showing 36 of ~574560 from 574555 documents
Energie rinnovabili e trasformazioni territoriali: il caso del fotovoltaico in Sicilia
2021
La presente comunicazione intende trattare il tema delle trasformazioni territoriali sono avvenute negli ultimi due decenni in Sicilia, in seguito alla costruzione di centinaia di impianti fotovoltaici di piccole, medie e grandi dimensioni. Tali impianti sono stati costruiti causando spesso profondi mutamenti paesaggio, con trasformazioni territoriali che non hanno tenuto conto delle caratteristiche di produttività dei suoli, della vicinanza di aree protette e siti della Rete Natura 2000 e soprattutto senza il reale coinvolgimento delle comunità locali che spesso hanno subito passivamente tali trasformazioni. Gli strumenti di pianificazione territoriale, quali il Piano Paesistico Regionale,…
Effect of genetic variation in CYP450 on Gonadal impairment in a European cohort of female childhood cancer survivors, based on a candidate gene appr…
2021
Background: Female childhood cancer survivors (CCSs) carry a risk of therapy-related gonadal dysfunction. Alkylating agents (AA) are well-established risk factors, yet inter-individual variability in ovarian function is observed. Polymorphisms in CYP450 enzymes may explain this variability in AA-induced ovarian damage. We aimed to evaluate associations between previously identified genetic polymorphisms in CYP450 enzymes and AA-related ovarian function among adult CCSs. Methods: Anti-Müllerian hormone (AMH) levels served as a proxy for ovarian function in a discovery cohort of adult female CCSs, from the pan-European PanCareLIFE cohort (n = 743
Controlled solution-based fabrication of perovskite thin films directly on conductive substrate
2021
Abstract Organometallic perovskites are one of the most investigated materials for high-efficiency thin-film devices to convert solar energy and supply energy. In particular, methylammonium lead iodide has been used to realize thin-film perovskite solar cells, achieving an efficiency higher than 20%. Different fabrication procedures based on the spin-coating technique have been proposed, which do not ensure homogenous morphologies. In this work, we present a scalable process to fabricate methylammonium lead iodide thin films directly on conductive substrates, consisting of electrodeposition and two subsequent chemical conversions. A thorough investigation of the morphological, structural an…
Effektivität der sequentiellen systemischen Therapie bei Patienten mit einem fortgeschrittenen HCC - Erfahrungen aus dem klinischen Alltag
2021
The Impact of School Closure on Adolescents’ Wellbeing, and Steps toward to a New Normal : The Need for an Assessment Tool Update?
2021
International audience; Close to 200 countries have implemented school closures to decrease the spread of the COVID-19 coronavirus. Though the closures have seemed necessary, their effects on the wellbeing of children and adolescents have raised serious concerns. To truly understand the impact of such disruption on young people’s wellbeing, and their views on how to move towards a new normal, we must adopt different approaches to gather the data to secure children’s and adolescents’ rights to be heard in the issues that concern their lives. Current ways to examine the impacts of school closure have been dominated by gathering information concerning the children and adolescents, using mainly…
Translation, Adaption, and Psychometric Testing of the Myanmar Version of the Medical Outcomes Study Social Support Survey for People Living With HIV…
2021
Introduction: Valid and reliable instruments are crucial for measuring perceived social support among people living with HIV (PLHIV). We aimed to investigate the psychometric properties of the English version of the 19-item Medical Outcomes Study Social Support Survey (MOS-SSS) adapted for PLHIV in Myanmar.Methods: Based on a standard cross-cultural procedure, we adapted the MOS-SSS and formed a Myanmar version of the scale (MOS-SSS-M), and then tested its validity and reliability. A sample of 250 eligible PLHIV was collected from a closed Facebook group that included more than 10,000 Myanmars, most of whom were PLHIV.Results: The MOS-SSS-M achieved a Cronbach’s α of 0.82–0.95. Confirmatory…
Les pratiques de recherche sur la santé en contexte numérique
2021
Cette note de lecture s’intéresse à l’ouvrage Les pratiques de recherche sur la santé en contexte numérique (2021). Laurent Morillon invite 20 auteurs à poser un regard réflexif sur leurs recherches en santé faisant intervenir un environnement numérique. L’ouvrage, sous différents exemples, montre à quel point les questionnements éthiques et l’adoption d’une posture réflexive par les chercheurs sont essentiels pour apporter un nouvel éclairage sur les pratiques de la science. This text reviews the book Les pratiques de recherche sur la santé en contexte numérique (2021). Laurent Morillon invites 20 authors to take a reflective look at their research about health involving a digital environm…
Association between Serum Osteoprotegerin Levels and Severity of Coronary Artery Disease in Patients with Acute Myocardial Infarction
2021
International audience; Background. Osteoprotegerin (OPG), a glycoprotein of the tumour necrosis factor (TNF) superfamily, is one of the main biomarkers for vascular calcification. Aim. We aimed to evaluate the association between serum OPG levels and extent of coronary lesions in patients with acute myocardial infarction (MI). Methods. Consecutive patients hospitalized for an acute MI who underwent coronary angiography were included. SYNTAX score was calculated to assess the severity of coronary artery disease. The population was analysed in low (5 (3–6)), medium (11 (9–13)) and high (20 (18–23)) tertiles of SYNTAX score. Results. Among the 378 patients included, there was a gradual increa…
The Impact of CSR/ESG Reporting on the Cost of Capital: An Example of US Healthcare Entities
2021
PURPOSE: Identifying the direction and strength of the relationship between individual elements of ESG and ESG as a whole and the cost of capital (weighted average, equity, and debt) in the healthcare industry.
Fascioliasis in Llama, Lama glama, in Andean Endemic Areas: Experimental Transmission Capacity by the High Altitude Snail Vector Galba truncatula and…
2021
Simple Summary The infection by the liver fluke Fasciola hepatica in South American camelids, mainly llamas and alpacas, has been the focus of many studies. However, their capacity to participate in the transmission of the disease and their potential reservoir role in human or animal endemic areas have never been studied. Therefore, all development stages of an isolate from Argentine llama of the high Andean plateau have been experimentally investigated, from egg embryogenesis to metacercarial infectivity, by using the vector snail Galba truncatula from the high altitude Bolivian Altiplano human hyperendemic area. Although eggs shed by llamas may successfully develop until the adult stage i…
Carga de comorbilidad y beneficio de la revascularización en ancianos con síndrome coronario agudo
2021
Resumen Introduccion y objetivos El objetivo es evaluar la interaccion entre carga de comorbilidad y beneficio de la revascularizacion en ancianos con sindrome coronario agudo sin elevacion del ST (SCASEST). Metodos Estudio retrospectivo que incluyo a 7.211 pacientes de edad ≥ 70 anos y procedentes de 11 registros de SCASEST espanoles. Se evaluaron 6 comorbilidades (diabetes mellitus, arteriopatia periferica, enfermedad cerebrovascular, enfermedad pulmonar cronica, insuficiencia renal y anemia). Se calculo una puntuacion de propension para comparar el efecto de la revascularizacion frente al tratamiento conservador. El objetivo fue la mortalidad a 1 ano. Resultados Al ano habian fallecido 1…
Testing a model for the monitoring of worked-out algebra-problem examples: from behaviours to outcomes on a math task
2021
This study aimed at testing an extension of a theoretical model for the metacognitive monitoring mechanism implied in the detection of inconsistencies when the information provided includes abstract symbols in addition to plain text. Ninety-four postgraduates of STEM specialities were asked to read a worked-out algebra-problem example and to report any incoherence, inconsistency, or error detected in the statement or in the solving procedure. A set of model inspired indexes was defined to describe participants¿ behaviour along the task. The Read & Answer software was used to record online individual processing data and participants¿ reports. Results supported model predictions. Indexes corr…
Earth Bricks with Halloysite Nanoclay: Research and Experimentation for the Sustainability of Materials
2021
The paper illustrates the experimentation activities on rammed earth and nanotechnologies conducted by the authors. The experimental research was carried out with the aim of improving the performance of rammed earth bricks with clay nanotubes, creating a ‘new material’ with reduced embodied energy and low CO2 emissions into the atmosphere. Specifically, the analysed performances are related to the compressive strength that expand their area of use as a building material.
Pathogenesis and molecular mechanisms of anderson–fabry disease and possible new molecular addressed therapeutic strategies
2021
Anderson–Fabry disease (AFD) is a rare disease with an incidenceof approximately 1:117,000 male births. Lysosomal accumulation of globotriaosylceramide (Gb3) is the element characterizing Fabry disease due to a hereditary deficiency α-galactosidase A (GLA) enzyme. The accumulation of Gb3 causes lysosomal dysfunction that compromises cell signaling pathways. Deposition of sphingolipids occurs in the autonomic nervous system, dorsal root ganglia, kidney epithelial cells, vascular system cells, and myocardial cells, resulting in organ failure. This manuscript will review the molecular pathogenetic pathways involved in Anderson–Fabry disease and in its organ damage. Some studies reported that i…
SAU et diagnostic de l’œdème pulmonaire cardiogénique
2021
Acute cardiogenic pulmonary oedema in the elderly does not differ fundamentally from that seen in the young patient. Appropriate pathways must be established, with regular nursing follow-up, to enable rapid detection and treatment of episodes of acute heart failure. The paramedical team plays an essential role in liaising with families, providing nursing care and listening to the patient at the bedside.
Exploring the mechanisms by which reindeer droppings induce fen peat methane production
2021
Abstract Peatlands, especially fens, are known to emit methane. Reindeer (Rangifer tarandus) use mires mainly as spring and summer pastures. In this work we observed that adding reindeer droppings to fen peat increased the potential methane production by 40%. This became apparent when droppings originating from reindeer kept in pen or pasture in winter were added to methanogenic fen peat samples. The droppings introduced Methanobacteriaceae (Methanobrevibacter; > 90% of the mcrA MiSeq reads) to the peat, which was originally populated by Methanosarcinaceae, Methanosaetaceae, Methanoregulaceae, Methanobacteriaceae, Methanomassiliicoccaceae, Methanocellaceae and Methanomicrobiaceae. The origi…
Effect of Heat Exchange Transient Conditions with Moving Water-Air Interface on Space Charge Accumulation in Undersea HVdc Cables
2021
The accumulation of space charge inside the dielectric layer of an HVdc cable is one of the most important issue to be considered in the design stage and during the operating conditions. The separation of space charge is due to several factors including the dependence on temperature of the electrical conductivity of the insulation and the establishment of a thermal gradient under load conditions. This article is focused on the investigation of the effect of an axial heat transmission on the space charge and electric field distributions in an HVdc cable. In order to assess the impact of this phenomenon, a case study involving a cable immersed partly in water and partly in air has been simula…
Molecular Proteomics and Signalling of Human Platelets in Health and Disease
2021
Platelets are small anucleate blood cells that play vital roles in haemostasis and thrombosis, besides other physiological and pathophysiological processes. These roles are tightly regulated by a complex network of signalling pathways. Mass spectrometry-based proteomic techniques are contributing not only to the identification and quantification of new platelet proteins, but also reveal post-translational modifications of these molecules, such as acetylation, glycosylation and phosphorylation. Moreover, target proteomic analysis of platelets can provide molecular biomarkers for genetic aberrations with established or non-established links to platelet dysfunctions. In this report, we review …
Inverse Conformational Selection in Lipid–Protein Binding
2021
International audience; Interest in lipid interactions with proteins and other biomolecules is emerging not only in fundamental biochemistry but also in the field of nanobiotechnology where lipids are commonly used, for example, in carriers of mRNA vaccines. The outward-facing components of cellular membranes and lipid nanoparticles, the lipid headgroups, regulate membrane interactions with approaching substances, such as proteins, drugs, RNA, or viruses. Because lipid headgroup conformational ensembles have not been experimentally determined in physiologically relevant conditions, an essential question about their interactions with other biomolecules remains unanswered: Do headgroups excha…
La garde-robe de Notre-Dame de Bon-Espoir et ses ornements
2021
International audience
Pathogenic lipid‐binding antiphospholipid antibodies are associated with severity of COVID‐19
2021
Abstract Background Coronavirus disease 19 (COVID‐19)–associated coagulopathy is a hallmark of disease severity and poor prognosis. The key manifestations of this prothrombotic syndrome—microvascular thrombosis, stroke, and venous and pulmonary clots—are also observed in severe and catastrophic antiphospholipid syndrome. Antiphospholipid antibodies (aPL) are detectable in COVID‐19 patients, but their association with the clinical course of COVID‐19 remains unproven. Objectives To analyze the presence and relevance of lipid‐binding aPL in hospitalized COVID‐19 patients. Methods Two cohorts of 53 and 121 patients from a single center hospitalized for PCR‐proven severe acute respiratory syndro…
Quantifying transmission fitness costs of multi-drug resistant tuberculosis.
2021
As multi-drug resistant tuberculosis (MDR-TB) continues to spread, investigating the transmission potential of different drug-resistant strains becomes an ever more pressing topic in public health. While phylogenetic and transmission tree inferences provide valuable insight into possible transmission chains, phylodynamic inference combines evolutionary and epidemiological analyses to estimate the parameters of the underlying epidemiological processes, allowing us to describe the overall dynamics of disease spread in the population. In this study, we introduce an approach to Mycobacterium tuberculosis (M. tuberculosis) phylodynamic analysis employing an existing computationally efficient mod…
The solution behavior of dopamine in the presence of mono and divalent cations: A thermodynamic investigation in different experimental conditions
2021
The interactions of dopamine [2-(3,4-Dihydroxyphenyl)ethylamine, (Dop-)] with methylmercury(II) (CH3Hg+), magnesium(II), calcium(II), and tin(II) were studied in NaCl(aq) at different ionic strengths and temperatures. Different speciation models were obtained, mainly characterized by mononuclear species. Only for Sn2+ we observed the formation of binuclear complexes (M2L2 and M2LOH (charge omitted for simplicity)
Effects of 5-Azacitidine on Dnmt2/Trdmt1 expression levels and endoplasmic reticulum stress in cellular models of insulinoma
2021
Diabetes mellitus affects people all over the world of all ages or social groups making it a worldwide healthcare challenge. Moreover, untreated or badly treated diabetes carries a risk of serious complications including premature death (IDF Diabetes Atlas 9th edition, 2019). The main symptom of diabetes is insulin secretion and/or action disorder leading to hyperglycemia what results in impaired carbohydrate, fat, and protein metabolism (“Diagnosis and Classification of Diabetes Mellitus,” 2013). Dnmt2/ Trdmt1 in its structure and sequence is similar to DNA methyltransferases, however, it has been shown that mainly methylates aspartic acid transfer RNA, specifically at the cytosine-38 resi…
An emergent infectious disease: Clostridioides difficile infection hospitalizations, 10-year trend in Sicily
2021
Abstract Background Clostridioides difficile is the most common cause of healthcare-associated diarrhoea worldwide and C. difficile infection is an emerging infectious disease. In the US, its rates are monitored trough an active surveillance system, but many European Union member states still lack this, and in Italy no epidemiological data on C. difficile infection are available except for a few single-centre data. Aim To provide data on the C. difficile infection incidence in Sicily (the biggest and 5th most populous region of Italy) during a 10-year period. Methods We revised all the regional standardized discharge forms between 2009 and June 2019 using the code ICD-9 00845 of the Interna…
Arteriosclerosis and other diseases in heads of government and its consequences for the population.
2021
Abstract Heads of government with cerebrovascular arteriosclerosis and other diseases in key historical moments have led to decisions that have marked the destiny of countries not always in a beneficial direction. Severe diseases in political leaders in power have often been hidden from citiziens with the collaboration of personal physicians. The confidentiality of the patient-doctor relationship in special political circumstances should be re examined and subjected to debate. Legal provisions to ensure total transparency of medical information about the health of heads of government should be implemented. Transparency ensures the trust of citizens.
Acoustic Emission-Based Condition Monitoring and Remaining Useful Life Prediction of Hydraulic Cylinder Rod Seals
2021
The foremost reason for unscheduled maintenance of hydraulic cylinders in industry is caused by wear of the hydraulic seals. Therefore, condition monitoring and subsequent estimation of remaining useful life (RUL) methods are highly sought after by the maintenance professionals. This study aimed at investigating the use of acoustic emission (AE) sensors to identify the early stages of external leakage initiation in hydraulic cylinders through run to failure studies (RTF) in a test rig. In this study, the impact of sensor location and rod speeds on the AE signal were investigated using both time- and frequency-based features. Furthermore, a frequency domain analysis was conducted to investig…
Financial Stress and Basis in Energy Markets
2021
We investigate the relationship between energy commodities bases, inventory and financial stress from 1994 to 2018. We find that, from the 1998 Asian crisis the effect of financial stress on energy commodities bases gradually increased and from the 2008 crisis became positive, while the effect of inventory showed a gradual decline over time. The reactions of bases to changes in financial stress is nonlinear, as they are higher in the high financial stress periods. This is more profound in crude oil market than heating oil and natural gas. Moreover, the reactions of bases to the changes in inventory is nonlinear, as the reactions are lower when the inventory level is high confirming the theo…
Les réadmissions après résection pulmonaire en France : la base de données du PMSI
2021
BACKGROUND Readmission within 30 days is an indicator of the quality of care, because it often reflects post-discharge care that is not optimal. The objective of this work is to measure over time on the one hand the readmission rate and on the other hand the number of hospitals with a standardized readmission rate beyond the national average. METHOD All patients with major pulmonary resection for lung cancer in France were extracted from the PMSI national database. Readmission within 30 days was defined as any new hospitalization either in the same hospital or in another establishment. RESULTS From January 1, 2005 to December 31, 2018, 110,603 patients were included. The 30-day all-cause re…
Pathways towards a sustainable future envisioned by early-career conservation researchers
2021
Scientists have warned decision-makers about the severe consequences of the global environmental crisis since the 1970s. Yet ecological degradation continues and little has been done to address climate change. We investigated early-career conservation researchers' (ECR) perspectives on, and prioritization of, actions furthering sustainability. We conducted a survey (n = 67) and an interactive workshop (n = 35) for ECR attendees of the 5th European Congress of Conservation Biology (2018). Building on these data and discussions, we identified ongoing and forthcoming advances in conservation science. These include increased transdisciplinarity, science communication, advocacy in conservati…
A Solution for Medical Information Management
2021
Abstract Nowadays, the amount of data that is being generated by medical devices has exponentially increased. The aim of this paper is to develop an integrated health data management tool, that aggregates data from various sources, which are in various formats. With the aid of artificial intelligence (AI), this data will be processed and will help healthcare professionals be aware of the improvements that could make the healthcare system be more preventive, predictive and personalized. This paper introduces an integrated medical information management system – that intends to manage medical activities in hospitals, clinics and laboratories and describes its development and future directions…
Creating space for interpreting within extended turns at talk
2021
Abstract In consecutively interpreted conversations, long multi-unit turns pose an interactional problem, as the interpreter may need to intervene into the turn space of the current speaker to interpret. This paper explores multimodal practices employed by medical professionals and interpreters to manage the temporary suspension of extended turns-in-progress. Using data from video-interpreted hospital encounters, we show how video-mediation poses challenges to the fine-tuned coordination involved in creating temporary suspension. We identify one practice used by medical professionals by which they produce turns in several chunks, or ‘installments’, temporarily suspending the ongoing turn an…
Bio-inspired Ni dinuclear complexes as heterogeneous catalysts for hydrogen evolution
2021
Abstract A major challenge in the sustainable production of hydrogen is lowering the electrochemical overpotential and the activation energy of the hydrogen evolution reaction. Some enzymes have two metallic Ni centers and catalyze this reaction with high activity. Taking inspiration from them, we have developed two novel dinuclear Ni(II) complexes, Ni-PATIO and Ni-PACO, with promise as molecular catalysts. Ni-PACO exhibits a square-planar geometry for both Ni(II) and two-fold rotational symmetry both in solid and solution states, whereas Ni-PATIO displays one square-planar Ni(II) center and one octahedral Ni(II) configuration, which confer it magnetic properties. We show that both complexe…
Apport des plateformes de partage photographique pour l'identification des préférences paysagères
2021
International audience
Adsorption of water in Na-LTA zeolites: an ab initio molecular dynamics investigation
2021
The very wide range of applications of LTA zeolites, including the storage of tritiated water, implies that a detailed and accurate atomic-scale description of the adsorption processes taking place in their structure is crucial. To unravel with an unprecedented accuracy the mechanisms behind the water filling in NaA, we have conducted a systematic ab initio molecular dynamics investigation. Two LTA structural models, the conventional Z4A and the reduced one ZK4, have been used for static and dynamic ab initio calculations, respectively. After assessing this reduced model with comparative static DFT calculations, we start the filling of the α and β cages by water, molecule by molecule. This …
Georadar Investigations in the Church of San Paolo (San Giacomo Dei Militari, Palermo).
2021
Summary As part of a research project aimed at drawing up a restoration project for the church of San Paolo, the monument was investigated with georadar surveys. The investigations were followed in a targeted manner by archaeological excavations, under the supervision of the Superintendence of Cultural and Environmental Heritage of Palermo. The San Paolo church is located in the oldest part of the city. The geophysical investigations will be useful to identify any pre-existing structures on which the church could be founded. The georadar investigations focused on the central nave and one of the side aisles to identify buried structures and crypts. The data showed several anomalies. One of t…