showing 36 of ~574560 from 574555 documents
Nemirstības pētnieks Kārlis Ābele
2021
Atzīmējot botāniķa un literāta, Lāčplēša kara ordeņa kavaliera Kārļa Ābeles (1896 - 1961) 125. jubileju apkopota pētnieka biogrāfija, raksturojot gan viņa zinātnisko, gan literāro darbību.
The invasive seaweed Asparagopsis taxiformis erodes the habitat structure and biodiversity of native algal forests in the Mediterranean Sea
2021
Abstract Invasive seaweeds are listed among the most relevant threats to marine ecosystems worldwide. Biodiversity hotspots, such as the Mediterranean Sea, are facing multiple invasions and are expected to be severely affected by the introduction of new non-native seaweeds in the near future. In this study, we evaluated the consequences of the shift from the native Ericaria brachycarpa to the invasive Asparagopsis taxiformis habitat on the shallow rocky shores of Favignana Island (Egadi Islands, MPA, Sicily, Italy). We compared algal biomass and species composition and structure of the associated epifaunal assemblages in homogenous and mixed stands of E. brachycarpa and A. taxiformis. The r…
Aristóteles y el coro trágico (Poética 1456a)
2021
Reed Warbler Hosts Do Not Fine-Tune Mobbing Defenses During the Breeding Season, Even When Cuckoos Are Rare
2021
Hosts of brood parasitic cuckoos often employ mobbing attacks to defend their nests and, when mobbing is costly, hosts are predicted to adjust their mobbing to match parasitism risk. While evidence exists for fine-tuned plasticity, it remains unclear why mobbing does not track larger seasonal changes in parasitism risk. Here we test a possible explanation from parental investment theory: parents should defend their current brood more intensively as the opportunity to replace it declines (re-nesting potential), and therefore “counteract” any apparent seasonal decline to match parasitism risk. We take advantage of mobbing experiments conducted at two sites where reed warblers (Acrocephalus sc…
On the Importance of Ligand-Centered Excited States in the Emission of Cyclometalated Ir(III) Complexes
2021
The photophysical behavior of the cyclometalating Ir(III) complexes [Ir(ppy)2(bpy)]+, where Hppy is 2-phenylpyridine and bpy is 2,2′-bipyridine (complex 1), and [Ir(diFppy)2(dtb-bpy)]+, where diFppy is 2-(2,4-difluorophenyl)pyridine and dtb-bpy is 4,4′-di-tert-butyl-2,2′-bipyridine (complex 2), has been theoretically investigated by performing density functional theory calculations. The two complexes share the same molecular skeleton, complex 2 being derived from complex 1 through the addition of fluoro and tert-butyl substituents, but present notable differences in their photophysical properties. The remarkable difference in their emission quantum yields (0.196 for complex 1 in dichloromet…
Quality of life as a therapeutic objective in the management of hepatic encephalopathy and the potential role of rifaximin-α
2021
Objective Quality of life (QoL) is impaired in patients with hepatic encephalopathy and rifaximin-α can improve QoL within 6 months. This study assessed the importance of QoL as a therapeutic objective in hepatic encephalopathy management; whether QoL is routinely assessed in hepatic encephalopathy patients in clinical practice and the role of rifaximin-α in this context. Methods A survey was conducted of healthcare professionals (HCPs) from Europe and Australia involved in hepatic encephalopathy management. HCPs rated the importance of a range of therapeutic objectives on a 1–7 Likert scale (1 = not at all important; 7 = extremely important). HCPs were also required to provide three patien…
Understanding the microbial biogeography of ancient human dentitions to guide study design and interpretation
2021
AbstractThe oral cavity is a heterogeneous environment, varying in factors such as pH, oxygen levels, and salivary flow. These factors affect the microbial community composition and distribution of species in dental plaque, but it is not known how well these patterns are reflected in archaeological dental calculus. In most archaeological studies, a single sample of dental calculus is studied per individual and is assumed to represent the entire oral cavity. However, it is not known if this sampling strategy introduces biases into studies of the ancient oral microbiome. Here, we present the results of a shotgun metagenomic study of a dense sampling of dental calculus from four Chalcolithic i…
Algorithmically deduced FREM2 molecular pathway is a potent grade and survival biomarker of human gliomas
2021
Gliomas are the most common malignant brain tumors with high mortality rates. Recently we showed that the FREM2 gene has a role in glioblastoma progression. Here we reconstructed the FREM2 molecular pathway using the human interactome model. We assessed the biomarker capacity of FREM2 expression and its pathway as the overall survival (OS) and progression-free survival (PFS) biomarkers. To this end, we used three literature and one experimental RNA sequencing datasets collectively covering 566 glioblastomas (GBM) and 1097 low-grade gliomas (LGG). The activation level of deduced FREM2 pathway showed strong biomarker characteristics and significantly outperformed the FREM2 expression level it…
AtPGAP1 functions as a GPI inositol-deacylase required for efficient transport of GPI-anchored proteins
2021
Abstract Glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) play an important role in a variety of plant biological processes including growth, stress response, morphogenesis, signaling, and cell wall biosynthesis. The GPI anchor contains a lipid-linked glycan backbone that is synthesized in the endoplasmic reticulum (ER) where it is subsequently transferred to the C-terminus of proteins containing a GPI signal peptide by a GPI transamidase. Once the GPI anchor is attached to the protein, the glycan and lipid moieties are remodeled. In mammals and yeast, this remodeling is required for GPI-APs to be included in Coat Protein II-coated vesicles for their ER export and subsequent t…
A analise comparativa da junção dentina-esmalte em mamiferos
2021
Orientador : Sergio Roberto Peres Line Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba Resumo: O estudo da morfologia e da micro-estrutura dos dentes tem provido boas informações a respeito da função e evolução dos mamíferos. Entre as características estruturais estudadas a junção dentina-esmalte tem recebido relativamente pouca atenção. Neste trabalho nós realizamos uma análise comparativa da micro-estruturas da junção dentina-esmalte entre diversos mamíferos. Entre as espécies estudadas somente duas (HUMANO e Miguelsoria parayirunhor) apresentaram um complexo tipo de junção dentina esmalte. Nossos resultados mostraram a topografia da junç…
La actualidad biohermenéutica de Aristóteles
2021
Antitumor Effect of Cabozantinib in Bone Metastatic Models of Renal Cell Carcinoma
2021
Background: The presence of bone metastases in renal cell carcinoma (RCC) negatively affects patients’ survival. Data from clinical trials has highlighted a significant benefit of cabozantinib in bone metastatic RCC patients. Here, we evaluated the antitumor effect of cabozantinib in coculture models of renal cell carcinoma (RCC) and osteoblasts (OBs) to investigate whether and how its antiproliferative activity is influenced by OBs. Methods: Bone/RCC models were generated, coculturing green fluorescent protein (GFP)-tagged Caki-1 and 786-O cells with human primary OBs in a “cell–cell contact” system. RCC proliferation and the OB molecular profile were evaluated after the cabozantinib treat…
Analysis of the Impact of Disease Acceptance, Demographic, and Clinical Variables on Adherence to Treatment Recommendations in Elderly Type 2 Diabete…
2021
This project aimed to analyze the impact of disease acceptance and selected demographic and clinical factors on the adherence to treatment recommendations in elderly type 2 diabetes mellitus patients. The observational study was performed using standardized research questionnaires: the Acceptance of Illness Scale (AIS), the Self-Care of Diabetes Inventory (SCODI), and the Adherence in Chronic Diseases Scale (ACDS). Two hundred patients with T2DM were studied (age M = 70.21 years, SD = 6.63 years). The median degree of disease acceptance was 29 (min–max = 8–40) and the median level of adherence was 24 (min–max = 13–28). Disease acceptance was a significant (p = 0.002) independent predictor o…
Meson and glueball spectroscopy within the graviton soft wall model
2021
The graviton soft wall model (GSW) provides a unified description of the scalar glueball and meson spectra with a unique energy scale. This success has led us to extend the analysis to the description of the spectra of other hadrons. We use this model to calculate masses of the odd and even ground states of glueballs for various spins, and show that the GSW model is able to reproduce the Regge trajectory of these systems. In addition, the spectra of the $\rho$, $a_1$ and the $\eta$ mesons will be addressed. Results are in excellent agreement with current experimental data.Furthermore such an achievement is obtained without any additional parameters. Indeed, the only two parameters appearing…
New constraints on the Al25(p,γ) reaction and its influence on the flux of cosmic γ rays from classical nova explosions
2021
The astrophysical $^{25}\mathrm{Al}(p,\ensuremath{\gamma})\phantom{\rule{0.16em}{0ex}}^{26}\mathrm{Si}$ reaction represents one of the key remaining uncertainties in accurately modeling the abundance of radiogenic $^{26}\mathrm{Al}$ ejected from classical novae. Specifically, the strengths of key proton-unbound resonances in $^{26}\mathrm{Si}$, that govern the rate of the $^{25}\mathrm{Al}(p,\ensuremath{\gamma})$ reaction under explosive astrophysical conditions, remain unsettled. Here, we present a detailed spectroscopy study of the $^{26}\mathrm{Si}$ mirror nucleus $^{26}\mathrm{Mg}$. We have measured the lifetime of the ${3}^{+}$, 6.125-MeV state in $^{26}\mathrm{Mg}$ to be $19(3)\phanto…
Survival causal patterns of social and commercial entrepreneurial initiatives in Spain
2021
This research aims at analysing the influence of a holistic configuration of factors related to industry and the characteristics of the entrepreneur and the business, on the survival of social and commercial entrepreneurial initiatives in both, new and consolidated companies. The sample ranges from 2,851 to 2,109 firms, according to the period considered, and has been obtained from the reports of the projects submitted to the Assistance Programme to Young Entrepreneurs, promoted by the Valencian Institute of Youth. Other sources of information have been the Institute’s own reports and the Chambers of Commerce. A configurational analysis is performed using the Fuzzy-Set Qualitative Comparati…
Dyes of a Shadow Theatre: Investigating Tholu Bommalu Indian Puppets through a Highly Sensitive Multi-Spectroscopic Approach
2021
Tholu Bommalu are typical leather puppets of the traditional Indian shadow theatre. Two of these objects are part of a collection in the International Puppets Museum “Antonio Pasqualino” (Palermo, Sicily, Italy), which can count on one hundred-seventy-three of artifacts. These Indian puppets were investigated to obtain information related to the use of dyes for their manufacturing through a multi-technical approach exploiting the combination of highly sensitive spectroscopic techniques. Wet cotton stubbons were used to entrap small particles of dyes on the fibers from the art objects for the consequent analyses. Visible Light Micro-Reflectance spectroscopy was employed for the preliminary i…
Populaarimusiikkitoiminnassa koettu sukupuolittunut epäasiallisuus
2021
Vuonna 2016 alkunsa saanut #MeToo-liike kiinnitti huomiota sukupuolitettuun vallankäyttöön ja seksuaaliseen häirintään historiallisella tavalla. Kyselytutkimukseen perustuva artikkeli valottaa tilannetta populaarimusiikin toimijoiden osalta ja selvittää, millaisia kokemuksia kyselyyn vastanneilla oli sukupuolitetusta epäasiallisuudesta. Tutkimus toteutettiin vuonna 2020, ja siihen vastasi 150 populaarimusiikin parissa toimivaa henkilöä. This article discusses gendered inappropriateness in Finnish popular music, particularly the experiences of those who currently work professionally in the field. The survey was an anonymised online survey with provided scaled questions and open-answer option…
Does conversion during minimally invasive rectal surgery for cancer have an impact on short-term and oncologic outcomes? Results of a retrospective c…
2021
International audience; Background: Although minimally invasive rectal surgery (MIRS) for cancer provides better recovery for similar oncologic outcomes over open approach, conversion is still required in 10% and its impact on short-term and long-term outcomes remains unclear. The aim of our study was to evaluate the impact of conversion on postoperative and oncologic outcomes in patients undergoing MIRS for cancer. Methods: From June 2011 to March 2020, we reviewed 257 minimally invasive rectal resections for cancer recorded in a prospectively maintained database, with 192 robotic and 65 laparoscopic approaches. Patients who required conversion to open (Conversion group) were compared to t…
false
2021
Hosts of brood parasitic cuckoos often employ mobbing attacks to defend their nests and, when mobbing is costly, hosts are predicted to adjust their mobbing to match parasitism risk. While evidence exists for fine-tuned plasticity, it remains unclear why mobbing does not track larger seasonal changes in parasitism risk. Here we test a possible explanation from parental investment theory: parents should defend their current brood more intensively as the opportunity to replace it declines (re-nesting potential), and therefore “counteract” any apparent seasonal decline to match parasitism risk. We take advantage of mobbing experiments conducted at two sites where reed warblers (Acrocephalus sc…
Comparing the Effect of Product-Based Metrics on the Translation Process
2021
Characteristics of the translation product are often used in translation process research as predictors for cognitive load, and by extension translation difficulty. In the last decade, user-activity information such as eye-tracking data has been increasingly employed as an experimental tool for that purpose. In this paper, we take a similar approach. We look for significant effects that different predictors may have on three different eye-tracking measures: First Fixation Duration (duration of first fixation on a token), Eye-Key Span (duration between first fixation on a token and the first keystroke contributing to its translation), and Total Reading Time on source tokens (sum of fixations…
New constraints on the Al 25 (p,γ) reaction and its influence on the flux of cosmic γ rays from classical nova explosions
2021
The astrophysical Al25(p,γ)Si26 reaction represents one of the key remaining uncertainties in accurately modeling the abundance of radiogenic Al26 ejected from classical novae. Specifically, the strengths of key proton-unbound resonances in Si26, that govern the rate of the Al25(p,γ) reaction under explosive astrophysical conditions, remain unsettled. Here, we present a detailed spectroscopy study of the Si26 mirror nucleus Mg26. We have measured the lifetime of the 3+, 6.125-MeV state in Mg26 to be 19(3)fs and provide compelling evidence for the existence of a 1- state in the T=1,A=26 system, indicating a previously unaccounted for=1 resonance in the Al25(p,γ) reaction. Using the presently…
Classification of Targets Using Statistical Features from Range FFT of mmWave FMCW Radars
2021
Radars with mmWave frequency modulated continuous wave (FMCW) technology accurately estimate the range and velocity of targets in their field of view (FoV). The targeted angle of arrival (AoA) estimation can be improved by increasing receiving antennas or by using multiple-input multiple-output (MIMO). However, obtaining target features such as target type remains challenging. In this paper, we present a novel target classification method based on machine learning and features extracted from a range fast Fourier transform (FFT) profile by using mmWave FMCW radars operating in the frequency range of 77–81 GHz. The measurements are carried out in a variety of realistic situations, including p…
Prevention of eating disorders-Efficacy and cost-benefit of a school-based program ("MaiStep") in a randomized controlled trial (RCT).
2021
Objective Given the severity of eating disorders, effective and easily implementable prevention programs which reduce incidence rates and in addition have health-economic benefits are essential. The majority of research on prevention programs focuses on questionnaire-based efficacy or the reduction of eating disorder symptoms while neglecting the health-economic perspective. By contrast, the present study focuses on both an efficacy analysis considering diagnostic criteria (DSM-5) and on evaluating the cost-benefit of a universal prevention program for eating disorders ("MaiStep"). Method A three-arm randomized controlled trial with baseline, posttreatment and 12-month follow-up was conduct…
How an inquiry-oriented textbook shaped a calculus instructor’s planning
2021
We investigate how an inquiry-oriented, dynamic, open-source calculus textbook shaped one college instructor’s planning. We rely on Dietiker et al.’s [(2018). Research commentary: Curricular notici...
Synthesis and X-ray Crystal Structure of New Substituted 3-4′-Bipyrazole Derivatives. Hirshfeld Analysis, DFT and NBO Studies
2021
A new compounds named 3-4′-bipyrazoles 2 and 3 were synthesized in high chemical yield from a reaction of pyran-2,4-diketone 1 with aryl hydrazines under thermal conditions in MeOH. Compound 2 was unambiguously confirmed by single-crystal X-ray analysis. It crystalizes in a triclinic crystal system and space group P-1. Its crystal structure was found to be in good agreement with the spectral characterizations. With the aid of Hirshfeld calculations, the H…H (54.8–55.3%) and H…C (28.3–29.2%) intermolecular contacts are the most dominant, while the O…H (5.8–6.5%), N…H (3.8–4.6%) and C…C (3.0–4.9%) are less dominant. The compound has a polar nature with a net dipole moment of 6.388 Debye. The …
Combining high performance thin layer chromatography with minispectrometer-fiber optic probe-coupled to smartphone for in place analysis: Lactose qua…
2021
ABSTRACT An in place colorimetric method has been proposed for estimation of the quantity of lactose in several matrix (milk, water effluents and surfaces). Analyzing the amount of this carbohydrate it can be control the product, the cleanliness of the parts of the dairy companies and it can avoid contamination of milk products produced there. This method combines the use of HPTLC for sugars separation with novel analytical devices as minispectrophotometer with fiber optic coupled to a smartphone. In order to measure the lactose a colorimetric reaction has been used. Variable volumes of samples or stock solutions were deposited in nano-silica gel layer, a mobile phase of acetonitrile:water:…
Sometimes less is more—the impact of the number of His residues on the stability of Zn(ii)–SmtB and BigR4 α-5 domain complexes
2021
The increasing number of antibiotic-resistant pathogens has become one of the major health problems of modern times, including infections caused by Mycobacterium tuberculosis. One of the possible mammalian immune system responses to mycobacterial infection is the increase of the zinc(II) concentration in phagosomes to a toxic level. The mycobacterial SmtB protein belongs to the family of ArsR/SmtB transcription regulators. In the presence of high concentrations of metals, SmtB dissociates from DNA and activates the expression of metal efflux proteins. In this work, we focus on the α5 zinc(II) binding domains of SmtB/BigR4 proteins (the latter being the SmtB homolog from non-pathogenic M. sm…
Author response: Inducible and reversible inhibition of miRNA-mediated gene repression in vivo
2021
Course of social support and associations with distress after partial laryngectomy
2021
PURPOSE Social support has been shown to be positively associated with quality of life and adjustment after a cancer diagnosis. The present study investigates the course of social support up to one year after partial laryngectomy and its association with distress. DESIGN Longitudinal questionnaire study. SAMPLE A total of 428 patients after partial laryngectomy (mean age: 64, SD = 11, 91% male). METHODS Patients completed questionnaires before treatment (t1), one week after a partial laryngectomy (t2), 3 months (t3), and one year (t4) thereafter. Social support was evaluated at t2, t3, and t4 using a brief version of the Social Support Questionnaire. Distress was measured at t2, t3, and t4 …
Afterword: Brokerage as social practice
2021
This afterword argues for a narrow and analytically strong concept of brokerage, which is oriented towards the classical definition by Boissevain. His ideal type emphasises the agency of brokers who actively pursue their own interests and act at an equal distance to the groups between which they mediate. Furthermore, the text argues for thinking of brokerage as a bundle of social practices instead of as brokers in the sense of a social type. While few social actors are fully-fledged brokers, many of them engage in brokerage.
Semiautomated quantification of the fibrous tissue response to complex three‐dimensional filamentous scaffolds using digital image analysis
2021
Fibrosis represents a relevant response to the implantation of biomaterials, which occurs not only at the tissue-material interface (fibrotic encapsulation) but also within the void fraction of complex three-dimensional (3D) biomaterial constructions (fibrotic ingrowth). Usual evaluation of the biocompatibility mostly depicts fibrosis at the interface of the biomaterial using semiquantitative scores. Here, the relations between encapsulation and infiltrating fibrotic growth are poorly represented. Virtual pathology and digital image analysis provide new strategies to assess fibrosis in a more differentiated way. In this study, we adopted a method previously used to quantify fibrosis in visc…
Customising clinical studies for the new nursing generation
2021
Nursing education in the Nordic countries follows the European Union directive requirements, and clinical studies for nursing students in the Nordic countries have many similarities. Now a new generation of students with different needs and characteristics is entering the nursing profession. The faculty, teachers and nurses will face challenges in meeting this new generation’s needs. The primary aim of this discussion paper is to explore and compare the current clinical studies in the five Nordic countries. The secondary aim is to find means to address the future challenges with a focus on the new generation. The idea of Objective Structured Clinical Reflection creates the possibility to d…
Diuron environmental levels effects on marine nematodes: Assessment of ecological indices, taxonomic diversity, and functional traits
2021
Abstract Coastal marine systems are the most sensitive zones to emerging pollutants. The present study aims to investigate the effect of Diuron on the meiofaunal assemblages, collected from the Bizerte channel (Tunisia). Microcosm experiments were set up using four increasing Diuron concentrations [D1 (10 ng g−1 dry weight (DW)), D2 (50 ng g−1 DW), D3 (250 ng g−1 DW) and (1250 ng g−1 DW)] compared to non-contaminated sediments (controls) and all plots were incubated for 30 days. Our results show that Diuron-supplemented sediments provoked the significant decrease of meiofaunal abundance as well as a change in nematodes' diversity and structure composition. All univariate indices, as well as…
Blocking Jak/STAT signalling using tofacitinib inhibits angiogenesis in experimental arthritis
2021
Abstract Objective During rheumatoid arthritis (RA), the angiogenic processes, occurring with pannus-formation, may be a therapeutic target. JAK/STAT-pathway may play a role and the aim of this work was to investigate the inhibiting role of a JAK-inhibitor, tofacitinib, on the angiogenic mechanisms occurring during RA. Methods After ethical approval, JAK-1, JAK-3, STAT-1, STAT-3 and VEGF expression was evaluated on RA-synovial-tissues. In vitro, endothelial cells (ECs), stimulated with 20 ng/ml of VEGF and/or 1 μM of tofacitinib, were assessed for tube formation, migration and proliferation, by Matrigel, Boyden chamber assay and ki67 gene-expression. In vivo, 32 mice received collagen (coll…
The Inflammatory Feed-Forward Loop Triggered by the Complement Component C3 as a Potential Target in Endometriosis
2021
Copyright © 2021 Agostinis, Zorzet, Balduit, Zito, Mangogna, Macor, Romano, Toffoli, Belmonte, Morello, Martorana, Borelli, Ricci, Kishore and Bulla. The complement system is a major component of humoral innate immunity, acting as a first line of defense against microbes via opsonization and lysis of pathogens. However, novel roles of the complement system in inflammatory and immunological processes, including in cancer, are emerging. Endometriosis (EM), a benign disease characterized by ectopic endometrial implants, shows certain unique features of cancer, such as the capacity to invade surrounding tissues, and in severe cases, metastatic properties. A defective immune surveillance against…