showing 36 of ~574560 from 574555 documents
Adventures of Clinical Psychology
2021
Clinical psychology strives to fully grasp the person in his totality and in his individuality, helping him adequately address his own deep internal suffering and discomfort, social uneasiness, and harmonize his own needs, desires and, attachments [...]
How villages contribute to their local air quality – The influence of traffic- and biomass combustion-related emissions assessed by mobile mappings o…
2021
Abstract Mobile mapping experiments were performed in two villages (~400 and ~2500 inhabitants, respectively) in France and Germany in both summer and winter in order to assess the pollutant distribution of several particulate matter (PM) related pollutants (particle number concentration, PM1, PM2.5, PM10; PM1 chemical composition, including inorganic and organic species, black carbon, and polyaromatic hydrocarbons) as well as CO2. Two dominating local emission contributions were found: traffic contributed to organic aerosol (OA), CO2, particle number concentration, PM1, black carbon, and polyaromatic hydrocarbons, whereas significant primary emission contributions from biomass combustion w…
Structural, energetic and kinetic database of catalytic reactions: Benzyl alcohol to benzaldehyde oxidation on MnOx clusters
2021
Abstract Data here reported are connected with the research article “Benzyl Alcohol to Benzaldehyde Oxidation on MnO x Clusters: Unraveling Atomistic Features” Gueci et al. [1] . This work described and discussed structural and energetic results, calculated by Density Functional Theory (DFT). In order to get kinetic information, DFT results were refined by an original approach, which will be shortly described in the following article. The crossed analysis of experimental and computational energetic and kinetic data allowed to (i) reconstruct the complicated lattice that connects the primary and secondary mechanisms of the reaction and (ii) identify alternative process pathways capable of by…
Balconi, veli e schermi. Come il panorama contemporaneo affonda il paesaggio antico
2021
The article puts in a sequence the ideas of wall, picture, frame, window, veil, screen and balcony in order to describe the process of "close range" spectacularisation whereby the gaze gives up the ancient landscape because it loves too much the modernity of "panorama".
Patterns of inter- and intra-regional differences in human capital and earnings : Evidence from Finland and Sweden 1987–2015
2021
In this paper, we examine the long-term patterns of geographical disparities in human capital and income in Finland and Sweden over the period 1987–2015. Using nationwide longitudinal population register data, we analyze disparities at different spatial scales, between and within functional labor market regions determined by observed travel-to-work patterns. Contrary to the findings from many other developed economies indicating inter-regional divergence in per capita income, we find indications of inter-regional convergence in per capita earnings among the functional labor market regions in both countries after 2000. However, small, and peripheral regions have not recovered from the macroe…
Knowledge exchange through science diplomacy to assist disaster risk reduction
2021
Abstract This paper analyses science diplomacy efforts to reduce disaster risks and proposes establishing national knowledge exchange centers (KECs) to help individual states adhere to their Sendai Framework goals. KECs are considered to be interconnected globally and work together to promote resilience efforts by facilitating sharing of information and strategies in risk monitoring, assessment, and ultimately reduction across the globe. KECs can provide high-quality scientific evidence for informed decisionmaking along with a component related to disaster science media to ensure that appropriate knowledge reaches a variety of people who need it in different forms tailored for them. KECs ca…
Vigencia de los derechos constitucionales en el Estado de Excepción con motivo de la emergencia sanitaria del COVID-19.
2021
El Estado de Excepción es una figura jurídica excepcional, que el jefe de Estado decreta frente a situaciones cuya solución escapan la actuación ordinaria, como la pandemia por el COVID–19; en este contexto, el presidente constitucional del Ecuador en uso de sus atribuciones, promulgó el 16 de marzo del 2020, el Decreto No. 1017 de Estado de Excepción y posterior solicitud de prórroga. El presente artículo tiene como objetivo analizar la vigencia de los derechos constitucionales en el Estado de Excepción con motivo de la emergencia sanitaria del COVID-19. Entre los resultados que arrojó la investigación, tenemos que el control constitucional, es un elemento que garantiza equilibrio en la se…
Prostate Specific Antigen Dynamics and Features in Prostate Cancer
2021
Abstract Despite the common use of the prostate-specific antigen (PSA) serum level as a tumour marker in diagnosis of prostate cancer, it seems that the PSA doubling time (PSADT) and PSA velocity (PSAV) could be more useful indicators of tumour behaviour and prognosis for patients. The aim of the study was to evaluate the value of PSAV and PSADT in the diagnosis of prostate cancer and their relationship with prostate cancer histopathological characteristics. Eighty-six patients undergoing radical prostatectomy were enrolled in the study. Based on the PSA measurements the PSA dynamic values were calculated: PSADT and PSAV. In addition, clinical and histo-pathological characteristics, includi…
Case Report: The JAK-Inhibitor Ruxolitinib Use in Aicardi-Goutieres Syndrome Due to ADAR1 Mutation
2021
Type I Interferonopathies comprise inherited inflammatory diseases associated with perturbation of the type I IFN response. Use of Janus kinase (JAK) inhibitors has been recently reported as possible tools for treating some of those rare diseases. We describe herein the clinical picture and treatment response to the JAK-inhibitor ruxolitinib in a 5-year-old girl affected by Aicardi-Goutières Syndrome type 6 (AGS6) due to ADAR1 mutation. The girl's interferon score (IS) was compared with that of her older brother, suffering from the same disorder, who was not treated. We observed a limited, but distinct neurological improvement (Gross Motor Function and Griffiths Mental Development Scales). …
Diagnosis of silent coronary ischemia with selective coronary revascularization might improve 2-year survival of patients with critical limb-threaten…
2021
Abstract Background Patients with critical limb-threatening ischemia (CLTI) have had poor long-term survival after lower extremity revascularization owing to coexistent coronary artery disease. A new cardiac diagnostic test, coronary computed tomography-derived fractional flow reserve (FFRCT), can identify patients with ischemia-producing coronary stenosis who might benefit from coronary revascularization. We sought to determine whether the diagnosis of silent coronary ischemia before limb salvage surgery with selective postoperative coronary revascularization can reduce the incidence of adverse cardiac events and improve the survival of patients with CLTI compared with standard care. Metho…
Dendrimers as Non-Viral Vectors in Gene-Directed Enzyme Prodrug Therapy.
2021
Gene-directed enzyme prodrug therapy (GDEPT) has been intensively studied as a promising new strategy of prodrug delivery, with its main advantages being represented by an enhanced efficacy and a reduced off-target toxicity of the active drug. In recent years, numerous therapeutic systems based on GDEPT strategy have entered clinical trials. In order to deliver the desired gene at a specific site of action, this therapeutic approach uses vectors divided in two major categories, viral vectors and non-viral vectors, with the latter being represented by chemical delivery agents. There is considerable interest in the development of non-viral vectors due to their decreased immunogenicity, higher…
Correction to: A haplotype-resolved, de novo genome assembly for the wood tiger moth (Arctia plantaginis) through trio binning
2021
Evaluation of the Oxiris Membrane in Cardiogenic Shock Requiring Extracorporeal Membrane Oxygenation Support: Study Protocol for a Single Center, Sin…
2021
Background: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is the rescue treatment proposed to patients with refractory cardiogenic shock. The VA-ECMO implantation promotes inflammation and ischemia-reperfusion injuries through the VA-ECMO flow, causing digestive mucosa barrier disrupture and inducing translocation of bacterial wall components—Lipopolysaccharides (LPS) with further inflammation and circulatory impairment. LPS is a well-studied surrogate indicator of bacterial translocation. Oxiris membrane is a promising and well-tolerated device that can specifically remove LPS. The main study aim is to compare the LPS elimination capacity of Oxiris membrane vs. a non-absorban…
Prevalencia del síndrome de desgaste en radiólogos españoles
2021
Objetivos Analizar la prevalencia y grado del síndrome de desgaste profesional entre radiólogos en España. Como objetivos secundarios se pretende identificar sus posibles factores desencadenantes y atenuantes para implementar intervenciones preventivas y correctivas, disminuyendo el estrés asociado y aumentando el rendimiento y la satisfacción laboral de los radiólogos. Material y métodos Estudio transversal y observacional realizado mediante una encuesta en línea, anónima y voluntaria, desarrollada a través de formularios de Google® y dirigida a radiólogos especialistas y en formación. La encuesta se estructura en tres apartados: una valoración cualitativa del grado del síndrome de desgast…
Heterogeneity of volatile sources along the Halmahera arc, Indonesia
2021
co-auteur étranger; International audience; The parallel Halmahera and Sangihe arcs in eastern Indonesia are sites of active arc-arc collision of considerable interest in developing understanding of the geodynamics and geochemistry of subduction zones. Owing to the comparative remoteness of the region, few ground-based studies of the volcanoes have been undertaken. Here, we report and integrate gas measurements and (isotope) geochemical analyses of lava samples for Dukono, Ibu, Gamkonora, Gamalama, and Makian volcanoes of the Halmahera arc. Summing gas fluxes for all five volcanoes indicates arcscale emission budgets for H 2 O, CO 2 , SO 2 , H 2 S, and H 2 of 96300±27000, 2093±450, 944±400,…
"On n’arrête pas le progrès". L’invention d’un mythe moderne avant 1914
2021
International audience
Numerical analysis of a new cross-flow type hydraulic turbine for high head and low flow rate
2021
Cross-flow turbines have recently been proposed for energy recovery in aqueducts when the outlet pressure is greater than zero, owing to their constructive simplicity and good efficiency within a large range of flow rates and head drops. In the case of high head drop (higher than 150 m) and relatively small discharge (lower than 0.2 m3/s), the traditional design of these turbines leads to very small widths of the nozzle and the runner; as a consequence, friction losses grow dramatically and efficiency drops down to very low values. Standard Pelton turbines require zero outlet pressure and cannot be used as alternatives. A new counter-pressure hydraulic turbine for high head and low flow rat…
Evaluación de la ingesta alimentaria: una reflexión que nos acerque al futuro
2021
El mantenimiento de un óptimo estado de salud es un tema de relevancia que ha llevado a científicos/as y clínicos/as a estudiar, investigar e innovar con el fin de disminuir las brechas y vacíos existentes de conocimiento. Actualmente, la epidemiología nutricional es un área de investigación que cobra cada día más importancia, cuyo objeto de estudio se centra fundamentalmente en el rol de la alimentación en el proceso salud-enfermedad. A partir del estudio del consumo dietético y su relación con las enfermedades crónicas, se ha observado que la dieta es uno de los factores modificables que influyen directamente en la prevención de estas enfermedades1. Además, el interés en estudiar la relac…
A Comparative Analysis of the Power of Selected European Countries. The Economic Determinants
2021
The ever-increasing need for in-depth analysis and quantification of the national power, in particular ‘hard’ and ‘soft’ power-generating factors as well as difficulties in identifying a comprehensive and effective method for scientific determination of the national power, have given rise to research in the indicated scientific issues within this article. The presented considerations aim to define the assumptions for a descriptive sub-model that would enable a comparison of Poland’s power in the economic sphere (which is a component of the non-military sphere) with the power of selected European countries. The research hypothesis is that, among the variety of descriptive variables in the ec…
Interbrain emotional connection during music performances is driven by physical proximity and individual traits.
2021
How musical emotions and the pleasure derived from music, regardless of the musical valence, can be shared between individuals is a fascinating question, and investigating it can shed light on the function of musical reward. We carried out our investigations in a natural setting during an international competition for orchestra conductors. Participants (n = 15) used a dedicated smartphone app to report their subjective emotional experiences in real time while we recorded their cerebral activity using electroencephalography and their electrodermal activity. The overall behavioral real-time behavioral ratings suggest a possible social influence on the reported and felt pleasure. The physicall…
Representations of the Life-giving Spring feast in Romanian iconography
2021
This article explores the development of the theme of the Life-giving Spring in Byzantine iconography. The path towards its establishment was initiated at the moment when a representation rule, an original convention was set. Thereafter, because of its diffusion in time and space, the theme became enriched by particular mentalities and sensibilities of the epochs and the communities that adopted it as a form of devotion for the Virgin Theotokos. As a result, the representations we have known so far are extremely varied. Contribution: The final purpose of this approach, as well as its contribution, is to highlight the diverse unity of the iconographic tradition and illustrate both the evolut…
Mechanisms of irreversible aquaporin-10 inhibition by organogold compounds studied by combined biophysical methods and atomistic simulations
2021
Abstract The inhibition of glycerol permeation via human aquaporin-10 (hAQP10) by organometallic gold complexes has been studied by stopped-flow fluorescence spectroscopy, and its mechanism has been described using molecular modelling and atomistic simulations. The most effective hAQP10 inhibitors are cyclometalated Au(III) C^N compounds known to efficiently react with cysteine residues leading to the formation of irreversible C–S bonds. Functional assays also demonstrate the irreversibility of the binding to hAQP10 by the organometallic complexes. The obtained computational results by metadynamics show that the local arylation of Cys209 in hAQP10 by one of the gold inhibitors is mapped int…
La jornada continua como un recurso para la maternidad intensiva. Una mirada desde la Comunidad Valenciana
2021
La “ideología de la maternidad intensiva” (Hays, 1998) según la cual la prioridad de la madre es dar respuesta a las necesidades de los hijos e hijas mediante la inversión de grandes cantidades de recursos económicos, temporales y emocionales, proporciona en este artículo una perspectiva clarificadora para comprender mejor el apoyo de un gran número de familias a la jornada continua en las escuelas. El artículo representa una primera aproximación a la relación entre maternidad intensiva y jornada escolar, a partir de la reflexión teórica que suscita la bibliografía existente sobre la construcción social de la maternidad, los análisis realizados sobre la jornada escolar en el ámbito español …
Affaire Halimi. Un arrêt stupéfiant
2021
Le 14 avril 2021, dans l'arret Halimi, la Chambre criminelle de la Cour de cassation declare irresponsable penalement le toxicomane, pris d'une bouffee delirante, qui a defenestre sa victime, anime par des mobiles antisemites. L'arret vient trancher un debat ouvert de longue date en consacrant l'indifference a la faute anterieure de l'agent pour apprecier l'abolition du discernement. Les motifs qui ont conduit a cette decision controversee ne se trouvent pas tant dans l'arret, mais dans la litterature abondante qui l'a accompagne.
Intersecting Defects and Supergroup Gauge Theory
2021
Journal of physics / A 54(43), 435401 (2021). doi:10.1088/1751-8121/ac2716
Optical super-resolution sensing of a trapped ion's wave packet size
2021
We demonstrate super-resolution optical sensing of the size of the wave packet of a single trapped ion. Our method extends the well known ground state depletion (GSD) technique to the coherent regime. Here, we use a hollow beam to strongly saturate a coherently driven dipole-forbidden transition around a sub-diffraction limited area at its center and observe state dependent fluorescence. By spatially scanning this laser beam over a single trapped $^{40}\mathrm{Ca}^+$ ion, we are able to measure the wave packet sizes of cooled ions. Using a depletion beam waist of $4.2(1)\,\mu$m we reach a spatial resolution which allows us to determine a wave packet size of $39(9)\,$nm for a near ground sta…
Pioneras en escena : el Pioneer Club y el teatro británico de la década de 1890
2021
espanolLas artes escenicas fueron un ingrediente esencial en la actividad de los clubes femeninos de Londres a partir de la decada de 1890, que contribuyo a la renovacion del teatro britanico del cambio de siglo. Sin embargo, su presencia en estos espacios ha sido sistematicamente olvidada por la historia teatral del periodo. El objetivo de este articulo es trazar un mapeo de su influencia desde una triple perspectiva: ludico-formativa; como promotor de dramaturgas con escasa visibilidad en los circulos mas comerciales, y de renovacion escenica. Para esta ultima, acudimos al estudio de caso del Pioneer Club que, como concluiremos, nutrio el discurso progresista de los ibsenitas y movimiento…
Peer-assessment using test exams in a Sakai-based e-learning platform
2021
We report our work on the implementation of a learning innovation based on the combination of peer-assessment and formative learning. The methodology consists on the students themselves to propose, review and select questions for the subsequent creation of a "multiple choice" exam to assess their progress. This learning innovation is carried out with a minimum intervention from the lecturer by using testing tools from the Sakai-based e-learning platform of our institution in combination with several software functions that have been created to automate the aggregation and processing of the students’ contributions. According to the feedback collected from the students, these learning tasks h…
Involvement of Microglia in Neurodegenerative Diseases: Beneficial Effects of Docosahexahenoic Acid (DHA) Supplied by Food or Combined with Nanoparti…
2021
Neurodegenerative diseases represent a major public health issue and require better therapeutic management. The treatments developed mainly target neuronal activity. However, an inflammatory component must be considered, and microglia may constitute an important therapeutic target. Given the difficulty in developing molecules that can cross the blood–brain barrier, the use of food-derived molecules may be an interesting therapeutic avenue. Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid (22:6 omega-3), has an inhibitory action on cell death and oxidative stress induced in the microglia. It also acts on the inflammatory activity of microglia. These data obtained in vitro or…
Mandible histology in Metoposaurus krasiejowensis (Temnospondyli, Stereospondyli) from the Upper Triassic of Poland
2021
Recent studies that have systematically augmented our knowledge of dermal bones of the Late Triassic temnospondyl amphibian Metoposaurus krasiejowensis have mostly focused on shoulder girdle elements and the skull. So far, histological data on the mandible are still scant. For the present study, two mandibles have been examined, using 50 standard thin sections. Dermal bones of the mandible reveal a uniform diploë structure, with the external cortex consisting of moderately vascularised, parallel-fibred bone, as well as a distinct alternation of thick zones and thinner annuli. Dense bundles of well-mineralised Sharpey’s fibres are seen in the external cortex over the entire length of the man…
Coordinación docente y precariedad. Modelos de coordinación en la enseñanza de la Sociología en Andalucía
2021
espanolDesde la implantacion de los Sistemas de Garantia de Calidad, la ensenanza universitaria ha incorporado mecanismos y figuras de coordinacion a la practica docente. Sin embargo, su aplicacion dista de ser homogenea. Un mecanismo disenado originalmente para la mejora de la calidad docente ha cobrado una nueva significacion e importancia debido al contexto de precarizacion generalizada de las plantillas de profesorado en la universidad. Este trabajo plantea un analisis del contexto, las bases teoricas y los distintos modelos de coordinacion implementados en una serie de universidades donde se imparte el grado de Sociologia en Andalucia, pero los resultados son perfectamente extrapolable…
Thilachium madagascariense (Capparaceae), a new species from eastern Madagascar with a key to the species of the genus
2021
SummaryThilachium madagascariense Fici, a small tree characterised by 1-foliolate leaves with articulate petioles, leaf blades elliptic or narrowly obovate with base attenuate and apex acuminate, flowers in groups of 2 – 3 at the top of lateral twigs and a high number of stamens, is described and illustrated from forest habitats of eastern Madagascar. The new species is similar to T. laurifolium Baker, a species endemic to central and eastern Madagascar, differing in the longer leaves with acuminate apex, flowers conferted at the top of lateral twigs, shorter pedicels, higher number of stamens and shorter gynophore. Its affinities are discussed and an updated key is provided for all the spe…
Seniors in the 21st century: social, medical and psychological support
2021
The subject of the analysis addresses seniors. Social, medical and psychological support can be classified as particularly important considering problems seniors face in their everyday life. This implies the need to narrow down the field of analysis to those aspects that the authors are able to responsibly undertake based on their professional experiences and education. Hence, the idea of this article is to explain and justify the need to develop tridisciplinary cooperation: sociology, medicine and psychology. The analysis of issues related to supporting seniors shows also the need to stimulate the processes of the seniors activation and counteracting social marginalization.
La costruzione dei climats viticoli in Borgogna; il legame tra vino e luogo nel Medioevo
2021
International audience
Decay assessment of stone-built cultural heritage: The case study of the cosenza cathedral façade (south calabria, italy)
2021
This study aims to assess the different decay phenomena affecting the Cosenza Cathedral façade (Calabria, South Italy) through the evaluation of the relative damage indices. For this goal, a multidisciplinary approach was applied exploiting both nondestructive and microdestructive techniques. Such a combination enabled proposing an intervention priority scale that can be helpful to institutions when planning a prompt restoration intervention. The results suggest the efficiency of this approach to obtain a multidisciplinary diagnostic and conservation system for the management and valorization of the Cultural Heritage also in terms of monitoring, maintenance, and selection of the most suitab…
Russian School in the Socio-Political Space of Latvia (1991 – 2021)
2021
Russian-language teaching schools, or bilingual schools, are the most important institution for the reproduction of the ethno-cultural collective identity of the Russian and Russian-speaking population in modern Latvia. The present and future of these schools are included in a very complex legal and socio-political context. On the one hand, Latvian legislation proclaims the right of ethnic minorities to preserve their identity, on the other hand, the dominant political discourse is focused on reducing teaching in Russian in these schools to a minimum. The article shows that it is the political context constructed by the leading political parties, and not the rights guaranteed by the constit…