showing 36 of ~574560 from 574555 documents
The global forest above-ground biomass pool for 2010 estimated from high-resolution satellite observations
2021
Funding Information: We are thankful to the GlobBiomass project team and Frank Martin Seifert (ESA) for valuable suggestions and stimulating scientific discussions. We are thankful to Takeo Tadono (JAXA EORC), Masato Hayashi, (JAXA EORC), Kazufumi Kobayashi (RESTEC), Åke Rosenqvist (soloEO), and Josef Kellndorfer (EBD) for support with the use and interpretation of the ALOS PALSAR mosaics. Support by the CCI Land Cover project team, in particular Sophie Bontemps (UCL), is greatly acknowledged. The help from Martin Jung (MPI-BGC) in feature selection and Ulrich Weber (MPI-BGC) for data processing for the GSV-to-AGB conversions is greatly acknowledged. Forest inventory data for the validation…
Robotic-assisted minimally invasive esophagectomy (RAMIE) for esophageal cancer training curriculum—a worldwide Delphi consensus study
2021
Summary Background Structured training protocols can safely improve skills prior initiating complex surgical procedures such as robotic-assisted minimally invasive esophagectomy (RAMIE). As no consensus on a training curriculum for RAMIE has been established so far it is our aim to define a protocol for RAMIE with the Delphi consensus methodology. Methods Fourteen worldwide RAMIE experts were defined and were enrolled in this Delphi consensus project. An expert panel was created and three Delphi rounds were performed starting December 2019. Items required for RAMIE included, but were not limited to, virtual reality simulation, wet-lab training, proctoring, and continued monitoring and educa…
Quality-preserving low-cost probabilistic 3D denoising with applications to Computed Tomography
2021
AbstractWe propose a pipeline for a synthetic generation of personalized Computer Tomography (CT) images, with a radiation exposure evaluation and a lifetime attributable risk (LAR) assessment. We perform a patient-specific performance evaluation for a broad range of denoising algorithms (including the most popular Deep Learning denoising approaches, wavelets-based methods, methods based on Mumford-Shah denoising etc.), focusing both on accessing the capability to reduce the patient-specific CT-induced LAR and on computational cost scalability. We introduce a parallel probabilistic Mumford-Shah denoising model (PMS), showing that it markedly-outperforms the compared common denoising methods…
The Indeterminacy of Precedent : Negotiating the Admissibility of Victim Participant Testimony before the International Criminal Court
2021
Abstract The icc represents a legal laboratory that is still consolidating itself, with multiple unclarities in evidence and procedural law requiring resolution through jurisprudence. Our paper draws on interaction analysis to unpack this process, focusing on the jurisprudential construction of ‘dual status’ victim participant testimony. To elucidate how this evidentiary/procedural element is locally negotiated, we examine an excerpt from the Ongwen hearing transcripts, in which the defense objects against the testimony by a dual status witness called by the victim participants’ legal representative. The analysis traces how the defense counsel’s objection is anchored in a trajectory of prio…
Fluorovinylsulfones and -Sulfonates as Potent Covalent Reversible Inhibitors of the Trypanosomal Cysteine Protease Rhodesain: Structure–Activity Rela…
2021
Rhodesain is a major cysteine protease of Trypanosoma brucei rhodesiense, a pathogen causing Human African Trypanosomiasis, and a validated drug target. Recently, we reported the development of α-halovinylsulfones as a new class of covalent reversible cysteine protease inhibitors. Here, α-fluorovinylsulfones/-sulfonates were optimized for rhodesain based on molecular modeling approaches. 2d, the most potent and selective inhibitor in the series, shows a single-digit nanomolar affinity and high selectivity toward mammalian cathepsins B and L. Enzymatic dilution assays and MS experiments indicate that 2d is a slow-tight binder (Ki = 3 nM). Furthermore, the nonfluorinated 2d-(H) shows favorabl…
Una revisión sistemática acerca del reconocimiento facial de las emociones en la Enfermedad de Alzheimer: una perspectiva evolutiva y de género
2021
La correcta identificación de las emociones básicas (alegría, miedo, asco, tristeza, sorpresa e ira) desempeñan un importante papel en las relaciones sociales y conductas ligadas a la propia supervivencia. En la Enfermedad de Alzheimer (EA) la capacidad de reconocimiento emocional podría estar ya alterada en fases iniciales. Por ello, el objetivo principal del presente trabajo fue realizar una revisión sistemática de la literatura acerca del reconocimiento facial en personas con EA, identificando posibles variables moduladoras. Se realizó una búsqueda en las bases de datos Web of Science y PsycINFO. Después de aplicar los criterios de inclusión-exclusión se seleccionaron un total de 28 artí…
Impact of the environmental taxes on reduction of emission from transport in Latvia
2021
Transport has a significant contribution to climate change and many post-Soviet republics, including Latvia, struggle to decrease these emissions to reach carbon neutrality by 2050. In this paper, ...
Physiotherapy Students’ Experiences about Ethical Situations Encountered in Clinical Practices
2021
(1) Background: It is important to explore the ethical situations that physiotherapy students encountered in their clinical practices. (2) Methods: Qualitative, explorative, descriptive study. The participants included third-year physiotherapy students. They had to write five narratives about ethical situations encountered in their clinical practices. Krippendorff's method for qualitative content analysis was used to cluster units within the data to identify emergent themes. The study protocol was approved by the authors' University Ethic Committee of Human Research (H1515588244257). (3) Result: 280 narratives were reported by 64 students (23.34 ± 4.20 years, 59% women). Eight categories we…
Evolución de la colaboración científica en la Psicología española entre 1970 y 1989
2021
El objetivo de la presente investigación es analizar la evolución de la colaboración científica en la psicología española a través de trabajos firmados por un autor o autora perteneciente a una institución española de psicología entre 1970 y 1989. Se analizaron un total de 2891 trabajos publicados en 29 revistas de psicología entre los años 1970 y 1989, analizando la colaboración científica a través del estudio de redes mediante el programa UCINET y el software Netdraw. Los resultados indican que a lo largo de los años se produce un aumento del número de trabajos, autores y firmas, así como de la colaboración científica, siendo en el periodo entre 1985 y 1989 cuando los trabajos en coautorí…
Nota editorial. Introducción al tema monográfico “Cerebro y conducta: un enfoque neurocientífico/psicofisiológico”, en honor y recuerdo del Prof. Jes…
2021
Nota editorial en la que se presenta el monográfico y se hace un breve comentario de los artículos que lo componen Editorial note in which the special theme is presented and a brief comment is made on the articles that compose it.
Nekrolog Göran Hammarström (9. April 1922 – 15. Dezember 2019)
2021
Am 15. Dezember 2019 verstarb in Melbourne im Alter von 97 Jahren der Schwede Goran Hammarstrom. Mit ihm verliert die Sprachwissenschaft einen bedeutenden Linguisten des 20. Jahrhunderts. Hammarstr...
Learning to survive amidst nested crises: can the coronavirus pandemic help us change educational practices to prepare for the impending eco-crisis?
2021
The ongoing ecological crisis and the more recent Coronavirus crisis challenge the grand narrative of Enlightenment that human beings are ‘masters of nature’. For millennia, human social learning has allowed Homo sapiens to outpace most of our competitor creatures and live a comfortable life, but this competitive success has resulted in cataclysmic failure for the ecosystem. However, people’s unique ability to learn gives us hope that we can overcome the nested crises, or learn to live with them. What is required is not more knowledge, but instead, collective learning to change practices, institutionalized in educational processes. Drawing on the theory of practice architectures, this paper…
The relationship between fear of COVID-19 and intention to get vaccinated. The serial mediation roles of existential anxiety and conspiracy beliefs
2021
Abstract Today, we witness the progress toward global COVID-19 vaccinations organized by countries worldwide. Experts say a mass vaccination plan is the only effective antidote against the spread of SARS-COV-2. However, a part of the world population refuses vaccination. The present study aimed to understand the impact of some individual variables on the intention to get vaccinated. Through a serial mediation model, we tested the influence of fear of COVID-19 on the intention to get vaccinated and the serial mediating effect of existential anxiety and conspiracy beliefs. Via a cross-sectional design this research was conducted with the participation of 223 French adults (Female: 69.5%; Male…
Respuesta cardiovascular al estrés en pacientes con epilepsia farmacorresistente: datos preliminares
2021
El estrés es un factor de riesgo para las enfermedades cardiovasculares en la población general. La epilepsia se ha considerado un modelo adecuado de estrés crónico, con mayor incidencia de mortalidad cardiovascular que la población general. Este estudio proporciona datos preliminares sobre la respuesta cardiovascular ante un estresor cognitivo y una evaluación neuropsicológica en pacientes con epilepsia, explorando las relaciones entre la respuesta cardiovascular y el rendimiento cognitivo dependiendo del hemisferio responsable de la epilepsia. Treinta y cinco pacientes con epilepsia farmacorresistente, 17 con el área epileptógena(AE) en el hemisferio izquierdo (LH) y 18 con AE en el hemis…
How do early family systems predict emotion recognition in middle childhood?
2021
Facial emotion recognition (FER) is a fundamental element in human interaction. It begins to develop soon after birth and is important in achieving developmental tasks of middle childhood, such as developing mutual friendships and acquiring social rules of peer groups. Despite its importance, FER research during middle childhood continues to be rather limited. Moreover, research is ambiguous on how the quality of one's early social-emotional environment shapes FER development, and longitudinal studies spanning from infancy to later development are scarce. In this study, we examine how the cohesive, authoritarian, disengaged and enmeshed family system types, assessed during pregnancy and inf…
Verbal fluency in school-aged Spanish children: analysis of clustering and switching organizational strategies, employing different semantic categori…
2021
La tarea de fluidez verbal (FV) es una medida de la flexibilidad cognitiva y la estrategia de búsqueda dentro del léxico y el tema semántico. En este trabajo, se probó el uso de estrategias organizativas, es decir, agrupación y cambio en la fluidez semántica y fonológica en niños españoles sanos divididos en dos grupos: el grupo 1 de niños más pequeños (de 8 a 9 años) y el grupo 2 de niños mayores (de 10 años de edad) –11) introducción de diferentes letras (F, A, S y P, M, R) y categorías semánticas (animales y comidas o bebidas). La fluidez semántica fue mayor que la fluidez fonológica en ambos grupos de edad. Además, los niños mayores mostraron un mejor desempeño de ambas fluencias que lo…
Modeling and Performance Assessment of the Split-Pi Used as a Storage Converter in All the Possible DC Microgrid Scenarios. Part I: Theoretical Analy…
2021
The integration of an electrical storage system (ESS) into a DC microgrid using a bidirectional DC/DC converter provides substantial benefits but requires careful design. Among such converter topologies, the Split-pi converter presents several merits at the cost of non-isolated operation. However, the few works in the literature on the Split-pi presented only closed-loop control with a single control loop; furthermore, they neglected the reactive components’ parasitic resistances and did not perform any experimental validation. This work aimed at investigating the use of the Split-pi converter as a power interface between an ESS and a DC microgrid. Five typical microgrid scenarios are prese…
The Role of Statins on Helicobacter pylori Eradication: Results from the European Registry on the Management of H. pylori (Hp-EuReg)
2021
Statins could increase the effectiveness of Helicobacter pylori eradication therapies due to their anti-inflammatory effect. The aim of this study was to analyze the impact of this therapeutic association in real life. This is a multicenter, prospective, non-interventional study aimed at evaluating the management of H. pylori by European gastroenterologists. Patients were registered in an e-CRF by AEG-REDCap from 2013 to 2020. The association between statin use and H. pylori eradication effectiveness was evaluated through multivariate analysis. Overall, 9988 and 705 patients received empirical and culture-guided treatment, respectively. Overall, statin use was associated with higher effecti…
Magnetic Control over the Fractal Dimension of Supramolecular Rod Networks
2021
<p>Controlling supramolecular polymerization is of fundamental importance to create advanced materials and devices. Here we show that the thermodynamic equilibrium of Gd<sup>3+</sup>-bearing supramolecular rod networks is shifted reversibly at room temperature in a static magnetic field of up to 2 T. Our approach opens opportunities to control the structure formation of other supramolecular or coordination polymers that contain paramagnetic ions.</p>
false
2021
Data collected in criminal investigations may suffer from issues like: (i) incompleteness, due to the covert nature of criminal organizations; (ii) incorrectness, caused by either unintentional data collection errors or intentional deception by criminals; (iii) inconsistency, when the same information is collected into law enforcement databases multiple times, or in different formats. In this paper we analyze nine real criminal networks of different nature (i.e., Mafia networks, criminal street gangs and terrorist organizations) in order to quantify the impact of incomplete data, and to determine which network type is most affected by it. The networks are firstly pruned using two specific m…
Ansiedad social subclínica en adultos jóvenes sanos: cortisol y ansiedad subjetiva en respuesta a estrés agudo
2021
No existe consenso sobre el patrón de liberación de cortisol y su relación con la ansiedad subjetiva en situaciones de estrés en población con ansiedad social. Nuestro objetivo fue determinar la respuesta de cortisol y ansiedad subjetiva en individuos con ansiedad social sometidos a un estresor psicosocial agudo. 26 universitarios (58.6% hombres), edad media = 21.62 ± 0.43, fueron expuestos a la versión estrés o control del Maastricht Acute Stress Test. El cortisol salival y la ansiedad subjetiva fueron medidos antes, durante y post-estrés. Los participantes mostraron un incremento en los niveles de cortisol durante las fases de estrés y post-estrés, con una respuesta significativamente may…
Autonomic, hormonal, and subjective responses to a modified version of the TSST: a pilot study
2021
El objetivo de esta investigación fue estudiar las respuestas hormonales, autonómicas y afectivas a una versión modificada del estresor TSST en una muestra de jóvenes universitarios compuesta de treinta y ocho sujetos (11 hombres y veintisiete mujeres, 11 en la fase lútea del ciclo menstrual, 16 mujeres en la fase folicular). La respuesta hormonal se evaluó con niveles de cortisol. La frecuencia cardíaca y la actividad electrodérmica se registraron durante toda la sesión experimental y la ansiedad rasgo y estado se evaluaron antes y después de la tarea. La fase de discurso provocó la frecuencia cardíaca más alta, la mayor frecuencia de respuestas inespecíficas y el mayor nivel de conductanc…
Novel Porous Carbon Material for the Detection of Traces of Volatile Organic Compounds in Indoor Air
2021
International audience; A highly sensitive and selective silicon-based microanalytical prototype was used to identify a few ppb of volatile organic compounds (VOCs) in indoor air. Herein, a new nonactivated tannin-derived carbon synthesized by an environmentally friendly method, DM2C, a MIL-101(Cr) MOF, and a DaY zeolite were selected for the preconcentration of BTEX compounds (i.e., benzene, toluene, ethylbenzene, and xylenes). Integrating a small amount of these nanoporous solids inside a miniaturized preconcentration unit led to excellent preconcentration performance. By taking advantage of the high adsorption−desorption capacities of the DM2C adsorbent, concentrations as low as 23.5, 30…
Prognostic value of Thyroid Transcription Factor-1 expression in lung adenocarcinoma in patients treated with anti PD-1/PD-L1.
2021
ABSTRACT Anti-PD1/PD-L1-directed immune checkpoint inhibitors are game changers in advanced non-small-cell lung cancer, but biomarkers are lacking. The aim of our study was to find clinically relevant biomarkers of the efficacy of ICI in non-squamous NSCLC. We conducted a retrospective study of patients receiving ICI for advanced non squamous NSCLC in two cohorts. For a subset of patients, RNAseq data were generated on tumor biopsy taken before ICI. The primary end point was progression-free survival under ICI. Secondary end point was overall survival from ICI initiation. In the cohort, we studied 231 patients. Clinico-pathological characteristics included KRAS mutant status (n = 88), TTF1-…
Sex-specific anesthesia via olfactory receptor inhibition in Drosophila
2021
International audience
Mucin induces CRISPR-Cas defence in an opportunistic pathogen
2021
AbstractParasitism by bacteriophages has led to the evolution of a variety of defense mechanisms in their host bacteria. However, it is unclear what factors lead to specific defenses being deployed upon phage infection. To explore this question, we exposed the bacterial fish pathogenFlavobacterium columnareto its virulent phage V156 in the presence of a eukaryotic host signal (mucin). All tested conditions led to some level of innate immunity, but the presence of mucin led to a dramatic increase in CRISPR spacer acquisition, especially in low nutrient conditions where over 60% of colonies had obtained at least one new spacer. Additionally, we show that the presence of a competitor bacterium…
So close yet so far: the disjunct global range of Orthotrichum consobrinum (Orthotrichaceae) includes North America
2021
Integrated longitudinal immunophenotypic, transcriptional, and repertoire analyses delineate immune responses in patients with COVID-19
2021
To understand how a protective immune response against SARS-CoV-2 develops over time, we integrated phenotypic, transcriptional and repertoire analyses on PBMCs from mild and severe COVID-19 patients during and after infection, and compared them to healthy donors (HD). A type I IFN-response signature marked all the immune populations from severe patients during the infection. Humoral immunity was dominated by IgG production primarily against the RBD and N proteins, with neutralizing antibody titers increasing post infection and with disease severity. Memory B cells, including an atypical FCRL5+ T-BET+ memory subset, increased during the infection, especially in patients with mild disease. A…
A Single-Center (Sibiu, Romania), Retrospective Study (March–November 2020) of COVID-19 Clinical and Epidemiological Features in Children
2021
The aim of this study was to describe and analyze epidemiological and clinical features of children screened for COVID-19 at Sibiu Pediatric Clinical Hospital during the first 9 months (March–November) of coronavirus disease pandemic in Romania. A total of 203 pediatric patients with a confirmed diagnosis of COVID-19 were included in the study. The median age of the patients was 121 (IQR 18–181) months and 52.22% had mild clinical type with pneumonia, 35.47% were moderate cases, 3.94% severe cases, 0.99% critically ill cases and 7.39% were asymptomatic. The most common symptoms were fever (n = 130, 64.03%), nasal congestion (n = 138, 67.98%), cough (n = 128, 63.05%) followed by sore throat …
false
2021
The Depressive and Anxious Avoidance in Prolonged Grief Questionnaire (DAAPGQ) was developed to measure depressive and anxious avoidance behaviors, which, according to cognitive-behavioral models, are supposed to play an important role in the development and maintenance of prolonged grief. The present study aimed to develop a German version of the DAAPGQ and evaluate its psychometric properties and validity within a representative sample of the German general population (N = 2531). The German-language DAAPGQ was developed using a forward-backward translation procedure. Then, a subsample of individuals who reported having lost a significant other (N = 1371) of a representative sample was ass…
Molecular chaperones and mirnas in epilepsy: Pathogenic implications and therapeutic prospects
2021
Epilepsy is a pathologic condition with high prevalence and devastating consequences for the patient and its entourage. Means for accurate diagnosis of type, patient monitoring for predicting seizures and follow up, and efficacious treatment are desperately needed. To improve this adverse outcome, miRNAs and the chaperone system (CS) are promising targets to understand pathogenic mechanisms and for developing theranostics applications. miRNAs implicated in conditions known or suspected to favor seizures such as neuroinflammation, to promote epileptic tolerance and neuronal survival, to regulate seizures, and others showing variations in expression levels related to seizures are promising ca…
The Treatment of Medication-Related Osteonecrosis of the Jaw (MRONJ): A Systematic Review with a Pooled Analysis of Only Surgery versus Combined Prot…
2021
Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse reaction of antiresorptive and antiangiogenic agents, and it is also a potentially painful and debilitating condition. To date, no specific studies have prospectively evaluated the efficacy of its treatment and no robust standard of care has been established. Therefore, a systematic review (2007–2020) with a pooled analysis was performed in order to compare MRONJ surgical techniques (conservative or aggressive) versus combined surgical procedures (surgery plus a non-invasive procedure), where 1137 patients were included in the pooled analysis. A statistically significant difference in the 6-month improvement rate, comp…
Electrical conductivity of glass fiber-reinforced plastic with nanomodified matrix for damage diagnostic
2021
The electrical conductivity of glass fiber-reinforced plastic (GFRP) with epoxy matrix modified by multiwall carbon nanotubes (MWCNT) was studied. The electrical conductivity of nanomodified lamina and multi-layered GFRP was investigated on several levels using a structural approach. Components of the electrical conductivity tensor for unidirectional-reinforced monolayer were calculated similarly as in micromechanics using the conductivity of the nanomodified matrix. The electrical conductivity of multilayer composite was calculated using laminate theory and compared with values measured experimentally for various fiber orientation angles. Calculated and experimental data were in good agree…
Inclusive heavy-flavour production at central and forward rapidity in Xe–Xe collisions at √sNN = 5.44 TeV
2021
The first measurements of the production of muons and electrons from heavy-flavour hadron decays in Xe–Xe collisions at sNN=5.44 TeV, using the ALICE detector at the LHC, are reported. The measurement of the nuclear modification factor RAA is performed as a function of transverse momentum pT in several centrality classes at forward rapidity (2.5<y<4) and midrapidity (|y|<0.8) for muons and electrons from heavy-flavour hadron decays, respectively. A suppression by a factor up to about 2.5 compared to the binary-scaled pp reference is observed in central collisions at both central and forward rapidities. The RAA of muons from heavy-flavour hadron decays is compared to previous measurements in…
The equal collective gains value in cooperative games
2021
AbstractThe property of equal collective gains means that each player should obtain the same benefit from the cooperation of the other players in the game. We show that this property jointly with efficiency characterize a new solution, called the equal collective gains value (ECG-value). We introduce a new class of games, the average productivity games, for which the ECG-value is an imputation. For a better understanding of the new value, we also provide four alternative characterizations of it, and a negotiation model that supports it in subgame perfect equilibrium.