showing 36 of ~574560 from 574555 documents
Developing and Validating a Behavioural Model of Cyberinsurance Adoption
2021
Business disruption from cyberattacks is a growing concern, yet cyberinsurance uptake remains low. Using an online behavioural economics experiment with 4800 participants across four EU countries, this study tests a predictive model of cyberinsurance adoption, incorporating elements of Protection Motivation Theory (PMT) and the Theory of Planned Behaviour (TPB) as well as factors in relation to risk propensity and price. During the experiment, participants were given the opportunity to purchase different cybersecurity measures and cyberinsurance products before performing an online task. Participants likelihood of suffering a cyberattack was dependent upon their adoption of cybersecurity me…
Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth.
2021
We would like to thank all the families that participated in these studies for their generous contribution. Detailed acknowledgements and funding can be found in Sup plementary Material.
Anton Tchekhov
2021
International audience; « J'ai vécu dans la paresse, j'ai beaucoup ri, mangé, bu ». Anton Tchekhov, mi-écrivain, mi- médecin, appelait ses écritures des « balivernes », balivernes qui, en passant, s'intitulent : Platonov, Ivanov, La Mouette, Oncle Vania, Les Trois Sœurs, La Cerisaie... Doux-amer, tendre et dérisoire, Tchekhov disait : « Le bonheur n'existe pas. Seul existe le désir d'y parvenir». Les « drôles d'énergumènes »de ses pièces rêvent-ils de l'atteindre un beau jour ?
Emergency Treatment of Anaphylactic Reactions in Air Rescue Missions: An Eight-Year Analysis of a German Rescue Helicopter Base.
2021
AbstractIntroduction:Anaphylactic reactions can lead to a life-threatening situation. In the event of anaphylaxis, rapid and targeted emergency treatment is indicated.Study Objective:The study sought to determine the emergency therapy administered for anaphylaxis in children and adults. Focus was placed on therapy with adrenaline. In addition, the study aimed to investigate demographic data, triggers, and hospitalization rates of the different severities of anaphylaxis.Methods:A retrospective analysis of anaphylactic reactions was conducted using data from prehospital emergency missions performed by the Air Rescue Dresden/Germany from 2008 through 2015 using the standardized application pro…
Commentary: Rational Adaptation in Lexical Prediction: The Influence of Prediction Strength
2021
Biomonitoring of Phthalates, Bisphenols and Parabens in Children: Exposure, Predictors and Risk Assessment
2021
Exposure to emerging contaminants, such as phthalates, bisphenols and parabens in children has been associated with possible neurodevelopment and endocrine alterations. In the present study, the biomonitoring of biomarkers in children (5–12 years old) from the Valencia Region (Spain) have been implemented using urines from the BIOVAL program. More than 75% of the children studied (n = 562) were internally exposed (>
Gamificación y TIC en la formación literaria. Una propuesta didáctica innovadora en Educación Secundaria
2021
La gamificación en la formación literaria puede aportar una serie de ventajas en su aplicación didáctica de manera que repercuta en un aprendizaje significativo en el aula. Los participantes en el juego de la experiencia que presentamos, organizados en grupos, tienen que superar un reto mediante la resolución de una serie de enigmas o pruebas relacionadas antes de que se acabe el tiempo establecido. De esta forma, el alumnado lee, interpreta, dialoga, opina, escribe y crea para poder conseguir el objetivo de resolver la situación planteada. Los recursos digitales y la lectura comprensiva permiten que los enigmas se resuelvan mediante el trabajo colaborativo y se consiga elaborar un producto…
Assessment of Oxygen Expansion during Internal Bleaching with Enamel and Dentin: A Comparative In Vitro Study.
2021
Internal bleaching is a conservative, non-invasive, and simple treatment that is frequently performed in daily clinical practice. The present in vitro study analyzes the oxygen expansion of different bleaching agents resulting from the oxidation reaction when interacting with enamel and dentin. Enamel and dentin were crushed separately until obtaining a fine powder with particles of an approximate size between 0.06 and 0.2 mm. Each enamel and dentin sample were mixed with 37% carbamide peroxide (CP 37%), 30% hydrogen peroxide (HP 30%), sodium perborate (SP) combined with HP 30% (HP 30% + SP) and SP with distilled water (SP). A total of 280 1 mm diameter glass tubes were used with 70 for eac…
Carbonyl Hypoiodites as Extremely Strong Halogen Bond Donors
2021
Abstract Neutral halogen‐bonded O−I−N complexes were prepared from in situ formed carbonyl hypoiodites and aromatic organic bases. The carbonyl hypoiodites have a strongly polarized iodine atom with larger σ‐holes than any known uncharged halogen bond donor. Modulating the Lewis basicity of the selected pyridine derivatives and carboxylates leads to halogen‐bonded complexes where the classical O−I⋅⋅⋅N halogen bond transforms more into a halogen‐bonded COO−⋅⋅⋅I−N+ ion‐pair (salt) with an asymmetric O−I−N moiety. X‐ray analyses, NMR studies, and calculations reveal the halogen bonding geometries of the carbonyl hypoiodite‐based O−I−N complexes, confirming that in the solid‐state the iodine at…
Multicomponent Physical Exercise Training in Multimorbid and Palliative Oldest Adults
2021
Exercise counteracts aging and pathology symptoms, but there is still scarce research on exercise programs for multimorbid and/or palliative old patients (MPO-Ps). In order to analyze whether the multicomponent physical–cognitive training is beneficial for this population, 17 MPO-Ps (81.59 ± 5.63 years) completed a >
Endometrial Factor in Unexplained Infertility and Recurrent Implantation Failure
2021
AbstractUnexplained infertility (UI) and recurrent implantation failure (RIF) are diagnoses based on failed pregnancy attempts within current infertility treatment models. Both diagnoses are made when fertility is unexplained based on current diagnostic methods and has no clear cause; UI is diagnosed when testing is inconclusive, and RIF is diagnosed after three failed in vitro fertilization cycles. In both cases, interventions are often introduced without an understanding of the cause of the infertility, frequently leading to frustration for patients and caregivers. Here, we review evidence to support an influence of endometrial factor in patients given these poorly defined diagnoses and p…
Improving Dissolution Behavior and Oral Absorption of Drugs with pH-Dependent Solubility Using pH Modifiers: A Physiologically Realistic Mass Transpo…
2021
Orally dosed drugs must dissolve in the gastrointestinal (GI) tract before being absorbed through the epithelial cell membrane. In vivo drug dissolution depends on the GI tract's physiological conditions such as pH, residence time, luminal buffers, intestinal motility, and transit and drug properties under fed and fasting conditions (Paixao, P. et al. Mol. Pharm. 2018 and Bermejo, et al. M. Mol. Pharm. 2018). The dissolution of an ionizable drug may benefit from manipulating in vivo variables such as the environmental pH using pH-modifying agents incorporated into the dosage form. A successful example is the use of such agents for dissolution enhancement of BCS class IIb (high-permeability,…
“Managing the Impossible?” Comparing How Countries Address the Dahrendorf Quandary
2021
This paper examines the policy approaches and measures that developed market economies countries have adopted to “manage” what has become known as the Dahrendorf Quandary, a profound challenge facing globalizing economies: over time, staying economically competitive requires either adopting measures detrimental to the cohesion of society or restricting civil liberties and political participation. Examining a range of countries over time, it is found that their policy choices and subsequent performance are too varied to support the inevitable, almost mechanical, incompatibility the Quandary implies. While balancing the relationship between economic globalization, social cohesion, and democra…
Kinematic parameters after tibial nonunion treatment using the Ilizarov method
2021
Abstract Background Analysis of the outcomes of Ilizarov treatment of tibial nonunion shows functional deficits in the lower limbs of some patients. Biomechanical gait parameters are an important measure for assessing musculoskeletal disorder treatments that aim to restore normal gait. The purpose of our study was to compare the kinematic parameters in patients with tibial nonunion treated using the Ilizarov method and those in a control group of healthy volunteers. Methods The study population consisted of 23 patients (age 54.9 ± 16.4 years) who were treated for tibial nonunion using the Ilizarov method, as well as 22 healthy adult controls (age 52.7 ± 10.6 years). Kinematic parameters wer…
Folk theories of algorithmic operations during Internet use: A mixed methods study
2021
We used the folk theory perspective to investigate Internet users’ understanding of algorithms during their Internet use. Empirically, we conducted a mixed-method study. First, we carried out semi-...
A linear regression-based machine learning pipeline for the discovery of clinically relevant correlates of gait speed reserve from multiple physiolog…
2021
Frailty in older adults is characterized by reduced physiological reserve. Gait speed reserve (GSR: maximum minus usual gait speed) could help identify frailty and act as a proxy for physiological reserve. Utilizing data from 2397 participants aged 50+ from wave 3 of The Irish Longitudinal Study on Ageing, we developed a stepwise linear regression-based machine learning pipeline to select the most important GSR predictors from 34 manually selected features across multiple domains. Variables were selected one at a time such that they maximized the mean adjusted r-squared score from a 5-fold cross-validation. A peak score of (0.16 +/- 0.03) was achieved with 14 variables (giving adjusted-r-sq…
Sédation profonde et continue maintenue jusqu’au décès en réanimation : mise au point de la Commission d’Ethique de la SRLF
2021
La mise en œuvre de la sédation profonde et continue maintenue jusqu’au décès en réanimation peut s’avérer complexe car il faut tenir compte de la singularité de chaque patient et de son entourage. Cet aspect de la prise en charge devrait être évoqué autant que possible avec le patient et ses proches bien avant que la question de la fin de vie ne se pose. Formation des soignants, information des patients et des proches et adaptation de l’environnement en fin de vie représentent les pistes d’amélioration de la prise en charge de la fin de vie en réanimation.
Vaccination en général et vaccination anti-COVID
2021
This book presents a societal research analysis of an exploratory study of the general public concerning the obstacles to vaccination. It highlights the fact that sociological anchors would be determinant in the decision making regarding vaccination. This study more broadly invites us to consider modern and post-modern anchors as possible determinants in the positions of individuals in relation to various subjects of science-society.
Knot placement in the Distributed non-linear lag models (DNLM) framework
2021
Quantization in Graph Convolutional Neural Networks
2021
Estimating the dwarfing rate of an extinct Sicilian elephant.
2021
Summary Evolution on islands, together with the often extreme phenotypic changes associated with it, has attracted much interest from evolutionary biologists. However, measuring the rate of change of phenotypic traits of extinct animals can be challenging, in part due to the incompleteness of the fossil record. Here, we use combined molecular and fossil evidence to define the minimum and maximum rate of dwarfing in an extinct Mediterranean dwarf elephant from Puntali Cave (Sicily). 1 Despite the challenges associated with recovering ancient DNA from warm climates, 2 we successfully retrieved a mitogenome from a sample with an estimated age between 175,500 and 50,000 years. Our results sugge…
Maternal occupational exposure to chemicals and neurocognitive development at 4-5 years of age
2021
Carlo Goldoni
2021
International audience; « On ne peut nier que je sois né sous l'influence d'une étoile comique, puisque ma vie même a été une comédie ». Picaresque, cette vie de Carlo Goldoni nous fait entrer de plain-pied dans la folle et fascinante société vénitienne du XVIIIe siècle, puis à la cour de Louis XVet de Louis XVI. Rien d'étonnant pour ce Molière italien, ancêtre de la comédie néo-réaliste des Dino Risi, Vittorio de Sica et autres Pietro Germi...
Mechanism for ultrafast electric-field driven skyrmion nucleation
2021
We show how a Dzyaloshinskii-Moriya interaction can be generated in an ultrathin metal film from a femtosecond pulse in electric field. This interaction does not require structural inversion-symmetry breaking, and its amplitude can be tuned depending on the amplitude of the field. We perform first-principles calculations to estimate the strength of the field-induced magnetoelectric coupling for ferromagnetic Fe, Co, and Ni, and antiferromagnetic Mn, as well as FePt and MnPt alloys. Last, using atomistic simulations, we demonstrate how an isolated antiferromagnetic skyrmion can be coherently nucleated from the collinear background by an ultrashort pulse in electric field on a hundred-femtose…
Trace elements and plasma metabolomics in a general population from Spain: The Hortega Study
2021
An experimental study on long term outcomes after magnetic esophageal compression anastomosis in piglets
2021
Abstract Background/Purpose Previous studies have shown that a patent, watertight esophageal anastomosis can be accomplished safely using specially-shaped magnets in piglets. However, it is unclear whether such a magnetic esophageal compression anastomosis (MECA) remains patent in the long-term. The purpose of this study was to evaluate the long-term outcome of MECA in an experimental pig model over an observation period of 2 months. Methods Ten piglets underwent creation of an MECA with custom-made 8 mm magnets and a U-shaped esophageal bypass loop to allow peroral nutrition at eight weeks of life. Two weeks later, the bypass loop was closed surgically, requiring the pigs to swallow via th…
Genetic variation and urine cadmium levels: ABCC1 effects in the Strong Heart Family Study
2021
Abstract Genetic effects are suspected to influence cadmium internal dose. Our objective was to assess genetic determinants of urine cadmium in American Indian adults participating in the Strong Heart Family Study (SHFS). Urine cadmium levels and genotyped short tandem repeat (STR) markers were available on 1936 SHFS participants. We investigated heritability, including gene-by-sex and smoking interactions, and STR-based quantitative trait locus (QTL) linkage, using a variance-component decomposition approach, which incorporates the genetic information contained in the pedigrees. We also used available single nucleotide polymorphisms (SNPs) from Illumina’s Metabochip and custom panel to ass…
The balancing act of combining school and football in the transition from a non-professional club into junior-elite academy football
2021
Football players in the transition from junior-to-senior are usually involved in dual careers, combining school and football – a process that makes them dependent on a holistic talent-development journey. The aim of the current study was to describe how male junior elite football players (N=10; 5=living at home, 5=living away from home) perceived stressors in the transition from a non-professional club into a junior elite academy. Furthermore, the school transition (between lower- and upper-secondary school) and social transition (based on the school and football transitions) as a consequence of the football transition into academy football. Based on Wylleman and Lavallee’s (2004) and Stamb…
Soilμ3d project: emergent properties of soil microbial functions from 3d modelling and spatial descriptors of pore scale heterogeneity
2021
International audience; The reduction of greenhouse gas emissions by improving the efficiency of agricultural systems through robust ecologically-based management practices represents the most important challenge facing agriculture. Models are needed to evaluate the effects of soil properties, climate, and agricultural management practices on soil carbon and on the nitrogen transformations responsible for GHG emissions. Models of Carbon and nitrogen cycles in soils need improvements so they can provide more accurate and robust predictions. They use empirical functions which account for the different environmental factors that affect microbial functions. However, these types of function have…
Laser-assisted nuclear decay spectroscopy of Au-176,Au-177,Au-179
2021
ispartof: PHYSICAL REVIEW C vol:104 issue:2 status: published
Verkörperung: Bild und Experiment bei Edgar Wind und die aktuelle Lage der morphologischen Forschung
2021
Edgar Wind’s The Experiment and Metaphysics examines, in the sense of Goethe’s morphological project, the common structures of scientific and artistic thinking in the light of the reflective value of the image and the technological processes of research and construction of reality. In Wind’s philosophy of em- bodiment the image plays a role in the artistic field comparable to the function of experiments in science. The picture is neither a ‘copy’ nor just a ‘part’ of reality, but rather an ‘embodiment’: at the same time the ‘result’ of human activity and a ‘condition’ for all interpretation of the world. It opens up as an embodiment to a temporality which is not just linear but ‘configured’…
Impact of maternal nutritional status during pregnancy on the associations between persistent organic pollutants and childhood overweight
2021
Metric Rectifiability of ℍ-regular Surfaces with Hölder Continuous Horizontal Normal
2021
Abstract Two definitions for the rectifiability of hypersurfaces in Heisenberg groups $\mathbb{H}^n$ have been proposed: one based on ${\mathbb{H}}$-regular surfaces and the other on Lipschitz images of subsets of codimension-$1$ vertical subgroups. The equivalence between these notions remains an open problem. Recent partial results are due to Cole–Pauls, Bigolin–Vittone, and Antonelli–Le Donne. This paper makes progress in one direction: the metric Lipschitz rectifiability of ${\mathbb{H}}$-regular surfaces. We prove that ${\mathbb{H}}$-regular surfaces in $\mathbb{H}^{n}$ with $\alpha $-Hölder continuous horizontal normal, $\alpha> 0$, are metric bilipschitz rectifiable. This impr…
Global health burden of PM2.5, black and organic carbon aerosols
2021
The Macroeconomy After Tariffs
2021
AbstractWhat does the macroeconomy look like in the aftermath of tariff changes? This study estimates impulse response functions from local projections using a panel of annual data that spans 151 countries from 1963 to 2014. Tariff increases are associated with persistent, economically and statistically significant declines in domestic output and productivity, as well as higher unemployment and inequality, real exchange rate appreciation, and insignificant changes to the trade balance. Output and productivity impacts are magnified when tariffs rise during expansions and when they are imposed by more advanced or smaller (as opposed to developing or larger) economies; effects are asymmetric, …