Singularities in L^p-quasidisks

2021

We study planar domains with exemplary boundary singularities of the form of cusps. A natural question is how much elastic energy is needed to flatten these cusps; that is, to remove singularities. We give, in a connection of quasidisks, a sharp integrability condition for the distortion function to answer this question. peerReviewed

Astrocytic potassium and calcium channels as integrators of the inflammatory and ischemic CNS microenvironment.

2021

Abstract Astrocytes are key regulators of their surroundings by receiving and integrating stimuli from their local microenvironment, thereby regulating glial and neuronal homeostasis. Cumulating evidence supports a plethora of heterogenic astrocyte subpopulations that differ morphologically and in their expression patterns of receptors, transporters and ion channels, as well as in their functional specialisation. Astrocytic heterogeneity is especially relevant under pathological conditions. In experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS), morphologically distinct astrocytic subtypes were identified and could be linked to transcriptome changes dur…

Effects of 24 h Compression Interventions with Different Garments on Recovery Markers during Running

2021

Compression and temperature manipulation are discussed as strategies to improve performance markers and recovery in sports. Here, we investigate the effects of compression stockings made with fabric, either combined or not with heating and cooling substances, on variables related to running performance and recovery. Ten trained runners (mean ± standard deviation age 45 ± 9 years old, body mass 69 ± 7 kg, height 166 ± 4 cm) with no experience of using compression garments performed an intense running session of 10 km, then wore a stocking for 24 h (randomized

Luminescence of non-bridging oxygen hole centers as a marker of particle irradiation of {\alpha}-quartz

2021

The origin of the "red" emission bands in the 600 nm-700 nm region, observed in quartz crystals used for luminescence dating and environmental dosimetry, is still controversial. Their reported spectral and lifetime characteristics are often similar to those of oxygen dangling bonds ("non-bridging oxygen hole centers, NBOHCs") in glassy silicon dioxide. The presence of these "surface radical type" centers in quartz crystal requires sites with highly disordered local structure forming nano-voids characteristic to the structure of glassy SiO2. Such sites are introduced in the tracks of nuclear particles ({\alpha}-irradiation, neutrons, ions). In case of electrons they are created only at large…

The nature of the extreme X-ray variability in the NLS1 1H 0707-495

2021

We examine archival XMM-Newton data on the extremely variable narrow-line Seyfert 1 (NLS1) active galactic nucleus (AGN) 1H 0707-495. We construct fractional excess variance (Fvar) spectra for each epoch, including the recent 2019 observation taken simultaneously with eROSITA. We explore both intrinsic and environmental absorption origins for the variability in different epochs, and examine the effect of the photoionised emission lines from outflowing gas. In particular, we show that the unusual soft variability first detected by eROSITA in 2019 is due to a combination of an obscuration event and strong suppression of the variance at 1 keV by photoionised emission, which makes the variance …

Role of RNA Motifs in RNA Interaction with Membrane Lipid Rafts: Implications for Therapeutic Applications of Exosomal RNAs

2021

RNA motifs may promote interactions with exosomes (EXO-motifs) and lipid rafts (RAFT-motifs) that are enriched in exosomal membranes. These interactions can promote selective RNA loading into exosomes. We quantified the affinity between RNA aptamers containing various EXO- and RAFT-motifs and membrane lipid rafts in a liposome model of exosomes by determining the dissociation constants. Analysis of the secondary structure of RNA molecules provided data about the possible location of EXO- and RAFT-motifs within the RNA structure. The affinity of RNAs containing RAFT-motifs (UUGU, UCCC, CUCC, CCCU) and some EXO-motifs (CCCU, UCCU) to rafted liposomes is higher in comparison to aptamers withou…

Statistical guidelines for quality control of next-generation sequencing techniques.

2021

Condition-specific statistical guidelines and accurate classification trees for quality control of functional genomics NGS files (RNA-seq, ChIP-seq and DNase-seq) have been generated using thousands of reference files from the ENCODE project and made available to the community.

Adaptive sparse representation of continuous input for tsetlin machines based on stochastic searching on the line

2021

This paper introduces a novel approach to representing continuous inputs in Tsetlin Machines (TMs). Instead of using one Tsetlin Automaton (TA) for every unique threshold found when Booleanizing continuous input, we employ two Stochastic Searching on the Line (SSL) automata to learn discriminative lower and upper bounds. The two resulting Boolean features are adapted to the rest of the clause by equipping each clause with its own team of SSLs, which update the bounds during the learning process. Two standard TAs finally decide whether to include the resulting features as part of the clause. In this way, only four automata altogether represent one continuous feature (instead of potentially h…

The use of zooplankton metrics to determine the trophic status and ecological potential: An approach in a large Mediterranean watershed.

2021

In the European Water Framework Directive, zooplankton was not included as a Biological Quality Element despite its important place in the aquatic trophic web. In the present study on zooplankton abundances and biomasses, we used several metrics to test their ability to detect differences among trophic statuses and ecological potential levels, and collected a large sum of data in more than 60 reservoirs at Ebro watershed, on more than 300 sampling occasions over 10 years. Our results indicate that most zooplankton metrics are correlated to environmental variables that determine reservoirs’ trophic states, especially chlorophyll a and total phosphorus. The metrics with better sensitivity to …

Collective-Mode Enhanced Matter-Wave Optics

2021

International audience; In contrast to light, matter-wave optics of quantum gases deals with interactions even in free space and for ensembles comprising millions of atoms. We exploit these interactions in a quantum degenerate gas as an adjustable lens for coherent atom optics. By combining an interaction-driven quadrupole-mode excitation of a Bose-Einstein condensate (BEC) with a magnetic lens, we form a time-domain matter-wave lens system. The focus is tuned by the strength of the lensing potential and the oscillatory phase of the quadrupole mode. By placing the focus at infinity, we lower the total internal kinetic energy of a BEC comprising 101(37) thousand atoms in three dimensions to …

A study on the stability of carbon nanoforms–polyimidazolium network hybrids in the conversion of co2 into cyclic carbonates

2021

Three different carbon nanoforms (CNFs), single-walled and multi-walled carbon nanotubes (SWCNTs, MWCNTs) and carbon nanohorns (CNHs), have been used as supports for the direct polymerization of variable amounts of a bis-vinylimidazolium salt. Transmission electron microscopy confirmed that all CNFs act as templates on the growth of the polymeric network, which perfectly covers the nanocarbons forming a cylindrical (SWCNTs, MWCNTs) or spherical (CNHs) coating. The stability of these hybrid materials was investigated in the conversion of CO2 into cyclic carbonate under high temperature and CO2 pressure. Compared with the homopolymerized monomer, nanotube-based materials display an improved c…

Imprinting the complex dielectric permittivity of liquids into the spintronic terahertz emission

2021

We report an approach in time-domain terahertz (THz) spectroscopy for measuring the dielectric response of liquids based on inherent properties of spintronic THz emitters (STEs). The THz electric field radiated from the STE is inversely proportional to the sum of the complex refractive indices of the media surrounding the thin metallic stack of the STE and the stack's conductivity. We demonstrate that by bringing a liquid in contact with the emitter, its complex refractive index and accordingly its dielectric response are imprinted into the radiated electromagnetic field from the emitter. We use water as the test liquid and ascertain its dielectric loss and permittivity in the range of ∼0.…

Addressing Delicate and Variable Cancer Morphology in Spectral Histopathology Using Canine Visceral Hemangiosarcoma.

2021

Addressing Delicate and Variable Cancer Morphology in Spectral Histopathology Using Canine Visceral Hemangiosarcoma. DOI: 10.1021/acs.analchem.0c05190 DATASET: The size of the raw data was too heavy, so Images were extracted and cleaned up using Massive supercomputer. (massive.org.au). SUMMARY_PLSDA: Describes the analysis by PLSDA. SUMMARY_RF: Describes de analysis by Random Forest. Optimodel_Images: Collection of homemade functions used in the data treatment NOTE: PLS_Toolbox from Eigenvector is needed for running the codes. I would like to acknowledge Dr. Alex Henderson (https://www.research.manchester.ac.uk/portal/alex.henderson.html) for providing the functions used for importing th…

Application of polydopamine functionalized zinc oxide for glucose biosensor design

2021

Zinc oxide (ZnO) nanostructures are widely used in optical sensors and biosensors. Functionalization of these nanostructures with polymers enables optical properties of ZnO to be tailored. Polydopamine (PDA) is a highly biocompatible polymer, which can be used as a versatile coating suitable for application in sensor and biosensor design. In this research, we have grown ZnO-based nanorods on the surface of ITO-modified glass-plated optically transparent electrodes (glass/ITO). Then the deposition of the PDA polymer layer on the surface of ZnO nanorods was performed from an aqueous PDA solution in such a way glass/ITO/ZnO-PDA structure was formed. The ZnO-PDA composite was characterized by S…

Effects of COVID‐19 lockdown on eating disorders and obesity: A systematic review and meta‐analysis

2021

Abstract Objective This systematic review and meta‐analysis aimed to examine: the pooled prevalence of symptomatic behaviours and mental health deterioration amongst individuals with eating disorders (EDs) and obesity during the COVID‐19 confinement. Moreover, we examined changes in EDs and distress before and during the confinement, and the association between psychosocial factors and EDs symptoms. Method A systematic search was carried out in biomedical databases from January 2020 to January 2021. Both cross‐sectional and longitudinal studies that used quantitative measures of ED symptoms and psychological distress during and after the COVID‐19 confinement were included. Results A total o…

The Role of e-Tutor Competencies in Postgraduate e-Learning Courses: Spotlight on Emotion Management

2021

The role of e-learning in the existing and challenging educational era is crucial. However, it is necessary to overcome some drawbacks such as feelings of isolation and a lack of emotional contact. In this sense, emotion management is a key driver of student satisfaction in e-learning, which is significantly related to students’ motivation, learning, cognitive strategies, self-regulation, and personality antecedents in the classroom. This article examines an online postgraduate course in financial statements auditing, describing the resources used by the e-tutor to conduct affective tutorials, reduce students’ feelings of isolation, increase student involvement, and achieve success in e-lea…

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2021

Tamarins are a distinct group of small sized New World monkeys with complex phylogenetic relationships and poorly studied cytogenetic traits. In this study, we applied molecular cytogenetic analyses by fluorescence in situ hybridization with probes specific for telomeric sequences and ribosomal DNA loci after DAPI/CMA3 staining on metaphases from five tamarin species, namely Leontocebus fuscicollis, Leontopithecus rosalia, Saguinus geoffroyi, Saguinus mystax and Saguinus oedipus, with the aim to investigate the distribution of repetitive sequences and their possible role in genome evolution. Our analyses revealed that all five examined species show similar karyotypes, 2n = 46, which differ …

Solitary Fibrous Tumor: Integration of Clinical, Morphologic, Immunohistochemical and Molecular Findings in Risk Stratification and Classification Ma…

2021

Although solitary fibrous tumors (SFTs) have an unpredictable evolution, some specific clinicopathologic factors have been associated with the final outcome. We retrieved clinical, pathological and molecular data of 97 patients with a histological diagnosis of SFT and Signal transducer and activator of transcription 6 (STAT6) positivity. We retrospectively studied the pathological factors predictive of recurrence/metastasis and compared them with the clinical outcome. A wide immunohistochemical study and molecular analysis to detect NAB2/STAT6 gene fusion, tumor protein-53 (TP53) and/or (telomerase reverse transcriptase) TERT promotor mutation were performed. The risk of metastasis was calc…

An aphasia research agenda–a consensus statement from the collaboration of aphasia trialists

2021

Coordination of international aphasia research would minimise duplication of effort, support synergistic international activities across languages and multidisciplinary perspectives, and promote high-quality conduct and reporting of aphasia research, thereby increasing the relevance, transparency, and implementation of findings. The Collaboration of Aphasia Trialists (CATs) sought to develop an aphasia research agenda to direct future research activities, based on priorities shared by people with aphasia, family members, and healthcare professionals. Our established international research network spanning 33 countries contributed to this activity. Research literature reporting the prioritie…

Classification of Plant Ecological Units in Heterogeneous Semi-Steppe Rangelands: Performance Assessment of Four Classification Algorithms.

2021

Plant Ecological Unit’s (PEUs) are the abstraction of vegetation communities that occur on a site which similarly respond to management actions and natural disturbances. Identification and monitoring of PEUs in a heterogeneous landscape is the most difficult task in medium resolution satellite images datasets. The main objective of this study is to compare pixel-based classification versus object-based classification for accurately classifying PEUs with four selected different algorithms across heterogeneous rangelands in Central Zagros, Iran. We used images of Landsat-8 OLI that were pan-sharpened to 15 m to classify four PEU classes based on a random dataset collected in the field (40%). …

More data on ancient human mitogenome variability in Italy: new mitochondrial genome sequences from three Upper Palaeolithic burials.

2021

BACKGROUND: Recently, the study of mitochondrial variability in ancient humans has allowed the definition of population dynamics that characterised Europe in the Late Pleistocene and Early Holocene. Despite the abundance of sites and skeletal remains few data are available for Italy. - AIM: We reconstructed the mitochondrial genomes of three Upper Palaeolithic individuals for some of the most important Italian archaeological contexts: Paglicci (South-Eastern Italy), San Teodoro (South-Western Italy) and Arene Candide (North-Western Italy) caves. - SUBJECTS AND METHODS We explored the phylogenetic relationships of the three mitogenomes in the context of Western Eurasian ancient and modern va…

Protective, antioxidant and antiproliferative activity of grapefruit integropectin on sh-sy5y cells

2021

Tested in vitro on SH-SY5Y neuroblastoma cells, grapefruit IntegroPectin is a powerful protective, antioxidant and antiproliferative agent. The strong antioxidant properties of this new citrus pectin, and its ability to preserve mitochondrial membrane potential and morphology, severely impaired in neurodegenerative disorders, make it an attractive therapeutic and preventive agent for the treatment of oxidative stress-associated brain disorders. Similarly, the ability of this pectic polymer rich in RG-I regions, as well as in naringin, linalool, linalool oxide and limonene adsorbed at the outer surface, to inhibit cell proliferation or even kill, at high doses, neoplastic cells may have open…

Solid and Semisolid Innovative Formulations Containing Miconazole-Loaded Solid Lipid Microparticles to Promote Drug Entrapment into the Buccal Mucosa

2021

The currently available antifungal therapy for oral candidiasis (OC) has various limita- tions restricting its clinical use, such as short retention time, suboptimal drug concentration and low patients compliance. These issues could be overcome using micro or nanotechnology. In par- ticular, solid lipid microparticles (SLMs) resulted as a particularly promising penetration enhancer carrier for lipophilic drugs, such as the antifungal miconazole (MCZ). Based on these considera- tions, cetyl decanoate (here synthesized without the use of metal catalysis) was employed together with 1-hexadecanol to prepare MCZ-loaded SLMs. These resulted in a powder composed of 45–300 µm diameter solid spheric…

The defendant’s guilt beyond a reasonable doubt in the Italian criminal justice system

2021

The criminal law standard of Beyond A Reasonable Doubt (BARD) constitutes an evidentiary and judicial rule, formulated and applied for centuries in common law jurisdictions, which was expressly stated in the Italian Code of Criminal Procedure only about fifteen years ago. Unfortunately, the concept of reasonable doubt is inherently complex and does not easily lend itself to definition or refinement. In this regard, the Author examines especially the various positions and elaborations developed by legal literature and case-law in Italy, proposing a specific interpretation of the BARD rule that enhances and completes the particular procedural connotations of the adversarial system adopted i…

false

2021

The cell—cell signaling gene CDH13 is associated with a wide spectrum of neuropsychiatric disorders, including attention-deficit/hyperactivity disorder (ADHD), autism, and major depression. CDH13 regulates axonal outgrowth and synapse formation, substantiating its relevance for neurodevelopmental processes. Several studies support the influence of CDH13 on personality traits, behavior, and executive functions. However, evidence for functional effects of common gene variation in the CDH13 gene in humans is sparse. Therefore, we tested for association of a functional intronic CDH13 SNP rs2199430 with ADHD in a sample of 998 adult patients and 884 healthy controls. The Big Five personality tra…

X-ray Single Crystal Structure, Tautomerism Aspect, DFT, NBO, and Hirshfeld Surface Analysis of a New Schiff Bases Based on 4-Amino-5-Indol-2-yl-1,2,…

2021

Four different new Schiff basses tethered indolyl-triazole-3-thione hybrid were designed and synthesized. X-ray single crystal structure, tautomerism, DFT, NBO and Hirshfeld analysis were explored. X-ray crystallographic investigations with the aid of Hirshfeld calculations were used to analyze the molecular packing of the studied systems. The H···H, H···C, S···H, Br···C, O···H, C···C and N···H interactions are the most important in the molecular packing of 3. In case of 4, the S···H, N···H, S···C and C···C contacts are the most significant. The results obtained from the DFT calculations indicated that the thione tautomer is energetically lower than the thiol one by 13.9545 and 13.7464 kcal…

What you see is what you get? Measuring companies' projected employer image attributes via companies' employment webpages

2021

Information on a company's employment webpage sends signals about the employer image the company intends to project to applicants. Nonetheless, we know little about the content of recruitment signals sent via company employment webpages. This study develops a method to measure companies’ projected employer image attributes based on their employment webpages. Specifically, we analyze companies’ projected employer image attributes by applying computer‐aided text analysis (CATA) to the employment webpages of 461 Fortune 500 companies (i.e., more than 11,100 individual pages). Our results show that projected employer image attributes remain relatively stable over time. Moreover, we find relativ…

New upper bounds for some instances from benchmark for vector packing problem

2021

This dataset is a result of the research: Đorđe Stakić, Miodrag Živković, Ana Anokić, "A Reduced Variable Neighborhood Search Approach to the Heterogeneous Vector Bin Packing Problem", Information Technology and Control, 2021, 50(4), 808-826, https://doi.org/10.5755/j01.itc.50.4.29009 Files are given by algorithm described in it. This dataset consists of 14 solutions with better bounds for instances described in paper: Heßler, K., Gschwind, T., Irnich, S. Stabilized branch-and-price algorithms for vector packing problems. European Journal of Operational Research, 2018, 271(2), 401-419. https://doi.org/10.1016/j.ejor.2018.04.047 File structure: Instance name: UB: solut…

Philogenetics of Sea Urchin Tripneustes gratilla using Cytochrome Oxidase Subunit 1 Gene

2021

Sea urchin Tripneustes gratilla is multifunction organism that can be used as potential food source because of its high nutrient content. This organism can also be utilized bioindicator of sea waters and as a modal of organism for studying biology’s purposes. The purposes of this research is studying Filogenetic of sea urchin T. gratilla from waters of Wasior and Serui. The research has been doing at the Biotechnology Laboratory of the state of University of Papua on November to December 2009. The sample was extracted by using Chelex 10 % and was amplified with PCR technic (polymerase chain reaction). Sequencing of CO I gens (cythocrome oxidase subunit I) was done using sequencher ABI 377 (…

Contributions from History of Art to cultural tourism: The Holy Chalice (Santo Cáliz) of Valencia as the axis of the tourist story that sustains the …

2021

ARCHITECTURAL SURVEY TECHNIQUES FOR DEGRADATION DIAGNOSTICS. AN APPLICATION FOR THE CULTURAL HERITAGE

2021

Abstract. The great technological development in recent years in the field of architectural survey has made possible increasingly expeditious and less invasive investigations with the aim of acquiring a series of data related to the asset and fundamental for the protection of cultural heritage. In addition, the synergy between the various techniques represents an added value able, not only, to fill possible gaps and lacks arising from application limits of the instruments, but also to enhance the peculiarities of the same. This paper presents an integrated survey activity (range-based, image-based and IR thermography techniques) aimed at applying the combination and collaboration of multipl…

false

2021

Employees in female-dominated sectors are exposed to high workloads, emotional job demands, and role ambiguity, and often have insufficient resources to deal with these demands. This imbalance causes strain, threatening employees’ work ability. The aim of this study was to examine whether resource-providing leadership at the workplace level buffers against the negative repercussions of these job demands on work ability. Employees (N = 2383) from 290 work groups across three countries (Germany, Finland, and Sweden) in female-dominated sectors were asked to complete questionnaires in this study. Employees rated their immediate supervisor’s resource-providing leadership and also self-reported …

INVESTIGATION OF THE UNDERGROUND BUILDING HERITAGE AND THE MECHANISM OF WATER FLOWING IN QANĀTS IN PALERMO THROUGH INNOVATIVE SURVEYING TECHNIQUES

2021

Abstract. The valorisation, protection and preservation policies for the underground building heritage are often difficult to implement due to an inadequate knowledge of hypogeal constructions. The complex and widespread underground structures of the vast “Cavo” Heritage (“horizontal wells”, “shelf wells” or “well tunnels”), so called qanāts, hidden underground and built over the centuries in Palermo, representing an evocative testimony to the history of water culture in the ancient city. Through the historical and constructive analyses and the implementation and development of measurement and 3D representation and visualization, first actions have been carried out. The paper will present t…

Geodetic data analysis of VGOS experiments

2021

Very Long Baseline Interferometry (VLBI) serves as one of the common geodetic methods to define the global reference frames and monitor Earth's orientation variations. The technical upgrade of the VLBI method known as the VLBI Global Observing System (VGOS) includes a critical re-design of the observed frequencies from the dual band mode (S and X band, i.e. 2 GHz and 8 GHz) to observations in a broadband (2 – 14 GHz). Since 2019 the first VGOS experiments are available for the geodetic analysis in free access at the International VLBI service for Geodesy and Astrometry (IVS). Also regional-only subnetworks such as European VLBI stations have succeeded already in VGOS mode. Based on these br…

The BRICS: an analysis of the correlation of economic development and integration policies

2021

Dataset from: Small-scale patches of detritus as habitat for invertebrates within a Zostera noltei meadow

2021

This dataset is related to "Small-scale patches of detritus as habitat for invertebrates within a Zostera noltei meadow" (Valentina Costa, Renato Chemello, Davide Iaciofano, Sabrina Lo Brutto, Francesca Rossi)