showing 36 of ~574560 from 574555 documents
Idrarchia, resistenza marittima e la produzione della razza. Intervista a Marcus Rediker
2021
Marcus Rediker torna sul tema della tratta atlantica per discutere l’attualità della schiavitù quale costante nella storia e sviluppo del capitalismo. È sulle navi negriere durante il Middle Passage, «ancora ai margini della nostra coscienza moderna», che si produce la razza per come oggi la conosciamo, che si organizza l’accumulazione del capitale, che inizia a prender forma il capitalismo globale. Ma è nello stesso spazio atlantico che si costruisce la resistenza allo sfruttamento, la cooperazione radicale, la solidarietà conflittuale di schiavi ammutinati, marinai ribelli, fuggitivi e pirati. Il mare come luogo reale di comando e tensione al cambiamento, «come spazio delle principali tra…
Pursuing the Recovery of Severe Chronic Musculoskeletal Pain in Italy: Clinical and Organizational Perspectives from a SIAARTI Survey
2021
Alessandro Vittori,1 Emiliano Petrucci,2 Marco Cascella,3 Massimo Innamorato,4 Arturo Cuomo,3 Antonino Giarratano,5 Flavia Petrini,6 Franco Marinangeli7 1Department of Anesthesia and Critical Care, ARCO ROMA, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy; 2Department of Anesthesia and Intensive Care Unit, San Salvatore Academic Hospital of LâAquila, LâAquila, Italy; 3Department of Anesthesia and Critical Care, Istituto Nazionale Tumori - IRCCS, Fondazione Pascale, Naples, Italy; 4Department of Neuroscience, Pain Unit, Santa Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy; 5Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anaesthesia, Anal…
Approche qualitative et phénoménologique du premier épisode psychotique : vécu traumatique et transformation identitaire, quelques résultats prélimin…
2021
Resume But de l’etude Le premier episode psychotique constitue un evenement brutal pour les patients et s’accompagne d’une desorganisation psychique majeure avec une detresse importante. Plusieurs etudes recentes ont ainsi souligne la dimension traumatique du premier episode psychotique chez une large part des patients, et ont montre la prevalence du trouble de stress post-traumatique au sein de cette population. Toutefois, peu d’etudes ont porte leur attention sur cette dimension traumatique sous l’angle du vecu et de l’experience subjective des sujets confrontes au PEP, en dehors des criteres semiologiques du TSPT. Aussi, l’objectif de cette recherche consiste a investiguer de maniere app…
Qu’est-ce que la sociabilité ?
2021
International audience
Exact algorithms for the multi-compartment vehicle routing problem with flexible compartment sizes
2021
Abstract The multi-compartment vehicle routing problem with flexible compartment sizes is a variant of the classical vehicle routing problem in which customers demand different product types and the vehicle capacity can be separated into different compartments each dedicated to a specific product type. The size of each compartment is not fixed beforehand but the number of compartments is limited. We consider two variants for dividing the vehicle capacity: On the one hand the vehicle capacity can be discretely divided into compartments and on the other hand compartment sizes can be divided continuously. The objective is to minimize the total distance of all vehicle routes such that all custo…
“Your ride has arrived” – Exploring the nexus between subjective well-being, socio-cultural beliefs, COVID-19, and the sharing economy
2021
This study aimed to identify and explain different facets of the sharing economy and to differentiate between micro- and macro-mobility services. We also aimed to examine the correlation between the sharing economy and subjective well-being, cultural beliefs, and COVID-19. An exploratory research technique with face-to-face semi-structured interviews was used to collect data from a sample of 22 rideshare app users in a developing country between January and May 2020 and in July 2020. The data were analyzed using the NVivo 12 application. The major findings suggest that, considering their scope and use, sharing economy technology and services can be divided into four major domains: (1) hospi…
Identification of biological targets through the correlation between cell line chemosensitivity and protein expression pattern.
2021
Matching biological data sequences is one of the most interesting ways to discover new bioactive compounds. In particular, matching cell chemosensitivity with a protein expression profile can be a useful approach to predict the activity of compounds against definite biological targets. In this review, we discuss this correlation. First, we analyze case studies in which some known drugs, acting on known targets, show a good correlation between their antiproliferative activities and protein expression when a large panel of tumor cells is considered. Then, we highlight how the application of in silico methods based on the correlation between cell line chemosensitivity and gene/protein expressi…
The mTOR Inhibitor Temsirolimus Added to Rituximab Combined With Dexamethasone, Cytarabine, and Cisplatinum (R-DHAP) for the Treatment of Patients Wi…
2021
There is a high need for novel treatment options in relapsed and refractory diffuse large B-cell lymphoma. Single agent mammalian target of rapamycin (mTOR) inhibitor treatment has shown promising efficacy in this entity. Here, we report on the results of the mTOR-inhibitor temsirolimus combined to standard rituximab-DHAP salvage regimen in a prospective, multicenter, phase II, open-label study. The STORM regimen consisted of rituximab 375 mg/m(2) (day 2) and DHAP (dexamethasone 40 mg day 3-6, cisplatinum 100 mg/m(2) day 3, cytarabine 2 × 2 g/m(2) day 4) with temsirolimus added on day 1 and 8 of a 21-day cycle, with 2 to 4 cycles planned. In part I, dose levels of 25, 50, 75, and 100 mg fo…
Changes in Speech Range Profile Are Associated with Cognitive Impairment
2021
Background and Purpose The aim of this study was to describe the variations in the speech range profile (SRP) of patients affected by cognitive decline. Methods We collected the data of patients managed for suspected voice and speech disorders, and suspected cognitive impairment. Patients underwent an Ear Nose and Throat evaluation and Mini-Mental State Examination (MMSE). To obtain SRP, we asked the patients to read 18 sentences twice, at their most comfortable pitch and loudness as they would do in daily conversation, and recorded their voice on to computer software. Results The study included 61 patients. The relationship between the MMSE score and SRP parameters was established. Increas…
Genetic variants associated with human eye size are distinct from those conferring susceptibility to myopia
2021
Purpose: Emmetropization requires coordinated scaling of the major ocular components, corneal curvature and axial length. This coordination is achieved in part through a shared set of genetic variants that regulate eye size. Poorly coordinated scaling of corneal curvature and axial length results in refractive error. We tested the hypothesis that genetic variants regulating eye size in emmetropic eyes are distinct from those conferring susceptibility to refractive error.Methods: A genome-wide association study (GWAS) for corneal curvature in 22,180 adult emmetropic individuals was performed as a proxy for a GWAS for eye size. A polygenic score created using lead GWAS variants was tested for…
Mitigation revisited. An operative and integrated definition of the pragmatic concept, its strategic values, and its linguistic expression
2021
Abstract This paper provides a definition of mitigation based on three interconnected dimensions: cognitive, rhetorical/social, and linguistic. According to the definition provided, some specific requirements from all three dimensions must be met for a linguistic expression to be considered an instance of pragmatic mitigation (self-image protection, communicative effectiveness and some specific semantic-pragmatic characteristics mainly related with Levinson's (2000) M-heuristics, respectively). The definition builds on previous contributions and considers important descriptive problems, such as the heterogeneity of the linguistic mechanisms used to express mitigation and the partiality or i…
Multi-scenario multi-objective robust optimization under deep uncertainty: A posteriori approach
2021
This paper proposes a novel optimization approach for multi-scenario multi-objective robust decision making, as well as an alternative way for scenario discovery and identifying vulnerable scenarios even before any solution generation. To demonstrate and test the novel approach, we use the classic shallow lake problem. We compare the results obtained with the novel approach to those obtained with previously used approaches. We show that the novel approach guarantees the feasibility and robust efficiency of the produced solutions under all selected scenarios, while decreasing computation cost, addresses the scenario-dependency issues, and enables the decision-makers to explore the trade-off …
Surface Modification of Porous Polyethylene Implants with an Albumin-Based Nanocarrier-Release System
2021
Background: Porous polyethylene (PPE) implants are used for the reconstruction of tissue defects but have a risk of rejection in case of insufficient ingrowth into the host tissue. Various growth factors can promote implant ingrowth, yet a long-term gradient is a prerequisite for the mediation of these effects. As modification of the implant surface with nanocarriers may facilitate a long-term gradient by sustained factor release, implants modified with crosslinked albumin nanocarriers were evaluated in vivo. Methods: Nanocarriers from murine serum albumin (MSA) were prepared by an inverse miniemulsion technique encapsulating either a low- or high-molar mass fluorescent cargo. PPE implants …
A Novel Bio-Inspired Approach for High-Performance Management in Service-Oriented Networks
2021
Service-continuity in distributed computing can be enhanced by designing self-organized systems, with a non-fixed structure, able to modify their structure and organization, as well as adaptively react to internal and external environment changes. In this paper, an architecture exploiting a bio-inspired management approach, i.e., the functioning of cell metabolism, for specialized computing environments in Service-Oriented Networks (SONs) is proposed. Similar to the processes acting in metabolic networks, the nodes communicate to each other by means of stimulation or suppression chains giving rise to emergent behaviors to defend against foreign invaders, attacks, and malfunctioning. The mai…
Combined Effects of Auditing and Discretionary Accruals on the Cost of Debt: Evidence From Spanish SMEs
2021
Previous literature shows mixed evidence on the effect of discretionary accruals and auditing on the cost of debt. We hypothesize that, in the SMEs setting, auditing can act as a substitute for accruals quality, and thus audits may mitigate the effect of discretionary accruals on the cost of debt. Using a sample of Spanish SMEs, we find that auditing is negatively related with the cost of debt, while higher discretionary accruals are related with a lower cost of debt. Nonetheless, this effect is lower than that one observed for audits. When considering the combined effect of both variables, the effect of discretionary accruals is replaced by that of auditing. These results suggest that, am…
Levels of 137Cs in game and soil in Opole Anomaly, Poland in 2012–2020
2021
Abstract Once deposited, radiocesium remains in the environment for a long time, and constantly enters the food chain. Over time, game species tend to accumulate 137Cs by two orders of magnitude more than farm animals. This occurs especially in places heavily contaminated, thus meat products made out of local game should be treated with caution. One of such areas, known as the Opole Anomaly, is located in South-Western Poland and represents one of most 137Cs contaminated regions across Europe after the Chernobyl accident. The aim of the study was to find out the 137Cs activity in soil and local game, the value of the soil-to-game aggregated transfer factor and to assess the effective dose o…
Thermal solitons along wires with flux-limited lateral exchange
2021
We obtain some exact solutions in the context of solitons, for heat conduction with inertia along a cylinder whose heat exchange with the environment is a non-linear function of the difference of temperatures of the cylinder and the environment, due to a flux-limiter behavior of the exchange. We study the consequences of heat transfer and information transfer along the wire, and we compare the situation with analogous solitons found in nonlinear lateral radiative exchange studied in some previous papers. We also find further exact solutions in terms of Weierstrass elliptic functions for the sake of completeness.
Metaficción y autoficción en cuatro autoras contemporáneas. Cristina Fallarás, Sara Mesa, Nuria Labari y Aixa De La Cruz.
2021
Un trabajo sobre algunas novelas publicadas en España en los últimos años que certifican la transformación y ampliación del concepto de metaficción literaria. Dichos cambios, atestiguados por estudios iniciales sobre el tema como, por ejemplo, La metaficción en la novela española contemporánea, (Orejas, 2003) o True lies: Narrative self-consciouness in the contemporary spanish novel (Amago, 2006), insisten en que las categorías tradicionales de la metaficción en la época posmodernista resultan un tanto usuradas yendo a favor de una elaboración del concepto general. De esta manera, elementos como la autoreferencialidad, la autoconciencia y la autoreflexión se incluyen en las características …
The influence of environmental conditions on the lifespan of mosses under long-term active biomonitoring
2021
Abstract Biomonitoring with living organisms is most often used in order to gather quick information about environmental quality – for example the level of heavy metals polluting the air. Experiments are not often performed when the bioindicator is exposed to pollutants over the long time (6 months and more) because this period required to obtain credible results and the risk not yet studied of physiological changes and of degeneration of the living material which would undoubtedly affect the biomonitoring results. The aim of study was to evaluate the physiological condition of Pleurozium schreberi moss species subjected to continuous exposure for a year, using the moss-bag method, under va…
Anatomía quirúrgica aplicada a abordajes transperitoneales de la aorta abdominal y los troncos viscerales. Artículo dinámico
2021
Resumen Los cirujanos cardiovasculares y del aparato digestivo deberian estar al corriente de las multiples alternativas de abordaje de la aorta abdominal y sus troncos viscerales. Articulo narrativo, ilustrado y dinamico de las diferentes maniobras quirurgicas descritas con este objetivo. Diseccion de 5 cadaveres realizadas durante tres cursos nacionales de Anatomia Quirurgica aplicada a aorta integral, Cirugia hepatobiliopancreatica y Cirugia abdominal digestiva. Maniobras quirurgicas descritas: abordaje aortico inframesocolico longitudinal, abordaje aortico supraceliaco, abordaje del tronco celiaco, tres tipos de abordaje de la arteria mesenterica superior: retroperitoneal tras maniobra …
The adaptive value of tandem communication in ants:Insights from an agent-based model
2021
AbstractSocial animals often share information about the location of resources, such as a food source or a new nest-site. One well-studied communication strategy in ants is tandem running, whereby a leader guides a recruit to a resource. Tandem running is considered an example of animal teaching because a leader adjusts her behaviour and invests time to help another ant to learn the location of a resource more efficiently. Tandem running also has costs, such as waiting inside the nest for a leader and a reduced walking speed. Whether and when these costs outweigh the benefits of tandem running is not well understood. We developed an agent-based simulation model to investigate the conditions…
The tougher the environment, the harder the adaptation? A psychological point of view in extreme situations
2021
IF: 2.8 (Q1); International audience; Grounded within a multidimensional and multilevel approach, the aim of this study was to investigate the time course of Psychological Adaptation Process (PAP) dimensions (social, emotional, occupational, and physical) during one-year polar winter-overs in Subantarctic and Antarctic stations. The effects of perceived control (PC) at the start of polar winter on the dynamics of the PAP dimensions were also examined. The present findings clarify some changes in PAP in extreme environments: (a) The dimensions of psychological adaptation evolved differently as a function of environmental conditions; and (b) PC influenced the trajectories of PAP dimensions. T…
Urology practice during the COVID-19 vaccination campaign
2021
Introduction: The current scenario of the COVID-19 pandemic is significantly different from that of the first, emergency phase. Several countries in the world are experiencing a second, or even a third, wave of contagion, while awaiting the effects of mass vaccination campaigns. The aim of this report was to provide an update of previously released recommendations on prioritization and restructuring of urological activities. Methods: A large group of Italian urologists directly involved in the reorganization of their urological wards during the first and second phase of the pandemic agreed on a set of updated recommendations for current urology practice. Results: The updated recommendations…
Quand les outils des filandières deviennent des éléments de parure. Nouvelles considérations autour d’éléments de parures grecque et italique (IXe-VI…
2021
International audience
La disciplina statale dell'immigrazione tra profili di criticità costituzionale e diritto vivente alla luce di alcune recenti vicende normative
2021
La disciplina statale dell'immigrazione non è riuscita a risolvere le aporie connesse allo squilibrio tra diritti umani ed esercizio del potere pubblico statuale: ciò rende necessaria un'interpretaziine adeguatrice che è operata dalla giurisdizioni coinvolte. Il diritto di matrice giurisprudenziale si sovrappone così al diritto positivo, sostituendosi ad esso con modalità che interrogano sui limiti del diritto vivente anche con riguardo al ruolo della Corte costituzionale. L'ultimo intervento normativo in materia, il D.L. n. 130/2020, non ha eliminato tutte le incertezze ed ambiguità della disciplina preesistente, essendosi limitato il legislatore a recepire, con alcune correzioni minimali,…
Simultaneous atrial and ventricular restitution and fibrillation analyses using a low-cost scalable panoramic whole-heart optical mapping configurati…
2021
Abstract Introduction Optical mapping (OM) is the primary method for imaging electrophysiologically relevant parameters from the outer surface of Langendorff-perfused hearts. However, current panoramic OM systems are financially challenging, require multiple sensors to map wide areas of the surface with overlapping regions and missing areas of interest due to the intrinsic shape of the heart. We proposed different panoramic configurations to dynamically characterize atrial and ventricular function during arrhythmia and, in presence of a coronary occlusion. Methods We devised both a multi-sensor and a single sensor system integrated with the perfusion circuit comprising sensor elements, a co…
Diagnosis of silent coronary ischemia with selective coronary revascularization might improve 2-year survival of patients with critical limb-threaten…
2021
Abstract Background Patients with critical limb-threatening ischemia (CLTI) have had poor long-term survival after lower extremity revascularization owing to coexistent coronary artery disease. A new cardiac diagnostic test, coronary computed tomography-derived fractional flow reserve (FFRCT), can identify patients with ischemia-producing coronary stenosis who might benefit from coronary revascularization. We sought to determine whether the diagnosis of silent coronary ischemia before limb salvage surgery with selective postoperative coronary revascularization can reduce the incidence of adverse cardiac events and improve the survival of patients with CLTI compared with standard care. Metho…
Care management in a French cohort with Down syndrome from the AnDDI-Rares/CNSA study.
2021
Down syndrome (DS) is a genetic neurodevelopmental disorder. In individuals with DS, a multidisciplinary approach to care is required to prevent multiple medical complications. The aim of this study was to describe the rehabilitation, medical care, and educational and social support provided to school-aged French DS patients with varying neuropsychological profiles. A mixed study was conducted. Quantitative data were obtained from a French multicentre study that included patients aged 4-20 years with diverse genetic syndromes. Qualitative data were collected by semi-structured face-to-face interviews and focus groups. Ninety-five DS subjects with a mean age of 10.9 years were included. Sixt…
Altered atrial restitution dynamics and refractoriness in metabolic syndrome due to up-regulation of potassium repolarizing currents increases suscep…
2021
Abstract Background Metabolic alterations, such as Metabolic Syndrome (MS), describe an association of factors including diabetes, hypertension, obesity and dyslipidemia, linked to higher risk and prevalence of overall cardiovascular disease, arrhythmogenesis and sudden cardiac death. Obese and diabetic patients have shown an increased risk for developing atrial fibrillation (AF). However, underlying mechanisms are not understood. Purpose To study the effects of MS and obesity remodeling in atrial restitution dynamics, frequency-dependent adaptation, refractoriness and its potential susceptibility to AF. Methods Electrophysiological experimental data from High-fat (HF-O, standard rabbit cho…
Formation of translucent nanostructured zirconia ceramics
2021
Abstract In this work the mechanisms that affect the optical transparency of nanostructured translucent ZrO2 ceramics are studied. The translucent ceramic samples were obtained from a low agglomeration nanosized powder at low pressure and low temperature sintering. Even low pressures cause structural changes and defect creation in the nanocrystals. Annealing was used to study the grain formation, structure and impact of defects. Significant changes in translucency were observed with increase in pore size. In order to further understand the defect creation, the obtained ceramics were doped with Er3+ ions and studied optically. Photoluminescence studies revealed a change in the ratio of green…
Studying nerve transfers: Searching for a consensus in nerve axons count
2021
Axonal count is the base for efficient nerve transfer; despite its capital importance, few studies have been published on human material, most research approaches being performed on experimental animal models of nerve injury. Thus, standard analysis methods are still lacking. Quantitative data obtained have to be reproducible and comparable with published data by other research groups. To share results with the scientific community, the standardization of quantitative analysis is a fundamental step. For this purpose, the experiences of the Italian, Austrian, German, Greek, and Iberian-Latin American groups have been compared with each other and with the existing literature to reach a consen…
Tear Osmolarity During the First Postoperative Month After Cataract Surgery
2021
Abstract The purpose of this study was to evaluate tear osmolarity changes in a healthy ocular surface in an eye that had been operated on within the first month after cataract surgery. This aim was achieved by forming two groups from the included patients. Patients with one eye exposed to cataract surgery formed the study group, while the eyes of the same patients with no cataract surgery were set as the control group. Both the operated and non-operated eye of each patient were scanned before surgery, the following morning, one week and one month after surgery. Tear osmolarity did not differ between the groups before the operation. On the first day after the surgery, tear osmolarity signif…
Measurements of the center-of-mass energies of e+e- collisions at BESIII
2021
Chinese physics / C 45(10), 103001 (2021). doi:10.1088/1674-1137/ac1575
Do Age and Sex Play a Role in the Intraocular Pressure Changes after Acrobatic Gymnastics?
2021
To evaluate the effects of an acrobatic gymnastics (AG) training session on intraocular pressure (IOP), a familiarization session was employed to confirm the participant’s suitability for the study. Forty-nine gymnasts (63.27% females, 18–40 years old) voluntarily agreed to participate. As age, sex, baseline IOP, and central corneal thickness (CCT) were considered as potential predictors of the IOP variations, in the second session measurements of the above parameters were taken before and after 90 min of AG. A mixed-factorial analysis of variance evaluated differences. Linear regression was conducted to potentially predict the IOP variation with the exercise. After the scheduled exercise, …
Bilateral De-Jure Exchange Rate Regimes and Foreign Direct Investment: A Gravity Analysis
2021
Abstract This paper introduces a novel dataset on bilateral de-jure exchange rate regimes. The new dataset accounts for the fact that officially pegging to one currency is uninformative about the exchange rate regime prevailing vis-a-vis other currencies, and it allows characterizing bilateral exchange rate regimes based on countries’ ex-ante announcements rather than ex-post observations. We use this data to estimate the effect of expected exchange rate volatility on foreign direct investment (FDI). Starting from a simple model that suggests that announced exchange rate stability enhances bilateral FDI flows, we provide empirical evidence that lends support to this claim: countries that ar…
SF3B1 modulators affect key genes in metastasis and drug influx: a new approach to fight pancreatic cancer chemoresistance.
2021
Aim: Because mutations of splicing factor 3B subunit-1 (SF3B1) have been identified in 4% of pancreatic ductal adenocarcinoma (PDAC) patients, we investigated the activity of new potential inhibitors of SF3B1 in combination with gemcitabine, one of the standard drugs, in PDAC cell lines. Methods: One imidazo[2,1-b][1,3,4]thiadiazole derivative (IS1) and three indole derivatives (IS2, IS3 and IS4), selected by virtual screening from an in-house library, were evaluated by the sulforhodamine-B and wound healing assay for their cytotoxic and antimigratory activity in the PDAC cells SUIT-2, Hs766t and Panc05.04, the latter harbouring the SF3B1 mutations. The effects on the splicing pattern of pr…