showing 36 of ~574560 from 574555 documents
Cancer in Children With Fanconi Anemia and Ataxia-Telangiectasia—A Nationwide Register-Based Cohort Study in Germany
2021
PURPOSE Fanconi anemia (FA) and ataxia-telangiectasia (AT) are rare inherited syndromes characterized by abnormal DNA damage response and caused by pathogenic variants in key DNA repair proteins that are also relevant in the pathogenesis of breast cancer and other cancer types. The risk of cancer in children with these diseases is poorly understood and has never been assessed in a population-based cohort before. METHODS We identified 421 patients with FA and 160 patients with AT diagnosed between 1973 and 2020 through German DNA repair disorder reference laboratories. We linked patients' laboratory data with childhood cancer data from the German Childhood Cancer Registry. RESULTS Among 421 …
Reversing arrows: Duality
2021
What do you get reversing all arrows? The drawing ‘Duality’ is an homage to mirrors, classical art themes, and abstract mathematics.I’m looking for beauty in the arts and beauty in science. It’s a ...
Does Oxygen Content Play a Role in Spontaneous Closure of Perimembranous Ventricular Septal Defects?
2021
(1) Background: the impact of a series of laboratory parameters (haemoglobin, haematocrit, foetal haemoglobin, peripheral oxygen saturation, iron, transferrin, ferritin, and albumin) on perimembranous ventricular septal defects spontaneous healing was tested. (2) Methods: one hundred and seven patients were enrolled in the study (57% males; mean age 2.1 ± 0.4 years) and were subsequently subdivided into two groups: self-healing (n = 36) and in need of intervention (n = 71). Self-healing subjects were defined on the basis of an absence of residual shunts at colorDoppler across the previous defect. (3) Results: no statistically significant differences were reported in the size of perimembrano…
Influence of Female Sex Hormones on Ultra-Running Performance and Post-Race Recovery: Role of Testosterone
2021
In recent years, increasing numbers of women have participated in extremely long races. In adult males, there is a clear association between physiological levels of endogenous sex hormones and physical performance. However, the influence of plasmatic sex hormones and the effects of different types of hormonal contraception (HC) on the modulation of physical performance in adult females remain to be fully clarified. Eighteen female ultra-endurance athletes were recruited to participate in the study. Different variables were studied, including hematological parameters, body mass index, and body composition. Strength measurements were obtained using the squat-jump and hand-grip test. A repeate…
Parenting behavior and psychodynamic conflicts: Cross-sectional findings in a normative sample of adolescents and their parents
2021
Policing prostitution: regulating the lower classes in late Imperial Russia
2021
The Determinants of Living with Long-Term Conditions: An International Cross-Sectional Study
2021
It is essential that healthcare and social professionals understand the daily lives of people with chronic diseases, and the variables that influence them. The aim of this study was to identify the determinants influencing the process of living with long-term conditions. To investigate this, an observational, international, cross-sectional study was carried out. A consecutive sample of 1788 Spanish-speaking population living with chronic obstructive pulmonary disease, chronic heart failure and type 2 diabetes mellitus were included. Descriptive statistics and multiple linear regression models were performed. The linear regression models identified that social support (β = 0.39, p <
Parental Trust in Teachers and Children’s Interest in Reading and Math: A Longitudinal Study
2021
This study investigated cross-lagged associations between parental trust in a child’s teacher and children’s academic interest across Grades 1–4 in primary school. Parents rated trust in their child’s teacher, and 576 children reported their interest in reading and math at each grade. The results showed that high parental trust in a child’s teacher predicted the child’s high interest in math. In addition, the child’s high interest in reading in Grade 2 was related to the father’s subsequent trust in the teacher. peerReviewed
Does Affective Content of Sounds Affect Auditory Time-to-collision Estimation?
2021
Trust in Finnish Education: A Historical Perspective
2021
This article analyzes the origins of generalized trust in Finnish society and how this relates to trust in education. The study was based on a historical analysis of the role of education in building a Finnish society and nation state. The author discusses the development of a Nordic welfare state and analyzes the relationships between generalized trust and education from the perspectives of democracy, corruption, egalitarian attitudes, wealth, and culture. A reflection was performed of the relationships between generalized trust, school autonomy, and the professional autonomy of teachers. peerReviewed
Masada: From Jewish Revolt to Modern Myth
2021
For a site as famous as Masada (Arabic es-Sebba), we have been lacking a good overview. There is a popular treatment of the excavations (Yadin 1966), a resume of the excavations in light of the fin...
Qu’est-ce que la sociabilité ?
2021
International audience
Incidence and Clinical Impact of Right Ventricular Involvement (Biventricular Ballooning) in Takotsubo Syndrome
2021
Background The short- and long-term prognosis of Takotsubo syndrome (TTS) presenting with right ventricular (RV) involvement remains poorly understood. Research Question What is the incidence and clinical outcome of RV involvement in TTS? Study Design and Methods This study analyzed 839 consecutive patients with TTS (758 female subjects and 81 male subjects) in a multicenter registry. RV involvement was defined as wall motion abnormality of the RV free wall, with or without apical involvement. The median long-term follow-up was 2.1 years (interquartile range, 0.3-4.5 years). The primary outcome was in-hospital and out-of-hospital all-cause mortality. The secondary end point was a composite …
Multi-scenario multi-objective robust optimization under deep uncertainty: A posteriori approach
2021
This paper proposes a novel optimization approach for multi-scenario multi-objective robust decision making, as well as an alternative way for scenario discovery and identifying vulnerable scenarios even before any solution generation. To demonstrate and test the novel approach, we use the classic shallow lake problem. We compare the results obtained with the novel approach to those obtained with previously used approaches. We show that the novel approach guarantees the feasibility and robust efficiency of the produced solutions under all selected scenarios, while decreasing computation cost, addresses the scenario-dependency issues, and enables the decision-makers to explore the trade-off …
La Méditerranée comme mer carnivore. Sidérer pour penser l’accueil dans Como si nunca hubieran sido de Javier Gallego «Crudo» et Juan Gallego
2021
International audience; La Méditerranée, véritable cimetière migratoire, est devenue la frontière la plus dangereuse au monde pour les migrants irréguliers. Porter un regard sur ceux qui passent oblige incontestablement à questionner les politiques d’accueils. Nous proposons d’interroger un objet hybride qui se situe entre la bande dessinée et la poésie : Como si nunca hubieran sido (Madrid : Reservoir Books, 2018) de Javier Gallego « Crudo » et Juan Gallego. Un ouvrage qui interroge le projet européen face aux enjeux des migrations politiques, économiques, climatiques. Nous analyserons les formes de sidération qui permettent de penser les vies qui comptent et celles que l’on ne compte que …
Toward resourcefulness: Pathways for community positive health
2021
Abstract Communities play a central role in strengthening their health, but conventional community health promotion often adopts paternalistic and top-down approaches. Conversely, agentic approaches are critiqued for tasking marginalized communities to create change without opportunities. Taking into consideration these shortcomings, we ask how communities may be most effectively and appropriately supported in their pursuit of health. We review community health literature to articulate how community health is understood, moving from negative to positive conceptions; determined, moving from a risk-factor orientation to social determination; and promoted, moving from conventional to agentic…
Understanding the Significance of the Hypothalamic Nature of the Subthalamic Nucleus
2021
AbstractThe subthalamic nucleus (STN) is an essential component of the basal ganglia and has long been considered to be a part of the ventral thalamus. However, recent neurodevelopmental data indicated that this nucleus is of hypothalamic origin which is now commonly acknowledged. In this work, we aimed to verify whether the inclusion of the STN in the hypothalamus could influence the way we understand and conduct research on the organization of the whole ventral and posterior diencephalon. Developmental and neurochemical data indicate that the STN is part of a larger glutamatergic posterior hypothalamic region that includes the premammillary and mammillary nuclei. The main anatomic charact…
DNA-binding activities of compounds acting as enzyme inhibitors, ion channel blockers and receptor binders.
2021
The DNA-binding activities of compounds used as remedies can display DNA-protection, but also damaging effects in biological systems. The current review compiles literature data on DNA-binding activities of drugs widely used as remedies with different therapeutic indications. The compounds are classified according their mechanism of action: enzyme inhibitors, ion channel inhibitors, inhibitors of viral RNA replication and HIV protease and receptor agonists. DNA binding was reported for such widely used drugs as paracetamol, aspirin, metformin, statins and many others. The capability of the drug to bind DNA is sometimes coupled to genotoxic effects, but in some cases - to genome protection. …
The migration path of Gondwanian dinosaurs toward Adria: New insights from the Cretaceous of NW Sicily (Italy)
2021
Abstract The increasing dinosaur record from Italy questioned classic palaeogeographic scenarios for the Central Mediterranean area and suggest the proximity of landmass areas and a geographical connection between Gondwana and Laurasia during Cretaceous times. Besides several track-sites and exceptionally-preserved specimens (e.g. Scipionyx samniticus), the Italian dinosaur record also consists of isolated bones, among which the bone fragment of a theropod discovered in north-western Sicily. The bone occurs in a shallow-water carbonate succession (i.e. Pizzo Muletta, Palermo Mountains) pertaining to the Panormide Carbonate Platform (PCP). The bone was previously ascribed to the Cenomanian, …
A Rare Case of Water Intoxication in Unusual Chiropratic Prescription: A Medico-Legal Analysis Due to Alleged Malpractice.
2021
Introduction. Water intoxication is a well-recognized cause of symptomatic hyponatremia, whose often fatal consequences are described in a wide variety of conditions such as psychiatric disorders, metabolic dysfunctions, child abuse, drug abuse and several medical procedures. The case. We here report a rare case of a 67-year-old woman with severe acute hyponatremia due to an excessive voluntary water intake – 14 litres in two days – following a chiropractic prescription. The patient developed sudden severe symptoms, including water retention, sensory alteration, altered mental status and tonic-clonic seizures. She was thus admitted to the Intensive Care Unit with a diagnosis of coma due to …
Age and Gender-related Variations of Molecular and Phenotypic Parameters in A Cohort of Sicilian Population: from Young to Centenarians
2021
People are living longer, but lifespan increase does not coincide with a boost in health-span. Thus, improving the quality of life of older people is a priority. Centenarians reach extreme longevity in a relatively good health status, escaping or delaying fatal or strongly invalidating diseases. Therefore, studying processes involved in longevity is important to explain the biological mechanisms of health and well-being, since knowledge born from this approach can provide valuable information on how to slow aging. We performed the present study in a well characterized very homogeneous sample of 173 people from Western Sicily, to update existing literature on some phenotypic aspects of aging…
Treatment of patients with spinal muscular atrophy 5q: Towards a new protocol.
2021
First measurements of N-subjettiness in central Pb-Pb collisions at √sNN = 2.76 TeV
2021
The ALICE Collaboration reports the first fully-corrected measurements of the N-subjettiness observable for track-based jets in heavy-ion collisions. This study is performed using data recorded in pp and Pb-Pb collisions at centre-of-mass energies of √s = 7 TeV and √sNN = 2.76 TeV, respectively. In particular the ratio of 2-subjettiness to 1-subjettiness, τ2/τ1, which is sensitive to the rate of two-pronged jet substructure, is presented. Energy loss of jets traversing the strongly interacting medium in heavy-ion collisions is expected to change the rate of two-pronged substructure relative to vacuum. The results are presented for jets with a resolution parameter of R = 0.4 and charged jet …
Age is not just a number—Mathematical model suggests senescence affects how fish populations respond to different fishing regimes
2021
Abstract Senescence is often described as an age‐dependent increase in natural mortality (known as actuarial senescence) and an age‐dependent decrease in fecundity (known as reproductive senescence), and its role in nature is still poorly understood. Based on empirical estimates of reproductive and actuarial senescence, we used mathematical simulations to explore how senescence affects the population dynamics of Coregonus albula, a small, schooling salmonid fish. Using an empirically based eco‐evolutionary model, we investigated how the presence or absence of senescence affects the eco‐evolutionary dynamics of a fish population during pristine, intensive harvest, and recovery phases. Our si…
Spanish Adaptation of the Left-Wing Authoritarianism Index
2021
Notwithstanding long-simmering controversies around the construct, several studies have gathered consistent evidence of authoritarian attitudes among left-wing voters and activists. Recently, Costello et al. (Clarifying the structure and nature of left-wing authoritarianism. Journal of Personality and Social Psychology, 2021) validated, in the English-speaking context, a three-factor scale to measure left-wing authoritarianism, as well as two shortened versions of the same scale (Costello & Patrick, Development and initial validation of two brief measures of left-wing authoritarianism: A machine learning approach, 2021; composed of 39, 25 and 13 items, respectively). In this article, we use…
A Novel Bio-Inspired Approach for High-Performance Management in Service-Oriented Networks
2021
Service-continuity in distributed computing can be enhanced by designing self-organized systems, with a non-fixed structure, able to modify their structure and organization, as well as adaptively react to internal and external environment changes. In this paper, an architecture exploiting a bio-inspired management approach, i.e., the functioning of cell metabolism, for specialized computing environments in Service-Oriented Networks (SONs) is proposed. Similar to the processes acting in metabolic networks, the nodes communicate to each other by means of stimulation or suppression chains giving rise to emergent behaviors to defend against foreign invaders, attacks, and malfunctioning. The mai…
Iron isotope signature of magnetofossils and oceanic biogeochemical changes through the Middle Eocene Climatic Optimum.
2021
21 pages; International audience; Magnetotactic bacteria (MTB) intracellularly precipitate magnetite (Fe3O4) crystals that can be preserved in the geological record. When MTB die, the so-called magnetofossils constitute valuable proxies for paleoenvironmental reconstructions and are suspected to represent some of the oldest traces of biomineralization on Earth. Yet, the biogenicity of putative magnetofossils found in ancient terrestrial and extra-terrestrial samples is still largely debated and their significance for past climate still holds uncertainties. Here we studied a sedimentary sequence from the Indian Ocean (ODP Hole 711A) recording the Middle Eocene Climatic Optimum (MECO) through…
L'uomo e il suo ambiente. Al di là dell'opposizione natura/cultura
2021
Il saggio rappresenta la prosecuzione delle ultime ricerche di Claude Calame, grecista di fama mondiale: dopo il Prometeo genetista (Sellerio, Palermo 2016, ed. or. Paris 2011), adesso lo studioso svizzero propone una riflessione sui rapporti tra l’essere umano e il suo ambiente, maturata sulla base del serrato confronto tra l’idea originaria, greca, di physis e la nozione di ‘natura’ per come essa si è sviluppata a partire dal pensiero illuministico e deterministico. Dei cinque capitoli in cui il saggio è complessivamente strutturato, il primo (dal titolo En Grèce ancienne : l’homme et son milieu) ricostruisce con accuratezza storico-filologica e acume critico il concetto greco di physis, …
TAFA4 relieves injury-induced mechanical hypersensitivity through LDL receptors and modulation of spinal A-type K+ current
2021
Pain, whether acute or persistent, is a serious medical problem worldwide. However, its management remains unsatisfactory, and new analgesic molecules are required. We show here that TAFA4 reverses inflammatory, postoperative, and spared nerve injury (SNI)-induced mechanical hypersensitivity in male and female mice. TAFA4 requires functional low-density lipoprotein receptor-related proteins (LRPs) because their inhibition by RAP (receptor-associated protein) dose-dependently abolishes its antihypersensitive actions. SNI selectively decreases A-type K+ current (IA) in spinal lamina II outer excitatory interneurons (L-IIo ExINs) and induces a concomitant increase in IA and decrease in hyperpo…
La città di Alphabet. Architettura per prosumers.
2021
Attraverso alcuni aspetti salienti dell’ideazione, della produzione e dell’opposizione al progetto del Toronto Quayside di Sidewalk labs, l’articolo discute l’influenza delle infrastrutture digitali per l’informazione sul progetto della casa e del quartiere. L’ampliamento delle attività svolte da remoto nello spazio domestico, enfatizzato dal quotidiano della pandemia da Covid 19, costituisce per gli oligopolisti planetari degli urban data come Alphabet un utile volano pubblicitario e un acceleratore. La fusione dei nuovi vessilli della tecnoemancipazione e della sostenibilità in ipotesi sperimentali che mirano a costruirsi sia per intero che per parti realizza un nuovo orizzonte in cui lo …
Nésidioblastose traitée par pasiréotide LAR : à propos d’un cas
2021
Resume Une patiente de 56 ans, diabetique de type 2, presentait des episodes d’hypoglycemies, qui ont persiste apres arret du traitement antidiabetique. Une epreuve de jeune authentifie une hypoglycemie organique, a 0,34 g/L, insulinemie a 6 mUI/L, peptide C a 1,9 ng/mL (normes : 0,5–3,0 ng/mL) et proinsuline a 3,72, puis 4,5 pmol/L (normes : 1,28–3,84 pmol/L). Aucune lesion n’est retrouvee au scanner ou a l’echo-endoscopie. La scintigraphie a la somatostatine est negative. Ces elements font ainsi porter le diagnostic de nesidioblastose. Des traitements par diazoxide et octreotide sont successivement mis en place, sans succes. Sous pasireotide LAR, les hypoglycemies disparaissent, avec meme…
Strategies to Improve the Potential Functionality of Fruit-Based Fermented Beverages
2021
It is only recently that fermentation has been facing a dynamic revival in the food industry. Fermented fruit-based beverages are among the most ancient products consumed worldwide, while in recent years special research attention has been granted to assess their functionality. This review highlights the functional potential of alcoholic and non-alcoholic fermented fruit beverages in terms of chemical and nutritional profiles that impact on human health, considering the natural occurrence and enrichment of fermented fruit-based beverages in phenolic compounds, vitamins and minerals, and pro/prebiotics. The health benefits of fruit-based beverages that resulted from lactic, acetic, alcoholic…
Trouble dans la demande de mort. Les lois de bioéthique sur la fin de vie : pour quelle vision du monde commun ?
2021
International audience
Knowledge exchange through science diplomacy to assist disaster risk reduction
2021
Abstract This paper analyses science diplomacy efforts to reduce disaster risks and proposes establishing national knowledge exchange centers (KECs) to help individual states adhere to their Sendai Framework goals. KECs are considered to be interconnected globally and work together to promote resilience efforts by facilitating sharing of information and strategies in risk monitoring, assessment, and ultimately reduction across the globe. KECs can provide high-quality scientific evidence for informed decisionmaking along with a component related to disaster science media to ensure that appropriate knowledge reaches a variety of people who need it in different forms tailored for them. KECs ca…
Evidence for a dysfunction and disease-promoting role of the circadian clock in the diabetic retina.
2021
Diabetic retinopathy is a major complication of chronic hyperglycemia and a leading cause of blindness in developed countries. In the present study the interaction between diabetes and retinal clocks was investigated in mice. It was seen that in the db/db mouse - a widely used animal model of diabetic retinopathy - clock function and circadian regulation of gene expression was disturbed in the retina. Remarkably, elimination of clock function by Bmal1-deficiency mitigates the progression of pathophysiology of the diabetic retina. Thus high-fat diet was seen to induce histopathology and molecular markers associated with diabetic retinopathy in wild type but not in Bmal1-deficient mice. The d…
Serum Amyloid A Is Present in Human Saccular Intracranial Aneurysm Walls and Associates With Aneurysm Rupture
2021
AbstractSaccular intracranial aneurysm (sIA) rupture leads to a disabling subarachnoid hemorrhage. Chronic inflammation and lipid accumulation in the sIA wall contribute to wall degenerative remodeling that precedes its rupture. A better understanding of the pathobiological process is essential for improved future treatment of patients carrying sIAs. Serum amyloid A (SAA) is an acute-phase protein produced in response to acute and chronic inflammation and tissue damage. Here, we studied the presence and the potential role of SAA in 36 intraoperatively resected sIAs (16 unruptured and 20 ruptured), that had previously been studied by histology and immunohistochemistry. SAA was present in all…