Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Sitagliptin Phosphate Monohydrate

2021

Sitagliptin is an antihyperglycemic drug used in adults for the treatment of diabetes Type 2. Literature data and in-house experiments were applied in this monograph to assess whether methods based on the Biopharmaceutics Classification System (BCS) could be used to assess the bioequivalence of solid immediate-release (IR) oral dosage forms containing sitagliptin phosphate monohydrate, as an alternative to a pharmacokinetic study in human volunteers. The solubility and permeability characteristics of sitagliptin were reviewed according to the BCS, along with dissolution, therapeutic index, therapeutic applications, pharmacokinetics, pharmacodynamic characteristics, reports of bioequivalence…

Quantum technologies and the elephants

2021

Extraordinary progress in quantum sensors and technologies opens new avenues for exploring the Universe and testing the assumptions forming the basis of modern physics. This QST focus issue: focus on quantum sensors for new-physics discoveries is a next-decade roadmap on developing a wide range of quantum sensors and new technologies towards discoveries of new physics. It covers the next generation of various technologies, including atomic and nuclear clocks, atomic and diamond-based magnetometers, atom and laser interferometers, control of trapped atoms, ions, and molecules, optomechanical systems, and many others. In this editorial, we outline major problems of fundamental physics we aim …

Heteroditopic chemosensor to detect γ-hydroxybutyric acid (GHB) in soft drinks and alcoholic beverages.

2021

Drug-Facilitated Sexual Assault (DFSA) is a problem of considerable dimensions on a global scale. Among the different compounds used in DFSA assaults, 4-hydroxybutyric acid (GHB) is one of the most elusive due to its physical and biological characteristics. Therefore, the development of real-time detection methods to detect GHB not only in drinks but also in urine is very important for personal and social security. Here, we report two new heteroditopic chemosensors capable of recognizing and detecting GHB in soft drinks, alcoholic beverages and synthetic urine. The compounds have two moieties: a trifluoroacetyl group and a thiourea, which are able to interact respectively with the hydroxyl …

Sacripanti Unbuilt. Icons of Modernity

2021

The figure of Maurizio Sacripanti has been one of the most interesting on the Italian architectural scene since the Second World War but, in the light of the events of the last 40 years, he is also a character who, in his own right, is a corner- stone of the varied architectural thought of the peninsula. The projects of the Roman architect, from the ‘60s, far from neo-religionism, neo-liberty, neo-rationalism and other architectural trends that unfolded in those years, show us a very particular way of doing architecture characterized by a sort of apparent linguistic contradiction that instead finds its structure in a unitary and coherent thought in which there are references to other artist…

Pressure-Driven Symmetry-Preserving Phase Transitions in Co(IO3)2

2021

[EN] High-pressure synchrotron X-ray diffraction studies of cobalt iodate, Co(IO3)(2), reveal a counterintuitive pressure-induced expansion along certain crystallographic directions. High-pressure Raman and infrared spectroscopy, combined with density-functional theory calculations, reveal that with increasing pressure, it becomes energetically favorable for certain I-O bonds to increase in length over the full range of pressure studied up to 28 GPa. This phenomenon is driven by the high-pressure behavior of iodate ion lone electron pairs. Two pressure-induced isosymmetric monoclinic-monoclinic phase transitions are observed at around 3.0 and 9.0 GPa, which are characterized by increasing o…

Differences in Technical Development and Playing Space in Three UEFA Champions Leagues

2021

[Abstract] The analysis of football grows exponentially, with many researchers adopting it as an object of study. The thematic range that addresses it, as well as the different methodologies used, are of a very different nature—physical, psychological, technical, tactical—enriching every day the knowledge, and understanding of the game itself. The objective of this study has been to identify the differences between the different styles of play that lead to becoming the champion of the UEFA Champions League in the last 3 years of the pre-COVID stage, by analyzing the spatial performance developed, the association between the players that make up the different lines of the game system and the…

Déclaration et vérification des créances. Portée de l'autorité de chose jugée, après résolution d'un plan, de l'admission d'une créance garantie par …

2021

International audience; (Com. 17 févr. 2021, n° 19-20.738, arrêt n° 153 F-P+L, Sté Cooperl Arc Atlantique c/ Me M. ès qual. et a., D. 2021. Actu. 422 ; D. 2021. 835, note B. Ferrari ; Gaz. Pal. 13 avr. 2021, p. 54, note M. Guastella)

Elaboration of a Critical Paradigm for Interpreting Modern Architecture: The Almost Intangible Essence of Luigi Moretti's Casa del Balilla at Trecate

2021

Modern architecture is not, from a lexical point of view, uniquely definable. The heterogeneity of the twentieth century heritage is therefore a collective wealth that should be protected from the risk of falling into oblivion. In order to avoid this, it could prove fundamental to establish a process of the knowledge of these assets. This should not, however, result in a simple and passive recording of architectural facts: a deep understanding of the complexity of modern architecture, which has as its objective the protection of buildings, could be obtained, for example, through a real and proper decoding of signs, conducted by a critical use of the metalanguage most congenial to the archit…

The Colombian geochronological database (CGD)

2021

Geochronological databases are powerful tools for characterizing the crustal evolution and the age spectra of a region and allow comparison with other areas at a regional scale. In this contributio...

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2021

Strength training exercises are essential for rehabilitation, improving our health as well as in sports. For optimal and safe training, educators and trainers in the industry should comprehend exercise form or technique. Currently, there is a lack of tools measuring in-depth skills of strength training experts. In this study, we investigate how data mining methods can be used to identify novel and useful skill patterns from a binary multiple choice questionnaire test designed to measure the knowledge level of strength training experts. A skill test assessing exercise technique expertise and comprehension was answered by 507 fitness professionals with varying backgrounds. A triangulated appr…

Hospital and outpatient models for Hematopoietic Stem Cell Transplantation: A systematic review of comparative studies for health outcomes, experienc…

2021

The number of Hematopoietic Stem Cell Transplantations has risen in the past 20 years. The practice of outpatient Hematopoietic Stem Cell Transplantation programs is increasing in an attempt to improve the quality of patient care and reduce the demand for hospital admission. A systematic review of 29 comparative studies between in-hospital and outpatient treatment of Hematopoietic Stem Cell Transplantation, with no restriction by outpatient regime was conducted. This study aims to analyse the current evidence on the effects of the outpatient model on patient-centred outcomes, comparing both in-hospital and outpatient models for autologous and allogeneic HSCT using the Triple Aim framework: …

Impact of nitrogen doping on the band structure and the charge carrier scattering in monolayer graphene

2021

The addition of nitrogen as a dopant in monolayer graphene is a flexible approach to tune the electronic properties of graphene as required for applications. Here, we investigate the impact of the doping process that adds N dopants and defects on the key electronic properties, such as the mobility, the effective mass, the Berry phase, and the scattering times of the charge carriers. Measurements at low temperatures and magnetic fields up to 9 T show a decrease of the mobility with increasing defect density due to elastic, short-range scattering. At low magnetic fields weak localization indicates an inelastic contribution depending on both defects and dopants. Analysis of the effective mass …

Network Analysis of Persistent Somatic Symptoms in Two Clinical Patient Samples

2021

OBJECTIVE Previous attempts to group persistent somatic symptoms (PSS) with factor-analytic approaches have obtained heterogeneous results. An alternative approach that seems to be more suitable is the network theory. Compared to factor analysis, which focuses on the underlying factor of symptoms, network analysis focuses on the dynamic relationships and interactions among different symptoms. The main aim of this study is to apply the network approach to examine the heterogeneous structure of PSS within two clinical samples. METHODS The first dataset consisted of N = 254 outpatients who were part of a multicentre study. The second dataset included N = 574 inpatients, both with somatoform di…

Structure of SNX9 SH3 in complex with a viral ligand reveals the molecular basis of its unique specificity for alanine-containing class I SH3 motifs

2021

Class I SH3 domain-binding motifs generally comply with the consensus sequence [R/K]x0PxxP, the hydrophobic residue 0 being proline or leucine. We have studied the unusual 0 = Ala-specificity of SNX9 SH3 by determining its complex structure with a peptide present in eastern equine encephalitis virus (EEEV) nsP3. The structure revealed the length and composition of the n-Src loop as important factors determining specificity. We also compared the affinities of EEEV nsP3 peptide, its mutants, and cellular ligands to SNX9 SH3. These data suggest that nsP3 has evolved to minimize reduction of conformational entropy upon binding, hence acquiring stronger affinity, enabling takeover of SNX9. The R…

Déclaration et vérification des créances. Décision d'admission d'une créance au passif de la liquidation judiciaire d'une société civile. Absence d'i…

2021

International audience; (Com. 20 janv. 2021, n° 19-13.539, arrêt n° 59 F-P+I, Caisse régionale de Crédit Agricole mutuel du Languedoc c/ Mme M. J. et a., D. 2021. 132 ; Rev. sociétés 2021. 201, obs. L. C. Henry ; JCP 2021. 184 ; JCP E 2021. 1191, n° 11, obs. Ph. Pétel ; BJS 2021. 59, note F.-X. Lucas)

Engineered axon tracts within tubular biohybrid scaffolds

2021

[EN] Injuries to the nervous system that involve the disruption of axonal pathways are devastating to the individual and require specific tissue engineering strategies. Here we analyse a cells-biomaterials strategy to overcome the obstacles limiting axon regeneration in vivo, based on the combination of a hyaluronic acid (HA) single-channel tubular conduit filled with poly-L-lactide acid (PLA) fibres in its lumen, with pre-cultured Schwann cells (SCs) as cells supportive of axon extension. The HA conduit and PLA fibres sustain the proliferation of SC, which enhance axon growth acting as a feeder layer and growth factor pumps. The parallel unidirectional ensemble formed by PLA fibres and SC …

Déclaration et vérification des créances. Déclaration par une délégation de pouvoir irrégulière. Modalités de ratification par le créancier

2021

International audience; (Com. 10 mars 2021, n° 19-22.385, arrêt n° 278 FS- P, Caisse régionale de Crédit Agricole mutuel du Centre Ouest c/ M.A.G.D. et a., D. 2021. 572 ; JCP 2021. 229)

Déclaration et vérification des créances. Créancier inscrit à qui est inopposable la déclaration d'insaisissabilité d'un immeuble. Faculté de déclare…

2021

International audience; (Com. 24 mars 2021, n° 19-23.413, arrêt n° 270 F-P, Caisse d'épargne et de prévoyance Normandie c/ M.M.K., D. 2021. Actu. 694)

NAD+ Precursors and Antioxidants for the Treatment of Amyotrophic Lateral Sclerosis

2021

Charcot first described amyotrophic lateral sclerosis (ALS) between 1865 and 1874 as a sporadic adult disease resulting from the idiopathic progressive degeneration of the motor neuronal system, resulting in rapid, progressive, and generalized muscle weakness and atrophy. There is no cure for ALS and no proven therapy to prevent it or reverse its course. There are two drugs specifically approved for the treatment of ALS, riluzol and edaravone, and many others have already been tested or are following clinical trials. However, at the present moment, we still cannot glimpse a true breakthrough in the treatment of this devastating disease. Nevertheless, our understanding of the pathophysiology…

Cotisation foncière des entreprises. Créance postérieure privilégiée née pour les besoins du déroulement de la procédure

2021

International audience; (Com. 24 mars 2021, n° 20-13.832, arrêt n° 258 F-P, Comptable chargé du recouvrement des impôts des entreprises de Rennes Est c/ Sté MMJ, ès qual., D. 2021. 694)

Transposon-insertion Sequencing as a Tool to Elucidate Bacterial Colonization Factors in a <em>Burkholderia gladioli</em> Symbiont of &lt…

2021

Inferring the function of genes by manipulating their activity is an essential tool for understanding the genetic underpinnings of most biological processes. Advances in molecular microbiology have seen the emergence of diverse mutagenesis techniques for the manipulation of genes. Among them, transposon-insertion sequencing (Tn-seq) is a valuable tool to simultaneously assess the functionality of many candidate genes in an untargeted way. The technique has been key to identify molecular mechanisms for the colonization of eukaryotic hosts in several pathogenic microbes and a few beneficial symbionts. Here, Tn-seq is established as a method to identify colonization factors in a mutualistic Bu…

Grit, Self-Efficacy, Motivation and the Readiness to Change Index Toward Exercise in the Adult Population.

2021

This study examined the relationships between grit personality, self-efficacy, motivation (autonomous, controlled, and amotivation), and the readiness to change index toward exercise. Participants were 391 adults aged between 18 and 64 years old (M= 31.16;SD= 12.45) from Hermosillo, Sonora (Mexico) who completed questionnaires (i.e., the Grit Personality Scale, the Exercise Self-Efficacy Questionnaire, the Treatment Self-Regulation Questionnaire and the Stages of Change Questionnaire for Physical Activity) measuring the variables of interest. The reliability of the instruments was tested using Cronbach's alpha, whereas confirmatory factor analyses were performed for each instrument separate…

The influence of calculation method and relative strength on the load-velocity relationship in bench press exercise

2021

Purpose The objective of this study was: (1) to compare the effect of the calculation method using average (Avalue), and best value (Bvalue) of Mean Propulsive Velocity (MPV) on the Load Velocity Profile (LVprofile) during the barbell bench press exercise in elite handball players. In addition, (2) to analyze the relationship between the individual coefficient of variation (CVind) of an incremental load protocol in the bench press exercise with relative strength (Frel) in professional handball players. Methods Nineteen elite international handball players (age 18 [±1] y; body mass 93 [±14] kg; height 191 [±6] cm) performed an incremental test during the barbell bench press exercise. General…

Regulation of NADPH oxidase-mediated superoxide production by acetylation and deacetylation

2021

Oral treatment of apolipoprotein E-knockout (ApoE-KO) mice with the putative sirtuin 1 (SIRT1) activator resveratrol led to a reduction of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity in the heart. In contrast, the SIRT1 inhibitor EX527 enhanced the superoxide production in isolated human polymorphonuclear granulocytes. In human monocytic THP-1 cells, phorbol ester-stimulated superoxide production was enhanced by inhibitors of histone deacetylases (HDACs; including quisinostat, trichostatin A (TSA), PCI34051, and tubastatin A) and decreased by inhibitors of histone acetyltransferases [such as garcinol, curcumin, and histone acetyltransferase (HAT) Inhibitor II]. Thes…

Revendication par un affactureur du prix de revente d'un bien vendu avec réserve de propriété. Autorité de chose jugée de la décision statuant sur la…

2021

International audience; (Com. 9 déc. 2020, n° 19-16.542, arrêt n° 827 FS-P+B, Sté Factofrance c/ Sté Tech Data France et a., D. 2021. 4 ; Rev. sociétés 2021. 208, obs. F. Reille ; Gaz. Pal. 13 avr. 2021, p. 73, note E. Le Corre-Broly ; APC 2021. Comm. 24, obs. F. Petit)

Durch den eisernen Vorhang: Die Ära Brandt und das Ende des Kalten Kriegs, by Gottfried Niedhart

2021

Déclaration et vérification des créances. Admission des créances fiscales dans les conditions prévues par le Livre des procédures fiscales

2021

International audience; (Com. 3 févr. 2021, n° 19-20.683, arrêt n° 95 F-P, Mme V. B. et a. c/ Comptable public du pôle recouvrement spécialisé de la Marne, D. 2021. 284 ; JCP 2021. 182 ; JCP E 2021. 1191, n° 12, obs. A. Tehrani)

Monoscopic Photogrammetry to Investigate the Buildings in the Period of Modernism in Salerno: The Case Study of Torquato Tasso High School

2021

The city of Salerno and the expansion that underwent in the 1920s in order to respond to the urban expansion following the demographic increase that occurred at the beginning of the century will be the topics discussed in this paper. Transformations that created a face to the city that, in its forms, although not linked to the most advanced avant-garde, represent a testimony of the new characteristics of the “modern” city. Within this evolutionary process of the province of Salerno there is the 1928 project of two engineers, Michele and his son Luigi De Angelis for the construction of the “Regio” School. In a first moment, several projects found in the archives refer mainly to the various l…

Female gender and low physical activity are risk factors for academic stress in incoming nursing students.

2021

PURPOSE Nursing students suffer from stress more frequently than other students. The objective was to analyze the academic stressors that most affect new nursing students. DESIGN AND METHODS A cross-sectional study on new nursing students. FINDINGS Two hundred and eighty-two students, 78% women, mean age of 21.46 (6.1) years. Giving presentations in class and lack of time for homework are the items that cause the greatest academic stress. Women had higher levels of academic stress, and higher levels of physical activity are related to lower academic stress. PRACTICE IMPLICATIONS Women have a higher level of academic stress. Doing sport is a protective factor that diminishes academic stress …

Maison Particulière. Graphic Reading and Virtual Reconstruction

2021

De Stijl, a modern and avant-garde movement of the early twentieth century, is considered the link between the pre-1914 avant-garde and the post-1918 International Style. The name derives from the magazine founded in 1917 and used for the promotion of the ideals ofNeoplasticism, theorised by Theo VanDoesburg. In 1924 Van Doesburg published the essay Tot een beeldende architectuur in which he explained a 16 points manifesto on the neoplastic vision of modern architecture. The analysis of the drawings and contra-constructions and the comparative reading of all the original drawings allowed for a series of graphic interpretations, which made the project understandable. This interpretative-reco…

Data-Driven Pump Scheduling for Cost Minimization in Water Networks

2021

Pumps consume a significant amount of energy in a water distribution network (WDN). With the emergence of dynamic energy cost, the pump scheduling as per user demand is a computationally challenging task. Computing the decision variables of pump scheduling relies over mixed integer optimization (MIO) formulations. However, MIO formulations are NP-hard in general and solving such problems is inefficient in terms of computation time and memory. Moreover, the computational complexity of solving such MIO formulations increases exponentially with the size of the WDN. As an alternative, we propose a data-driven approach to estimate the decision variables of pump scheduling using deep neural netwo…

Physiotherapy Students’ Experiences about Ethical Situations Encountered in Clinical Practices

2021

(1) Background: It is important to explore the ethical situations that physiotherapy students encountered in their clinical practices. (2) Methods: Qualitative, explorative, descriptive study. The participants included third-year physiotherapy students. They had to write five narratives about ethical situations encountered in their clinical practices. Krippendorff's method for qualitative content analysis was used to cluster units within the data to identify emergent themes. The study protocol was approved by the authors' University Ethic Committee of Human Research (H1515588244257). (3) Result: 280 narratives were reported by 64 students (23.34 ± 4.20 years, 59% women). Eight categories we…

Family Firm Heterogeneity and Tax Aggressiveness: A Quasi-Experimental Analysis of the Impact of Different Family Generations

2021

This paper analyses tax aggressiveness in family firm generations. Moreover, taking into account the heterogeneity in family firms, we check whether the successive generations in control show different tax avoidance behaviour. The empirical evidence, based on the quasi-experiment of the 2012 Spanish thin capitalization rule, reveals that there is a positive relationship between tax aggressiveness and successive generations. Moreover, the founder and second generations follow a similar conservative tax avoidance approach, whereas the third and fourth generations are found to be more tax aggressive.

The Symmetry and Predictive Factors in Two-Stage Bilateral Hip Replacement Procedures

2021

Background: Approximately 10–25% of total hip replacement patients undergo a bilateral procedure. The purpose of this study was to compare selected parameters associated with the first and second hip arthroplasty in patients undergoing two-stage treatment due to bilateral hip osteoarthritis and establish the predictive factors for the second procedure. Methods: This study compared the data on bilateral total hip replacement surgeries conducted in the period between 2017 and 2021 (42 patients). The following parameters from the first and second procedure were compared: the prosthetic stem, head, and insert cup size

Autonomic, hormonal, and subjective responses to a modified version of the TSST: a pilot study

2021

El objetivo de esta investigación fue estudiar las respuestas hormonales, autonómicas y afectivas a una versión modificada del estresor TSST en una muestra de jóvenes universitarios compuesta de treinta y ocho sujetos (11 hombres y veintisiete mujeres, 11 en la fase lútea del ciclo menstrual, 16 mujeres en la fase folicular). La respuesta hormonal se evaluó con niveles de cortisol. La frecuencia cardíaca y la actividad electrodérmica se registraron durante toda la sesión experimental y la ansiedad rasgo y estado se evaluaron antes y después de la tarea. La fase de discurso provocó la frecuencia cardíaca más alta, la mayor frecuencia de respuestas inespecíficas y el mayor nivel de conductanc…

Heading at Enabling Settings for Learning

2021

The paper draws on two cases of learning settings that were converted to meet up-to-date educational requirements within these learning contexts. The authors address the role of stakeholder perspectives. Focusing on the learning situation, they present an articulation tool to aid dialogue between key stakeholder perspectives in a (re)design process. Dialogue is a way to figure out relevant issues and to establish the common ground between participants. The goal of a redesign process is that user requirements are well understood, and the design is embedded into local practices, informed of constraints and aware of potential opportunities regarding educational technology.