El fracaso de los proyectos de reforma en el virreinato peruano de principios del siglo XVIII. Las propuestas de Carmine Nicola Caracciolo, príncipe …

2021

Desde hace algunas décadas, una nueva corriente historiográfica ha dirigido su atención a las transformaciones que, en los ámbitos social, político y militar, impulsó el gobierno borbónico en las primeras décadas del siglo XVIII. Aunque en gran medida no tuvieron éxito, las reformas promovidas en las dos primeras décadas entre la Península Ibérica, Sicilia, Nueva España y Perú ponen de relieve un importante primer intento de hacer más funcional el gobierno de la Monarquía. Este artículo tiene como objetivo analizar las propuestas de las reformas que Carmine Nicola Caracciolo elaboró durante su mandato como Virrey del Perú (1716-1721). En particular, se reflexionará sobre aquellas propuestas…

Primary stroke prevention worldwide:translating evidence into action

2021

Abstract: Stroke is the second leading cause of death and the third leading cause of disability worldwide and its burden is increasing rapidly in low-income and middle-income countries, many of which are unable to face the challenges it imposes. In this Health Policy paper on primary stroke prevention, we provide an overview of the current situation regarding primary prevention services, estimate the cost of stroke and stroke prevention, and identify deficiencies in existing guidelines and gaps in primary prevention. We also offer a set of pragmatic solutions for implementation of primary stroke prevention, with an emphasis on the role of governments and population-wide strategies, includin…

Whispering Gallery Mode Resonator Temperature Compensation and Refractive Index Sensing in Glucose Droplets.

2021

Among the different types of photonic sensor devices, optical whispering gallery mode resonators (WGMRs) have attracted interest due to their high level of sensitivity, small size, and ability to perform real-time temperature measurements. Here we demonstrate the applicability of temperature measurements using WGMR in both air and liquid environments. We also show that WGMR allowed measurements of the refractive index variations in an evaporating glucose–water solution droplet. The thermal tuning of WGMR can be reduced by coating WGMRs with a thin layer of polymethyl methacrylate (PMMA). Dip-coating the silica microsphere multiple times significantly reduced the resonance shift, partially c…

Search for New Phenomena in Final States with Two Leptons and One or No b -Tagged Jets at s=13  TeV Using the ATLAS Detector

2021

A search for new phenomena is presented in final states with two leptons and one or no $b$-tagged jets. The event selection requires the two leptons to have opposite charge, the same flavor (electrons or muons), and a large invariant mass. The analysis is based on the full Run-2 proton-proton collision dataset recorded at a center-of-mass energy of $\sqrt{s} = 13$ TeV by the ATLAS experiment at the LHC, corresponding to an integrated luminosity of 139 fb$^{-1}$. No significant deviation from the expected background is observed in the data. A four-fermion contact interaction between two quarks ($b,s$) and two leptons ($ee$ or $\mu\mu$), inspired by the $B$-meson decay anomalies, is used as a…

Discordance in prognostic ability between physician assessed NYHA classification and self-reported health status in patients with acute heart failure

2021

Abstract Background Especially in patients with acute heart failure (AHF) the NYHA classification remains of uncertain representation of patients' actual health state. Alternatively, patient's subjective well-being, in terms of health-related quality of life (HRQL), showed to have an excellent prognostic ability in out clinic patients with chronic heart failure. Objectives It is unknown whether HRQL instruments can assess a more reliable prognostication in patients hospitalized due to AHF than the NYHA classification. Methods Goal Directed Afterload Reduction in Acute Congestive Cardiac Decompensation Study (GALACTIC) was a multicenter, randomized, open-label blinded-end-point trial that em…

A multiple-response chi-square framework for the analysis of Free-Comment and Check-All-That-Apply data

2021

International audience; Free-Comment (FC) and Check-All-That-Apply (CATA) provide a contingency table containing citation counts of descriptors by products. The analyses performed on this table are most often related to the chi-square statistic. However, such practices are not well suited because they consider experimental units as being the citations (one descriptor for one product by one subject) while the evaluations (vector of citations for one product by one subject) should be considered instead. This results in incorrect expected frequencies under the null hypothesis of independence between products and descriptors and thus in an incorrect chi-square statistic. Thus, analyses related …

Pharmacokinetic/Pharmacodynamic Model of Neutropenia in Real-Life Palbociclib-Treated Patients

2021

Palbociclib is an oral CDK4/6 inhibitor indicated in HR+/HER2- advanced or metastatic breast cancer in combination with hormonotherapy. Its main toxicity is neutropenia. The aim of our study was to describe the kinetics of circulating neutrophils from real-life palbociclib-treated patients. A population pharmacokinetic (popPK) model was first constructed to describe palbociclib pharmacokinetic (PK). Individual PK parameters obtained were then used in the pharmacokinetic/pharmacodynamic (PK/PD) model to depict the relation between palbociclib concentrations and absolute neutrophil counts (ANC). The models were built with a population of 143 patients. Palbociclib samples were routinely collec…

70 Patient reported outcome in platinum-resistant recurrent ovarian cancer and metastatic breast cancer treated with metronomic chemotherapy

2021

Introduction/Background* In the treatment of both platinum-resistant recurrent ovarian cancer (ROC) and metastatic breast cancer (MBC), symptom control and maintenance of quality of life (QoL) play a crucial role. In the advanced stage of disease, metronomic chemotherapy (MCT) may be a favourable treatment option. The aim of this study is to assess the QoL of heavily pretreated patients with ROC and MBC treated with MCT. Methodology PROmetronomic, FoR.UM 19-02193, is a monocentric, open-label, single-arm observational study to assess health-related patient-reported outcome data in ROC and MBC patients treated with MCT (cyclophosphamide 50 mg p.o. daily ± methotrexate 2.5 mg p.o. every other…

Matthew Lipman e la Philosophy for Children come strategia educativa per combattere il fenomeno della violenza e della discriminazione sociale.

2021

With this contribution I want to highlight in what terms pedagogy can modify and revolutionize social relationships and significantly transform social communities. To do this, the Philosophy for Children conceived by Ann Sharp and Matthew Lipman will be taken as a reference point. Specifically, attention will be paid to the figure of Lipman, who will be examined from a historical point of view and with the aim of enhancing the motivation that led him, in the 1970s, to think of a pedagogy which, making use of of philosophy, stimulate and educate a critical and divergent thought, with which to protect, or determine from scratch, the essence of democracy. In this regard, the figure of Lipman w…

Integrated CGH/WES Analyses Advance Understanding of Aggressive Neuroblastoma Evolution: A Case Study

2021

Neuroblastoma (NB) is the most common extra-cranial malignancy in preschool children. To portray the genetic landscape of an overly aggressive NB leading to a rapid clinical progression of the disease, tumor DNA collected pre- and post-treatment has been analyzed. Array comparative genomic hybridization (aCGH), whole-exome sequencing (WES), and pharmacogenetics approaches, respectively, have identified relevant copy number alterations (CNAs), single nucleotide variants (SNVs), and polymorphisms (SNPs) that were then combined into an integrated analysis. Spontaneously formed 3D tumoroids obtained from the recurrent mass have also been characterized. The results prove the power of combining C…

Comprehensive Analysis of VEGFR2 Expression in HPV-Positive and -Negative OPSCC Reveals Differing VEGFR2 Expression Patterns

2021

VEGF signaling regulated by the vascular endothelial growth factor receptor 2 (VEGFR2) plays a decisive role in tumor angiogenesis, initiation and progression in several tumors including HNSCC. However, the impact of HPV-status on the expression of VEGFR2 in OPSCC has not yet been investigated, although HPV oncoproteins E6 and E7 induce VEGF-expression. In a series of 56 OPSCC with known HPV-status, VEGFR2 expression patterns were analyzed both in blood vessels from tumor-free and tumor-containing regions and within tumor cells by immunohistochemistry using densitometry. Differences in subcellular colocalization of VEGFR2 with endothelial, tumor and stem cell markers were determined by doub…

Anharmonicity modeling in hydrogen bonded solvent dimers

2021

Abstract Harmonic and anharmonic frequencies of dimers and mixed dimers of water, methanol and benzene were computed and the results were critically analysed to investigate the anharmonicity of the normal mode vibrations within density functional theory (DFT) with empirically included Grimme correction for dispersion (D3). From several options, the B3LYP-D3/6-31++G* level of theory was selected as a good compromise between accuracy and calculation speed, suitable for future modeling of larger solvent clusters. The obtained raw harmonic and anharmonic second-order perturbation theory of vibrational frequencies (VPT2) were additionally scaled using a two-range procedure (below and above 2000 …

Ischemic hypoxic encephalopathy: The role of MRI of neonatal injury and medico-legal implication

2021

Hypoxic ischemic encephalopathy is one of the major causes of neonatal death and neurological disability in the child, and represents the most common birth injury claim. Intrapartum asphyxia often leads to several long-term sequalae, such as cerebral palsy and/or developmental delay, epilepsy. Through the neuroimaging it's possible to identify and define the different lesioned pictures and provide useful elements to establish the moment in which the damage occurred; indeed, timing of injury is a key element in the legal arena. Magnetic resonance imaging (MRI) is emerging as one of the most important tools in identifying the etiologic of neonatal encephalopathy as well as in predicting long-…

Cardiovascular primary prevention risk factors in a nationwide survey, ABC (atrial fibrillation, high blood pressure and high cholesterol) risk facto…

2021

Abstract Background The National Health Service in England “Long Term Plan” aims to prevent 150,000 strokes and myocardial infarctions over the next 10 years. To achieve this, resources are being allocated to improve early detection of conditions strongly associated with cardiovascular disease. This includes working towards people routinely knowing their “ABC” risk factors (“A”: atrial fibrillation (AF), “B': hypertension and “C”: high cholesterol) (1). Purpose The aims of this study were to: 1) determine the proportion of participants with “A”, “B”, and “C” criteria; and 2) to identify risk factors for patients fulfilling any of these criteria. Methods LIPIDOGRAM2015 was a nationwide cross…

Modelling of Social Policy and Initiatives under COVID-19: Rural NEET Youth Case Study

2021

NEET (Not in Education, Employment, or Training) youth rates in Europe are generally higher in rural regions than in urban areas and the share in rural regions is constantly increasing. During the COVID-19 pandemic, young people became even more vulnerable as they experienced social exclusion and mental health problems. The objective of this paper is to analyse NEET youth-related statistics in Europe and distinguish positive initiatives for young people in rural areas of the Baltic countries to encourage positive emotions and willingness to learn. Statistical analysis and case study methods were employed. Data on youth unemployment, NEET youth by age and gender, and poverty and social exclu…

Breast-Feeding from an Evolutionary Perspective.

2021

Lactation is the most critical period of mammal feeding given the compulsory dependence on milk of the offspring during a more or less extensive period following birth. This has also been the case for the human species until relatively recent times when heterologous milk processing has allowed the alternative of artificial lactation. The advantages and disadvantages of natural and artificial lactation (formula) have been widely discussed from the biological, psychological and cultural perspectives, without reaching a general agreement among the breastfeeding women themselves or among the health professionals concerned. On the subject of breastfeeding, the information available is enormous b…

Factors Affecting Occupational Burnout Among Nurses Including Job Satisfaction, Life Satisfaction, and Life Orientation: A Cross-Sectional Study

2021

Agnieszka Zborowska,1 Piotr Jerzy Gurowiec,2 Agnieszka Młynarska,3,4 Izabella Uchmanowicz1,5 1Department of Clinical Nursing, Wroclaw Medical University, Wroclaw, Poland; 2Institute of Health Sciences, University of Opole, Opole, Poland; 3Department of Gerontology and Geriatric Nursing, Medical University of Silesia, Katowice, Poland; 4Department of Electrocardiology, Upper Silesian Heart Centre, Katowice, Poland; 5Centre for Heart Diseases, Wroclaw Medical University, Wroclaw, PolandCorrespondence: Izabella UchmanowiczDepartment of Clinical Nursing, Faculty of Health Sciences, Wroclaw Medical University, Bartla 5, Wroclaw, 51-618, PolandTel +48 71 784 18 05Fax +48 71 345 93 24Em…

Epistemic independence and speaker roles: Highlighting the role of second speaker and mitigating the role of first speaker

2021

Abstract Definitions of attenuation tend to place their emphasis on different aspects of the communication process, especially facework, propositional content, illocutionary force and the roles of speech participants. This paper concentrates on the latter of these aspects. Although studies mention the possibility that attenuation applies to more than one participant, the analysis of particular examples within those studies shows that authors tend to refer mostly (or even only) to the speaker's role (e.g., Briz, 1998, 2003; Briz and Albelda, 2013; Villalba Ibanez, 2016). This study explores the possibility that attenuation of the role of another participant (i.e. a participant other than the…

Acceptance and validity of the methods used to implement a competency based medical education programme in an Intensive Care Department of a teaching…

2021

Abstract Objectives 1. To determine the satisfaction of tutors and residents with a specific methodology used to implement CoBaTrICE. 2. To determine the reliability and validity of the global rating scales designed ad hoc to assess the performance of the residents for training purposes. Design Prospective cohort study. Participants All the residents and tutors of the ICU Department of the Hospital Universitario y Politecnico la Fe de Valencia. Intervention CoBaTrICE implementation started in March 2016, it was based on: (1) Training the tutors in feedback techniques; (2) Performing multiple objective and structured work based assessments to achieve the competences of the program; and (3) T…

Electroencephalography as a Non-Invasive Biomarker of Alzheimer’s Disease: A Forgotten Candidate to Substitute CSF Molecules?

2021

Biomarkers for disease diagnosis and prognosis are crucial in clinical practice. They should be objective and quantifiable and respond to specific therapeutic interventions. Optimal biomarkers should reflect the underlying process (pathological or not), be reproducible, widely available, and allow measurements repeatedly over time. Ideally, biomarkers should also be non-invasive and cost-effective. This review aims to focus on the usefulness and limitations of electroencephalography (EEG) in the search for Alzheimer’s disease (AD) biomarkers. The main aim of this article is to review the evolution of the most used biomarkers in AD and the need for new peripheral and, ideally, non-invasive b…

Synthetic biomolecular condensates to engineer eukaryotic cells

2021

Abstract The compartmentalization of specific functions into specialized organelles is a key feature of eukaryotic life. In particular, dynamic biomolecular condensates that are not membrane enclosed offer exciting opportunities for synthetic biology. In recent years, multiple approaches to generate and control condensates have been reported. Notably, multiple orthogonally translating organelles were designed that enable precise protein engineering inside living cells. Despite being built from only very few components, orthogonal translation can be engineered with subresolution precision at different places inside the same cell to create mammalian cells with multiple expanded genetic codes.…

The Porto European Cancer Research Summit 2021.

2021

Key stakeholders from the cancer research continuum met in May 2021 at the European Cancer Research Summit in Porto to discuss priorities and specific action points required for the successful implementation of the European Cancer Mission and Europe's Beating Cancer Plan (EBCP). Speakers presented a unified view about the need to establish high‐quality, networked infrastructures to decrease cancer incidence, increase the cure rate, improve patient's survival and quality of life, and deal with research and care inequalities across the European Union (EU). These infrastructures, featuring Comprehensive Cancer Centres (CCCs) as key components, will integrate care, prevention and research acros…

Prostate Specific Antigen Dynamics and Features in Prostate Cancer

2021

Abstract Despite the common use of the prostate-specific antigen (PSA) serum level as a tumour marker in diagnosis of prostate cancer, it seems that the PSA doubling time (PSADT) and PSA velocity (PSAV) could be more useful indicators of tumour behaviour and prognosis for patients. The aim of the study was to evaluate the value of PSAV and PSADT in the diagnosis of prostate cancer and their relationship with prostate cancer histopathological characteristics. Eighty-six patients undergoing radical prostatectomy were enrolled in the study. Based on the PSA measurements the PSA dynamic values were calculated: PSADT and PSAV. In addition, clinical and histo-pathological characteristics, includi…

Feature Paper in Environmental Chemistry and Technology

2021

Attention to the environment and its problems has undergone unprecedented growth in recent years [...]

Characteristics, Trends, and Outcomes of Liver Transplantation for Primary Sclerosing Cholangitis in Female Versus Male Patients

2021

Background. The influence of sex on primary sclerosing cholangitis (PSC), pre- and postliver transplantation (LT) is unclear. Aims are to assess whether there have been changes in incidence, profile, and outcome in LT-PSC patients in Europe with specific emphasis on sex. Methods. Analysis of the European Liver Transplant Registry database (PSC patients registered before 2018), including baseline demographics, donor, biochemical, and clinical data at LT, immunosuppression, and outcome. Results. European Liver Transplant Registry analysis (n = 6463, 32% female individuals) demonstrated an increasing number by cohort (1980-1989, n = 159; 1990-1999, n = 1282; 2000-2009, n = 2316; 2010-2017, n =…

Quantitative assessment and localization of the hollowing of the temple after craniectomy and cranioplasty–The frontozygomatic shadow

2021

Background After cranioplasty, in many cases a not negligible soft tissue defect remains in the temporozygomatical area, also referred to as a hollowing defect of the temple. Objective To assess the precise localization and volume of the hollowing defect, to optimize future cranioplasties. Methods CT data of patients who received craniectomy and conventional CAD cranioplasty in our institution between 2012 and 2018 were analyzed. CT datasets prior to craniectomy and after cranioplasty were subtracted to quantify the volume and localization of the defect. Results Out of 91 patients, 21 had suitable datasets. Five cases had good cosmetic results with no defect visible, 16 patients had an app…

Protein Cargo of Salivary Small Extracellular Vesicles as Potential Functional Signature of Oral Squamous Cell Carcinoma

2021

The early diagnosis of oral squamous cell carcinoma (OSCC) is still an investigative challenge. Saliva has been proposed as an ideal diagnostic medium for biomarker detection by mean of liquid biopsy technique. The aim of this pilot study was to apply proteomic and bioinformatic strategies to determine the potential use of saliva small extracellular vesicles (S/SEVs) as a potential tumor biomarker source. Among the twenty-three enrolled patients, 5 were free from diseases (OSCC_FREE), 6 were with OSCC without lymph node metastasis (OSCC_NLNM), and 12 were with OSCC and lymph node metastasis (OSCC_LNM). The S/SEVs from patients of each group were pooled and properly characterized before perf…

Determination of albendazole and ivermectin residues in cattle and poultry-derived samples from India by micellar liquid chromatography

2021

We have developed a method, based on micellar liquid chromatography, to determine albendazole and ivermectin in dairy products and biological waste from bovine, as well as edible tissues from poultry. Anthelmitics were resolved in less than 10 min using a C18 column and a mobile phase of 0.15 mol/L sodium dodecyl sulfate – 6% 1-pentanol at buffered at pH 7 with a 0.01 M phosphate salt, running under isocratic mode at 1 mL/min. Detection was by absorbance at 292 nm. Method was successfully validated following official validation guidelines, in terms of: selectivity, sensitivity, calibration range (0.0125−0.5 mg/kg to 25−50 mg/kg), linearity (r2 > 9990), trueness (86.3–105.6%), precision (<12…

Análisis de casos de candidemia por Candida auris en una Unidad de Cuidados Intensivos de Anestesia en un hospital terciario

2021

Resumen Candida auris es una levadura emergente multirresistente. Objetivos Analizar la relacion entre la existencia de colonizacion por C. auris y la aparicion de candidiasis invasora. Descripcion de la muestra de pacientes colonizados, factores de riesgo para colonizacion y/o infeccion y calculo de las tasas de mortalidad. Metodologia Estudio observacional longitudinal en una Unidad de Cuidados Intensivos de Anestesia durante el ano 2018. Resultados Ingresaron 2.130 pacientes; 124 pacientes tuvieron estudios de vigilancia positivos, 118 casos fueron colonizacion cutanea y 52 faringea. Se identificaron los pacientes con hemocultivo positivo. Se encontro asociacion estadisticamente signific…

La mediazione domanda offerta di lavoro ai tempi del Covid

2021

In this paper we face the trade off between labour demand and supply for graduates in the Covid Era.

Engels on Corruption

2021

Kirja-arvio käsittelee johtavan saksalaisen korruptiotutkija Jens Ivo Engelsin kahta laajaa tutkimusta. Arviossa Engelsin havainnot yhdistetään Suomen lähihistorian kuuluisimpaan ”lautakasajupakkaan” eli silloisen pääministeri Matti Vanhasen tapaukseen vuodelta 2009. nonPeerReviewed

The AKIKI 2 trial: a case for strategy of initiation instead of timing - Authors' reply.

2021

Starptautiska zinātniska konference "Indivīds, sabiedrība un vara Baltijas reģiona vēstures lūzuma punktos": Konferences referātu tēzes, 2021. gada 1…

2021

Krājums apvieno konferencē “Indivīds, sabiedrība un vara Baltijas reģiona vēstures lūzuma punktos” nolasīto referātu tēzes. Latvijas, Lietuvas, Igaunijas un Polijas vēsturnieku, sociologu, teologu un juristu ziņojumos piedāvāts paraudzīties uz plašu parādību loku, kas bijušas novērojamas un ietekmējušas vēstures lūzuma punktus: sociālās kontroles mehānismu darbību, to daudzveidību un ietekmi uz indivīdu, sabiedrību un valsts politiku; etnisko grupu lomu, vietu Latvijā; Eiropas sava laika politisko centru un Latvijas teritorijas kontaktiem, to rezultātā radušos kultūras, prasmju un reliģisko strāvojumu mijiedarbību. Konference tiek organizēta un šīs tēzes sagatavotas VPP “Latvijas mantojums …

Initial viral load and decay kinetics of SARS-CoV-2 lineage B.1.1.7 in the upper respiratory tract of adults and children

2021

We read with interest the systematic review published by Walsh et al. in the Journal of Infection,1 focusing on the dynamics of SARS-CoV-2 RNA at the upper respiratory tract (URT). In this context, a novel SARS-CoV-2 variant lineage (B.1.1.7), first detected in the UK at the end of 2020 has transmission advantage over other lineages.2 Increased transmissibility of the B.1.1.7 variant has been linked to enhanced ACE2 affinity3 allegedly resulting in higher viral loads in URT, an observation that has been reported in some,3, 4, 5, 6 but not all7 large series published to date. In addition, longer duration of SARS-CoV-2 RNA shedding in URT has been reported in individuals infected by the B.1.1…

Diabetes und Impfen

2021

ZUSAMMENFASSUNGMenschen mit Diabetes mellitus haben ein krankheitsimmanent erhöhtes Infektionsrisiko. Impfungen stellen eine der wirksamsten und wichtigsten medizinischen Maßnahmen zur Prävention von Infektionen dar. Dieser Beitrag soll einen Überblick über die aktuellen Impfempfehlungen speziell für Menschen mit Diabetes mellitus geben.

Bio-based Materials. Standardizzazione e processi per la commercializzazione

2021

Il contributo si occupa degli aspetti normativi nel campo della produzione e uso di una malta con componenti organici derivanti dal riciclo di scarti agricoli e silvo-pastorali. Viene prestata attenzione alla normativa internazionale più diffusa e nota, a quella europea e a quella italiana. La riduzione del consumo di suolo e di risorse lapidee, degli scarti, la limitazione dell’utilizzo di materiali di cava naturali sono solo alcuni benefici che hanno indotto la comunità scientifica a investire nell’uso di materie prime-seconde di origine vegetale, ecosostenibili; oggi, lo stato dell’arte è molto ricco. Tuttavia, non ci sono ancora normative tecniche e procedurali relative ai materiali che…