showing 36 of ~574560 from 574555 documents
Neurological diseases and COVID-19: prospective analyses using the UK Biobank
2021
COVID-19 (Coronavirus disease-19) may present with neurological signs, but whether people already affected by neurological conditions are at a higher risk of contracting COVID-19 is still not known. We, therefore, aimed to investigate the association of previously diagnosed neurological conditions with COVID-19. 502,536 community-dwelling UK Biobank participants (54.4% male, mean age 56.6 ± 10.3 years) were included. Among these, 57,463 participants had a diagnosis of neurological conditions (11.43%) and a total of 1326 COVID-19-positive cases were identified (0.26%). Neurological conditions were identified through medical history and linkage to data on hospital admissions (ICD-10 code G00–…
¿Qué aporta la imagen tridimensional preoperatoria en la cirugía pancreática compleja?
2021
Resumen La posibilidad de modelizacion de imagenes diagnosticas en tres dimensiones (3 D) en cirugia pancreatica es una novedad que nos aporta multiples ventajas. Una mejor visualizacion de las estructuras nos permite una planificacion de la tecnica quirurgica mas precisa y nos facilita la realizacion de la cirugia en casos complejos. Presentamos el caso de un paciente diagnosticado de un adenocarcinoma de cabeza de pancreas borderline para ilustrar las ventajas de la modelizacion 3 D en cirugia pancreatica compleja. La ayuda de la tecnologia 3 D nos permitio planificar de manera optima la intervencion facilitando la reseccion quirurgica. El uso de esta herramienta podria traducirse en: men…
The potential role of SP-D as an early biomarker of severity of asthma
2021
Surfactant decreases the surface tension of peripheral airways and modulates the immunological responses of the lung. The alterations of surfactant due to the airway inflammation suggest a role in the pathogenesis of asthma. We aim to test the hypothesis that serum levels of SP-A (Surfactant Protein A) and SP-D (Surfactant Protein-D) are altered in patients with mild asthma compared to healthy controls and those alterations are related to functional abnormalities of peripheral airways, which are an early marker of progression of asthma. In this pilot study, we recruited 20 mild asthmatics and 10 healthy controls. We measured serum SP-A and SP-D and all subjects underwent clinical, lung func…
Genetic variants associated with human eye size are distinct from those conferring susceptibility to myopia
2021
Purpose: Emmetropization requires coordinated scaling of the major ocular components, corneal curvature and axial length. This coordination is achieved in part through a shared set of genetic variants that regulate eye size. Poorly coordinated scaling of corneal curvature and axial length results in refractive error. We tested the hypothesis that genetic variants regulating eye size in emmetropic eyes are distinct from those conferring susceptibility to refractive error.Methods: A genome-wide association study (GWAS) for corneal curvature in 22,180 adult emmetropic individuals was performed as a proxy for a GWAS for eye size. A polygenic score created using lead GWAS variants was tested for…
Determination of albendazole and ivermectin residues in cattle and poultry-derived samples from India by micellar liquid chromatography
2021
We have developed a method, based on micellar liquid chromatography, to determine albendazole and ivermectin in dairy products and biological waste from bovine, as well as edible tissues from poultry. Anthelmitics were resolved in less than 10 min using a C18 column and a mobile phase of 0.15 mol/L sodium dodecyl sulfate – 6% 1-pentanol at buffered at pH 7 with a 0.01 M phosphate salt, running under isocratic mode at 1 mL/min. Detection was by absorbance at 292 nm. Method was successfully validated following official validation guidelines, in terms of: selectivity, sensitivity, calibration range (0.0125−0.5 mg/kg to 25−50 mg/kg), linearity (r2 > 9990), trueness (86.3–105.6%), precision (<12…
La disciplina statale dell'immigrazione tra profili di criticità costituzionale e diritto vivente alla luce di alcune recenti vicende normative
2021
La disciplina statale dell'immigrazione non è riuscita a risolvere le aporie connesse allo squilibrio tra diritti umani ed esercizio del potere pubblico statuale: ciò rende necessaria un'interpretaziine adeguatrice che è operata dalla giurisdizioni coinvolte. Il diritto di matrice giurisprudenziale si sovrappone così al diritto positivo, sostituendosi ad esso con modalità che interrogano sui limiti del diritto vivente anche con riguardo al ruolo della Corte costituzionale. L'ultimo intervento normativo in materia, il D.L. n. 130/2020, non ha eliminato tutte le incertezze ed ambiguità della disciplina preesistente, essendosi limitato il legislatore a recepire, con alcune correzioni minimali,…
Search for New Phenomena in Final States with Two Leptons and One or No b -Tagged Jets at s=13 TeV Using the ATLAS Detector
2021
A search for new phenomena is presented in final states with two leptons and one or no $b$-tagged jets. The event selection requires the two leptons to have opposite charge, the same flavor (electrons or muons), and a large invariant mass. The analysis is based on the full Run-2 proton-proton collision dataset recorded at a center-of-mass energy of $\sqrt{s} = 13$ TeV by the ATLAS experiment at the LHC, corresponding to an integrated luminosity of 139 fb$^{-1}$. No significant deviation from the expected background is observed in the data. A four-fermion contact interaction between two quarks ($b,s$) and two leptons ($ee$ or $\mu\mu$), inspired by the $B$-meson decay anomalies, is used as a…
Ageing: Not only an age-related issue.
2021
Developments in the last century have led to an unprecedented increase in life expectancy. These changes open opportunities for humans to grow and develop in healthy and adaptive ways, adding life to years as well as years to life. There are also challenges, however - as we live longer, a greater number of people will experience chronic illness and disability, often linked to lifestyle factors. The current paper advances an argument that there are fundamental biological sex differences which, sometimes directly and sometime mediated by lifestyle factors, underpin the marked differences in morbidity and mortality that we find between the sexes. Furthermore, we argue that it is necessary to c…
SecureBallot: A secure open source e-Voting system
2021
Abstract Voting is one of the most important acts through which a community can make a collective decision. In recent years, many works have focused on improving traditional voting mechanisms and, as a result, a wide range of electronic voting (e-Voting) systems have been proposed. Even though some approaches have achieved a proper level of usability, the main challenges of e-Voting are essentially still open: protect the privacy of participants, guarantee secrecy, anonymity, integrity, uniqueness, and authenticity of votes, while making e-Voting as trustful as voting. In order to address this issue, we present SecureBallot, a secure open-source e-Voting system that completely decouples the…
New technologies for promoting physical activity in healthy children and in children with chronic respiratory diseases: A narrative review
2021
Physical activity (PA) is proven to benefit children and adolescents in several ways. New technologies may provide children with stimulating modalities for organizing their leisure time, accessing fitness programs, and obtaining daily goal reminders and peer support. Due to the current COVID-19 pandemic, following WHO recommendations for PA is difficult for many children, especially for those living in urban areas. Therefore, the use of digital tools to support and maintain PA could be useful in healthy children, as well as in those with chronic respiratory diseases (CRDs). This narrative review aims to summarize the most recent evidence about the role of new technologies in promoting PA in…
Long-term ISO 23936-2 sweet oil ageing of HNBR
2021
Abstract A hydrogenated nitrile butadiene rubber (HNBR) compound is subjected to ageing in a simulated oil and gas environment in accordance with ISO 23936-2 standard at two elevated temperatures (130 °C and 150 °C) for a period of up to 9 months. Shore D hardness, thermal expansion, dynamic mechanical analysis (DMA), Fourier transform infrared (FTIR) spectroscopy, compression and compression set (CS) measurements are made before and after the chemical exposure. The hardness, modulus at short times, degree of relaxation and CS increases while the coefficient of thermal expansion in HNBR tends to decrease with ageing time and temperature. Temperature is shown to impose a greater effect on th…
Ergonomic Comparison of Four Dental Workplace Concepts Using Inertial Motion Capture for Dentists and Dental Assistants
2021
When the inventory is arranged in a dental practice, a distinction can be made between four different dental workplace concepts (DWCs). Since the prevalence of musculoskeletal diseases in dental professionals is very high, preventive solution need to be investigated. As the conventionally used DWCs have, to date, never been studied in terms of their ergonomics, this study aims to investigate the ergonomic risk when working at the four different DWCs. In total, 75 dentists (37 m/38 f) and 75 dental assistants (16 m/59 f) volunteered to take part in this study. Standardized cooperative working procedures were carried out in a laboratory setting and kinematic data were recorded using an inerti…
Biomechanics of Machaeracanthus pectoral fin spines provide evidence for distinctive spine function and lifestyle among early chondrichthyans
2021
Acanthodians are a major group of Paleaozoic jawed vertebrates that constitute a paraphyletic assemblage of stem-chondrichthyans (Brazeau and Friedman, 2015). Representatives of this group are characterized, among other traits, by the presence of bony spines in front of all paired and median fins except the caudal (Denison, 1979), which has given rise to their colloquial name of 'spiny sharks'. The occurrence of pectoral fin spines is recognized as a potential gnathostome synapomorphy (Miller et al., 2003) or symplesiomorphy (Coates, 2003), being also present in other major groups of Paleaozoic jawed vertebrates, including placoderms (Young, 2010), 'non-acanthodian' chondrichthyans (Miller …
Sentinel Lymph Node in Aged Endometrial Cancer Patients “The SAGE Study”: A Multicenter Experience
2021
ObjectiveThe incidence of endometrial cancer is increasing in elderly people. Considering that aging progressively affects lymphatic draining function, we aimed to define its impact on IGC uptake during SLN mapping.MethodsA multicenter retrospective cohort of endometrial cancer patients with apparently early-stage endometrial cancer undergoing complete surgical staging with SLN dissection was identified in four referral cancer centers from May 2015 to March 2021. Patients were classified in Group 1 (&lt;65 years old) and Group 2 (≥65 years old). The primary endpoint was the assessment of the overall, bilateral, and unsuccessful SLN mapping in the two groups. Secondary outcomes were the …
Do Age and Sex Play a Role in the Intraocular Pressure Changes after Acrobatic Gymnastics?
2021
To evaluate the effects of an acrobatic gymnastics (AG) training session on intraocular pressure (IOP), a familiarization session was employed to confirm the participant’s suitability for the study. Forty-nine gymnasts (63.27% females, 18–40 years old) voluntarily agreed to participate. As age, sex, baseline IOP, and central corneal thickness (CCT) were considered as potential predictors of the IOP variations, in the second session measurements of the above parameters were taken before and after 90 min of AG. A mixed-factorial analysis of variance evaluated differences. Linear regression was conducted to potentially predict the IOP variation with the exercise. After the scheduled exercise, …
Recent advances on portable sensing and biosensing assays applied for detection of main chemical and biological pollutant agents in water samples: A …
2021
Abstract The quality analysis of water, pharmaceutical and environmental compounds is a basic subject for human health. The presence of low-quality drugs, biological toxins and chemical compounds in water or forbidden additives in the nourishments lead to irreversible problems in human health. Hence, multiple analytical approaches have been presented for investigating the quality of environmental, pharmaceutical, and food compounds and monitoring the detection of toxic compounds and pollutants in water. Sensing tools based on analytical strategies are required for identifying and quantifying the different pollutants including biological and chemical contaminants in water samples. Among diff…
Epistemic independence and speaker roles: Highlighting the role of second speaker and mitigating the role of first speaker
2021
Abstract Definitions of attenuation tend to place their emphasis on different aspects of the communication process, especially facework, propositional content, illocutionary force and the roles of speech participants. This paper concentrates on the latter of these aspects. Although studies mention the possibility that attenuation applies to more than one participant, the analysis of particular examples within those studies shows that authors tend to refer mostly (or even only) to the speaker's role (e.g., Briz, 1998, 2003; Briz and Albelda, 2013; Villalba Ibanez, 2016). This study explores the possibility that attenuation of the role of another participant (i.e. a participant other than the…
Post-Induction Management in Patients With Left-Sided RAS and BRAF Wild-Type Metastatic Colorectal Cancer Treated With First-Line Anti-EGFR-Based Dou…
2021
BackgroundFew data regarding post-induction management following first-line anti-epidermal growth factor receptor (EGFR)-based doublet regimens in patients with left-sided RAS/BRAF wild-type metastatic colorectal cancer (mCRC) are available.MethodsThis multicenter, retrospective study aimed at evaluating clinicians’ attitude, and the safety and effectiveness of post-induction strategies in consecutive patients affected by left-sided RAS/BRAF wild-type mCRC treated with doublet chemotherapy plus anti-EGFR as first-line regimen, who did not experience disease progression within 6 months from induction initiation, at 21 Italian and 1 Spanish Institutions. The measured clinical outcomes were: p…
« Le musée de Dole : 200 ans d'histoire », Musée des Beaux-Arts de Dole, 200 ans d'histoire
2021
International audience
Aberrant Subnetwork and Hub Dysconnectivity in Adult Bipolar Disorder: A Multicenter Graph Theory Analysis
2021
Abstract Neuroimaging evidence implicates structural network-level abnormalities in bipolar disorder (BD); however, there remain conflicting results in the current literature hampered by sample size limitations and clinical heterogeneity. Here, we set out to perform a multisite graph theory analysis to assess the extent of neuroanatomical dysconnectivity in a large representative study of individuals with BD. This cross-sectional multicenter international study assessed structural and diffusion-weighted magnetic resonance imaging data obtained from 109 subjects with BD type 1 and 103 psychiatrically healthy volunteers. Whole-brain metrics, permutation-based statistics, and connectivity of h…
In the literature: August 2021
2021
The death penalty in Valencia (1450-1500), numbers, urban spaces and funeral ritualities from the Brotherhood of Innocents and Helpless
2021
Mediante una combinación de fuentes documentales de origen y procedencia diversa, se han computado fehacientemente 737 ejecuciones en Valencia entre los años 1450 y 1500. El artículo analiza este aspecto de la realidad social, judicial y política de la Valencia del Renacimiento a la luz de los recientes planteamientos historiográficos sobre la materia. Se destaca el impacto del Santo Oficio (a partir de 1482) dentro del contexto penal de la ciudad, se analiza el papel restaurador y reconciliador de la Cofradía de Inocentes y Desamparados, y se aborda la contribución de esta singular hermandad a la re-significación de los espacios urbanos y periurbanos. Through a combination of documentary s…
Alimenti funzionali e nuovi prodotti alimentari
2021
..
[The impact of COVID-19 on hand surgery: a French retrospective comparative study in COVID-19 and non-COVID-19 hand trauma centers].
2021
Introduction: En 2020, la pandémie a divisé la France en zone COVID-19 et non COVID-19. L’objectif principal de notre étude était de comparer la variabilité de l’activité chirurgicale et de consultation de 2 centres SOS main entre la période de pandémie et hors pandémie. Les objectifs secondaires étaient d’identifier les patients à risque afin de développer des moyens de prévention en traumatologie de la main. Méthodes: Il s’agit d’une étude rétrospective bi-centrique à visée épidémiologique sur les admissions aux urgences traumatologiques pendant le premier confinement français. Les données ont été comparées à la même période en 2019 (groupe contrôle). 2055 patients ont consulté pour un tr…
Recreational noise pollution of traditional festivals reduces the juvenile productivity of an avian urban bioindicator.
2021
Noise is a pollutant of emergent concern for ecologists and conservation biologists. Recreational noise pollution, especially unpredictable and intermittent sounds, and its effects on wildlife and biodiversity have been poorly studied. Researchers have paid very little attention to the effect of noisy traditional festivals (fireworks and powder-guns). This study aimed to explore the effect of these recreational activities on the juvenile productivity of an urban avian bioindicator: the house sparrow. We studied five pairs of localities in the Valencia Region (E Spain) with noisy traditional festivals. Each pair was composed of one locality with festivals during the breeding season and the c…
Dimethyl fumarate treatment restrains the antioxidative capacity of T cells to control autoimmunity
2021
Abstract Dimethyl fumarate, an approved treatment for relapsing-remitting multiple sclerosis, exerts pleiotropic effects on immune cells as well as CNS resident cells. Here, we show that dimethyl fumarate exerts a profound alteration of the metabolic profile of human CD4+ as well as CD8+ T cells and restricts their antioxidative capacities by decreasing intracellular levels of the reactive oxygen species scavenger glutathione. This causes an increase in mitochondrial reactive oxygen species levels accompanied by an enhanced mitochondrial stress response, ultimately leading to impaired mitochondrial function. Enhanced mitochondrial reactive oxygen species levels not only result in enhanced T…
Digital selection of composite resin shade using cross polarized photography and a standardized white balance gray reference card
2021
Purpose The aim of the present case report was to describe, through a clinical case, a step-by-step technique, for the digital selection of composite resin shades using cross polarization and white balance employing a standardized reference card. Case Description After intraoral impression, a digital diagnostic wax up was developed. A 3D printed cast was used to fabricate a lingual polyvinyl siloxane matrix. First a cross-polarized image of the contralateral central incisor was taken in RAW format, using a gray reference card. The digital image was manipulated using this card as a reference, to obtain reliable color values. The obtained color values, from the contralateral central incisor, …
Strategies to develop radiomics and machine learning models for lung cancer stage and histology prediction using small data samples
2021
Abstract Predictive models based on radiomics and machine-learning (ML) need large and annotated datasets for training, often difficult to collect. We designed an operative pipeline for model training to exploit data already available to the scientific community. The aim of this work was to explore the capability of radiomic features in predicting tumor histology and stage in patients with non-small cell lung cancer (NSCLC). We analyzed the radiotherapy planning thoracic CT scans of a proprietary sample of 47 subjects (L-RT) and integrated this dataset with a publicly available set of 130 patients from the MAASTRO NSCLC collection (Lung1). We implemented intra- and inter-sample cross-valida…
Progress of Phototherapy Applications in the Treatment of Bone Cancer
2021
Bone cancer including primary bone cancer and metastatic bone cancer, remains a challenge claiming millions of lives and affecting the life quality of survivors. Conventional treatments of bone cancer include wide surgical resection, radiotherapy, and chemotherapy. However, some bone cancer cells may remain or recur in the local area after resection, some are highly resistant to chemotherapy, and some are insensitive to radiotherapy. Phototherapy (PT) including photodynamic therapy (PDT) and photothermal therapy (PTT), is a clinically approved, minimally invasive, and highly selective treatment, and has been widely reported for cancer therapy. Under the irradiation of light of a specific wa…
Anaesthetic protocol for paediatric glaucoma examinations: the prospective EyeBIS Study protocol
2021
IntroductionNeonates and young infants with diagnosed or highly suspected glaucoma require an examination under anaesthesia to achieve accurate intraocular pressure (IOP) measurements, since crying or squinting of the eyes may increase IOP and lead to falsely high values. IOP considerably depends on perioperative variables such as haemodynamic factors, anaesthetics, depth of anaesthesia and airway management. The aim of this paper is to report the design and baseline characteristics of EyeBIS, which is a study to develop a standardised anaesthetic protocol for the measurement of IOP under anaesthesia in childhood glaucoma, by investigating the link between the magnitude of IOP and depth of …
Modeling vibrating panels excited by a non-homogeneous turbulent boundary layer
2021
Abstract Predicting the vibration response of an elastic structure excited by a turbulent flow is of interest for the civil and military transportation sector. The models proposed in the literature are generally based on the assumption that the turbulent boundary layer (noted TBL in the following) exciting the structure is spatially homogeneous. However, this assumption is not always fulfilled in practice, in particular when the excited area is close to the starting point of the TBL or with curved structures. To overcome this issue, this work proposes to extend two approaches generally used for dealing with homogeneous TBL, namely the spatial and the wavenumber approaches. The extension of …
Bases para la creación de las unidades clínicas cardiorrenales. Documento de consenso de los grupos de trabajo cardiorrenal de la SEC y la SEN
2021
Resumen La enfermedad renal es una de las comorbilidades halladas con mayor frecuencia en los pacientes con insuficiencia cardiaca. Su presencia se asocia a peor pronostico y genera gran incertidumbre sobre la monitorizacion y abordaje terapeutico. De este modo, las unidades cardiorrenales han surgido como elementos integradores, que desde un punto de vista multidisciplinar pretenden vehiculizar la asistencia, docencia e investigacion de este amplio espectro de pacientes. En el presente documento de consenso elaborado por el Grupo de Trabajo de Sindrome Cardiorrenal y Tratamiento de la Congestion en la Insuficiencia Cardiaca de la Sociedad Espanola de Cardiologia y el Grupo de Trabajo de Me…
Adipose stromal cells promote the transition of colorectal cancer cells toward a mesenchymal-like phenotype
2021
ABSTRACT Colon cancer progression is among the risks that increase with obesity. We have recently unveiled the molecular mechanism by which adipose tissue-released molecules, HGF and IL-6, make colorectal cancer (CRC) cells acquiring mesenchymal traits. Targeting of adipose-derived factors abrogate the metastatic potential of CRC stem cells (CR-CSCs) in obese patients.
Inverting the Wollaston Illusion: Gaze Direction Attracts Perceived Head Orientation
2021
In the early 19th century, William H. Wollaston impressed the Royal Society of London with engravings of portraits. He manipulated facial features, such as the nose, and thereby dramatically changed the perceived gaze direction, although the eye region with iris and eye socket had remained unaltered. This Wollaston illusion can be thought of as head orientation attracting perceived gaze direction when the eye region is unchanged. In naturalistic viewing, the eye region changes with head orientation and typically produces a repulsion effect. Here we explore if there is a flip side to the illusion. Does the gaze direction also alter the perceived direction of the head? We used copies of the o…
Prefazione a "SCIASCIARIO DIALETTALE. 67 parole dalle Parrocchie" (di Roberto Sottile)
2021
In questo volume postumo Roberto Sottile illustra 67 lemmi dialettali ricorrenti nella prosa di Leonardo Sciascia, a partire da un nucleo estratto da Le parrocchie di Regalpetra. A partire da questo nucleo, Sottile raccoglie le parole proprie della lingua letteraria di Sciascia, quelle rese oggetto di riflessione metalinguistica in "Kermesse/Occhio di capra" e quelle di origine anglo americana presenti ne "Gli zii di Sicilia". L’attenzione maggiore è posta sugli autoctonismi, parole che non hanno corrispondenti formali o semantici nell’italiano. Marina Castiglione, curatrice della collana, illustra i tempi e i modi in cui il dialettologo ha cominciato a mettere a fuoco questa categoria d'an…
Association between rheumatoid arthritis and periodontitis in an adult population – A cross sectional study
2021
Background This investigation was aimed to analyse the existence of an association between rheumatoid arthritis and periodontitis among Indian subjects. Material and Methods This observational study included a total of 110 individuals between 18-78 years of age, which were divided equally into RA (Rheumatoid Arthritis) and NRA (Non-Rheumatoid Arthritis) groups. General, Oral and a complete Periodontal examination included recording of Gingival Index (GI), Plaque index (PI), Pocket Probing Depth (PPD), Clinical attachment level (CAL) in a questionnaire form. Laboratory and rheumatologcal parameters like C-reactive protein (CRP), Erythrocyte sedimentation rate (ESR) and Disease Activity Score…