Città (in)vivibili

2021

Questo volume è strutturato in tre parti e raccoglie i contributi di studiosi con lunga esperienza e di giovani ricercatori che hanno voluto incuriosire il lettore con appassionanti e complessi viaggi in città (in)vivibili. This volume is structured in three parts and collects the contributions of scholars with long experience and young researchers who wanted to intrigue the reader with exciting and complex trips to (in) livable cities.

Linear Response Theory with finite-range interactions

2021

International audience; This review focuses on the calculation of infinite nuclear matter response functions using phenomenological finite-range interactions, equipped or not with tensor terms. These include Gogny and Nakada families, which are commonly used in the literature. Because of the finite-range, the main technical difficulty stems from the exchange terms of the particle–hole interaction. We first present results based on the so-called Landau and Landau-like approximations of the particle–hole interaction. Then, we review two methods which in principle provide numerically exact response functions. The first one is based on a multipolar expansion of both the particle–hole interactio…

Towards the Point of Care and Noninvasive Classification of Bladder Cancer from Urine Sediment Infrared Spectroscopy. Spectral differentiation of nor…

2021

Abstract Bladder cancer (BC) is the 9th cancer cause of death and one of most cost-intensive in the world. The diagnostic tools are still not at all satisfactory. Herein we evaluated the potential of infrared spectroscopy to detect molecular changes that precede and accompany the carcinogenesis in voided urine sediment. We collected 165 samples from patients being diagnosed for BC and measured them with attenuated total reflectance Fourier transformed infrared spectroscopy (ATR FTIR). Samples were primarily divided into three groups according to cytology that indicated the presence of normal, abnormal and cancer cells. ATR FTIR spectra of sediments were analyzed with the use of partial leas…

Partnership educativa tra scuola e Organizzazioni No Profit

2021

Attraverso il lavoro di ricerca svolto in tre differenti paesi europei, è stato messo a fuoco il tema della cooperazione tra le organizzazioni no profit (ONP) e le istituzioni scolastiche nella presa in carico educativa di minori di madrelingua differente da quella del Paese ospitante. Il lavoro muove dalla convinzione che in questo periodo di rapidi e drammatici cambiamenti derivanti da trasformazioni geopolitiche in tutto il mondo, il settore no profit, con la sua politica flessibile e indipendente, possa contribuire alla stabilizzazione di una situazione che richiede grande attenzione educativa.

Did the covid-19 pandemic change hip fracture incidence in elderly?

2021

The purpose of this study was to analyze the impact of the national lockdown on femoral neck fractures occurred in the elderly in an Italian city with more than 650 thousand people. We analyzed data related to patients over 65 years-old with femoral neck fractures admitted between March 9th and April 24th, 2020 to five public Hospitals in Palermo and four private Hospitals during lockdown. A total of 152 patients with hip fracture were observed with a significant reduction compared with the same period in 2017-2019. During the Lockdown period a reduction was observed of the mean age from 84.2 ±2.6 years old to 82.5±1.2 with a higher incidence in males, particularly in < 80-year-olds. The…

Numerical study of soliton stability, resolution and interactions in the 3D Zakharov–Kuznetsov equation

2021

International audience; We present a detailed numerical study of solutions to the Zakharov-Kuznetsov equation in three spatial dimensions. The equation is a three-dimensional generalization of the Korteweg-de Vries equation, though, not completely integrable. This equation is L-2-subcritical, and thus, solutions exist globally, for example, in the H-1 energy space.We first study stability of solitons with various perturbations in sizes and symmetry, and show asymptotic stability and formation of radiation, confirming the asymptotic stability result in Farah et al. (0000) for a larger class of initial data. We then investigate the solution behavior for different localizations and rates of de…

Phase I dose-escalation single centre clinical trial to evaluate the safety of infusion of memory T cells as adoptive therapy in COVID-19 (RELEASE)

2021

Abstract Background Effective treatments are still needed to reduce the severity of symptoms, time of hospitalization, and mortality of COVID-19. SARS-CoV-2 specific memory T-lymphocytes obtained from convalescent donors recovered can be used as passive cell immunotherapy. Methods Between September and November 2020 a phase 1, dose-escalation, single centre clinical trial was conducted to evaluate the safety and feasibility of the infusion of CD45RA− memory T cells containing SARS-CoV-2 specific T cells as adoptive cell therapy against moderate/severe cases of COVID-19. Nine participants with pneumonia and/or lymphopenia and with at least one human leukocyte antigen (HLA) match with the don…

First Principles Calculations of Atomic and Electronic Structure of TiAl3+- and TiAl2+-Doped YAlO3

2021

In this paper, the density functional theory accompanied with linear combination of atomic orbitals (LCAO) method is applied to study the atomic and electronic structure of the Ti3+ and Ti2+ ions substituted for the host Al atom in orthorhombic Pbnm bulk YAlO3 crystals. The disordered crystalline structure of YAlO3 was modelled in a large supercell containing 160 atoms, allowing simulation of a substitutional dopant with a concentration of about 3%. In the case of the Ti2+-doped YAlO3, compensated F-center (oxygen vacancy with two trapped electrons) is inserted close to the Ti to make the unit cell neutral. Changes of the interatomic distances and angles between the chemical bonds in the de…

Granulomas en dermatopatología: principales entidades. Parte II

2021

Part 2 of this series on granulomatous diseases focuses on skin biopsy findings. Whereas the first part treated noninfectious conditions (metabolic disorders and tumors, among other conditions), this part mainly deals with various types of infectious disease along with other conditions seen fairly often by clinical dermatologists.

Estrategias ante el uso de Internet por población usuaria en Atención Primaria: una clasificación sociológica

2021

Resumen: Objetivo: Analizar y clasificar las estrategias comunicativas que desarrollan los/las profesionales de atención primaria de salud de la Comunitat Valenciana ante el uso de Internet como fuente de información de salud por parte de la población usuaria, a través de las categorías analíticas de poder y control que, según Basil Bernstein, caracterizan los procesos de comunicación de los encuentros terapéuticos. Método: Estudio cualitativo mediante entrevistas en profundidad a profesionales de atención primaria de salud de la Comunitat Valenciana (n = 18). Para el análisis de los discursos se ha aplicado el lenguaje de descripción de la teoría de Bernstein con el objetivo de clasificar …

Sand Play for 0–8-Year-Old Children’s Health and Development: A Systematic Review Protocol

2021

Sand play may be a significant determinant of health and development in early childhood, but systematically synthesised evidence is absent in the literature. The main objective of this study was to present a planned methodology to systematically review, and synthesise, the evidence regarding sand play and its associations with 0–8-year-old children’s health and development. The systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols statement was registered to PROSPERO (CRD42021253852). Literature searches will be conducted using information from eight electronic databases. Studies will be included when participating children were aged 0–…

Volcanic Lakes in Africa: The VOLADA_Africa 2.0 Database, and Implications for Volcanic Hazard

2021

Volcanic lakes pose specific hazards inherent to the presence of water: phreatic and phreatomagmatic eruptions, lahars, limnic gas bursts and dispersion of brines in the hydrological network. Here we introduce the updated, interactive and open-access database for African volcanic lakes, country by country. The previous database VOLADA (VOlcanic LAke DAta Base, Rouwet et al., Journal of Volcanology and Geothermal Research, 2014, 272, 78–97) reported 96 volcanic lakes for Africa. This number is now revised and established at 220, converting VOLADA_Africa 2.0 in the most comprehensive resource for African volcanic lakes: 81 in Uganda, 37 in Kenya, 33 in Cameroon, 28 in Madagascar, 19 in Ethiop…

THE ROLE OF HYDROLOGICAL PROCESSES ON ENHANCED WEATHERING FOR CARBON SEQUESTRATION IN AGRICULTURAL SOILS

2021

With the aim to face climate change, some NCS (Natural Climate Solutions) are currently studied given their capability to sequester carbon from the atmospheric CO2, by means of some natural processes, and to store it within oceans, plants, soil, or other terrestrial environments. Among all the existing NCS, Enhanced Weathering (EW) acts in speeding up the chemical weathering that naturally occurs in soils. This is achieved by amending soils with crushed highly reactive silicate minerals, such as forsterite, better known as olivine. In general, EW reactions are faster at high temperature and soil water content and low soil pH, demonstrating that the most suitable places in the world to apply…

Questioning the Canon and Re-Writing/Re-Righting the Female Colonized Subject: Mary Seacole’s Wonderful Adventures and George Bernard Shaw’s The Adve…

2021

Albeit different in terms of formal solutions and conception, Mary Seacole’s 'Wonderful Adventures' (1857) and G.B. Shaw’s 'The Adventures of the Black Girl in Her Search for God' (1932) share an oppositional aesthetics which, in both cases, helps undermine any prevailing representation of the colonial Other. Indeed, Seacole’s and Shaw’s works manipulate the trope of travel in such a way as to overcome traditional conceptions of the literary canon as well as hegemonic visions of subjectivities. In taking into consideration the innovative representation of the Black colonized woman as delineated in both works, the essay aims to show the way in which they present an anti-normative identity mo…

Effect of genetic variation in CYP450 on Gonadal impairment in a European cohort of female childhood cancer survivors, based on a candidate gene appr…

2021

Background: Female childhood cancer survivors (CCSs) carry a risk of therapy-related gonadal dysfunction. Alkylating agents (AA) are well-established risk factors, yet inter-individual variability in ovarian function is observed. Polymorphisms in CYP450 enzymes may explain this variability in AA-induced ovarian damage. We aimed to evaluate associations between previously identified genetic polymorphisms in CYP450 enzymes and AA-related ovarian function among adult CCSs. Methods: Anti-Müllerian hormone (AMH) levels served as a proxy for ovarian function in a discovery cohort of adult female CCSs, from the pan-European PanCareLIFE cohort (n = 743

Statistical upscaling of ecosystem CO2 fluxes across the terrestrial tundra and boreal domain: Regional patterns and uncertainties

2021

The regional variability in tundra and boreal carbon dioxide (CO2) fluxes can be high, complicating efforts to quantify sink-source patterns across the entire region. Statistical models are increasingly used to predict (i.e., upscale) CO2 fluxes across large spatial domains, but the reliability of different modeling techniques, each with different specifications and assumptions, has not been assessed in detail. Here, we compile eddy covariance and chamber measurements of annual and growing season CO2 fluxes of gross primary productivity (GPP), ecosystem respiration (ER), and net ecosystem exchange (NEE) during 1990–2015 from 148 terrestrial high-latitude (i.e., tundra and boreal) sites to a…

Distinct single-component adjuvants steer human DC-mediated T-cell polarization via Toll-like receptor signaling toward a potent antiviral immune res…

2021

Significance Vaccines profit from the addition of adjuvants to better and more specifically initiate, amplify, and shape immune responses. Although the number of adjuvant candidates has steadily increased, peaking in the current SARS-CoV-2 pandemic, little is known about their inherent mode of action. Using human blood immune cells, we established a multilayer method to systematically assess the adjuvants’ effects on innate and adaptive immune cells. By employing a multiplex analysis with cells from 30 different donors, we determined important patterns of adjuvant function. Moreover, we demonstrate correlates of an antiviral immune response using a Toll-like receptor 7/8 ligand adjuvant and…

Metabolic Syndrome: From Molecular Mechanisms to Novel Therapies

2021

The metabolic syndrome (MetS) consists of a cluster of metabolic abnormalities including central obesity, insulin resistance, glucose intolerance, hypertension, and atherogenic dyslipidemia [...]

Dietary Glycaemic Index Labelling: A Global Perspective

2021

The glycaemic index (GI) is a food metric that ranks the acute impact of available (digestible) carbohydrates on blood glucose. At present, few countries regulate the inclusion of GI on food labels even though the information may assist consumers to manage blood glucose levels. Australia and New Zealand regulate GI claims as nutrition content claims and also recognize the GI Foundation’s certified Low GI trademark as an endorsement. The GI Foundation of South Africa endorses foods with low, medium and high GI symbols. In Asia, Singapore’s Healthier Choice Symbol has specific provisions for low GI claims. Low GI claims are also permitted on food labels in India. In China, there are no nation…

Electrochemical conversion of CO2 to formic acid using a Sn based electrode: A critical review on the state-of-the-art technologies and their potenti…

2021

Abstract The electrochemical conversion of carbon dioxide is considered one of the most promising strategies to convert waste-CO2 into value-added chemicals. This review focuses on the synthesis of formic acid/formate in aqueous electrolyte using Sn-based cathodes; this material is considered relatively cheap and shows promising results in terms of faradaic efficiency. In order to be suitable at an industrial scale, the process should present simultaneously high current densities, faradaic efficiencies close to 100%, high concentrations of formic acid and long-term stability. Analysing the main results reported in the literature, it was observed that to date further studies are necessary to…

Applying the trans-contextual model to promote sport injury prevention behaviors among secondary school students.

2021

The current study tested the effects of an intervention based on the trans-contextual model (TCM) on secondary school PE students' sport injury prevention behavior and on theory-based motivational and social cognition mediators. Participants were PE students (N = 1168; Mage = 13.322 ± 1.045, range = 12-16; female = 51.721%) who participated in a 3-month cluster-randomized controlled trial. Schools were randomly assigned to a treatment group, in which PE teachers received training to be more supportive of psychological needs in teaching sport injury prevention, or a control group, in which PE teachers received no training. Participants completed survey measures of TCM variables and self-rep…

Aposematism facilitates the diversification of parental care strategies in poison frogs

2021

AbstractMany organisms have evolved adaptations to increase the odds of survival of their offspring. Parental care has evolved several times in animals including ectotherms. In amphibians, ~ 10% of species exhibit parental care. Among these, poison frogs (Dendrobatidae) are well-known for their extensive care, which includes egg guarding, larval transport, and specialized tadpole provisioning with trophic eggs. At least one third of dendrobatids displaying aposematism by exhibiting warning coloration that informs potential predators about the presence of defensive skin toxins. Aposematism has a central role in poison frog diversification, including diet specialization, and visual and acoust…

Investigation of the Sympathetic Regulation in Delayed Onset Muscle Soreness: Results of an RCT

2021

Sports-related pain and injury is directly linked to tissue inflammation, thus involving the autonomic nervous system (ANS). In the present experimental study, we disable the sympathetic part of the ANS by applying a stellate ganglion block (SGB) in an experimental model of delayed onset muscle soreness (DOMS) of the biceps muscle. We included 45 healthy participants (female 11, male 34, age 24.16 ± 6.67 years [range 18–53], BMI 23.22 ± 2.09 kg/m2) who were equally randomized to receive either (i) an SGB prior to exercise-induced DOMS (preventive), (ii) sham intervention in addition to DOMS (control/sham), or (iii) SGB after the induction of DOMS (rehabilitative). The aim of the study was t…

Acute tissue damage induced by monopolar microelectrodes and radiofrequency in vocal cords after transoral cordectomy

2021

Abstract Introduction: In 2006 and 2009, we reported the levels of acute and chronic tissue damage after cordectomy associated with use of the microlectrodes using high frequency energy. In 2010, we shifted to radiofrequency rather than high frequency electrogenerators. Objective: The aim of this study is to evaluate acute tissue damage in the larynx after cordectomy using microelectrodes coupled to a radiofrequencygenerator. Methods: We studied 22 patients with a stage T1 glottic squamous cell carcinoma. The patients were randomly assigned to the two operating mode: cutting or coagulation (11 patients each mode). The strength of the study is that there are no previous studies on the effect…

British-American Contrasts in the Use of the Past Perfect: Negotiating Ambiguity versus Redundancy?

2021

Abstract The present study provides an empirical analysis of British-American contrasts in the overall use of the past perfect as well as its functional distribution. Studies on variation according to national variety report a decline of the past perfect spearheaded by American English (cf. Elsness, J. 1997. The Perfect and Preterite in Contemporary and Earlier English (Topics in English Linguistics 21). Berlin: Mouton de Gruyte; Bowie, J., S. Wallis, and B. Aarts. 2013. “The Perfect in Spoken British English.” In The Verb Phrase in English. Investigating Recent Language Change with Corpora, edited by B. Aarts, J. Close, G. Leech, and S. Wallis, 318–52. Cambridge: Cambridge University Press…

1624P Impact of the COVID-19 pandemic in the cancer fast-track programme

2021

Background: The COVID-19 pandemic has disrupted many aspects of clinical practice in oncology, particularly in making timely cancer diagnosis. Our public health system has been concerned about potential delays leading to a higher proportion of patients with advanced stages. Our cancer diagnosis fast-track program (CFP) in the Clinic-Malvarrosa Health department in Valencia (Spain) is connecting primary care (PC) with different specialists to speed cancer diagnosis and treatment upon well founded suspicion. A 10-year evaluation of our CFP has recently been published. The aim of this analysis was to investigate the impact of the COVID-19 pandemic on the CFP. Methods: We analysed the programme…

Mental Health Status of Healthcare Workers During the COVID-19 Outbreak

2021

Background: The COVID-19 pandemic is a massive health crisis that has exerted enormous physical and psychological pressure. Mental healthcare for healthcare workers (HCWs) should receive serious consideration. This study served to determine the mental-health outcomes of 1,556 HCWs from 45 countries who participated in the COVID-19 IMPACT project, and to examine the predictors of the outcomes during the first pandemic wave. Methods: Outcomes assessed were self-reported perceived stress, depression symptom, and sleep changes. The predictors examined included sociodemographic factors and perceived social support. Results: The results demonstrated that half of the HCWs had moderate levels of pe…

Recent developments, current challenges, and future directions in electrophysiological approaches to studying intelligence

2021

Abstract EEG studies represent an important sub-discipline in the field of intelligence research and have significant potential to advance the theoretical understanding and practical applications of the construct. This commentary reviews key themes and major developments in the field from the last several decades, and outlines open questions and future directions for the next phase of research. Two main areas of progress in recent years relate to (1) improvements in study design and psychometric approaches, and (2) increased integration with cognitive psychology and neuroscience. In turn, these advances have clarified several themes and pressing issues. These include: The need to establish …

51P Pooled analysis safety profile of futibatinib in patients with advanced solid tumors, including intrahepatic cholangiocarcinoma (iCCA)

2021

Micromechanical Modeling of Aortic Pathologies

2021

Geografie del collasso. L'Antropocene in 9 parole chiave

2021

Covid-19 è il primo grande trauma collettivo dell’Antropocene, una catena di eventi materiali, culturali e sociali che stanno aggredendo il nostro immaginario con un impatto incalcolabile. Un effetto profondo della pandemia sarà costringere l’umanità al prossimo step cognitivo: l’accettazione della fine della pace climatica dell’Olocene. Abbiamo bisogno di tempo, ma il tempo a disposizione è poco. Negare il trauma, fare come l’erbivoro assalito dalla belva che si anestetizza per non vedere la fine è qualcosa che non possiamo permetterci. Dissoluzione degli ecosistemi terrestri, questione animale, mutamento climatico, inquinamento e dissesto demografico, diaspora, populismo, suprematismo, er…

Toll Like Receptors as Sensors of the Tumor Microbial Dysbiosis: Implications in Cancer Progression

2021

Microbiota is a complex ecosystem of active microorganisms resident in the body of mammals. Although the majority of these microorganisms resides at the distal gastrointestinal tract, high-throughput DNA sequencing technology have made possible to understand that several other tissues of the human body host their own microbiota, even those once considered sterile, such as lung tissue. These bacterial communities have important functions in maintaining a healthy body state and the host immune system has evolved multiple mechanisms by which maintaining a symbiotic relationship with the microbiota. The maintenance of this dialogue allows the induction of protective responses to pathogens and r…

Association between food insecurity and fall-related injury among adults aged ≥65 years in low- and middle-income countries: The role of mental healt…

2021

Purpose:\ud \ud We investigated the association between food insecurity and fall-related injury among older adults from six low- and middle-income countries (LMICs), and the extent to which this association is mediated by mental health.\ud \ud Methods:\ud \ud Cross-sectional, community-based, nationally representative data from the WHO Study on global AGEing and adult health (SAGE) were analyzed. Past 12-month food insecurity was assessed with two questions on frequency of eating less and hunger due to lack of food. Fall-related injury referred to those that occurred in the past 12 months. Multivariable logistic regression analysis and mediation analysis were conducted to assess association…

Development of Network Security Education

2021

Distance education has grown tremendously over the last decade. Internet technologies have enabled a large-scale dispensation of lectures, exercises, and training. Virtual Learning Management Systems (LMSs) offer a number of tools to realize distance education and distance learning. In this work, we present a virtual system architecture for training cyber security professionals with hands-on skills. The architecture is based on a VirtualBox virtualization environment. Guest machines are installed on an instance of VirtualBox. The installed environment offers a safe and isolated workbench for experiments. After installation and configuration of the environment, students perform a number of i…

Impaired cognitive control in patients with brain tumors

2021

Though the assessment of cognitive functions is proven to be a reliable prognostic indicator in patients with brain tumors, some of these functions, such as cognitive control, are still rarely investigated. The objective of this study was to examine proactive and reactive control functions in patients with focal brain tumors and to identify lesioned brain areas more at "risk" for developing impairment of these functions. To this end, a group of twenty-two patients, candidate to surgery, were tested with an AX-CPT task and a Stroop task, along with a clinical neuropsychological assessment, and their performance was compared to that of a well-matched healthy control group. Although overall ac…

Asymmetric and symmetric fission of excited nuclei of Hg180,190 and Pb184,192,202 formed in the reactions with Ar36 and Ca40,48 ions

2021

Background: Observation of asymmetric fission of $^{180}\mathrm{Hg}$ has led to intensive theoretical and experimental studies of fission of neutron-deficient nuclei in the lead region.Purpose: The study of asymmetric and symmetric fission modes of $^{180,190}\mathrm{Hg}$ and $^{184,192,202}\mathrm{Pb}$ nuclei.Methods: Mass-energy distributions of fission fragments of $^{180,190}\mathrm{Hg}$ and $^{184}\mathrm{Pb}$ formed in the $^{36}\mathrm{Ar}+^{144,154}\mathrm{Sm}$ and $^{40}\mathrm{Ca}+^{144}\mathrm{Sm}$ reactions, respectively, at energies near the Coulomb barrier have been measured using the double-arm time-of-flight spectrometer CORSET and compared with previously measured $^{192,20…