Role of peroxiredoxin 6 in the chondroprotective effects of microvesicles from human adipose tissue-derived mesenchymal stem cells

2021

Este artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://www.sciencedirect.com/science/article/pii/S2214031X21000656?via%3Dihub Background: Osteoarthritis (OA) is a joint disease characterized by cartilage degradation, low-grade synovitis and subchondral bone alterations. In the damaged joint, there is a progressive increase of oxidative stress leading to disruption of chondrocyte homeostasis. The modulation of oxidative stress could control the expression of inflammatory and catabolic mediators involved in OA. We have previously demonstrated that extracellular vesicles (EVs) present in the secretome of human mesenchymal stem cells from adipose tissu…

Tertiary Chiral Nanostructures from C‐H∙∙∙F Directed Assembly of Chiroptical Superatoms

2021

Chiral hierarchical structures are universal in nature, whereas quite challenging to mimic in man-made synthesis. We report herein the synthesis and structure of tertiary chiral nanostructures with 100% optical purity. A novel synthetic strategy, using chiral reducing agent, R and S -BINAPCuBH 4 (BINAP is 2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl), is developed to access to atomically precise, intrinsically chiral [Au 7 Ag 6 Cu 2 ( R - or S -BINAP) 3 (SCH 2 Ph) 6 ]SbF 6 nanoclusters in one-pot synthesis. The clusters represent the first tri-metallic superatoms with inherent chirality and fair stability. Both metal distribution (primary) and ligand arrangement (secondary) of the enantiomer…

Influence of boron on the essential properties for new generation scintillators

2021

Abstract Cerium doped yttrium aluminum (YAG:Ce) and lutetium aluminum garnets (LuAG:Ce) are some of the most popular materials used as scintillators. While the scintillators themselves are materials that absorb and convert high-energy radiation into light. The decay time in YAG:Ce and LuAG:Ce is about 60 ns, therefore the essential task for their improvement would be to shorten it as much as possible. For this reason, in this work, the aforementioned garnets were doped with different amounts of boron. B3+ ion has a suitable neutron capture cross section and can therefore absorb gamma radiation. Because of the extremely strong absorption of thermal neutrons and the weak interaction with MeV …

Obesity and Mental Health: A Longitudinal, Cross-Cultural Examination in Germany and China

2021

The present study examines the relationship between obesity and mental health using longitudinal data. Participants with data at baseline and one-year follow-up were included from two countries: Germany (364) and China (9007). A series of structural equation models with three mediators and one moderator were conducted separately for female and male students in Germany and China. Zero-order correlations indicated that overweight/obesity was significantly related to later depression and anxiety in Chinese males. Additional effects of obesity on later mental health flowed through effects on attractiveness (Chinese and German females, and Chinese males), physical health (Chinese males), and lif…

Satisfaction with and reliability of in-hospital video-EEG monitoring systems in epilepsy diagnosis – A German multicenter experience

2021

OBJECTIVE: To analyze satisfaction with and reliability of video-electroencephalography-monitoring systems (VEMS) in epilepsy diagnostics.; METHODS: A survey was conducted between December 2020 and January 2021 among German epilepsy centers using well-established customer satisfaction (CS) and quality assurance metrics.; RESULTS: Among 16 participating centers, CS with VEMS was low, with only 13% of customers actively recommending their system. Only 50% of users were satisfied with the overall performance of their VEMS, and a low 18% were satisfied with the manufacturer's customer service. User interface, software stability, lack of regular updates, and missing customer-oriented improvement…

Exploring the mechanisms by which reindeer droppings induce fen peat methane production

2021

Abstract Peatlands, especially fens, are known to emit methane. Reindeer (Rangifer tarandus) use mires mainly as spring and summer pastures. In this work we observed that adding reindeer droppings to fen peat increased the potential methane production by 40%. This became apparent when droppings originating from reindeer kept in pen or pasture in winter were added to methanogenic fen peat samples. The droppings introduced Methanobacteriaceae (Methanobrevibacter; > 90% of the mcrA MiSeq reads) to the peat, which was originally populated by Methanosarcinaceae, Methanosaetaceae, Methanoregulaceae, Methanobacteriaceae, Methanomassiliicoccaceae, Methanocellaceae and Methanomicrobiaceae. The origi…

Quality of Life in Patients Rehabilitated with Implant-Supported Prostheses – A Systematic Review

2021

Abstract Oral health-related quality of life can be defined as the perception of the impact that oral health has on the quality of life. The quality of life is characterized by a person’s perception of his/her social status and the activities he/she carries out in daily life, in relation to his/her standards, objectives, concerns and expectations, as well as the system of values and cultural conditions within he/she lives in. Objective: The objective of this study was to systematically review the dental literature to identify and classify relevant articles on the quality of life associated with the oral health of patients rehabilitated with implant-supported prostheses. Materials and method…

Non-neoplasic and non-syndromic palatal perforations. Presentation of 5 cases and systematic review of the literature

2021

Background Palatal perforations not associated with syndromes or neoplasms are rare lesions whose frequency has increased recently. However, their clinical and demographic characteristics have not been fully described. Therefore, this report aimed to establish the demographic and clinical characteristics of patients with non-syndromic and non-neoplastic palatal perforations. Material and Methods The file of an oral medicine teaching clinic from January 2004 to December 2018 was reviewed to identify and isolate all cases with a diagnosis of palatal perforation. Cases with a diagnosis of palatal perforation related to congenital alteration, syndrome, or neoplasia were excluded. Age, sex, medi…

I RODITORI DI CAVA MONTICINO (BRISIGHELLA, RA)

2021

Rodents are the most abundant group of small mammals occurring in Brisighella deposits. They are represented by 12 species in total, among which 2 hamsters (Apocricetus cf. barrierei and Ruscinomys cf. lasallei), 2 dormice (Muscardinus sp. and Myomimus sp.), 1 porcupine (Hystrix (Hystrix) depereti), 2 sciurids (Atlantoxerus cf. rhodius and Hylopetes sp.) and 5 species of muridae (Apodemus cf. gudrunae, Centralomys benericettii, Occitanomys sp, Paraethomys meini and Stephanomys debruijni). This association suggests a relatively dry open environment, interrupted by forest environment with more or less dense underground.

Ipotesi di riqualificazione per un alloggio duplex del quartiere Cappuccinelli a Trapani

2021

L’edilizia residenziale pubblica può costituire un ambito privilegiato d’intervento per conseguire gli obiettivi di efficienza energetica e impatto ambientale connessi alla strategia di riqualificazione a lungo termine del patrimonio edilizio nazionale. In particolare, il recente Decreto “Rilancio” e gli strumenti fiscali finalizzati a favorire il recupero e l’efficienza energetica degli edifici esistenti pon- gono in una condizione particolarmente vantaggiosa gli interventi sull’edilizia residenziale. L’ar- ticolo illustra i primi risultati di uno studio – che si innesta in una ricerca più ampia finalizzata a dimostrare i benefici derivabili dall’uso della vegetazione per migliorare le con…

Saada kaikki ja olla onnellinen : äitiyrittäjyys tuottavuuden ja affektien aikakaudella

2021

Artikkelissa tutkin uusliberaalin postfeminismin kehyksen läpi työntekijyyden ja äitiyden ristiriitaisuuksia ja ratkaisuyrityksiä. Empiirisenä kohteena on äitiyrittäjyysilmiö. Siinä on kyse yrittäjyydestä, joka on rinnakkaista tai alisteista naisen äitiroolille. Äitiyrittäjyydellä pyritään "saamaan kaikki": ratkaisemaan tuottavaan työhön kutsuvan ja intensiivistä äidinhoivaa korostavan ideologian välinen affektiivinen hankaus tavalla, joka toisi mukanaan onnen ja tasapainon tunteen. Artikkelin 21 yrittäjämuotoisesti esimerkiksi media- ja käsityöaloilla, työskentelevän idin haastattelukerronnan analyysi osoittaa, että äideillä on paljonkin työhön liittyviä tavoitteita, mutta niiden rinnalla …

Insight into the role of the zeolitization process in enhancing the adsorption performance of kaolinite/diatomite geopolymer for effective retention …

2021

Abstract Diatomite/kaolinite-based geopolymer (GP) was synthesized and incorporated in zeolitization process (Z/GP) to investigate the role of the zeolite phases in inducing its retention capacity of the dissolved Sr (II) ions in water. The retention of Sr (II) ions using Z/GP in comparison with GP was evaluated based on both batch and fixed-bed column studies. In the batch study, the zeolitized geopolymer (Z/GP) shows enhancement in the Sr (II) retention capacity (193.7 mg/g) as compared to the normal geopolymer (102 mg/g). Moreover, the recyclability studies demonstrate higher stability for Z/GP than GP with a retention percentage higher than 90% for five reusing runs. The kinetic and the…

Evaluation of adsorption ability of Cyclodextrin-Calixarene Nanosponges towards Pb2+ ion in aqueous solution

2021

Abstract Different cyclodextrin-calixarene nanosponges (CyCaNSs) have been characterized by means of FFC-NMR relaxometry, and used as sorbents to remove Pb2+ ions from aqueous solutions. Considering that the removal treatments may involve polluted waters with different characteristics, the adsorption experiments were performed on solutions without and with the addition of background salts, under different operational conditions. The adsorption abilities and affinities of the nanosponges towards Pb2+ ions were investigated by measuring the metal ion concentration by means of Inductively Coupled Plasma Emission Spectroscopy (ICP-OES) and Differential Pulse Anodic Stripping Voltammetry (DP-ASV…

Molecular Proteomics and Signalling of Human Platelets in Health and Disease

2021

Platelets are small anucleate blood cells that play vital roles in haemostasis and thrombosis, besides other physiological and pathophysiological processes. These roles are tightly regulated by a complex network of signalling pathways. Mass spectrometry-based proteomic techniques are contributing not only to the identification and quantification of new platelet proteins, but also reveal post-translational modifications of these molecules, such as acetylation, glycosylation and phosphorylation. Moreover, target proteomic analysis of platelets can provide molecular biomarkers for genetic aberrations with established or non-established links to platelet dysfunctions. In this report, we review …

Proteomic signature of the Dravet syndrome in the genetic Scn1a-A1783V mouse model.

2021

Abstract Background Dravet syndrome is a rare, severe pediatric epileptic encephalopathy associated with intellectual and motor disabilities. Proteomic profiling in a mouse model of Dravet syndrome can provide information about the molecular consequences of the genetic deficiency and about pathophysiological mechanisms developing during the disease course. Methods A knock-in mouse model of Dravet syndrome with Scn1a haploinsufficiency was used for whole proteome, seizure, and behavioral analysis. Hippocampal tissue was dissected from two- (prior to epilepsy manifestation) and four- (following epilepsy manifestation) week-old male mice and analyzed using LC-MS/MS with label-free quantificati…

Linear relationship between effective radius and precipitation water content near the top of convective clouds: measurement results from ACRIDICON–CH…

2021

Quantifying the precipitation within clouds is a crucial challenge to improve our current understanding of the Earth's hydrological cycle. We have investigated the relationship between the effective radius of droplets and ice particles (re) and precipitation water content (PWC) measured by cloud probes near the top of growing convective cumuli. The data for this study were collected during the ACRIDICON–CHUVA campaign on the HALO research aircraft in clean and polluted conditions over the Amazon Basin and over the western tropical Atlantic in September 2014. Our results indicate a threshold of re∼13 µm for warm rain initiation in convective clouds, which is in agreement with previous studie…

Ethical Issues Invoked by Industry 4.0

2021

Industry 4.0 is universally referred to as the fourth industrial revolution. It is a current trend of automation and data exchange in manufacturing technologies. The computerisation of manufacturing includes, amongst other, cyber-physical systems, the Internet of Things (IoT), cloud computing and cognitive computing. There are many challenges in the realisation of Industry 4.0. In order to adopt a “smart factory” and improved (software) processes many ethical considerations need to be identified and considered if a company is to obtain an ethical development and deployment of Industry 4.0. The purpose of normative ethics is to scrutinise standards about the rightness and wrongness of action…

EXTRACELLULAR VESCICLES DERIVED FROM GUT MICROBIOTA IN INFLAMMATORY BOWEL DISEASE AND COLORECTAL CANCER

2021

The human gut microbiome encompasses inter alia, the myriad bacterial species that create the optimal host-micro-organism balance essential for normal metabolic and immune function. Various lines of evidence suggest that dys-regulation of the microbiota-host interaction is linked to pathologies such as inflammatory bowel disease (IBD) and colorectal cancer (CRC). Extracellular vesicles (EVs), found in virtually all body fluids and produced by both eukaryotic cells and bacteria are involved in cell-cell communication and crosstalk mechanisms, such as the immune response, barrier function and intestinal flora. This review highlights advancements in knowledge of the functional role that EVs ma…

Sociodemographic factors as determinants of quality of life and quality of social interactions among heterosexual couples undergoing assisted reprodu…

2021

Introduction When facing with stressful physical and psychosocial events, sociodemographic factors can be an important factor for quality of life and quality of social interactions [1]. The experience of infertile couples undergoing ART is a complex and stressful process that may have a negative effect on quality of life [2]. There is a need to better understand how certain sociodemographic factors impact on the quality of life and in the quality of social interactions of patients undergoing ART, in order to be able to anticipate the consequences from an integrated care perspective.MethodsThis study aims to assess the relationship between sociodemographic factors (sex, marital status and em…

The effects of the Nordic hamstring exercise on sprint performance and eccentric knee flexor strength: A systematic review and meta-analysis of inter…

2021

Objectives: The primary aim of this study was to investigate the effects of the Nordic hamstring exercise (NHE) on sprint performance (i.e., 5, 10 and 20 m) and explore associations between study characteristics and sprint outcomes in team sport players. Secondary aims were to (1) investigate the effects of the NHE on eccentric strength of the knee flexors (ESKF) with categorical subgroup analysis to determine differences between recreationally, well-trained individuals and young athletes, (2) determine the relation between ESKF and sprint performance in team sport players, and (3) explore the effect of study characteristics (i.e., weekly volume, time duration and body mass) on ESKF.Methods…

Longitudinal associations of physical activity, sedentary time, and cardiorespiratory fitness with arterial health in children – the PANIC study

2021

We investigated the longitudinal associations of physical activity (PA), sedentary time (ST), and cardiorespiratory fitness (CRF) with arterial health among children. In our primary analyses, we investigated 245 children (girls 51.8%) aged 6-9 years participating in the baseline examinations who had data on arterial health at 2-year follow-up. We also utilized a subsample of 90 children who had a complete arterial health data at baseline and 2-year follow-up. ST (≤1.5 METs), light PA (>1.5-4 METs), moderate PA (>4-7 METs), vigorous PA (>7METs), and moderate-to-vigorous PA (MVPA, >4 METs) were assessed by combined movement and heart rate monitoring and CRF by maximal exercise testing on a cy…

Volcanic Lakes in Africa: The VOLADA_Africa 2.0 Database, and Implications for Volcanic Hazard

2021

Volcanic lakes pose specific hazards inherent to the presence of water: phreatic and phreatomagmatic eruptions, lahars, limnic gas bursts and dispersion of brines in the hydrological network. Here we introduce the updated, interactive and open-access database for African volcanic lakes, country by country. The previous database VOLADA (VOlcanic LAke DAta Base, Rouwet et al., Journal of Volcanology and Geothermal Research, 2014, 272, 78–97) reported 96 volcanic lakes for Africa. This number is now revised and established at 220, converting VOLADA_Africa 2.0 in the most comprehensive resource for African volcanic lakes: 81 in Uganda, 37 in Kenya, 33 in Cameroon, 28 in Madagascar, 19 in Ethiop…

Airways cephalometric norms from a sample of Caucasian Children

2021

Background: The diagnosis of the respiratory pattern and the analysis of airway dimension using lateral cephalometric radiographs include the study of the adenoid region, free air space of the nasopharynx and oropharynx, soft palate and posterior part of the tongue. The objective of this study is to identify the airways cephalometric norms from a sample of Caucasian children, in relation to gender, age and type of malocclusion. Material and Methods: A total of 480 patients of both sexes were included in the study, the age ranged between 6-12 years. The radiographic records were analyzed using the Nemoceph® 11.3.0 software and the diagnosis of skeletal class was performed using the Steiner a…

Streamlining distributed Deep Learning I/O with ad hoc file systems

2021

With evolving techniques to parallelize Deep Learning (DL) and the growing amount of training data and model complexity, High-Performance Computing (HPC) has become increasingly important for machine learning engineers. Although many compute clusters already use learning accelerators or GPUs, HPC storage systems are not suitable for the I/O requirements of DL workflows. Therefore, users typically copy the whole training data to the worker nodes or distribute partitions. Because DL depends on randomized input data, prior work stated that partitioning impacts DL accuracy. Their solutions focused mainly on training I/O performance on a high-speed network but did not cover the data stage-in pro…

A Phase I dose-escalation study of third-line regorafenib with trifluridine/tipiracil in metastatic colorectal cancer

2021

Aim: To determine a recommended Phase II dose of the oral fluoropyrimidine trifluridine/tipiracil (FTD/TPI) combined with the multi-kinase inhibitor regorafenib (REG) in refractory metastatic colorectal cancer patients. Materials & methods: A conventional 3 + 3 dose finding design was used. FTD/TPI was administered on days 1–5 and 8–12 of a 28-day cycle, REG on days 2–22. Two dose levels were used: FTD/TPI 25 mg/m2 b.i.d. + REG 120 mg/d, then escalated to FTD/TPI 35 mg/m2 b.i.d. + REG 120 mg/d. Results: In total, 12 patients were treated at two dose levels. Three dose-limiting toxicities were observed; all were grade 3 hypertension causally attributed to REG. Recommended Phase II dose …

Volatile organic compounds (VOCs) in exhaled breath as a marker of hypoxia in multiple chemical sensitivity

2021

Abstract In the history of diagnostics, breath analysis was one of the first method used until the breakthrough of biochemical testing technology. Today, breath analysis has made a comeback with the development of gas analyzers and e‐noses, demonstrating its power in its applicability for diagnosing a wide range of diseases. The physical basis of multiple chemical sensitivity (MCS), an emerging environmental disease, is difficult to understand because it is based on the scenario of chronic hypoxia, with a complex of chemical compounds that trigger the syndrome and result in multiple symptoms. The aim of this study was to investigate MCS by analyzing exhaled volatile organic compounds (VOCs)…

Diagnostische Arbeit mit dem Befundbogen der Konfliktachse der OPD-KJ: Empirische Ergebnisse an stationären und ambulanten Patient_innen

2021

Zusammenfassung. In der Kinder- und Jugendlichenpsychiatrie und -psychotherapie findet die Operationalisierte Psychodynamische Diagnostik (OPD-KJ) in den letzten Jahren zunehmend Anwendung. Dieser Beitrag stellt die Konfliktachse der OPD-KJ vor, die eine Operationalisierung von sieben psychodynamischen Konflikten und den jeweils zugeordneten Verarbeitungsmodi enthält. Er beschreibt empirische Ergebnisse zum Vergleich der Konfliktachsenratings und des Strukturratings in einer ambulanten und einer stationären Gruppe von Kindern und Jugendlichen (gesamt N = 186, 12.7 Jahre, 54 % weiblich). Die Befunde zeigen an der Gesamtgruppe, dass die diagnosespezifischen Geschlechtsunterschiede verschwind…

Cosmological radiation density with non-standard neutrino-electron interactions

2021

Neutrino non-standard interactions (NSI) with electrons are known to alter the picture of neutrino decoupling from the cosmic plasma. NSI modify both flavour oscillations through matter effects, and the annihilation and scattering between neutrinos and electrons and positrons in the thermal plasma. In view of the forthcoming cosmological observations, we perform a precision study of the impact of non-universal and flavour-changing NSI on the effective number of neutrinos, $N_{eff}$. We present the variation of $N_{eff}$ arising from the different NSI parameters and discuss the existing degeneracies among them, from cosmology alone and in relation to the current bounds from terrestrial exper…

Effectiveness of appropriate care pathways for frail older adults: a pilot study in Valencia (Spain)

2021

Introduction Frail older adults often have multiple health and social problems [1] but experience reduced care coordination due to fragmented service provision [2], and therefore are in need of integrated care. A comprehensive model integrating the provision of health and psychosocial care can promote health and wellbeing among frail older adults. This study explored the effects of a comprehensive model (APPCARE model) on health and wellbeing, and the healthcare resources use, of +75 frail older adults with complex and co-morbid clinical situations after their hospitalization. Methods Within the APPCARE model, two specific care pathways were designed and piloted in the city of Valencia (Spa…

Analysis of pseudouridines and other RNA modifications using hydraPsiSeq protocol

2021

Detection of RNA modified nucleotides using deep sequencing can be performed by several approaches, including antibody-driven enrichment and natural or chemically induced RT signatures. However, only very few RNA modified nucleotides generate natural RT signatures and antibody-driven enrichment heavily depends on the quality of antibodies used and may be highly biased. Thus, the use of chemically-induced RT signatures is now considered as the most trusted experimental approach. In addition, the use of chemical reagents allows inclusion of simple "mock-treated" controls, to exclude spontaneous RT arrests, SNPs and other misincorporation-prone sites. Hydrazine is a well-known RNA-specific rea…

Palliative Care Principles and Anesthesiology Clinical Practice: Current Perspectives

2021

Background Palliative care is a person-centered approach aiming to relieve patient's health-related suffering and it is often needed when caring for critically ill patients to manage symptoms and identify goals of care. Aim To describe the integration of palliative care principles in anesthesiology clinical practice, within and outside the ICU and to analyze the additional challenges that COVID-19 pandemic is posing in this context. Methods For the purpose of this review, PubMed database was searched for studies concerning palliative care and end of life care, in contexts involving anesthesiologists and intensivists, published in the last 5 years. Results Anesthesiologists and intensivists …

1543P Gemcitabine in classic Kaposi’s sarcoma: A pilot study

2021

Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis

2021

Development of primary liver cancer is a multistage process. Detailed understanding of sequential epigenetic alterations is largely missing. Here, we performed Infinium Human Methylation 450k BeadChips and RNA-Seq analyses for genome-wide methylome and transcriptome profiling of cirrhotic liver (n = 7), low- (n = 4) and high-grade (n = 9) dysplastic lesions, and early (n = 5) and progressed (n = 3) hepatocellular carcinomas (HCC) synchronously detected in 8 patients with HCC with chronic hepatitis B infection. Integrative analyses of epigenetically driven molecular changes were identified and validated in 2 independent cohorts comprising 887 HCCs. Mitochondrial DNA sequencing was further em…

Day-to-Day Variability and Year-to-Year Reproducibility of Accelerometer-Measured Free-Living Sit-to-Stand Transitions Volume and Intensity among Com…

2021

(1) Background: The purpose of this study was to evaluate the day-to-day variability and year-to-year reproducibility of an accelerometer-based algorithm for sit-to-stand (STS) transitions in a free-living environment among community-dwelling older adults. (2) Methods: Free-living thigh-worn accelerometry was recorded for three to seven days in 86 (women n = 55) community-dwelling older adults, on two occasions separated by one year, to evaluate the long-term consistency of free-living behavior. (3) Results: Year-to-year intraclass correlation coefficients (ICC) for the number of STS transitions were 0.79 (95% confidence interval, 0.70-0.86, p < 0.001), for mean angular velocity-0.81 (95% c…

Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent N-Acylethanolamine-Hydrolyzing Acid Ami…

2021

Inhibition of intracellular N-acylethanolamine-hydrolyzing acid amidase (NAAA) activity is a promising approach to manage the inflammatory response under disabling conditions. In fact, NAAA inhibition preserves endogenous palmitoylethanolamide (PEA) from degradation, thus increasing and prolonging its anti-inflammatory and analgesic efficacy at the inflamed site. In the present work, we report the identification of a potent, systemically available, novel class of NAAA inhibitors, featuring a pyrazole azabicyclo[3.2.1]octane structural core. After an initial screening campaign, a careful structure–activity relationship study led to the discovery of endo-ethoxymethyl-pyrazinyloxy-8-azabicyclo…

Architectural Implementation of a Reconfigurable NoC Design for Multi-Applications

2021

With the increasing number of applications running on a Network-on-Chip (NoC) based System-on-Chip (SoC), there is a need for designing a reconfigurable NoC platform to achieve acceptable performance for all the applications. This paper proposes a novel architecture for implementing a reconfiguration logic to the NoC platform executing multiple applications. The proposed architecture reconfigures SoC modules to the routers in the NoC with the help of tri-state buffers based on the applications running. The overhead in implementing the reconfiguration circuitry is significantly less, approximately 0.9% of the area and 1% of the total power consumed by the router network. The architectures pr…