, trains, ferries and aircraft in comparison to existing modes on 34 routes within Finland and across the Baltic Sea to Sweden and Estonia. By comparing the GHG emissions in carbon dioxide equivalents (CO2-eq) per passenger kilometer for each mode, we also cons…

Effects of weekend starvation and the duration of daily feeding on production parameters of rainbow trout Oncorhynchus mykiss

2021

Abstract It would often be practical to starve the cultivated fishes over the weekends, e.g. to save in labour costs. We evaluated the possibility that domesticated juvenile rainbow trout (Oncorhynchus mykiss) could compensate for the lost growth of the 2-day weekend starvation by either hyperphagic response and/or by lower feed conversion ratio, compared to the fish fed every day in an 8-week experiment. Rainbow trout (initial weight c. 30 g, temperature 16 °C) starved during the weekends were able to increase feed intake during the weekdays clearly above the intake of the control fish after the first two weekends, also seen as an increase of the compensation coefficients over the last fou…

Low contribution of Caribbean-based researchers to academic publications on biodiversity conservation in the insular Caribbean.

2021

11 pages; International audience; The insular Caribbean is among the most threatened global biodiversity hotspots, warranting urgent and effective action in conservation. However, the capacity of Caribbean-based researchers to address challenges in biodiversity conservation appears limited. To assess the latter, we used the contribution of Caribbean-based authors to the production of peer-reviewed journal papers on biodiversity conservation in the insular Caribbean as a proxy for research capacity. Moreover, because the insular Caribbean is a complex geopolitical system including sovereign states and overseas territories, we examined the contributions of these two groups to the number of pa…

The Lightfield Microscope Eyepiece

2021

Lightfield microscopy has raised growing interest in the last few years. Its ability to get three-dimensional information about the sample in a single shot makes it suitable for many applications in which time resolution is fundamental. In this paper we present a novel device, which is capable of converting any conventional microscope into a lightfield microscope. Based on the Fourier integral microscope concept, we designed the lightfield microscope eyepiece. This is coupled to the eyepiece port, to let the user exploit all the host microscope’s components (objective turret, illumination systems, translation stage, etc.) and get a 3D reconstruction of the sample. After the optical design, …

Re: Internal Jugular Vein and Cerebral Venous Sinus Infective Thrombophlebitis Detected With 99mTc-HMPAO White Blood Cell Scintigraphy.

2021

Expression of the Sonic Hedgehog Embryonic Signalling Pathway Components in Matched Pre-Treatment and Relapsed Small Cell Lung Cancer Biopsies

2021

Abstract Cancer stem cells may be responsible for tumour regrowth and acquisition of resistance in small cell lung cancer (SCLC). The Hedgehog pathway regulates survival and proliferation of tissue progenitor and stem cell populations, promoting the expression of stem cell related and proliferative genes. We evaluated the Sonic Hedgehog (Shh) embryonic signalling pathway in relapsed SCLC. Expression levels of Shh related genes GLI1, SMO, SUFU, PTCH1, HHIP, BCL2, BMI, ZEB1, ZEB2, N-MYC, Twist1 were analysed by qRT-PCR in matched pre-treatment and relapsed tumour fresh frozen biopsies of three SCLC patients. Expression of each gene was compared using the paired samples t-test, as well as comp…

Marine food web perspective to fisheries‐induced evolution

2021

Abstract Fisheries exploitation can cause genetic changes in heritable traits of targeted stocks. The direction of selective pressure forced by harvest acts typically in reverse to natural selection and selects for explicit life histories, usually for younger and smaller spawners with deprived spawning potential. While the consequences that such selection might have on the population dynamics of a single species are well emphasized, we are just beginning to perceive the variety and severity of its propagating effects within the entire marine food webs and ecosystems. Here, we highlight the potential pathways in which fisheries‐induced evolution, driven by size‐selective fishing, might reson…

Effects of natural extracts in the treatment of oral ulcers: A systematic review of evidence from experimental studies in animals

2021

Background To evaluate the clinical and histopathological effects of natural extracts in the treatment of oral ulcers induced in animal experimental models. Material and methods We carried out a search in the Medline, Scopus, WoS and Embase databases from the start of the databases to December 2020, and also made a manual search of the references. The search and selection were carried out by two researchers independently. The inclusion criteria were: experimental studies in animal models, in english, which complied with the study object. Results A total of 705 articles were identified. After selection by title, abstract and full text, 19 articles were finally included. Natural extracts of J…

Dimensioni umane della questione ecologica nella Grecia antica

2021

Il saggio studia i problemi dell’ecologia a livello macro, meso e micro, nella Grecia antica, e illustra in particolare casi di inquinamento olfattivo e bellico, mostrando anche come le ‘grandi opere’ siano, per una tradizione di pensiero, segno di mentalità tirannica e arrogante. Mette in evidenza, inoltre, l’‘inquinamento’ della vita sociale e individuale, prodotto da un’economia fondata sull’arricchimento tendenzialmente infinito e considerata innaturale, in contrapposizione al benessere offerto da un’economia rispettosa dell’ambiente e delle esigenze comunitarie e individuali, considerata “conforme a natura”. Infine, presenta il modello politico delle Leggi di Platone e della Politica d…

Do Age and Sex Play a Role in the Intraocular Pressure Changes after Acrobatic Gymnastics?

2021

To evaluate the effects of an acrobatic gymnastics (AG) training session on intraocular pressure (IOP), a familiarization session was employed to confirm the participant’s suitability for the study. Forty-nine gymnasts (63.27% females, 18–40 years old) voluntarily agreed to participate. As age, sex, baseline IOP, and central corneal thickness (CCT) were considered as potential predictors of the IOP variations, in the second session measurements of the above parameters were taken before and after 90 min of AG. A mixed-factorial analysis of variance evaluated differences. Linear regression was conducted to potentially predict the IOP variation with the exercise. After the scheduled exercise, …

L’educatore socio-pedagogico nei contesti scolastici per un agire inclusivo

2021

This work aims to reflect on the figure of the social educator, starting from the idea that over time has laboriously matured at a cultural level. In this context, the contribution aims to trace the specific professional, theoretical and practical, of the social educator and the pedagogist and the transversal skills necessary for the design of an inclusive educational action, especially in secondary schools. The DL 65/2017 highlights the importance of specific professional skills, essential to qualify with scientific foundation educational interventions in the different areas of services to the person, in all stages of his life

LISIBILITÉ ET LISIBILISATION DU VIN DANS LA COMMUNICATION DE SES ORGANISATIONS

2021

International audience; Vocable alimentaire dans l'air du temps, on parle aujourd'hui dans les discours du vin et autour du vin, de « lisibilité du vin », comme si le vin était lisible, qu'on pouvait le « lire », le décrypter. Notre propos ici est de recontextualiser et de reconceptualiser cette notion, mais non dans une optique métathéorique réaliste, comme si la réalité du vin et de ses discours nous étaient donnés d'emblée, et qu'il suffirait de les observer de manière objectivante pour s'en réapproprier les codes de genèse, de représentation et de diffusion des connaissances qui s'y rattachent, ainsi que les messages qui sont au coeur de la communication. Comme si les parcours de lectur…

Accidental migration of dental implant into the nasal cavity: Spontaneous expulsion through the nose

2021

Implant migration into the nasal fossa is a rare complication and it requires extraction by anterior rhinoscopy. We report a clinical case of placement of short dental implants, fixed or intruded in the nasal fossa floor, which was aspirated by the patient and spontaneously expelled a few days later. To the best of our knowledge, there have been no reports of spontaneously expulsion through the nasal cavity. Key words:Dental implant, nasal cavity, accidental migration.

Paesaggio e memorie dell'antico: dall'archeologia all'arte contemporanea

2021

The aim of this paper is to compare different perceptions of cultural landscapes: the landscape of a Hellenistic-Roman city, Halaesa, reconstructed through archaeological surveys, and the contemporary landscape – natural and cultural – that characterizes the Tusa river, so-called “Fiumara d’arte”, where some installations of modern art have been made. Here the modern art is integrated with the landscape, in which it seems to emphasize some peculiar aspects, result of complex interactions. This analysis allow us to use the archaeological data to understand the relationship between human activities the symbolic aspects which connect ancient and modern communities to their territories.

Qu’est-ce que la sociabilité ?

2021

International audience

A Review of the Most Common and Economically Important Diseases That Undermine the Cultivation of Tomato Crop in the Mediterranean Basin

2021

Tomato (Solanum lycopersicum L.), family Solanaceae, has become in the past fifty years one of the most important and extensively grown horticultural crops in the Mediterranean region and throughout the world. In 2019, more than 180 million tonnes of tomato have been produced worldwide, out of which around 42 million tonnes in Mediterranean countries. Due to its genetic properties, tomato is afflicted by numerous plant diseases induced by fungal, bacterial, phytoplasma, virus, and viroid pathogens. Not only is its genetic inheritance of great importance to the management of the numerous tomato pathogens, but equally as important are also the present climate changes, the recently revised phy…

Novel Concept for Electro-Hydrostatic Actuators for Motion Control of Hydraulic Manipulators

2021

Self-contained hydraulic cylinders have gained popularity in the recent years but have not been implemented for high power articulated hydraulic manipulators. This paper presents a novel concept for an electro-hydrostatic actuator applicable to large hydraulic manipulators. The actuator is designed and analyzed to comply with requirements such as load holding, overload handling, and differential flow compensation. The system is analyzed during four quadrant operation to investigate energy efficiency and regenerative capabilities. Numerical simulation is carried out using path control and 2DOF anti-swing of a hydraulic crane as a load case to illustrate a real world scenario. A comparison wi…

Compréhension de scènes urbaines basées sur la polarisation

2021

Humans possess an innate ability to interpret scenes under any condition. Computer Vision tends to mimic these capabilities by implementing intelligent algorithms to address complex understanding problems. In this regard, we are interested in understanding outdoor urban scenes in various weather conditions. This thesis specifically addresses the problems arising from the presence of specularity in the scenes. To this end, we aim to take advantage of polarization indices to define such surfaces in addition to traditional objects. In terms of understanding, we aim to introduce polarization to the fields of computer vision and deep learning.This thesis focuses on the following underlying challeng…

Simplified Model of PC Concrete Beams with Corroded Strands in Highway Viaduct: Case Study and Analytical Modeling

2021

AbstractIn this paper, several cases of failure of prestressed reinforced concrete (PC) beams of a viaduct in Italy due to cable corrosion are presented. Therefore, a simplified model to determine ...

Measurements of the center-of-mass energies of e+e- collisions at BESIII

2021

Chinese physics / C 45(10), 103001 (2021). doi:10.1088/1674-1137/ac1575

«Bracconiere di ricordi». Memoria e oblio in Gesualdo Bufalino

2021

The essay aims to analyze the connection between memory and oblivion that Bufalino investigates in his inventive work. Memory and its reverse, forgetfulness, are important themes of a writing that questions itself on the very reasons for its making. Bufalino’s narrative is populated with characters without a past, constructed by subtraction, through a chiaroscuro made up of full and above all voids, omissions, erasures. In the stories of the book L’uomo invaso e altre invenzioni the ghosts of oblivion and the emblematic images of erased memory, of the bleeding of memories affected by «wounds of passing time» coexist with references to the literary character of the “forgetful”, who suffers f…

Bio-based Materials. Standardizzazione e processi per la commercializzazione

2021

Il contributo si occupa degli aspetti normativi nel campo della produzione e uso di una malta con componenti organici derivanti dal riciclo di scarti agricoli e silvo-pastorali. Viene prestata attenzione alla normativa internazionale più diffusa e nota, a quella europea e a quella italiana. La riduzione del consumo di suolo e di risorse lapidee, degli scarti, la limitazione dell’utilizzo di materiali di cava naturali sono solo alcuni benefici che hanno indotto la comunità scientifica a investire nell’uso di materie prime-seconde di origine vegetale, ecosostenibili; oggi, lo stato dell’arte è molto ricco. Tuttavia, non ci sono ancora normative tecniche e procedurali relative ai materiali che…

Adecuación del uso de los servicios médicos de urgencias por parte del paciente adolescente

2021

Objetivo: Comparar la adecuación de las consultas a urgencias del paciente adolescente que está siendo atendido por el pediatra (12 a 14 años) y los que ya no lo están (15 a 18 años). Métodos: Estudio transversal con pacientes en edades entre 12 y 18 años que acudieron al Servicio de Urgencias del Hospital La Salud de Valencia durante el 2018. Los criterios de adecuación se basaron en el Protocolo de Adecuación de Urgencias Hospitalarias. Las variables de adecuación se describieron mediante frecuencias y como método de comparación se utilizó el test exacto de Fisher y la razón de momios. En todos los casos los contrastes de hipótesis fueron bilaterales, con un nivel de confianza de 95 % y l…

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2021

IntroductionPrimary ciliary dyskinesia (PCD) is a rare, genetic, multiorgan disease with an estimated prevalence of 1 in 10 000. It affects mainly the upper and lower airways due to impaired mucociliary clearance. Almost all patients have sinonasal or otologic (ear–nose–throat, ENT) problems, although the ENT clinical phenotype may present great variability. Despite that, data on PCD ENT manifestations are scarce and based on small single-centre studies. To date, we know little about the spectrum and severity of PCD ENT disease, its association with lung disease, its course over life and its determinants of prognosis.This study protocol describes the aims and methods of the first prospectiv…

Osteocondroma solitario de la escápula: localización poco habitual para un tumor frecuente

2021

Osteochondroma is a benign bone tumor that usually affects children and young adults. It is typically located in the metaphysis of long bones around the knee, although it could also affect flat bones like scapula. We report the case of a 11-year-old child with one year of evolution painful tumor at the dorsal surface of the scapula. He was diagnosed with osteochondroma of the scapula, uncommon location for this tumor. Due to the persistence of the symptomatology surgical excision was performed.